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| Number | Title | Issue Date |
| 8034774 | Compositions and methods for counteracting effects of reactive oxygen species and free radicals Peptide compounds and methods for upregulating expression of a gene encoding an antioxidative enzyme, such as superoxide dismutase or catalase, to counteract harmful oxidative effects of reactive oxygen species and other free radicals are described. The peptide comp... | 10/11/2011 |
| 8034773 | Immunostimulatory compositions and uses thereof The present invention provides novel immuno-stimulatory polypeptides, and methods for their use and identification. ... | 10/11/2011 |
| 7919465 | Peptide mimotopes that inhibits interaction between a platelet receptor and a platelet receptor ligand It is provided mimotope receptors and inhibitors that employ peptide mimics that mimic the shape and function of natural receptors and ligands, thus providing synthetic binding sites for ligands and receptors. Receptor mimics can be attached to carriers, such as lip... | 04/05/2011 |
| 7888323 | Potent compstatin analogs Compounds comprising peptides and peptidomimetics capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved complement activation-inhibitory activity as compared with currently available compounds.... | 02/15/2011 |
| 7863247 | Prevention of fetal alcohol syndrome and neuronal cell death with ADNF polypeptides The invention relates to methods for reducing a condition associated with fetal alcohol syndrome in a subject who is exposed to alcohol in utero with an ADNF polypeptide (e.g, ADNF I polypeptides, ADNF III polypeptides, or mixtures of ADNF I and ADNF III polypeptide... | 01/04/2011 |
| 7855179 | Template-fixed peptidomimetics with antimicrobial activity Template-fixed β-hairpin peptidomimetics of the general formula (I), wherein Z is a template-fixed chain of 12 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly or Pro, or of certain ty... | 12/21/2010 |
| 7851445 | Angiogenic heparin-binding epitopes, peptide amphiphiles, self-assembled compositions and related methods of use Peptide amphiphiles and related compositions comprising sulfated polysaccharides, such as but not limited to sulfated glycosaminoglycans, and methods of use relating to the encapsulation and/or controlled release of angiogenic growth factor(s). ... | 12/14/2010 |
| 7851444 | χ-conotoxin peptides (-1) An isolated, synthetic or recombinant χ-conotoxin peptide comprising the following sequence of amino acids: Xaa1 Xaa2 Gly Val Cys Cys Gly Tyr Lys Leu Cys His Pro Cys SEQ ID NO. 3 where Xaa1 is a N-terminal Xaa1 is a N-terminal pyroglutamate (pGlu) or D-pyroglutamat... | 12/14/2010 |
| 7842670 | Cosmetic and pharmaceutical compounds for inducing the synthesis of SIRT proteins in skin and methods of use thereof A cosmetic dermo-pharmaceutical, or dermatological composition having as an active agent in an acceptable cosmetic or pharmaceutical medium, at least one compound able to activate the synthesis or SIRT proteins in skin cells. ... | 11/30/2010 |
| 7838496 | Template-fixed peptidomimetics as medicaments against HIV and cancer Template-fixed β-hairpin peptidomimetics of the General Formula (I); wherein Z1 and Z2 are template-fixed chains of 4 and 6 or 5 and 7 α-amino acid residues and salts thereof. They have CXCR4-antagonizing properties and can be used as medicam... | 11/23/2010 |
| 7833983 | Analytical method and kit thereof The present invention relates to a peptide comprising a symmetrical dimethylated arginine, and constitute an immunologic determinant of antibodies present in sera from patients with systemic lupus erythematosus (SLE), and wherein the methylation is a prerequisite fo... | 11/16/2010 |
| 7816324 | Composition and method for the treatment of diseases affected by a peptide receptor The present invention includes peptidomimetic compound compositions and methods of making and using peptidomimetic compounds to modulate the activity of a peptide receptor for the treatment of one or more of hyperglycemia, insulin resistance, hyperinsulinemia, obesi... | 10/19/2010 |
| 7811993 | Methods and compositions for treating melanoma Novel BRAFV600E mutant peptides or a pharmaceutically acceptable salt thereof, that induce MHC Class I-dependent cytotoxic T cell responses in mammals are useful in prophylactic, diagnostic and therapeutic treatments for melanoma. Such compounds are also ... | 10/12/2010 |
| 7795220 | Conformationally constrained parathyroid hormones with alpha-helix stabilizers The present invention relates to conformationally constrained parathyroid hormone (PTH) analogs and derivatives of those analogs. The invention also provides methods of preparing and using the PTH analogs. Further, the invention encompasses compositions and methods ... | 09/14/2010 |
| 7795221 | Linear natriuretic peptide constructs Linear constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues and at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z... | 09/14/2010 |
| 7790687 | Treatment for neurodegeneration Polypeptides which are an N- and/or C-terminally truncated fragment of the human osteopontin (hOPN) sequence or species variant, and which minimally have a 15 amino acid sequence corresponding to amino acids 138 to 152 of hOPN, and polynucleotides encoding said poly... | 09/07/2010 |
| 7790686 | Injection solution of an LHRH antagonist An aqueous injectable solution of an LHRH antagonist, such as Cetrorelix, in an organic, pharmaceutically acceptable acid, such as gluconic acid. ... | 09/07/2010 |
| 7772188 | Methods and compositions for the treatment of gastrointestinal disorders The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogas... | 08/10/2010 |
| 7772187 | Substances directed against a specific sequence essential for heparanase catalytic activity and uses thereof as heparanase inhibitors An amino acid sequence derived from the N′ terminus region of the 50 Kd subunit of heparanase, preferably, the sequence including amino acid residues Lys158-Asn171 of human heparanase and any functional fragments thereof. Compositions for the... | 08/10/2010 |
| 7763586 | Melanoma antigens and their use in diagnostic and therapeutic methods The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, asses... | 07/27/2010 |
| 7745408 | Method of inducing melanogenesis in humans with MC1R variant alleles A method for inducing melanogenesis in a human subject having a melanocortin 1 receptor (MC1R) variant allele associated with loss of or diminished receptor function comprises administering to said subject an amount of an α-melanocyte stimulating hormone (α-MSH) a... | 06/29/2010 |
| 7745409 | Methods and compositions for the treatment of gastrointestinal disorders The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's di... | 06/29/2010 |
| 7741288 | Methods of screening of PP1-interacting polypeptides or proteins, peptides inhibiting PP1c binding to Bcl-2 proteins, Bcl-xand Bcl-w, and uses thereof The present invention relates to methods for identifying novel PP1-interacting polypeptides and proteins, compounds which are able to inhibit the binding of PP1c to certain factors naturally interacting with it, especially proteins of the Bcl-2 family (such as BCl-x... | 06/22/2010 |
| 7737119 | Cosmetic or pharmaceutical composition comprising peptides, uses and treatment processes The present invention has as an aim a cosmetic and/or dermatological and/or pharmaceutical composition comprising, as an active ingredient, at least a peptide of sequence X1-Y-Phe-Thr-X2-Ala-Thr-Z-Ile-X3-Leu-X4-Phe-Leu-X | 06/15/2010 |
| 7671025 | Neurotensin receptor agonists and opioid receptor agonists This document provides methods and materials for treating pain. For example, this document provides methods that involve administering a neurotensin receptor (NTR) agonist and an opioid receptor agonist to a mammal (e.g., a human). Compositions containing an NTR ago... | 03/02/2010 |
| 7666841 | Peptides with the capacity to bind to transforming growth factor β1 (TGF-β1) The described peptides possess the capacity to bind to Transforming Growth Factor TGF-β1 (TGF-β1), and are potential inhibitors of the biological activity of TGF-β1 through direct binding to this cytokine. These peptides can be used in the treatment of diseases o... | 02/23/2010 |
| 7645740 | Peptide sequence found in Laminin 5 for treating skin impairments Peptide of sequence TALRIRATYGEY (SEQ ID NO: 1) present on the gamma 2 chain of Laminin 5, a pharmaceutical composition containing the peptide and to the use of the composition for treating various skin alterations. More particularly, the treatment of the alteration... | 01/12/2010 |
| 7632817 | Peptide decoys for the preparation of medicaments intended for the prevention or treatment of autoimmune pathologies or disorders linked to the appearance of antibodies directed against exogenous proteins Peptide or pseudopeptide decoys binding to antibodies capable of being developed against endogenous proteins within the framework of autoimmune pathologies or against exogenous proteins administered to patients, in particular within the framework of pathologies due ... | 12/15/2009 |
| 7608589 | Peptidyl diacylglycerides Peptide and peptides that may be covalently linked to a lipid and methods of using such peptides and lipopeptides to prevent or treat disease are disclosed herein. ... | 10/27/2009 |
| 7595298 | Polypeptides having anti-HIV activity and compositions comprising same The present invention relates to a polypeptide represented by the formula: A1-Arg-A2-Cys-Tyr-A3-A4-X-A5-A6-Cit-Cys-A7 (I) (wherein A1 represents a hydrogen atom or an arginine, lysine, ornithine, citrulline, alanine residue, etc.; A2 represe... | 09/29/2009 |
| 7589063 | Molecules which promote hematopoiesis Peptides, methods for the preparation thereof, medicaments containing the peptides, and their use in selected indications, such as the treatment of various forms of anemia and stroke. ... | 09/15/2009 |
| 7585843 | Treatment of demyelinating autoimmune disease with modified ordered peptides Compositions and methods are provided for the treatment or prevention of autoimmune disease. Therapeutic doses of one or more modified therapeutic ordered peptide(s) comprising amino acids representing a consensus sequence of a protein identified as a target of the ... | 09/08/2009 |
| 7582610 | Melanocortin receptor templates, peptides and use thereof The present invention relates to novel chimeric peptides and templates containing a combination of antagonist and agonist endogenous ligand residues. In particular, the present invention relates to novel chimeric peptides and templates thereof based upon melanocorti... | 09/01/2009 |
| 7582609 | Method for the treatment of skin fibrosis and suitable compositions for such treatment A Method for the treatment of skin fibrosis with a peptide that inhibits TGF-β, and suitable compositions for its administration. The method includes in particular, the use of peptide P144, a compound that is a known inhibitor of TGF-β, for the treatment of skin f... | 09/01/2009 |
| 7563771 | Synthetic single domain polypeptides mimicking apolipoprotein E The present invention is directed to a synthetic apolipoprotein-E mimicking polypeptide consisting of a single domain. The invention is also directed to nucleic acid encoding the polypeptide, vectors including the nucleic acid, antibodies specific for the polypeptid... | 07/21/2009 |
| 7550436 | Compositions containing peptide and electrolyte excretion promoter and foods containing the same A composition containing a peptide and an electrolyte excretion promoter, which comprises a peptide or a peptide mixture which is obtained by lysing a food-origin protein with a protease and has an activity of inhibiting angiotensin converting enzyme, and one or mor... | 06/23/2009 |
| 7547677 | Plant virus transmission inhibitor and methods Provided is a peptide, peptide multimer or fusion protein containing such peptide which binds to the gut of sap-sucking insects, e.g., aphids. When bound, this peptide inhibits the binding of targeted virus to the insect gut. When this peptide or tandem repeat pepti... | 06/16/2009 |
| 7531515 | Peptides selectively lethal to malignant and transformed mammalian cells The present invention provides peptides corresponding to all or a portion of amino acid residues 12-26 of human p53 protein, which peptides are lethal to malignant or transformed cells when fused to a membrane-penetrating leader sequence. The subject peptides are th... | 05/12/2009 |
| 7524819 | Compositions and methods for counteracting effects of reactive oxygen species and free radicals Peptide compounds and methods for upregulating expression of a gene encoding an antioxidative enzyme, such as superoxide dismutase or catalase, to counteract harmful oxidative effects of reactive oxygen species and other free radicals are described. The peptide comp... | 04/28/2009 |
| 7514407 | Spheron component peptides and pharmaceutical compositions The present invention relates to racemized proteins and racemized protein components of spherons that are useful for identifying compounds capable of preventing and/or ameliorating symptoms of Alzheimer's Disease and/or dementia associated with cerebral amyloidosis.... | 04/07/2009 |
