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| Number | Title | Issue Date |
| 7786098 | Fluoroalkoxycombretastatin derivatives, method for producing the same and use thereof Combretastatin derivatives of formula (I), preparation and use thereof are disclosed, wherein: Rf is alkyl with 1-8 carbon atoms and 1-17 fluorine atoms, R is amino, substituted amino, hydroxyl, nitro, halo, alkyloxy, phosphate or amino acid side chain. S... | 08/31/2010 |
| 7659262 | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di-amino acid salts, and mono- and di-amino acid ester salts Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a r... | 02/09/2010 |
| 7659261 | Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a r... | 02/09/2010 |
| 7572778 | Fluorocombretastatin and derivatives thereof The present invention is related to new derivatives of Combretastatin, of Formula obtained by total synthesis. The strategy developed for each of the compounds is to i) replace a halogen (i.e. fluorine atom) to hydrogen on ... | 08/11/2009 |
| 7557096 | Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof Combretastatin A-4 has been previously selected for pre-clinical development as antineoplastic agent. However, it is essentially insoluble in water. New water soluble derivatives of combretastatin A-4 and its qualified analogs have been discovered and synthesized th... | 07/07/2009 |
| 7524832 | Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts and mono-and di-amino acid ester salts Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a r... | 04/28/2009 |
| 7358236 | Control of acute hypertension and cardiotoxicity in patients treated with vascular targeting agents The present invention provides a method of using anti-hypertensive agents (“AHAs”) to attenuate the transient increase in blood pressure observed in patients where Vascular Targeting Agents (“VTAs”) are administered to treat diseases associated with malignan... | 04/15/2008 |
| 7279466 | Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof Combretastatin A-4 has been previously selected for pre-clinical development as antineoplastic agent. However, it is essentially insoluble in water. New water soluble derivatives of combretastatin A-4 and its qualified analogs have been discovered and synthesized th... | 10/09/2007 |
| 7244718 | Water soluble prodrugs of hindered alcohols The present invention is directed to novel water-soluble prodrugs of aliphatic or aromatic hindered hydroxyl group containing pharmaceuticals. ... | 07/17/2007 |
| 7232809 | Mitochondrially targeted antioxidants The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the... | 06/19/2007 |
| 7229978 | Process for preparing water soluble phosphonooxymethyl derivatives of alcohol and phenol A process for making water-soluble phosphonooxymethyl ethers of hindered alcohol and phenol containing pharmaceuticals, such as camptothecin, propofol, etoposide, Vitamin E and Cyclosporin A. In particular, the process for preparing water-soluble phosphonooxymethyl ... | 06/12/2007 |
| 7135502 | Colchinol derivatives as vascular damaging agents The invention relates to the use of compounds of formula (I): wherein X is —C(O)—, —C(S)—, —C═NOH, or —CH(R7)— wherein R7 is hydrogen, hydroxy, C1-7alkoxy, —OR8 or —NR8R9 (wherein ... | 11/14/2006 |
| 7115593 | Fungicidal combinations of active substances The present invention relates to active compound combinations of a fluorobenzo-thiazole of the formula (I) and at least one of the compounds listed herein. The active compound combinations of the present inventio... | 10/03/2006 |
| 7105501 | Compositions with vascular damaging activity Compositions for the inhibition of the formation of new vaculature by angiogenesis are provided as in compounds which are salts comprising as an acidic component a compound of formula (1) wherein: R1, R2 and R3 are each independently... | 09/12/2006 |
| 7094773 | LTAhydrolase inhibitors The invention relates to compounds which constitute a class of medicaments which have an anti-inflammatory activity and which act by inhibiting leukotriene A4 (LTA4), and enzyme which is responsible for the biosynthesis of leukotriene LTB4... | 08/22/2006 |
| 7037906 | Methods for modulating tumor growth and metastasis Methods and pharmaceutical compositions for modulating tumor growth or metastasis are provided. ... | 05/02/2006 |
| 6995139 | Cyclic undecapeptide pro-drugs and uses thereof A pro-drug comprising a cyclic undecapeptide wherein the peptide chain thereof comprises at least one amino acid residue, useful as a medicinal product, including use for treatment of pathological conditions of the eye. ... | 02/07/2006 |
| 6916851 | Skin care cosmetic methods of sebum control using carboxyalkylates of branched alcohols and/or alkoxylates thereof Cosmetic skin care methods of using and process of making carboxyalkylates of branched alcohols and/or alkoxylates thereof and process of making same. The compounds and compositions provide control of sebum secretion from sebocytes, improved oil control and improved... | 07/12/2005 |
| 6855702 | Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a r... | 02/15/2005 |
| 6743784 | Estrogen mimetics lacking reproductive tract effects A method for treating symptoms, diseases and conditions in extra-reproductive tract tissues that are responsive to treatment with estrogen, using triarylethanes of formula (I) wherein R1 is —O(CH2... | 06/01/2004 |
| 6670344 | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable prod... | 12/30/2003 |
| 6649646 | Insecticidal and miticidal compositions The invention relates to an insecticidal and miticidal composition which contains as active ingredients chlorfenapyr in combination with one or more organophosphoric acid ester-type compounds and to a method for controlling insecticidal or miticidal pests... | 11/18/2003 |
| 6331532 | Mitochondrially targeted antioxidants The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cati... | 12/18/2001 |
| 6323190 | Estrogen mimetics lacking reproductive tract effects A method for treating symptoms, diseases and conditions in extra-reproductive tract tissues that are responsive to treatment with estrogen, using triarylethanes of formula (I) ##STR1## wherein R1 is --O(CH2)m R3... | 11/27/2001 |
| 6204257 | Water soluble prodrugs of hindered alcohols The present invention is directed to novel water-soluble prodrugs of aliphatic or aromatic hindered hydroxyl group containing pharmaceuticals.... | 03/20/2001 |
| 5698541 | 2,4-diphosphonoglutaric acid derivatives, processes for their production and pharmaceutical agents containing these compounds The invention concerns compounds of the general formula I ##STR1## in which R denotes a lower alkyl which can be substituted if desired by hydroxy, alkoxy, amino, dialkylamino, alkylmercapto, alkylsulfinyl, alkanesulfonyl, cycloalkyl, aryl or a heter... | 12/16/1997 |
| 5563129 | Hydroquinone derivatives and intermediates for production thereof There are disclosed novel hydroquinone derivatives of the formula: ##STR1## The derivatives of the formula (I) have various pharmacological activities such as antioxidation in living bodies and are useful as medicaments.... | 10/08/1996 |
| 5561122 | Combretastatin A-4 prodrug Disclosed herein are Combretastatin A-4 Prodrugs, having the general strure set forth below, which are useful in the treatment of one or more neoplastic diseases by means of chemotherapy. ##STR1##... | 10/01/1996 |
| 5525480 | N- and O-substituted aminophenols, method and use for diagnosis The present invention provides N- and O-substituted aminophenol derivatives of the general formula ##STR1## wherein R1, R2, R3, G and L are as hereinbefore defined. The present invention also provides intermediates fo... | 06/11/1996 |
| 5504073 | PLA2 inhibitors and their use for inhibition of intestinal cholesterol absorption Certain compounds have been synthesized and found to be effective inhibitors of phospholipase A2 (PLA2), and thereby useful in the treatment of intestinal cholesterol absorption and the disease states arising therefrom, such as hyper... | 04/02/1996 |
| 5441983 | Treatment of infection by enveloped virus with calix(N)arene compounds A method for inhibiting cell infection by an enveloped virus, by administering to an infection site, a therapeutically effective amount of a calix(n)arene compound derivatized, at its ring positions meta to the bridge attachements to the ring, with polar ... | 08/15/1995 |
| 5242908 | Use of benzylphosphonic acid derivatives for the treatment of diseases caused by viruses The use of a compound of the formula I ##STR1## in which V is an alkyl group, fluorine, chlorine, bromine, or iodine, n is an integer from 1 to 5, W is an alkyl, alkenyl, alkynyl or alkoxy group, cyanide, nitro, carboxyl, hydrogen or a cycloalkyl, ar... | 09/07/1993 |
| 5015635 | Pesticidal S-(halogenoalkyl)-dithiophosphoric(phosphonic) acid esters Pesticidal S-(halogenoalkyl)-dithiophosphoric (phosphonic) acid esters of the formula ##STR1## in which R1 represents an optionally substituted radical from the group consisting of alkyl, alkenyl, alkoxy, alkenyloxy and alkinyloxy, R2... | 05/14/1991 |
| 4992429 | Novel HMG-COA reductase inhibitors Disclosed are novel substituted cyclohexenyl phosphinylhydroxybutyrates as 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula: ##STR1## and pharmaceutically acceptable salts... | 02/12/1991 |
| 4946834 | Phosphonic acid substituted steroids as steroid 5-reductase inhibitors Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-reductase. Also invented are intermediates used in prepari... | 08/07/1990 |
| 4937237 | Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase Invented are phosphinic acid substituted analogues of steroidal synthetic compounds, pharamaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5--reductase, including using these compounds to r... | 06/26/1990 |
| 4933329 | Bis-S-alkylbenzene derivatives Novel bis-S-alkylbenzene derivatives capable of inhibiting lipoxygenase, inparticular, 5-lipoxygenase are disclosed. It is expected that the compounds, which are hardly metabolized in vivo, are highly useful in the treatment and/or prevention of various d... | 06/12/1990 |
| 4882319 | Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5--reductase Invented are phosphonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5--reductase, including using these compounds to re... | 11/21/1989 |
| 4835192 | Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor Compounds having the formula ##STR1## R1 is hydrogen, benzyl or alkanoyl, X is C2-4 alkylene; and Z-W is alkyl, phenylalkyl or pyridylalkyl which can have an oxygen atom as part of the alkyl chain and their use as CNS agents, antidia... | 05/30/1989 |
| 4731385 | Insecticidal and fungicidal composition for agricultural and horticultural use An insecticidal and fungicidal composition comprising (1) An insecticidally effective amount of a nitromethylene derivative of the formula ##STR1## in which X is a lower alkyl group, a lower alkoxy group, or a halogen atom, n is 0, 1 or 2 and m is 2 ... | 03/15/1988 |
