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| Number | Title | Issue Date |
| 8017579 | Treatment of viral infections The present invention relates to polypeptides, and derivatives or analogues thereof, comprising a tandem repeat of apolipoprotein B, or a truncation thereof, derived from an HSPG receptor binding region of apolipoprotein B. Such peptides are useful for treating or p... | 09/13/2011 |
| 8003609 | Method for ameliorating pain by modification of NMDA receptors through inhibition of Src The present invention provides a method for ameliorating inflammatory and/or neuropathic pain in a subject by modifying the activity of N-methyl-D-aspartate (NMDA) receptors in cells of the subject by inhibition of the interaction of the unique domain of the tyrosin... | 08/23/2011 |
| 7919464 | Use of a peptide that interacts with αvβ3 integrin of endothelial cell The present invention relates to the use of a peptide that interacts with the αvβ3 integrin of endothelial cells. More particularly, the invention relates to a method for inhibiting endothelial cell adhesion, endothelial cell migration and/or angiogenesis, using a... | 04/05/2011 |
| 7915223 | Antimicrobial agents A novel class of antimicrobial polymeric agents, which include a plurality of amino acid residues, such as positively charged amino acid residues, and at least one hydrophobic residue linking therebetween, such as an omega-amino-fatty acid residue, designed to exert... | 03/29/2011 |
| 7906484 | Complex for transferring an anionic substance into a cell The present invention relates to compositions and methods for the delivery of an anionic substance using complexes, comprising the anionic substance and a peptide. These complexes are useful for delivering said anionic substance into a cell, particularly in therapeu... | 03/15/2011 |
| 7902153 | Alpha-conotoxin peptides The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably i... | 03/08/2011 |
| 7897572 | Theraputic methods for type I diabetes The invention relates to the treatment and prevention of type I diabetes. More specifically, the invention relates to compounds that treat or prevent the body's immune system from destroying β-cells (i.e., insulin-producing cells in the pancreatic islets of Langerh... | 03/01/2011 |
| 7884074 | Compounds and methods for prevention and/or treatment of inflammation using the same The invention is directed to compounds and methods for prevention and/or treatment of inflammation using the same. ... | 02/08/2011 |
| 7879802 | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in com... | 02/01/2011 |
| 7867976 | Nogo epitopic fragments for modulating immune response Epitopic fragments of Nogo, including Nogo 45-66, elicit a specific and strong T cell response, and a B cell response. T cells reactive to Nogo antigens are capable of ameliorating ongoing disease, which may be induced with other antigens. The present invention prov... | 01/11/2011 |
| 7858585 | Hydrogels and uses thereof The present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in solution. Such self-assembly may be brought about by a change in one or mor... | 12/28/2010 |
| 7833982 | Methods of treating dermal ulcers with thrombin derived peptides Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated t... | 11/16/2010 |
| 7811992 | Anti-infarction molecules Disclosed are compositions and methods for treating ischemia and molecules related to hibernation states. FPA molecules having the sequence set forth in SEQ ID NO: 2 can be used for as anti-infarction agents. ... | 10/12/2010 |
| 7807645 | Method of treating degenerative disorders of the nervous system by administration of fibrinogen fragment The invention herein related to methods and compositions for treating nervous system disorders. The methods comprise peptides that bind to receptors important in disease progression, thus attenuating the disease. ... | 10/05/2010 |
| 7754690 | Method of using retro inverso peptides derived from leukemia inhibitory factor The invention provides methods of treatment using retro-inverso peptides derived from leukemia inhibitory factor (LIF) having between 18 and about 40 amino acids and including the sequence that is retro-inverso with respect to SEQ ID NO: 1. The peptides of the inven... | 07/13/2010 |
| 7749966 | Immunological modulation of insulin-like growth factor 1 for cancer prevention/treatment and prolonging longevity Provided is a simple and safe immunization procedure to reduce cancer incidence and increase longevity by modulating IGF-1 levels in the body. Described are cancer preventive vaccines and methods that elicit circulating antibodies specific to insulin-like growth fac... | 07/06/2010 |
| 7749967 | Peptides of a melanoma antigen and their use in diagnostic, prophylactic, and therapeutic methods Immunogenic peptides of a melanoma antigen recognized by T cells, designated gp100, bioassays using the peptides to diagnose, assess or prognose a mammal afflicted with cancer, more specifically melanoma or metastatic melanoma, and use of the proteins and peptides a... | 07/06/2010 |
| 7737118 | Rotational intrathecal analgesia A method of producing analgesia in a mammal is provided by rotational (alternating) intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor agonist, such as a μ-, δ-, or κ-opioid receptor agonist for a first p... | 06/15/2010 |
| 7732411 | Methods of therapy with thrombin derived peptides The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative peptide and/or inhibiting or reducing vascular occlusion or restenosi... | 06/08/2010 |
| 7723303 | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response This invention provides novel active agents (e.g. peptides, small organic molecules, amino acid pairs, etc.) peptides that ameliorate one or more symptoms of atherosclerosis and/or other pathologies characterized by an inflammatory response. In certain embodiment, t... | 05/25/2010 |
| 7718618 | Human cathelicidin antimicrobial peptides Provided are peptide and peptide consensus sequences, which inhibit bacterial growth and/or viral growth and mimic the activity of LL-37, CRAMP, and/or FALL-39. The peptides are useful as antimicrobials, anti-inflammatories and anti-viral agents. ... | 05/18/2010 |
| 7713934 | Thrombin peptide derivatives Disclosed are thrombin peptide derivatives comprising a polypeptide having the amino acid sequence SEQ ID NO. 2: Arg-Gly-Asp-Ala-Xaa-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val, or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Xaa is al... | 05/11/2010 |
| 7713935 | Compounds that modulate TRH actions The invention relates to compounds that inhibit thyrotropin-releasing hormone (TRH) degrading ectoenzyme and/or enhance, and/or mimic the biological actions of TRH. The compounds find therapeutic application, particularly in conditions involving neuronal cell injury... | 05/11/2010 |
| 7704953 | Phage displayed cell binding peptides The present disclosure relates to the construction, expression, and selection of genes that encode novel Trp cage polypeptides with desirable cell and/or tissue binding properties, as well as the novel Trp cage polypeptides themselves. A polypeptide of this disclosu... | 04/27/2010 |
| 7674771 | Antimicrobial peptides and utilization of the same Antimicrobial peptide provided by present invention is an artificially designed antimicrobial peptide that does not occur naturally, and includes a sequence composed of at least 6 contiguous amino acid residues selected from an amino acid sequence constituting lamin... | 03/09/2010 |
| 7674772 | Compositions and methods for treating atherosclerosis Reverse peptides and mimetics of a mammalian serum amyloid A isoform 2.1 (SAA2.1) domain or a portion thereof and compositions and pharmaceutical compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity. Methods of... | 03/09/2010 |
| 7666839 | Methods of treatment using specific binding agents of human angiopoietin-2 Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies. ... | 02/23/2010 |
| 7666840 | α-Conotoxin peptides The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably i... | 02/23/2010 |
| 7662782 | Melanocortin 1 receptor selective compounds The invention relates to methods of treatment comprising administering a compound of the general formula (1): to a patient or a healthy individual. ... | 02/16/2010 |
| 7659251 | Ligand for G-protein coupled receptor FPRL2 The present invention relates to methods, reagents and kits for detecting of formyl peptide receptor like-2 (FPRL2) polypeptide activity in a sample and identifying agents which modulate polypeptide activity. It further relates to antibodies raised against FPRL2. It... | 02/09/2010 |
| 7655629 | Peptides and their use for the treatment of HIV infections The invention relates to peptides with biological activity against infection having the amino acid sequence Z1-LE-X1-IP-X2-X3-X4-P-X5-X6-X7-X8-X9-X10 | 02/02/2010 |
| 7642244 | Neuropeptide-2 receptor (Y-2R) agonists and uses thereof Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification.... | 01/05/2010 |
| 7635681 | Cell-permeable peptide inhibitors of the JNK signal transduction pathway The invention provides cell-permeable peptides that selectively block the branch of the JNK signaling pathway controlled by the islet-brain (IB) proteins. The provided cell-permeable peptides block the binding of intermediate kinases in the c-Jun amino terminal kina... | 12/22/2009 |
| 7632816 | Treatment of Alzheimer amyloid deposition The present invention is directed to a method of preventing or treating Alzheimer's Disease or of inhibiting accumulation of amyloid-β deposits in a subject by administering to the subject an agent which inhibits interaction between amyloid-β and proteins which ch... | 12/15/2009 |
| 7629317 | Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived fr... | 12/08/2009 |
| 7615534 | Antimicrobial peptides and use thereof Artificially synthesized antimicrobial peptide that does not occur naturally is provided by the present invention. The antimicrobial peptide includes one unit, two units or more units of amino acid sequence composed of the following 8 amino acid residues: | 11/10/2009 |
| 7612044 | Melanoma antigens and their use in diagnostic and therapeutic methods The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, asses... | 11/03/2009 |
| 7595297 | Method of reducing injury to mammalian cells A method of inhibiting the binding between N-methyl-D-aspartate receptors and neuronal proteins in a neuron the method comprising administering to the neuron an effective inhibiting amount of a peptide replacement agent for the NMDA receptor or neuronal protein inte... | 09/29/2009 |
| 7592315 | Peptide viral entry inhibitors The present invention provides, inter alia, peptide compositions and methods for treating and preventing Flaviviridae virus (e.g., hepatitis C virus) infections. ... | 09/22/2009 |
| 7589062 | Two synthetic peptides for treatment and prevention of cancers Two synthetic peptides, Atroporin (AT) and Kaotree (KT), each consisting of ten amino acids and their use for the treatment and/or prevention of various types of cancers is disclosed. The amino acid sequence from the N-terminal for AT is Phe-Cys-Arg-Phe-Leu-Leu-Cys-... | 09/15/2009 |
