Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 7858576 | Method for targeting lysosomal enzymes Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subc... | 12/28/2010 |
| 7304162 | Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding dom... | 12/04/2007 |
| 7192905 | Organophosphate insecticide synergists for fly and tick control Combination of a cytochrome P450 monooxygenase inducer with an organophosphate pesticide (insecticide or acaracide) provides effective control of ticks and flies, particularly against organophosphate-resistant strains of the ticks and flies. In use, a pesticidally e... | 03/20/2007 |
| 7009054 | Quinolines and uses thereof This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use. ... | 03/07/2006 |
| 6649646 | Insecticidal and miticidal compositions The invention relates to an insecticidal and miticidal composition which contains as active ingredients chlorfenapyr in combination with one or more organophosphoric acid ester-type compounds and to a method for controlling insecticidal or miticidal pests... | 11/18/2003 |
| 6498151 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. ##STR1## The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated d... | 12/24/2002 |
| 6235727 | Sulfonylaminophosphinic and sulfonylaminophosphinic acid derivatives, methods for their preparation and use Compounds of the formula I ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading enzymes is involved.... | 05/22/2001 |
| 6110904 | Synergistic nematocidal compositions A method for suppressing plant damage by nematodes which comprises the concurrent administration, to the locus, soil or seeds of plants in need of such treatment, of (a) a metabolite of the fungus Myrothecium verrucaria and (b) a chemical pesticide, as we... | 08/29/2000 |
| 6083917 | Methods and compositions for the identification, characterization and inhibition of farnesyltransferase Disclosed are methods and compositions for the identification, characterization and inhibition of mammalian protein farnesyltransferases, enzymes involved in the farnesylation of various cellular proteins, including cancer related ras proteins such as p21... | 07/04/2000 |
| 5919816 | Formulations and methods of reducing toxicity of antineoplastic agents This invention provides for pharmaceutical formulations of compounds which are useful as protective agents when administered to patients also receiving antineoplastic drugs. The invention also includes methods of reducing the toxicity of various antineopl... | 07/06/1999 |
| 5525597 | Synergistic insecticidal compositions comprising capsicum and insecticidal use thereof Insecticidal compositions, comprising normally-employed insecticides but comprising also an effective activity-enhancing amount of capsaicin or other capsaicinoid, especially in the form of capsicum, exhibit synergistic effects against numerous insects, i... | 06/11/1996 |
| 5504073 | PLA2 inhibitors and their use for inhibition of intestinal cholesterol absorption Certain compounds have been synthesized and found to be effective inhibitors of phospholipase A2 (PLA2), and thereby useful in the treatment of intestinal cholesterol absorption and the disease states arising therefrom, such as hyper... | 04/02/1996 |
| 5189062 | Plant protecting agent ULV plant protecting arthropodicidal formulation comprising alkyl aryl polyglycol ether as further additives in addition to the active ingredient(s) dissolved in the mixture of alphatic hydrocarbons and sunflower oil. The formulation according to the inve... | 02/23/1993 |
| 5100667 | Process for pelletizing insecticidal N-hydrocarboyl phosphoroamidothioates and phosphoroamidodithioates A method of making, without use of a solvent, insecticidal pellet compositions of N-hydrocarboyl phosphoroamidothioates and phosphoroamidodithioates is provided.... | 03/31/1992 |
| 5064813 | Combination therapy for selected sex steroid dependent cancers A combination therapy for treatment of selected sex steroid dependent cancers in susceptible warm-blooded animals comprising administering to such animals whose hormone output of their testes or ovaries, respectively, is blocked a therapeutically effectiv... | 11/12/1991 |
| 4992429 | Novel HMG-COA reductase inhibitors Disclosed are novel substituted cyclohexenyl phosphinylhydroxybutyrates as 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula: ##STR1## and pharmaceutically acceptable salts... | 02/12/1991 |
| 4965256 | Flubenzimine containing agents for combating pests The foregoing invention relates to new soil pest combating agents which contain at least one conventional active agent, especially a carbamate, P-esters (phosphoric and phosphonic acid esters, including esteramides, as well as corresponding thiono-, thiol... | 10/23/1990 |
| 4965254 | Agents for combating pests The present invention relates to the use of the sulphenic acid amides of the general formula (I) ##STR1## in which X represents identical or different halogen atoms, Y1 and Y2 are identical or different and represent hydrogen, h... | 10/23/1990 |
| 4965255 | Carboximide containing agents for combating pests The foregoing invention relates to new soil pest combating agents which can be used in plant protection for combating nematodes and arthropods, especially insects, and which contain at least one conventional active agent, especially a carbamate, P ester (... | 10/23/1990 |
| 4873081 | Percutaneous absorption preparation A percutaneous absorption preparation which comprises calcium salt of an acidic anti-inflammatory or analgesic drug having carboxyl group as the active ingredient and present in an amount of 0.3-10% by weight; a medium for the active ingredient which is s... | 10/10/1989 |
| 4847067 | Mold and dust inhibiting product and method A mold and dust inhibiting composition which has particular utility in connection with the storage and handling of animal feeds, grains, and hay, and also in connection with the use of animal litter such as poultry litter, as well as having general utilit... | 07/11/1989 |
| 4824663 | Biocidal macroemulsions containing polyvinyl alcohol The present invention relates to new macroemulsions which contain 0.001 to 60 percent by weight of at least one active compound from the class comprising the phosphates and/or carbamates, 0 to 50 percent by weight of aromatic diluents, 0.001 to 20 percent by weight... | 04/25/1989 |
| 4804654 | Certain N-(R-sulfonyl) phosphonamidothioates and dithioates Compounds of the formula ##STR1## wherein the symbols have assigned meanings, and their use as insecticides and/or miticides.... | 02/14/1989 |
| 4725589 | Insecticidal composition for agricultural and horticultural use A synergistic insecticidal composition comprising a nitromethylene derivative of the formula ##STR1## in which X is a lower alkyl group, a lower alkoxy group or a halogen atom, n is 0, 1 or 2, and m is 2 or 3, and an insecticide which is a carboxylic acid... | 02/16/1988 |
| 4690947 | Synergistic composition for the control of arthropods Arthropodicidal compositions in the form of synergistic combinations of (A) cyano-(4-fluoro-3-phenoxyphenyl)-methyl 3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropanecarboxylate plus (B) O-ethyl-O-[4-(methylthio)-phenyl]-S-propyl phosphorodithioate, (A) plus... | 09/01/1987 |
| 4683225 | O-(substituted) benzyl dithiophosphonate insecticides Compounds having the formula ##STR1## in which R1 is methyl or ethyl; R2 is C1 -C6 alkyl; R3 is halogen, C1 -C4 alkyl, trifluoromethyl, thio-(C1 -C4 al... | 07/28/1987 |
| 4656163 | Compositions and methods of combating pests employing sulphenic acid amides in combination with known nematicides or insecticides The present invention relates to the use of the sulphenic acid amides of the general formula (I) ##STR1## in which X represents identical or different halogen atoms, Y1 and Y2 are identical or different and represent hydrogen, h... | 04/07/1987 |
| 4629491 | Oxidized sulfur derivatives of diaminophosphinyl compounds as urease inhibitors and urease inhibited urea based fertilizer compositions The invention relates to novel urease inhibited fertilizer compositions containing urea and a urease inhibiting amount of one or more diaminophosphinyl compounds having oxidized sulfur functions, and methods and composition for inhibiting the activity of ... | 12/16/1986 |
| 4614734 | Pesticidal phosphoroamido(di)thioates This invention relates to phosphoroamidothioate and phosphoroamidodithioate compounds, to compositions thereof which are useful as pesticides, for example, as athropodicides (that is, insecticides and acaricides), nematocides, and fungicides, and to a met... | 09/30/1986 |
| 4607026 | Cyclopropane thiocarboxylic esters and insecticidal and acaricidal use thereof This invention relates to stereoisomeric forms and mixtures thereof of compounds of the formula ##STR1## having insecticidal, nematocidal, and acaricidal properties.... | 08/19/1986 |
| 4588723 | Aminoalkyl-imidazothiadiazole-alkenecarboxylic acid amides, intermediates for their preparation and their use in medicaments The invention relates to aminoalkyl-imidazothiadiazole-alkenecarboxylic acid amides, processes for their preparation, intermediates which are used in their preparation, medicaments containing said active compounds for use as antihypertensive agents, diure... | 05/13/1986 |
| 4581350 | O-(perfluoroalkylthiophenyl) (thio or amido) phosphates as pesticides The invention relates to new organic phosphoric acid esters represented by the general formula ##STR1## wherein X represents O, S or NH, Y represents O or S, R1 represents a lower alkyl group, R2 represents a lower alkyl group or a l... | 04/08/1986 |
| 4576935 | Dihalovinylphenyl phosphates and their use as pesticides Dihalovinylphenyl phosphates of the formula I ##STR1## where A and B are each halogen or trihaloalkyl, X is oxygen or sulfur, Y and Z are each oxygen, sulfur or --NH--, R1 is alkyl, R2 is alkyl, haloalkyl, alkoxyalkyl or alkylth... | 03/18/1986 |
| 4568669 | Cyclopropyl-methyl-(thio)-phosphoric acid amides and their use for controlling pests Cyclopropyl-methyl-(thio)-phosphoric acid amides of the formula ##STR1## where R1, R2, R3, R4, R5 and X have the meanings given in the claims and description, a process for their preparation and ... | 02/04/1986 |
| 4567170 | 3-Chloro-3-phenylprop-2-enyl thiophosphates and their use for controlling pests Thiophosphates of the formula I ##STR1## where R1 is hydrogen, or not more than 4 identical or different substituents R1 may be present, each of which is fluorine, chlorine or bromine, straight-chain or branched alkyl of not mor... | 01/28/1986 |
| 4556650 | Phosphonic acid esters as pesticides This invention relates to novel phosphonic acid esters represented by the following general formula (I) ##STR1## wherein R1 represents a lower alkyl group or an aryl group, R2 represents a lower alkyl group or a lower alkoxy-lower al... | 12/03/1985 |
| 4535076 | Organophosphate pesticides Organophosphate derivatives of the formula ##STR1## in which X is O, S or NH, Y is O or S, R1 is a lower alkyl group, R2 is a lower alkyl group or a lower alkoxy-lower alkyl group, R3 is a fluoro-substituted lower alkyl group, ... | 08/13/1985 |
| 4522817 | Phosphoramidothionates and fungicidal use A fungicidal composition which comprises as an active ingredient a fungicidally effective amount of a phosphoramidothionate of the formula: ##STR1## wherein R1 is a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower c... | 06/11/1985 |
| 4443438 | Insecticidal and/or acaricidal composition exhibiting low toxicity to mammals and fish The present invention relates to insecticidal compositions of low toxicity to fishes and mammals characterized by containing m-(p-bromophenoxy)--cyanolbenzyl trans- or trans-rich-2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropanecarboxylate of the... | 04/17/1984 |
| 4440746 | Granular pesticide composition A granular pesticide composition is prepared by reacting polyvinyl alcohol, pesticide, a borate, and optional filler(s) in water until a gel is formed, drying the gel, and then grinding the product to the desired particle size. The product is then applied... | 04/03/1984 |
