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| Number | Title | Issue Date |
| 7244703 | Pharmaceutical compositions and methods for peptide treatment Compositions and methods for treating a patient with a pharmaceutically active peptide that combines a pharmaceutically active peptide, a permeation enhancer, and a carrier, are disclosed. ... | 07/17/2007 |
| 7238659 | Reducing axon degeneration with proteasome inhibitors Reduced degeneration of an axon predetermined to be subject to degenerative neuropathy in a term patient is effected by contacting the axon in situ with an effective amount of a ubiquitin-proteasome system (UPS) inhibitor sufficient to reduce degeneration of the axo... | 07/03/2007 |
| 7112561 | Pharmaceutical compositions and methods for insulin treatment Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed. ... | 09/26/2006 |
| 7012063 | Reducing axon degeneration with proteasome inhibitors Reduced degeneration of an axon predetermined to be subject to degenerative neuropathy in a term patient is effected by contacting the axon in situ with an effective amount of a ubiquitin-proteasome system (UPS) inhibitor sufficient to reduce degeneration of the axo... | 03/14/2006 |
| 6919322 | Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 07/19/2005 |
| 6762183 | Active substance combinations having insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties. ... | 07/13/2004 |
| 6680308 | Use of organophosphorus compounds for the therapeutic and prophylactic treatment of infections Use of organophosphorus compounds of general Formula (I) ##STR1## for the therapeutic and prophylactic treatment of infections in humans and animals caused by viruses, fungi and parasites.... | 01/20/2004 |
| 6566304 | Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a) to (b) as a soil additive for biologically controlling pla... | 05/20/2003 |
| 6506737 | Antimicrobial phosphonium and sulfonium polyhalide compositions An oxidizing species is described herein as a reaction product through an in situ preparation combining a protonizable phosphorus or sulfur compound, and a halide source at controlled proportions in an aqueous, non-aqueous, gel, aerosol, solid-phase or po... | 01/14/2003 |
| 6486142 | Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) The invention encompasses the novel class of compounds represented by formula I, which are inhibitors of the PTP-1B enzyme. ##STR1## The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases,... | 11/26/2002 |
| 6235727 | Sulfonylaminophosphinic and sulfonylaminophosphinic acid derivatives, methods for their preparation and use Compounds of the formula I ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading enzymes is involved.... | 05/22/2001 |
| 6174874 | Phosphonic acids derivatives as inhibitors of protein tyrosine phosphate 1B (PTP-1B) The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. ##STR1## The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases.... | 01/16/2001 |
| 6083503 | Interleukin-2 stimulated T lymphocyte cell death for the treatment of autoimmune diseases, allergic responses, and graft rejection A method for the treatment or prevention of autoimmune diseases, allergic or atopic disorders, and graft rejection is provided, comprising inducing the death by apoptosis of a subpopulation of T lymphocytes that is capable of causing such diseases, while ... | 07/04/2000 |
| 5972349 | Synthesis of polyribosylribitol phosphate oligosaccharides Polyribosylribitol phosphate oligosaccharides are produced in a multistep process. The compound of the formula: ##STR1## wherein R1 is a first protecting group and R2 is a second protecting group, is coupled to a solid polyethyl... | 10/26/1999 |
| 5709890 | Polyaspartic acid and its analogues in combination with insecticides An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or... | 01/20/1998 |
| 5665715 | Farnesyl:protein transferase inhibitors as anticancer agents The present invention relates to certain inhibitors of farnesyl:protein transferase which are useful as antineoplastic agents.... | 09/09/1997 |
| 5646133 | Polyaspartic acid and its analogues in combination with insecticides An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or... | 07/08/1997 |
| 5643895 | Phosphonoacetic esters and acids as anti-inflammatories Compounds useful in the treatment of inflammation structurally represented as Formula I ##STR1## one of X or Y is H and the other is selected from the group consisting of: ##STR2## or X and Y are taken together to form a ring selected from the g... | 07/01/1997 |
| 5626881 | Humate dietary supplement Humate, a composition of primarily humic acids, carbon, and organic matter, is used as a human dietary supplement. The humate may be mixed with food, liquid drinks, or flavoring and ingested. The powder, granule, or water-soluble powder form of humate may... | 05/06/1997 |
| 5574025 | Inhibitors of prenyl-protein transferases The compounds disclosed inhibit the prenylation of several proteins. These compounds are potent inhibitors of famesyl-protein transferase and geranylgeranyl-protein transferase. Further contained in this invention are chemotherapeutic compositions contain... | 11/12/1996 |
| 5463181 | Farnesyl: protein transferase inhibitors as anticancer agents The present invention relates to certain inhibitors of farnesyl:protein transferase which are useful as antineoplastic agents.... | 10/31/1995 |
| 5278152 | 2-formylbenzylphosphonic acid derivatives useful for the treatment of diseases caused by viruses The compound of the formula I ##STR1## in which R is an aldehyde group or a group which can be converted into an aldehyde, R1 and R2 are alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, hydrogen, sodium, potassium, calcium, magnesi... | 01/11/1994 |
| 5173482 | Immunosuppressive analogues and derivatives of succinylacetone Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: ##STR1## and that have i... | 12/22/1992 |
| 5007790 | Sustained-release oral drug dosage form Sustained-release oral drug-dosage forms that release drug in solution at a rate controlled by the solubility of the drug are described. The dosage form comprises a tablet or capsule which comprises a plurality of particles of a dispersion of a limited so... | 04/16/1991 |
| 4985413 | Poison bait for control of noxious insects A composition which comprises (a) at least one insecticide selected from the group consisting of organic phosphorous insecticides, carbamate insecticides and pyrethroid insecticide, (b) crystalline cellulose and (c) crop product powders evaporated with (d... | 01/15/1991 |
| 4937237 | Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase Invented are phosphinic acid substituted analogues of steroidal synthetic compounds, pharamaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5--reductase, including using these compounds to r... | 06/26/1990 |
| 4914110 | Quinoline derivatives, their preparation and therapeutic compositions containing the same The invention relates to new quinoline derivatives of the formula: ##STR1## wherein R stands for C2 H5, C2 H4 F, CH2 -O-CH2 -CH2 OH, ##STR2## to a process for their pre... | 04/03/1990 |
| 4882319 | Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5--reductase Invented are phosphonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5--reductase, including using these compounds to re... | 11/21/1989 |
| 4797391 | ((5,6-dichloro-3-oxo-9,9a-d isubstituted-2,3,9,9a-tetrahydrofluoren-7-yl)oxy)alkanoic acids and alkanimidamides The invention relates to novel [(5,6-dichloro-3-oxo-9,9a-disubstituted-2,3,9,9a-tetrahydro-fluoren-7-yl)o xy]alkanoic acids and alkanimidamides, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the ... | 01/10/1989 |
| 4686210 | S-(oxoalkyl)trithiophosphonate insecticides Compounds having the formula ##STR1## in which R1 is methyl or ethyl; R2 is C1 -C6 alkyl; R3 is hydrogen or methyl; and R4 is C1 -C4 alkyl; R3 and R | 08/11/1987 |
| 4659516 | Steroid derivatives A steroid derivative of the formula: wherein ST is a 7-linked steroid nucleus of the general formula: ##STR1## wherein the double bond(s) between carbon atoms 6 and 7 and/or carbon atoms 8 and 9 are optional; wherein the aromatic ring A may optiona... | 04/21/1987 |
| 4636495 | S-phenylacetonyl trithiophosphonate insecticides Compounds having the formula ##STR1## in which R1 is methyl or ethyl; R2 is C1 -C6 alkyl; and R3 is phenyl or substituted phenyl, are insecticides.... | 01/13/1987 |
| 4629491 | Oxidized sulfur derivatives of diaminophosphinyl compounds as urease inhibitors and urease inhibited urea based fertilizer compositions The invention relates to novel urease inhibited fertilizer compositions containing urea and a urease inhibiting amount of one or more diaminophosphinyl compounds having oxidized sulfur functions, and methods and composition for inhibiting the activity of ... | 12/16/1986 |
| 4607026 | Cyclopropane thiocarboxylic esters and insecticidal and acaricidal use thereof This invention relates to stereoisomeric forms and mixtures thereof of compounds of the formula ##STR1## having insecticidal, nematocidal, and acaricidal properties.... | 08/19/1986 |
| 4575500 | Antifungal substances and process for their production There is disclosed a series of macrolides isolated from the fermentation broth of a microorganism identified as MA-5000 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compound's structure is presented based upon ana... | 03/11/1986 |
| 4541858 | Chlorinated phosphorylmethylcarbonyl derivative plant protection agents Novel chlorinated phosphorylmethylcarbonyl derivatives of the formula ##STR1## in which R1 represents an optionally substituted radical from the series comprising alkyl, aryl, aralkyl, alkoxy and aralkoxy and R2 represents an optiona... | 09/17/1985 |
| 4478822 | Drug delivery system utilizing thermosetting gels This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a liquid at room temperature but forms a semi-solid or gel a... | 10/23/1984 |
| 4474753 | Topical drug delivery system utilizing thermosetting gels This invention relates to a unique drug delivery system for application to the skin which drug delivery system is a liquid at room temperature, but when administered topically to the skin becomes a semi-solid or gel when warmed by the body.... | 10/02/1984 |
| 4468389 | Pesticidal N-sulfonyl phosphorodiamido(di)thioates There are disclosed N-sulfonyl phosphorodiamido(di)thioates having pesticidal activity, especially miticidal activity against mites possessing resistance to organophosphorous compounds, when applied to pests or to loci to be freed from the pests by foliar... | 08/28/1984 |
| 4447420 | Fluorenone esters of phosphoric and phosphonic acids as insecticides This invention discloses novel insecticidal chemical compound of the following structural formula: ##STR1## wherein X and Y are each independently selected from the group consisting of halogen, alkyl, haloalkyl, nitro, alkylsulfinyl, alkylsulfonyl an... | 05/08/1984 |
