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A self defense weapon formed as a memo pad and which is easily held by a person's fingers, therefore making it possible to provide protection from a mugger and also to quickly and easily write a record or a message without failure of missing or forgetting significant information under a stressful situation.
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| Number | Title | Issue Date |
| 7403883 | Three-dimensional in-vitro spinal models and methods of analyzing substance distribution therein An in-vitro model apparatus of a human spine and methods for detecting and analyzing substance distribution patterns therein. In one embodiment, the model apparatus includes a column body defining a passageway that substantially mimics the size, shape, and structure... | 07/22/2008 |
| 7015209 | Hair-growing agent A hair-growing agent comprising, as active ingredients, one or more members selected from the group consisting of lysophosphatidic acids, and phosphatidic acids wherein the fatty acid residue moiety consists only of straight-chain fatty acid residues having an even ... | 03/21/2006 |
| 6875886 | Modified PSMA ligands and uses related thereto The instant invention provides reagents and methods for diagnosis, detection and treatment of cancers (for example, prostate cancers). In particular, the invention provides methods to generate various functionalized PSMA ligands, and their uses in diagnosis, detecti... | 04/05/2005 |
| 6806261 | Methods for treating certain diseases using naaladase inhibitors The present invention relates to methods for regulating the release of TGF-β from living cells in vitro or in vivo, comprising bringing the cells into contact with an effective amount of a NAALADase inhibitor. Such methods are believed to be useful for affecting ne... | 10/19/2004 |
| 6762183 | Active substance combinations having insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties. ... | 07/13/2004 |
| 6699902 | Acetyloxymethyl esters and methods for using the same Novel acetyloxymethyl esters are disclosed. Methods of treating an illness, including cancer, hemological disorders and inherited metabolic disorders, and treating or ameliorating other conditions using these compounds are also disclosed. The compounds ar... | 03/02/2004 |
| 6562803 | Hair-growing agent The present invention provides a hair-growing agent comprising, as an active ingredient, a phosphatidic acid represented by formula (I): ##STR1## (wherein R1 represents straight-chain alkyl having an odd number of carbon atoms, straight-chain a... | 05/13/2003 |
| 6444657 | Methods for treating certain diseases using naaladase inhibitors The present invention relates to methods of using NAALADase inhibitors to regulate TGF-ଲ and to treat neurodegenerative disorders, extracellular matrix formation disorders, cell-growth related diseases, infectious diseases, immune related diseases, ... | 09/03/2002 |
| 6440443 | Microencapsulation formulations of cadusafos Pesticidal formulations of cadusafos are provided. An aqueous capsule suspension is provided, containing from about 150 to about 360 grams of cadusafos per liter of formulation and having lower mammalian toxicity than aqueous cadusafos microemulsion formu... | 08/27/2002 |
| 6413948 | Pharmaceutical compositions and methods of effecting a neuronal activity in an animal using naaladase inhibitors The present invention relates to a method of treating a glutamate abnormality and a method of effecting a neuronal activity in an animal using a NAALADase inhibitor, and a pharmaceutical composition comprising an effective amount of a NAALADase inhibitor ... | 07/02/2002 |
| 6395718 | Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors The present disclosure relates to a method of inhibiting angiogenesis comprising administering a N-Acetylated -Linked Acidic Dipeptidase (NAALADase) inhibitor to a patient in need thereof, and a pharmaceutical composition comprising an anti-angioge... | 05/28/2002 |
| 6384022 | Prodrugs of NAALAdase inhibitors The present invention relates to prodrugs of NAALADase inhibitors, pharmaceutical compositions comprising the same, and methods of using the same to treat glutamate abnormalities and prostate diseases.... | 05/07/2002 |
| 6376478 | Pharmaceutical compositions and methods for treating anxiety, anxiety disorders and memory impairment using naaladase inhibitors The present invention relates to pharmaceutical compositions and methods of using NAALADase inhibitors for treating glutamate-mediated diseases, disorders and conditions selected from the group consisting of anxiety, anxiety disorders and memory impairmen... | 04/23/2002 |
| 6288047 | Lipid-based immune modulator composition A method of treating an individual with an immune system with decreased activity by administering an effective amount of a lipid preparation derived from a natural source and enriched to contain at least 10% (w/w) phosphatidic acid (PA) is disclosed.... | 09/11/2001 |
| 6251881 | Method of treating diabetic angiopathy This invention relates to a method of treating patients afflicted with diabetic angiopathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set for... | 06/26/2001 |
| 6174874 | Phosphonic acids derivatives as inhibitors of protein tyrosine phosphate 1B (PTP-1B) The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. ##STR1## The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases.... | 01/16/2001 |
| 6030961 | Oxyalkylene phosphate compounds and uses thereof This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound hearing, treating cutaneous ulcers, treating gastrointestinal disorders, treating b... | 02/29/2000 |
| 5955453 | Membrane-permeant phosphoinositides Membrane-permeant phosphoinositides, including phosphatidylinositol phosphate esters, are described. A membrane-permeant phosphoinositide includes groups that neutralize the charges of the phosphate moieties of the phosphoinositide. A cell can be treated ... | 09/21/1999 |
| 5955452 | Covalent lipid-phosphono-carboxylic acid conjugates and application thereof as antiviral medicaments The present invention concerns new lipid derivatives of phosphonocarboxylic acids of the general formula I, ##STR1## in which the meaning of the symbols is elucidated in the description, tautomers thereof and their physiologically tolerated salts of ... | 09/21/1999 |
| 5939455 | Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives This invention provides a method of augmenting the therapeutic activity of an oxyalkylene-containing compound, butyric acid, a butyric acid salt or butyric acid derivative by administering an inhibitor of ଲ-oxidation of fatty acids to a patient or t... | 08/17/1999 |
| 5908610 | Stable microbubble suspensions comprising saturated phospholipios for ultrasonic echography Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a st... | 06/01/1999 |
| 5880112 | Naaladase inhibitors The present disclosure relates to dipeptidase inhibitors, and more particularly, to N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzyme inhibitors which are proposed as novel agents for the treatment of prostate cancer. NAALADase is enzyme w... | 03/09/1999 |
| 5863536 | Phosphoramidate derivatives The present invention includes phosphoramidate derivatives, compositions containing the same, and methods of using them as NAALADase inhibitors, particularly for the treatment of glutamate abnormalities and associated nervous tissue insult in a animal and... | 01/26/1999 |
| 5846955 | Acylated phospholipid drugs This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the glycerol portion of a glycerolphospholipid ester having the fo... | 12/08/1998 |
| 5824661 | Sulfur-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism Compounds of the formula ##STR1## where m and n are integers 0 to 10 and m+n equals 0 to 10, (a) X is O or S (b) Z is a covalent bond; a monocyclic or polycyclic carbocycle ring moiety; or a monocyclic or polycyclic heterocyclic ring moiety containing ... | 10/20/1998 |
| 5712261 | Method for preventing or treating hypertriglyceridemia A method is provided for preventing and/or treating hypertriglyceridemia, and/or atherosclerosis and/or pancreatitis resulting from hypertriglyceridemia, employing a squalene synthetase inhibitor.... | 01/27/1998 |
| 5709890 | Polyaspartic acid and its analogues in combination with insecticides An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or... | 01/20/1998 |
| 5686060 | Stable microbubble suspensions comprising saturated phospholipids for ultrasound echography Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a st... | 11/11/1997 |
| 5683994 | Phosphosuccinic acid derivatives, processes for the production thereof and pharmaceutical agents containing these compounds Compounds of formula I are disclosed, ##STR1## as well as processes for their production and pharmaceutical agents containing these compounds suitable for treating disorders of calcium metabolism.... | 11/04/1997 |
| 5646133 | Polyaspartic acid and its analogues in combination with insecticides An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or... | 07/08/1997 |
| 5597549 | Stable microbubble suspensions as enhancement agents for ultrasound echography Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a st... | 01/28/1997 |
| 5591728 | New phosphonic acid compounds Compound of formula (I): ##STR1## in which: R1 represents a hydroxyl, alkoxy or amino (unsubstituted or substituted) group, R2 represents an unsubstituted or substituted alkyl group, X1 represents --NH--, X2 rep... | 01/07/1997 |
| 5580891 | N-[heteroaryl-1-pyrrolidinyl)alkyl]-2-benoxazolinones and related compounds and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 12/03/1996 |
| 5563129 | Hydroquinone derivatives and intermediates for production thereof There are disclosed novel hydroquinone derivatives of the formula: ##STR1## The derivatives of the formula (I) have various pharmacological activities such as antioxidation in living bodies and are useful as medicaments.... | 10/08/1996 |
| 5561128 | N-[(4-(hete roaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 10/01/1996 |
| 5527789 | Method of inhibiting carcinogenesis by treatment with dehydroepiandrosterone and analogs thereof A method of combatting cancer in a subject comprising administering to said subject dehydroepiandrosterone (DHEA) or an analog thereof in an amount effective to combat cancer is disclosed in which heart failure induced by the DHEA or analog thereof is com... | 06/18/1996 |
| 5484833 | Derivatives of non-steroidal anti-inflammatory, analgesic and/or antipyretic substances, their use and pharmaceutical formulations containing them Novel derivatives of non-steroidal anti-inflammatory, analgesic and/or antipyretic substances are provided which are useful in the treatment of superficial or deep inflammatory conditions, such as erythemas of various origins, inflammation of the joints o... | 01/16/1996 |
| 5470845 | Methods of using -phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia -Phosphonosulfonate compounds are provided which inhibit the enzyme squalene synthetase and thereby inhibit cholesterol biosynthesis. These compounds have the formula ##STR1## wherein R2 is OR5 or R5a ; R3... | 11/28/1995 |
| 5411948 | Use of host cell phospholipids for inhibiting microbial colonization Methods for the in vitro and in vivo inhibition of microbial colonization are provided. The methods use host cell phospholipid molecules ("receptors") which bind microorganisms.... | 05/02/1995 |
| 5336671 | Fungicidal compositions containing benzyl-tris(aryl)phosphonium salts The invention provides fungicidal compositions containing benzyl-tris(aryl)-phosphonium salts of the general formula ##STR1## in which R1 represents an optionally substituted alkyl or alkoxy group; R2 represents a hydrogen atom ... | 08/09/1994 |
