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| Number | Title | Issue Date |
| 7935686 | Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous acid, 3-aminopropylphosphinic acid, and analogs thereof, pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous acid, 3-aminopropylphosphinic acid, and analogs th... | 05/03/2011 |
| 7919482 | Chemically stable, insecticidally active phosphoroamidothioate pellet compositions and methods for their manufacture Chemically stable, insecticidally active pellets having a low moisture content and at least about 95% active ingredient are described, as well as a method for manufacturing them. The active ingredient is selected from a class of N-hydrocarboyl phosphoroamidothioate ... | 04/05/2011 |
| 7749985 | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic ac... | 07/06/2010 |
| 7718635 | Triterpenic acid derivative and preparation for external application for skin comprising the same In a triterpenic acid having hydroxyl groups, at least one of the hydroxyl groups is phosphorylated to produce a phosphorylated triterpenic acid and/or a salt thereof, thereby improving the solubility of the triterpenic acid in a preparation for external application... | 05/18/2010 |
| 7678780 | Method of treating cancer using platelet releasate Platelets are concentrated from the blood of a patient. The platelets are treated by a method such as ultrasound or agitation to obtain platelet releasate. This releasate as a whole or a component thereof is formulated into an injectable formulation which is adminis... | 03/16/2010 |
| 7494985 | Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous acid, 3-aminopropylphosphinic acid, and analogs thereof, pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous acid, 3-aminopropylphosphinic acid, and analogs th... | 02/24/2009 |
| 7473685 | Process for preparation of chemically stable, dry-flow, low compact, dust free, soluble granules of phosphoroamidothioates Dry flow, low compact, dust free, soluble granules of phosphoroamidothioates, preferably acephate, are produced by the process of 1) pre-mixing technical grade phosphoroamidothioate with specified adjuvants and other inert ingredients; 2) grinding to produce a groun... | 01/06/2009 |
| 7407927 | Masking agent for agrichemicals Objectionable odors from agrichemicals can be masked by adding one or more terpene or their oxygenated derivatives to the formulation before, during, or after application. A particularly preferred formulation is a granulated insecticide that includes an insecticidal... | 08/05/2008 |
| 7381416 | Selenohydroxy acids and their derivatives, applications in nutrition, cosmetics and pharmaceutics The purpose of this invention is: new selenohydroxy acid compounds and their derivatives; their process for the preparation; use of the new compounds as precursors of L(+)-selenomethionine and/or s... | 06/03/2008 |
| 7354955 | (2S)-amino(phenyl)acetic acid and derivatives as αδ voltage-gated calcium channel ligands The present invention relates to a method for treating pain, reflex sympathetic dystrophy, spasticity, and bipolar disorder using ligands of the α2δ voltage-gated calcium channel, wherein the ligand comprises (2s)-aminophenyl acetic acid and derivatives... | 04/08/2008 |
| 7340357 | Arbitrary waveform generator with configurable digital signal processing unit An arbitrary waveform generator including a digital signal procession unit and a memory. The digital signal processing unit may be configurable to interconnect a plurality of processing components in different configurations to process data received from the memory ... | 03/04/2008 |
| 7328733 | Inner tube compositions having improved heat resistance characteristics Halogenated isobutylene-co-alkylstyrene polymer, preferably halogenated isobutylene-co-methylstyrene polymer, even more preferably brominated isobutylene-co-paramethylstyrene polymer (BIMS), blends thereof, and blends with a second rubber, show improved heat resista... | 02/12/2008 |
| 7264629 | Photodynamic therapy for the treatment of hair loss Photodynamic therapy (PDT) is used to stimulate and/or restore hair growth in areas of hair loss. Methods and compositions relating to PDT treatment for alopecia are disclosed. In light of PDT use to remove unwanted hair by inactivating or destroying hair follicles ... | 09/04/2007 |
| 7205285 | Acyl phosphonate inhibitors of β-lactamases The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic β-lactamase inhibitors presently available, and which do not possess a β-lactam pharmacophore. These new inhibitors are fully synthetic... | 04/17/2007 |
| 7192600 | Process for using water-sensitive insecticides as an active ingredient in a water-based pest bait A method of preparing a rapid acting bait composition which is water based and contains a water-sensitive insecticide as an active ingredient is described. The composition is easily applied into cracks and crevices and voids or other pest harborage areas to rapidly ... | 03/20/2007 |
| 7186703 | Derivatives of branched-chain lipophilic molecules and uses thereof The present invention discloses novel phospho-derivatives of branched-chain lipophilic molecules useful for permeabilizing biological barriers and for inhibiting tumor growth. The invention further discloses pharmaceutical compositions comprising said molecules and ... | 03/06/2007 |
| 7157094 | Granulated active ingredients Granulated forms of various active ingredients can be prepared with a small amount of a dissolvable polymer and a solvent for that polymer. The solvent dissolves at least a portion of the polymer. This dissolved polymer acts as a particle lubricant for the extrusion... | 01/02/2007 |
| 7138486 | Insulinotropic hormone derivatives and uses thereof Derivatives of glucagon-like peptide I (GLP-1) and especially GLP-1 (7-37) have been found to have insulinotropic activity. The invention pertains to a composition comprising an acid addition salt of GLP-I (7-37) and to a composition comprising a carboxylate salt of... | 11/21/2006 |
| RE39264 | Pharmaceutical combination The invention relates to pharmaceutical compositions for topical administration comprising a topically acceptable antiviral substance and an antiinflammatory glucocorticoid in a pharmaceutically acceptable carrier. The pharmaceutical composition can be used in the p... | 09/05/2006 |
| 7074355 | Process for dry granulation by agitative balling for the preparation of chemically stable, dry-flow, low compact, dust free, soluble spherical granules of phosphoroamidothioate Chemically stable, dry-flow, low compact, dust free, soluble granules of phosphoroamidothioate are prepared using a substantially dry granulation process including an agitative balling process. In a preferred embodiment, spherically shaped acephate granules are prod... | 07/11/2006 |
| 7056701 | Hormone and albumin fusion protein Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucl... | 06/06/2006 |
| 7053123 | Substituted (e)-styryl benzylsulfones for treating proliferative disorders (E)-Styryl benzylsulfones useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: R1 is selected from the group consisting of halogen, C1–C6 alkoxy, nitro, phosphonato, amino, sulfamyl... | 05/30/2006 |
| 7033580 | Hair-growing agent Disclosed is a safe and effective hair-growing agent comprising a protein kinase C-specific inhibitor. ... | 04/25/2006 |
| 7015209 | Hair-growing agent A hair-growing agent comprising, as active ingredients, one or more members selected from the group consisting of lysophosphatidic acids, and phosphatidic acids wherein the fatty acid residue moiety consists only of straight-chain fatty acid residues having an even ... | 03/21/2006 |
| 6964952 | Therapeutic composition for broad spectrum dermal disease The invention relates to a therapeutic composition for broad spectrum dermal disease and in particular, to a composition comprising principal lipid components of skin, preferably having about 30 to 90% by weight of a carrier for applying to skin; 0.01 to 5.0% by wei... | 11/15/2005 |
| 6949529 | Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof The present invention provides therapeutic compositions containing lysophosphatidic acids, methods for making the compositions, and methods of use thereof. ... | 09/27/2005 |
| 6943267 | Thiophosphonate inhibitors of phosphatase enzymes and metallophosphatases Compounds of the general formula wherein R is selected from the group consisting essentially of hydrogen, methyl, ethyl, phenyl, a carboxyl, or naphthyl substituted or a carbonyl substituted, alkyl of from 3 to 20 carb... | 09/13/2005 |
| 6919322 | Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 07/19/2005 |
| 6914056 | Pharmaceutical compositions comprising cyclic glycerophosphates and analogs thereof for promoting neural cell differentiation Cyclic glycerophosphates and analogs thereof (CGs) are shown to exert neutral promoting activities in target cells. Such activities include promotion of neuronal outgrowth, promotion of nerve growth, provision of dopaminotrophic supporting envrionment in a diseased ... | 07/05/2005 |
| 6875886 | Modified PSMA ligands and uses related thereto The instant invention provides reagents and methods for diagnosis, detection and treatment of cancers (for example, prostate cancers). In particular, the invention provides methods to generate various functionalized PSMA ligands, and their uses in diagnosis, detecti... | 04/05/2005 |
| 6835721 | Immunomodulatory compounds and methods of use thereof The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of... | 12/28/2004 |
| 6806261 | Methods for treating certain diseases using naaladase inhibitors The present invention relates to methods for regulating the release of TGF-β from living cells in vitro or in vivo, comprising bringing the cells into contact with an effective amount of a NAALADase inhibitor. Such methods are believed to be useful for affecting ne... | 10/19/2004 |
| 6803051 | Multi-layer barrier preventing wood pest access to wooden structures A method and device are disclosed which prevent the intrusion of insects onto wood structures by using a barrier capable of retaining pesticide. In the disclosed method, the barrier maintains a minimal effective level of insecticide for a predetermined period of tim... | 10/12/2004 |
| 6762183 | Active substance combinations having insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties. ... | 07/13/2004 |
| 6761897 | Chemically stable, insecticidally active phosphoroamidothioate pellet compositions and methods for their manufacture Chemically stable, insecticidally active pellets having a low moisture content and at least about 95% active ingredient are described, as well as a method for manufacturing them. The active ingredient is selected from a class of N-hydrocarboyl phosphoroamidothioate ... | 07/13/2004 |
| 6713466 | Processes for preparing sterol esters A food additive useful for lowering serum cholesterol in humans contains a sterol or stanol ester of a fatty acid or a dicarboxylic acid ester of a sterol or stanol made by reacting a sterol, stanol and a carboxylic acid in the presence of an effective amount of a c... | 03/30/2004 |
| 6670399 | Compounds and methods for modulating cerebral amyloid angiopathy The invention provides methods of inhibiting cerebral amyloid angiopathy. The invention further provides methods of treating a disease state characterized by cerebral amyloid angiopathy in a subject with an A inhibitor having the structure: where... | 12/30/2003 |
| 6613743 | Sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides of formula I which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and phy... | 09/02/2003 |
| 6608046 | ଲ-lactamase and DD-peptidase inhibitors The invention provides novel ଲ-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic ଲ-lactamase inhibitors presently available, and which do not possess ଲ-lactam pharmacophore. These new inhibi... | 08/19/2003 |
| 6599889 | Acyl phosphonate inhibitors of ଲ-lactamases The invention provides novel ଲ-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic ଲ-lactamase inhibitors presently available, and which do not possess a ଲ-lactam pharmacophore. These new inhi... | 07/29/2003 |
