Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 8178515 | β-hydroxy-γ-aminophosphonates and methods for the preparation and use thereof The present invention provides β-hydroxy-γ-aminophosphonates, β-amino-γ-aminophosphonates, and analogs thereof that inhibit carnitine acyltransferases. The invention also provides compositions comprising these β-hydroxy-γ-aminophosphonates, β-amino-γ-aminoph... | 05/15/2012 |
| 8158611 | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disor... | 04/17/2012 |
| 8022051 | Composition for protection and improvement of skin, or reinforcing skin barrier function comprising phosphatidylserine Disclosed is a composition containing phosphatidylserine as an effective ingredient, and more particularly to a composition containing phosphatidylserine as an effective ingredient for protecting and improving a skin, reinforcing a skin barrier function, suppressing... | 09/20/2011 |
| 7998933 | Process for treating the skin comprising applying to the skin at least one composition comprising at least one N-aminoacylamide The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing, whether chronobiologic or light-induced, and in particular skin agei... | 08/16/2011 |
| 7973023 | Oxidized lipids and uses thereof in the treatment of inflammatory diseases and disorders Novel synthetic oxidized lipids and methods utilizing oxidized lipids for treating and preventing an inflammation associated with an endogenous oxidized lipid are provided. ... | 07/05/2011 |
| 7968530 | Organic derivatives, their salts and use for the control of phytopathogens Organic compounds are described, which are capable of forming quaternary salts, quaternary salts thereof with a structure having general formula (I) and their use for the control of phytopathogen fungi. ... | 06/28/2011 |
| 7964584 | Method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising benzamidine derivatives or their salts, and alendronic acid or its salt The present invention relates to a pharmaceutical composition for preventing and treating osteoporosis, comprising N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}be... | 06/21/2011 |
| 7923439 | Hydroxamate compositions The present disclosure provides compositions including a first component including at least one phospholipid possessing at least one vinyl group, a second component including a furanone possessing vinyl and/or acrylate groups, and a third component including a hydro... | 04/12/2011 |
| RE42275 | Peptidomimetic inhibitors of PSMA, compounds comprising them, and methods of use Compounds of the formula, A—L—B, wherein A is glutamate or a glutamate analog; L is a phosphoramidate or a phosphoramidate analog; and B is serine or a serine analog are described which are potent inhibitors of prostate-specific membrane antigen (PMSA). Such com... | 04/05/2011 |
| 7902176 | Oxidized lipids and uses thereof in the treatment of inflammatory diseases and disorders Novel synthetic oxidized lipids and methods utilizing oxidized lipids for treating and preventing an inflammation associated with an endogenous oxidized lipid are provided. ... | 03/08/2011 |
| 7888337 | Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity Novel phosphonate compounds are described. The compounds have activity as neuraminidase inhibitors against wild-type and H274Y mutant of H1N1 and H5N1 viruses. The present disclosure also provides an enantioselective synthetic route to known neuraminidase inhibitors... | 02/15/2011 |
| 7776844 | N-(phosphonoalkyl)-amino acids, derivatives thereof and compositions and methods of use The present invention relates to an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof, the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof being in a form as a free acid, salt, partial salt, lactone, amide or ester, or i... | 08/17/2010 |
| 7759326 | Aminophosphonic acid derivative, salt thereof, and modulator of S1P receptor Aminophosphonic acid derivatives (e.g., 2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentylphosphonate monoester) are represented by the following general formula (1): and act as effective S1P receptor modul... | 07/20/2010 |
| 7754703 | Cycloalkane-containing sphingosine 1-phosphate agonists The present invention provides sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type. The compounds invention include compounds having a phosphate moiety as well as compou... | 07/13/2010 |
| 7696185 | Peptidomimetic inhibitors of PSMA, compounds comprising them, and methods of use Compounds of the formula, A—L—B, wherein A is glutamate or a glutamate analog; L is a phosphoramidate or a phosphoramidate analog; and B is serine or a serine analog are described which are potent inhibitors of prostate-specific membrane antigen (PMSA). Such com... | 04/13/2010 |
| 7696184 | Amino-propanol derivatives as sphingosine-1-phosphate receptor modulator The present invention relates to amino-propanol derivatives, process for their production, their uses in treating and/or preventing diseases or disorders mediated by lymphocyte interactions, and pharmaceutical compositions containing them. For example, Compounds of ... | 04/13/2010 |
| 7678779 | Methods for the administration of amifostine and related compounds The present invention provides methods of administering amifostine, WR-1065, or a combination thereof, to patients receiving radiation therapy or chemotherapy in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compound... | 03/16/2010 |
| 7638505 | Organophosphoric derivatives useful as anti-parasitic agents The present invention relates to novel phosphonic acid compounds having the structural formula (I): wherein: (a) R is a group of 1 to 5 substituents independently selected from the group consisting of fluoro, chloro, bromo, C1-4 alkoxy, C1-4 al... | 12/29/2009 |
| 7625882 | Oxidized lipids and uses thereof in the treatment of inflammatory diseases and disorders Novel synthetic oxidized lipids and methods utilizing oxidized lipids for treating and preventing an inflammation associated with an endogenous oxidized lipid are provided. ... | 12/01/2009 |
| 7598232 | Amino-substituted ()-2,6-dialkoxystyryl 4-substituted-benzylsulfones for treating proliferative disorders Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I); wherein: X, X1, X2, Ra, R1, R2,R3, R4, R5, R6... | 10/06/2009 |
| 7572776 | N-(phosphonoalkyl)-amino acids, derivatives thereof and compositions and methods of use The present invention relates to an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof, the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof being in a form as a free acid, salt, partial salt, lactone, amide or ester, or i... | 08/11/2009 |
| 7504388 | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disor... | 03/17/2009 |
| 7504389 | Protein tyrosine phosphatase inhibitors and methods of use thereof The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in whic... | 03/17/2009 |
| 7456157 | Aminophosphonic acid derivatives, addition salts thereof and S1P receptor modulators Aminophosphonic acid derivatives (e.g., 2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentylphosphonate monoester) are represented by the following general formula (1): and act as effective S1P receptor modul... | 11/25/2008 |
| 7429575 | N-(phosphonoalkyl)-amino acids, derivatives thereof and compositions and methods of use The present invention relates to an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof, the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof being in a form as a free acid, salt, partial salt, lactone, amide or ester, or i... | 09/30/2008 |
| 7427608 | Protection against and treatment of hearing loss The present invention provides a method for protecting against or treating hearing loss in a subject. This method involves administering an effective amount of a protein tyrosine kinase inhibitor to the subject to protect against or to treat hearing loss. ... | 09/23/2008 |
| 7419970 | Cosmetic compositions comprising N-acylamino amides The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing, whether chronobiologic or light-induced, and in particular skin agei... | 09/02/2008 |
| 7410956 | Caspase inhibitor prodrugs The present invention relates to compounds of formula I which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of caspase inhibitors from these compounds through selective bond cleavage. ... | 08/12/2008 |
| 7407779 | Modification of solid 3-sn-phosphoglycerides Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structur... | 08/05/2008 |
| 7402576 | Phosphinic acid analogs of glutamate Inhibitors of axillary malodour having the formula wherein R has the same meaning as given in the specification. ... | 07/22/2008 |
| 7384925 | Functionalized stilbene derivatives as improved vascular targeting agents Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubul... | 06/10/2008 |
| 7375097 | Increasing ATP availability by inhibition of creatine kinase (CK) leakage resulting from high-intensity exercise The present invention relates to a method of increasing Adenosine Triphosphate levels in a mammal wherein 2-(carbamimidoyl-methyl-amino)ethoxyphosphonic acid inhibits the leakage of the Adenosine Triphosphate-dependant enzyme Creatine Kinase. Via the inhibition of C... | 05/20/2008 |
| 7368441 | Method of increasing intracellular concentrations of phosphate and increasing the force of muscular contractions The present invention relates to a method of increasing the intracellular concentration of phosphate by employing 2-(carbamimidoyl-methyl-amino)ethoxyphosphonic acid as vehicle and method to transport Phosphate into the cell. The increase in intracellular phosphate ... | 05/06/2008 |
| 7368440 | Methods for the administration of amifostine and related compounds The present invention provides methods of administering amifostine, WR-1065, or a combination thereof, to patients receiving radiation therapy or chemotherapy in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compound... | 05/06/2008 |
| 7354906 | Composition of anti-HIV drugs and anti-cortisol compounds and method for decreasing the side effects of anti-HIV drugs in a human The present invention is based, in part, upon the discovery that the use of an anti-HIV drug in combination with at least one cortisol blocker such as procaine, reduces the side effects associated with anti-HIV drugs. The invention also relates to a method of treati... | 04/08/2008 |
| 7345033 | Carbamoyl-and thiocarbamoyl-phosphonates and pharmaceutical compositions comprising them The present invention provides a compound of the following formula I: R3—NH—C(═X)—P(═O)OR1OR2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I... | 03/18/2008 |
| 7342122 | Bisphosphonate complexes Bisphosphonate compounds are disclosed, particularly bisphosonate conjugates useful in the treatment of soft tissues surrounding bone and bone-related diseases, such as bone cancer and osteoporosis. ... | 03/11/2008 |
| 7319095 | Use of GABAreceptor agonists The present invention relates to the use of GABAB receptor agonists for the treatment as well as the prevention of cough. ... | 01/15/2008 |
| 7314959 | Amino thiol compounds and compositions for use in conjunction with cancer therapy The invention provides novel polyamine and amino thiol compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are administered locally to provide protection against the adverse side-ef... | 01/01/2008 |
| 7291599 | Use of inhibitors of enzymes having activities of amino peptidase N and/or dipeptidyl peptidase IV and of pharmaceutical preparations thereof for a therapy and prevention of chronical neurodegenerative diseases The invention relates to a process for the treatment of neurodegenerative diseases wherein mis-folded proteins accumulate in characteristic lesions and contribute substantially to a pathogenesis and to an inflammatory reaction magnifying the damage, by the isolated ... | 11/06/2007 |
