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| Number | Title | Issue Date |
| 4201771 | Antibiotic A43F The antibiotic A43F is active against a variety of plant pathogenic fungi. The antibiotic A43F is produced by growing an as yet unclassified species of fungus (ATCC No. 20529) on suitable fermentation media and isolating the bioactive component therefrom.... | 05/06/1980 |
| 4192875 | Cyclic hexapeptide Synthetic novel cyclic hexapeptide having the structure: ##STR1## and the dipeptide ##STR2## are prepared. Oral administration of these peptides improves the digestive efficiency of certain herbivorous animals.... | 03/11/1980 |
| 4190648 | Peptides having somatostatin activity Peptides having the structural formula: ##STR1## wherein A is D-Thr, D-Val; B is D-Phe, D-Tyr; C is D-Phe, D-Tyr, O-Me-D-Tyr; wherein the ring formed by the peptide backbone contains 26 atoms and pharmaceutically acceptable non-toxic acid addition salts t... | 02/26/1980 |
| 4188373 | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes Pharmaceutical vehicles for delivery of pharmacologically active chemical materials to mucous membranes, as well as pharmaceutically active compositions containing such vehicles, are provided. The pharmaceutical vehicles are clear, water-miscible, physiol... | 02/12/1980 |
| 4170640 | Antibiotic mixtures The use of various polycyclic nitrogen-containing compounds, such as triphenylmethane dyes to potentiate the bioactivity of antibiotics of the phleomycin series.... | 10/09/1979 |
| 4164563 | Non-greasy compositions Compositions for topical application to skin are provided wherein greasy, occlusive viscous bases are made non-greasy while remaining occlusive. The compositions comprise a mixture of from about 40 to 90%, and preferably from about 60 to 90%, by weight of... | 08/14/1979 |
| 4161521 | Somatostatin analogs Somatostatin analogs having the structural formula: ##STR1## are prepared by controlled stepwise procedures starting with individual amino acid components. These peptides have the property of lowering blood glucose, inhibiting gastric secretion, inhi... | 07/17/1979 |
| 4146612 | Somatostatin analogs Somatostatin analogs having the structural formula: ##STR1## wherein A is Phe, Tyr, O-Me-Tyr, B is Phe, Tyr, C is Thr, Val, R is H or COOH, wherein the ring formed by the peptide backbone contains 26 atoms and pharmaceutically acceptable non-toxic acid ad... | 03/27/1979 |
| 4117118 | Organic compounds This invention provides new antibiotics produced by cultivating a strain of the fungus species, Cylindrocarpon lucidum Booth or Tolypocladium inflatum Gams in contact with a nutrient medium, the antibiotics being useful anti-inflammatory and immunosuppres... | 09/26/1978 |
| 4115544 | Ocular system made of bioerodible esters having linear ether An ophthalmological bioerodible dosage form for ophthalmic drugs is disclosed. The dosage form comprises particles of 10 to 300 microns made of drug dispersed within a drug release rate controlling material which bioerodes in the environment of the eye.... | 09/19/1978 |
| 4115554 | Somatostatin analogs Somatostatin analogs having the structural formula: ##STR1## wherein R is H, COOH, A is (Asn)n, -Abu, Pro, Ala wherein n = 0 or 1, B is Phe, Tyr, C and D are independently Thr, Val, E is Ser, Pro, Ala, Gly, Wherein at least one of A and E is ... | 09/19/1978 |
| 4108985 | Dihydrocyclosporin C The present invention provides dihydrocyclosporin C of formula, ##STR1## useful as an immunosuppressive.... | 08/22/1978 |
| 4108987 | Cyclic hexapeptides Synthetic novel cyclic hexapeptides having the structure: Cyclo[(N-alkylamino acid)-X-(N-alkylamino acid)'-X-(N-alkylamino acid)"-X] wherein (N-alkylamino acid), (N-alkylamino acid)' and (N-alkylamino acid)" have the structure: ##STR1## wherein R1 | 08/22/1978 |
| 4102998 | Process for the prevention of venereal disease An intrauterine contraceptive device comprising an elongated shank having divergent convoluted portions at its distal end, said convoluted portions being generally sinusoidal in nature, said device having incorporated in said shank a permanent magnet and ... | 07/25/1978 |
| 4100271 | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes Pharmaceutical vehicles for delivery of pharmacologically active chemical materials to mucous membranes, as well as pharmaceutically active compositions containing such vehicles, are provided. The pharmaceutical vehicles are clear, water-miscible, physiol... | 07/11/1978 |
| 4086334 | Composition and method for the treatment of disorders of calcium metabolism The water-soluble calcitonins and the water-soluble pharmaceutically-acceptable compounds of acidic nature which are effective against Paget's disease and which contain at least two acidic groups separated by not more than two carbon atoms act synergistic... | 04/25/1978 |
| 4081530 | Extended chain derivatives of somatostatin Compounds of the formula 1 or 1a ##STR1## wherein R1 is H--, H--Gly or H--Leu and R2 is H or COOH and pharmaceutically acceptable salts thereof, are disclosed. The compounds of formulae 1 and 1a are useful for the management of ... | 03/28/1978 |
| 4020157 | Shortened analogs of somatostatin Compounds of the formula 1 or 1a ##STR1## In which R is hydrogen or NHR1 in which R1 is lower aliphatic acyl containing from 1 - 6 carbon atoms or benzoyl, and pharmaceutically acceptable salts thereof are disclosed. The compounds of... | 04/26/1977 |
| 4003991 | Ophthalmic formulation An ophthalmic "ointment" comprising water, a solid water-soluble polymer of controlled molecular weight, and a medicament or therapeutic agent such as pilocarpine in its pharmacologically acceptable salts.... | 01/18/1977 |
| 4000259 | Cyclic dodecapeptide analogs of somatostatin and intermediates Cyclic dodecapeptide analogs of somatostatin without cysteine amino acid residues and intermediates obtained in the synthesis of such compounds are described. These cyclic dodecapeptides inhibit the secretion of glucagon and hence have application in the ... | 12/28/1976 |
| 3985873 | Solution containing trimethoprim, sulfacetamide and polymyxin Ophthalmic solution suitable for treatment of microbial, especially bacterial, infections of and around the eye containing sulfacetamide, a medicinally or pharmaceutically acceptable water soluble mono salt of trimethoprim, a medicinally or pharmaceutical... | 10/12/1976 |
| 3983209 | Method for treating burns A method is disclosed for treating the burned surface of an animal by administering to said surface a contact composition comprising a hydrophobic, bioerodible polymer containing an agent selected from the group consisting of antibacterial, antibiotic, an... | 09/28/1976 |
| 3943246 | Organic compounds This invention concerns a novel use of oxytocin and desamino-oxytocin for treating impotency in the human male.... | 03/09/1976 |
| 3934008 | N-acyl and desamino human calcitonin and analogs thereof The new hypocalcaemically active peptides of formula I and corresponding compounds in which one or more of the asparagine and glutamic acid radicals are replaced by the aspartic acid or glutamic acid radical and/or the aspartic acid radical is replaced by the ... | 01/20/1976 |
