Bizarre Patents
Mouthguard made at least partially from an edible candy
A mouthguard includes a U-shaped upper bite plate which removably fits over upper teeth of a person, with the entire upper bite plate being made from a soft, deformable and edible gummi candy.
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| Number | Title | Issue Date |
| 6645509 | Polypeptide expressed in the horny layer of epidermis and use thereof The present invention relates to a cosmetic or pharmaceutical composition comprising, in a physiologically acceptable medium, a purified natural or synthetic epidermis-specific polypeptide which is involved in horny layer cell cohesion. The invention also... | 11/11/2003 |
| 6632456 | Compositions for inhalation A pharmaceutical composition including a mixture of active compounds (A) a pharmaceutically active polypeptide, and (B) an enhancer compound which enhances the systemic absorption of the polypeptide in the lower respiratory tract of a patient, the mixture... | 10/14/2003 |
| 6630447 | Peptide inhibitors of LFA-1/ICAM-1 interaction Cyclic peptides inhibit LFA-1 interaction with ICAM-1 and are useful in treatment of hematopoietic neoplasms and in adjunct therapy in prevention of retinoic acid syndrome and diseases involving emigration of leukocytes into organ tissue.... | 10/07/2003 |
| 6630147 | Pseudomycin natural products The invention relates to pseudomycin natural products including pseudomycins A' and B', methods for making such pseudomycins, and methods employing antifungal activity of these pseudomycins. NMR and mass spectrometry indicate a formula for pseudomycin A' ... | 10/07/2003 |
| 6624144 | Matrix metalloproteinase inhibitors and down-regulators The present invention relates to novel matrix metalloproteinase (MMP) inhibitors and down-regulators, to a process for the preparation of these inhibitors, to pharmaceutical compositions comprising these inhibitors/down-regulators, to the use of the novel... | 09/23/2003 |
| 6623731 | Compounds and compositions for delivering active agents Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and method... | 09/23/2003 |
| 6620782 | Substituted 2-aminobenzamide caspase inhibitors and the use thereof The present invention is directed to novel 2-aminobenzamide thereof, represented by the general Formula I: ##STR1## where R1 -R3, X, and A--D are defined herein. The present invention also relates to the discovery that compounds havi... | 09/16/2003 |
| 6617345 | Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor, a leukotriene B4 receptor inhibitor and a cyclosporin Treatment with a cyclooxygenase-2 inhibitor and a leukotriene B4 receptor antagonist is described as being useful in reducing recipient rejection of transplanted organs and for treatment of autoimmune diseases.... | 09/09/2003 |
| 6613739 | Deuterated cyclosporine analogs and their use as immunomodulating agents Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by... | 09/02/2003 |
| 6613734 | Peptides-containing liposomal surfactants The present invention discloses useful surfactant molecules including polypeptides, proteins, and a variety of other organic molecules, as well as methods of making and using same. Surfactant compositions, including liposomal surfactant compositions, are ... | 09/02/2003 |
| 6610735 | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents A method of increasing the bioavailability upon oral administration of a pharmacologically active target agent, particularly an antitumor or antineoplastic agent which exhibits poor or inconsistent oral bioavailability (e.g., paclitaxel, docetaxel or etop... | 08/26/2003 |
| 6610655 | Pentapeptide with specific conformation, its production and use Cyclic pentapeptides are disclosed having the following formula (I)-Cyclo(-A1 -A2 -A3 -A4 -A5 -)-wherein A1, A2, A3, A4 and A5 are amino acid residues... | 08/26/2003 |
| 6608028 | Insulin-like growth factor agonist molecules Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.... | 08/19/2003 |
| 6608027 | Macrocyclic peptides active against the hepatitis C virus The present invention covers macrocyclic compounds of formula I active in-vitro and in cellular assays against the NS3 protease of the hepatitis C virus. ##STR1## wherein W, R21, R22, R3, R4, D and A are as defi... | 08/19/2003 |
| 6605593 | Deuterated cyclosporine analogs and their use as immunomodulating agents Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by... | 08/12/2003 |
| 6602849 | Cyclic somatostatin analogs The present invention is directed to cyclic derivatives containing an imidazole cis amide bond mimetic which bind selectively to somatostatin receptor subtypes and the use thereof in treating conditions which can be treated by eliciting an agonist or anta... | 08/05/2003 |
| 6596268 | Viruses for the treatment of cellular proliferative disorders Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pa... | 07/22/2003 |
| 6593297 | Compounds and methods for inhibiting cancer metastasis Agents for inhibiting cancer metastasis are provided. The methods comprise administering to a patient an antimetastatic agent that comprises one or more of: (a) a peptide sequence that is at least 50% identical to an OB-cadherin CAR sequence; (b) a non-pe... | 07/15/2003 |
| 6593292 | Compositions and methods for enhancing drug delivery across and into epithelial tissues This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, and the like. The compositions and methods are also useful for d... | 07/15/2003 |
| 6583114 | Fracture healing using pthrp analogs This invention provides methods of bone healing and fracture repair comprising administering to a patient in need thereof an effective amount of a polypeptide analog of parathyroid hormone related peptide (PTHrP) and salts thereof, wherein amino acid resi... | 06/24/2003 |
| 6566327 | Histogranin peptides and their analgesic use The invention relates to linear and cyclic peptide and pseudopeptide compounds useful as analgesics, pharmaceutical compositions comprising such compounds, the use of the compounds and the compositions in the treatment of pain, and commercial packages con... | 05/20/2003 |
| 6565831 | Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The method comprises suppressing or otherwise i... | 05/20/2003 |
| 6565859 | Galenical formulations A pharmaceutical composition containing macrolide, e.g. a rapamycin compound in an emulsion preconcentrate or microemulsion preconcentrate for oral administration. The carrier medium for the rapamycin compound includes a hydrophilic phase, a lipophilic ph... | 05/20/2003 |
| 6562786 | Compounds and methods for modulating apoptosis Cyclic peptides and compositions comprising such cyclic peptides are provided. The cyclic peptides comprise a classical cadherin cell adhesion recognition sequence HAV. Methods for using such peptides and compositions for inducing apoptosis in cadherin-ex... | 05/13/2003 |
| 6555126 | Method for treating, controlling, and preventing Diabetes Mellitus This invention pertains to a method that can control, treat, and prevent Diabetes Mellitus. The method includes means of administering a potent product, including mainly the active ingredient Linalool, in any one of several forms, alone or with other addi... | 04/29/2003 |
| 6551994 | Compounds and methods for inhibiting the interaction between -catenin and ଲ-catenin Modulating agents for inhibiting an interaction between -catenin and ଲ-catenin are provided. The modulating agents comprise one or more of: (a) a ଲ-catenin HAV motif; (b) a peptide analogue or mimetic of a ଲ-catenin HAV motif; or ... | 04/22/2003 |
| 6548527 | Treatments for immune-mediated ear disorders Disclosed herein are methods for treating immune-mediated ear disorders, such as IMCVDs, or their symptoms, involving administration of a therapeutically-effective amount of a TNF antagonist, such as etanercept or infliximab, or a therapeutically-effectiv... | 04/15/2003 |
| 6541451 | Streptogramin derivatives, their preparation and compositions containing them B-Group streptogramin compounds of formula (I): ##STR1## are useful as antimicrobial agents, optionally combined with at least one A-group streptogramin compound.... | 04/01/2003 |
| 6541450 | Parathyroid hormone analogues for the treatment of osteoporosis This invention describes analogues of human parathyroid hormone which have increased activities in bone restoration, and increased bioavailability. The peptides described are derivatives of hPTH-(1-31) which are cyclized for example, by formation of lacta... | 04/01/2003 |
| 6531139 | Self-emulsifying formulation for lipophilic compounds The present invention provides a novel pharmaceutical composition based on the use of a particular oil phase which comprises a lipophilic, pharmaceutically active agent, a mixture of diglyceride and monoglyceride in a ratio of from about 9:1 to about 6:4 ... | 03/11/2003 |
| 6525022 | Receptor specific atrial natriuretic peptides Human receptor selective atrial natriuretic factor variants containing various substitutions, especially G16R, show equal potency and binding affinity for the human A-receptor but have decreased affinity for the human clearance or C-receptor. These ANF va... | 02/25/2003 |
| 6521599 | Stable pharmaceutical formulation for intravenous or intramuscular administration of active peptide compounds A stable pharmaceutical formulation for intravenous or intramuscular administration of Octreotide, which is characterized in that the vehicle for injection of the peptide or pharmaceutically acceptable salts thereof contains glycine in concentrations rang... | 02/18/2003 |
| 6521595 | Nonimmunosuppressive [γ-hydroxy-methylleucine4] cyclosporin A, hair growth stimulator and external composition for skin using the same The present invention relates to methods for treating alopecia and stimulating hair growth and pharmaceutical compositions using nonimmunosuppressive [γ-hydroxy-methylleucine4 ] cyclosporin A having superior hair growth-promoting effect, where... | 02/18/2003 |
| 6521594 | Method and composition for treating thrombosis The invention provides cyclic peptides which inhibit platelet aggregation without causing prolonged bleeding time. The invention provides RGD or KGD containing peptides which are cyclized and contain hydrophobic amino acids adjacent to the carboxy terminu... | 02/18/2003 |
| 6518244 | Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof Combined use of a heparin cofactor II agonist and a platelet GPIIb/IIIa receptor antagonist to inhibit both platelet aggregation and thrombin generation resulting from disease, injury or responses to wound repairs. The combined use of the heparin cofactor... | 02/11/2003 |
| 6518242 | Derivatives of glycopeptide antibacterial agents Novel antibacterial agents that act as multibinding agents are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to a transglycosylase enzyme substrate thereby modulati... | 02/11/2003 |
| 6514710 | Method of using cyclic peptides to inhibit binding to urokinase-type plasminogen activator receptor Cyclic peptide compounds having 11 amino acids joined by a linking unit L, such that the linear dimension between the C carbon of the first amino acid and the C carbon of eleventh amino acid is between about 4 and 12 Å... | 02/04/2003 |
| 6511962 | Derivatives of laspartomycin and preparation and use thereof The present invention provides a laspartomycin core peptide, a laspartomycin core peptide derivative, a antimicrobial laspartomycin derivative, a method for making laspartomycin core peptides, methods for making laspartomycin core peptide derivatives, met... | 01/28/2003 |
| 6509315 | Didemnin analogs and fragments and methods of making and using them The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes numerous didemnin analogs and fragments and methods of maki... | 01/21/2003 |
| 6506726 | Purification of Echinocandin cyclopeptide compounds A method is described for separating and purifying a wide variety of fermentation cyclopeptide products containing at least one protonatable amino group (including the deacylated Echinocandin-type compounds) from their fermentation or mixed broths and par... | 01/14/2003 |
