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| Number | Title | Issue Date |
| 8129361 | Amine compound and pharmaceutical use thereof Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of... | 03/06/2012 |
| 8124594 | Methods using phosphatidylserine, lysophosphatidylserine, and/or salts thereof to increase testosterone levels Methods using phosphatidylserine, lysophosphatidylserine, and/or salts thereof to increase testosterone levels in subjects in need thereof are disclosed herein. The methods can be useful for subjects having age related decline in testosterone, exercise induced decli... | 02/28/2012 |
| 7550449 | Carba cyclic phosphatidic acid derivative It is an object of the present invention to synthesize a carba cyclic phosphatidic acid derivative having a novel structure by substituting O at position sn-2 of the glycerol skeleton with CH2, and study the action of the obtained derivative to suppress c... | 06/23/2009 |
| 7205001 | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt, complex, organic compound or ionic solution to treat tumors of epithel... | 04/17/2007 |
| 7176192 | Method for treating patients for radiation exposure This invention relates to a method of treating a patient suffering from ionizing radiation exposure, or of treating a patient about to undergo ionizing radiation therapy. The method includes administering to a patient in need of treatment an effective amount of a th... | 02/13/2007 |
| 7163703 | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt, complex, organic compound or ionic solution to treat tumors of epithel... | 01/16/2007 |
| 6969728 | Modulators of TNF-α signaling The present invention provides compounds which are modulators of TNF-α signaling and methods of use thereof for treating a patient having a TNF-α mediated condition. The compounds can be represented by the following structural formulas: | 11/29/2005 |
| 6939855 | Anti-inflammatory compositions and method The disclosed invention includes pharmaceutical compositions and methods for treating inflammatory conditions, particularly those that are characterized by increased binding of alpha-9 integrin to one or more of its ligands. Also disclosed are methods for selecting ... | 09/06/2005 |
| 6906047 | Aqueous ifosfamide composition This invention is directed towards a ready-to-use aqueous composition of ifosfamide. In one embodiment, the invention is directed to an aqueous ifosfamide composition which comprises ifosfamide, a pharmaceutically acceptable buffer, and water. The concentration of i... | 06/14/2005 |
| 6699851 | Cytotoxic compounds and their use Novel amides of polyunsaturated fatty acids with cysteamine-S-phosphate have been synthesized. Combinations of the all-trans-retinoic acid and/or amides of the 13-cis-retinoic acid with O-phospho-L-tyrosine, and N-docosahexaenoyl-cysteamine-S-phosphate, ... | 03/02/2004 |
| 6699850 | Compositions and methods for inhibiting bone resorption The present invention relates to oral compositions and methods for inhibiting bone resoprtion in a mammal while counteracting the occurrence of potentially adverse gastrointestinal effects. The compositions useful herein comprise the combination of a phar... | 03/02/2004 |
| 6673358 | Wet wipes containing a mono alkyl phosphate Wet wipes impregnated with a solution which includes a mono alkyl phosphate are described. In particular, the solution in the wet wipes includes a phosphate ester surfactant which includes a mono alkyl phosphate having the following structural formula: ... | 01/06/2004 |
| 6630512 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 10/07/2003 |
| 6627660 | Stabilized thyroxine compounds Throxinyldimethylphosphinate was invented as a prodrug to stabilize thyroxine, a drug widely used to treat hypothyroidism. The presence of the dimethylphosphinate group at the phenolic hydroxyl of thyroxine is key to preventing thyroxine from decomposing ... | 09/30/2003 |
| 6624152 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 09/23/2003 |
| 6566304 | Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a) to (b) as a soil additive for biologically controlling pla... | 05/20/2003 |
| 6509325 | Method for inhibiting melanogenesis and uses thereof The present invention provides a method for treating a subject infected with a mammalian pathogenic fungus which uses melanin in virulence, by administering to the subject an amount of glyphosate effective to treat the infection. The present invention fur... | 01/21/2003 |
| 6489312 | Pharmaceutical formulations comprising aminoalkyl phosphorothioates The present invention provides novel pharmaceutical compositions comprising aminoalkyl phosphorothioate compounds in combination with surfactants, hydrotropes and chelating agents. The compositions are well-suited for subcutaneous administration.... | 12/03/2002 |
| 6476006 | Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates The present invention provides compacted pharmaceutical composition for oral administration to a patient which expands upon contact with gastric fluid to retain a dosage form in the patient's stomach for an extended period of time, the formulation compris... | 11/05/2002 |
| 6440443 | Microencapsulation formulations of cadusafos Pesticidal formulations of cadusafos are provided. An aqueous capsule suspension is provided, containing from about 150 to about 360 grams of cadusafos per liter of formulation and having lower mammalian toxicity than aqueous cadusafos microemulsion formu... | 08/27/2002 |
| 6399592 | Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss Disclosed is a combination therapy for treating and for preventing bone loss by the use of estrogen and a bisphosphonate selected from: alendronate, clodronate, tiludronate, YM175, BM 210995, or mixture thereof. Also described is a pharmaceutical composit... | 06/04/2002 |
| 6372728 | Formulation for treatment of osteoporosis The present invention provides pharmaceutical formulations comprising at least one bisphosphonate and an absorption enhancing agent essentially consisting of a medium chain glyceride or a mixture of medium chain glycerides. The said pharmaceutical formula... | 04/16/2002 |
| 6358936 | Compounds for the treatment of cancer It is shown that the potency of anti-cancer drugs, here exemplified by doxorubicin, can be increased by the use of polyunsaturated fatty acid amides and in particular specific combinations of such compounds, forming complexes with doxorubicin. Further, a ... | 03/19/2002 |
| 6352970 | Treatment of skeletal disorders This invention relates to methods for treating bone loss in a mammal by administering to the mammal a therapeutically effective amount of leptin or a leptin mimetic. This invention also relates to methods for treating bone fracture, enhancing bone healing... | 03/05/2002 |
| 6329354 | Methods for the treatment of osteoporosis Methods of treatment for osteoporosis in a human or other animal subject, comprising: administering a bone-active phosphonate to said subject, at a level of at least about 0.1 LED per day of said treatment; and administering an estrogen hormone to said su... | 12/11/2001 |
| 6306840 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 10/23/2001 |
| 6303588 | Therapeutic methods utilizing naturally derived bio-active complexes and delivery systems therefor Methods are disclosed for correcting biological information transfer in a patient in need of such therapy which comprise administration to a patient of a composition comprising a therapeutically effective amount of a biocomplex comprising at least one bio... | 10/16/2001 |
| 6291441 | Method of treating inflammatory bowel disorders This invention relates to a method of treating patients suffering from the inflammatory bowel disorders. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the fo... | 09/18/2001 |
| 6218435 | Reduction of hair growth A method of reducing hair growth in a mammal includes applying, to an area of skin from which reduced hair growth is desired, a dermatologically acceptable composition containing a suppressor of the metabolic pathway for the conversion of glucose to acety... | 04/17/2001 |
| 6117856 | Topical bisphosphonates for prevention of bone resorption Bisphosphonates inhibit bone resorption associated with periodonatal or orthopedic surgery when applied topically to the bone. A novel formulation for topical application contains a gelatin matrix which is soaked in a solution containing a bone absorption... | 09/12/2000 |
| 6087349 | Method for blocking neoplastic transformation of cells induced by ras oncogenes A method is provided by blocking or preventing the prenylation of CAAX box containing proteins including ras oncogene products thereby preventing and/or treating ras-related tumors which includes the step of administering a therapeutically effective amoun... | 07/11/2000 |
| 6017905 | Phosphonamide ACAT inhibitors The present invention is directed to compounds useful for the regulation of cholesterol of Formula I, methods for using them and pharmaceutical compositions thereof, ##STR1## wherein Ar and Ar1 are each independently selected from unsubsti... | 01/25/2000 |
| 5985859 | Methods of inhibiting bacterial sialidase A method of inhibiting bacterial sialidase comprising administering to a subject an inhibiting effective amount of a compound of formula I: ##STR1## wherein A is CO2 H, PO2 H, or SO2 H; B is N; R1 and R | 11/16/1999 |
| 5972349 | Synthesis of polyribosylribitol phosphate oligosaccharides Polyribosylribitol phosphate oligosaccharides are produced in a multistep process. The compound of the formula: ##STR1## wherein R1 is a first protecting group and R2 is a second protecting group, is coupled to a solid polyethyl... | 10/26/1999 |
| 5968498 | Freshness retaining gel composition The freshness of meat, vegetables and fruits in a refrigerator or food storage box can be retained for a long period of time by using (1) a freshness retaining gel composition which comprises a freshness retainer component comprising an isothiocyanic acid... | 10/19/1999 |
| 5955092 | Skin care compositions containing an n-substituted fatty acid amide and retinol or retinyl ester N-substituted fatty acid amides which sufficiently inhibit LRAT or ARAT catalyzed esterification of retinol into inactive retinyl esters, have the same effect on keratinocytes as retinoic acid. Thus, effects of the retinol or retinyl esters in combination... | 09/21/1999 |
| 5885974 | Therapeutic methods utilizing naturally derived bio-active complexes and delivery systems therefor Methods are disclosed for correcting biological information transfer in a patient in need of such therapy which comprise administration to a patient of a composition comprising a therapeutically effective amount of a biocomplex comprising at least one bio... | 03/23/1999 |
| 5760022 | Pharmaceutical composition with improved bioavailability of inositol phosphate The invention relates to an inositol phosphate containing pharmaceutical composition which comprises an aliphatic ester or ether for improvement of the bioavailability of the inositol phosphate in mammals including man at non-parenteral administration. Th... | 06/02/1998 |
| 5753634 | Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism Disclosed are quaternary nitrogen-containing, saturated or unsaturated monocyclic and bicyclic ring-containing bisphosphonate compounds, and pharmaceutically-acceptable salts and esters thereof. These compounds, which are useful for treating or preventing... | 05/19/1998 |
| 5733478 | Method and composition for reducing the degradation rate of agrochemicals in storage A method for reducing the rate of degradation of stored agrochemicals, particularly pesticides, is provided which essentially involves incorporating a stabilizing compound into the agrochemical in preparation for storage, with the stabilizing compound sel... | 03/31/1998 |
