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| Number | Title | Issue Date |
| 7700552 | Macrocyclic inhibitors of hepatitis C virus Compounds of the formula (I): and N-oxides, salts and stereoisomers thereof wherein A is OR1, NHS(═O)pR2, NHR3, NRaRb, C(═O)NHR3 or C(═O)NRaRb wherein; R1 is hydrogen, C1-C6 | 04/20/2010 |
| 7651997 | Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents and for other purposes. Methods of making these analogs and methods of... | 01/26/2010 |
| 7642235 | Macrocyclic peptides active against the hepatitis C virus Compounds of formula I: wherein D, R4, R3, L0, L1, L2, R2 and RC are defined herein; or a pharmaceutically acceptable salt thereof, useful as inhi... | 01/05/2010 |
| 7521419 | Peptide-based compounds The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors. ... | 04/21/2009 |
| 7439226 | Serine protease inhibitors The present disclosure concerns peptides and peptidomimetics having inhibitory activity against serine proteases. The disclosed peptides and peptidomimetics are particularly useful as selective inhibitors of matriptase and MTSP1. Pharmaceutical compositions comprisi... | 10/21/2008 |
| 7429565 | Antiviral phosphonate analogs The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing su... | 09/30/2008 |
| 7414023 | Peptide ligands for prostate specific antigen The present invention relates to novel peptide ligands for prostate specific antigen (PSA) binding specifically with it and enhancing its enzyme activity, to a process for preparation of these peptides, to diagnostic and pharmaceutical compositions comprising these ... | 08/19/2008 |
| 7351790 | Peptide-based compounds The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise a targeting vector which binds to receptors associated with integrin receptors. ... | 04/01/2008 |
| 7348310 | Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them The invention relates to aplidine derivatives of the general formula: which are useful for the treatment of tumors. ... | 03/25/2008 |
| 7309708 | Hepatitis C virus inhibitors Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds... | 12/18/2007 |
| 7265257 | Absorbent articles comprising a bodily exudate modifying agent and a film-forming skin care formulation Absorbent articles having enhanced absorption of bodily exudates are disclosed. The absorbent articles comprise a bodily exudate modifying agent and a skin care formulation. The bodily exudate modifying agent is capable of reducing the viscosity of bodily exudates s... | 09/04/2007 |
| 7265118 | Regulation of substrate activity A method for regulating substrate activity in vivo is useful for the treatment of medical disorders such as inflammation, arteriolosclerosis and angiogenesis. The method involves the administration of an effective amount of a DPP-IV inhibitor to a patient in need of... | 09/04/2007 |
| 7259138 | Anti-tumor agents A method for treating subjects with abnormal cell proliferation is provided. The method involves administering to subjects in need of such treatment an effective amount of an agent of Formula I, to inhibit cell proliferation such as that associated with tumor growth... | 08/21/2007 |
| 7250529 | Synthesis process for 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid A highly advantageous process for the preparation of 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid or a salt thereof is described. The process comprises subjecting 1-acetyl 3-hydroxyadamantane to liquid phase oxidation with permanganate to produce 2-(3-hydroxy-1-adaman... | 07/31/2007 |
| 7217690 | Compositions of sunflower trypsin inhibitors The present invention provides methods of using small cyclic peptides that can inhibit or prevent skin irritation caused by proteolytic activity. ... | 05/15/2007 |
| 7199101 | Gelling agent for oil A gelling agent for an oil, which contains at least one compound (A) and at least one compound (B), and a gel composition containing the gelling agent and an oil: wherein R1 is a straight chain or bran... | 04/03/2007 |
| 7196061 | Compounds that modulate neuronal growth and their uses Cyclic peptides and peptidomimetics are provided that bind to and/or modulate activities associated with Trk receptors, including processes associated with the growth and repair of the central nervous system (e.g., neuronal growth and survival, axonal growth, neurit... | 03/27/2007 |
| 7173004 | Macrocyclic isoquinoline peptide inhibitors of hepatitis C virus Macrocyclic isoquinoline peptides are disclosed having the general formula: A compound of formula I: wherein R1 to R9, Q and W are described in the description. Compositions comprising ... | 02/06/2007 |
| 7163950 | Surfactants as malarial chloroguine resistance reversal agents According to the first aspect of the invention, a composition for reversing malarial resistance to quinolines is disclosed. The composition includes a surfactant, such as nonylphenolethoxylate (NPE) in an admixture with a pharmaceutically acceptable carrier, excipie... | 01/16/2007 |
| 7148257 | Methods of treating mesothelioma with suberoylanilide hydroxamic acid Methods for treating mesothelioma comprising administering the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) are disclosed. ... | 12/12/2006 |
| 7138103 | Use of bi-specific antibodies for pre-targeting diagnosis and therapy The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds construct. The targetable construct comprises a carrier portion which comprises or bears at least... | 11/21/2006 |
| 7125845 | Aza-peptide macrocyclic hepatitis C serine protease inhibitors The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (... | 10/24/2006 |
| 7125675 | Method for inhibiting tumor invasion or spreading in a subject The present invention provides for a method for inhibiting tumor invasion or metastasis in a subject which comprises administering to the subject a therapeutically effective amount of a form of soluble Receptor for Advanced Glycation Endproducts (RAGE). The present ... | 10/24/2006 |
| 7122519 | Didemnin analogs and fragments and methods of making and using them The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes numerous didemnin analogs and fragments and methods of making them. Me... | 10/17/2006 |
| 7122553 | Liposomal formulation of irinotecan The present invention is for novel compositions and methods for treating cancer, particularly, for treating cancer in mammals and more particularly in humans. The therapeutic compositions of the present invention include liposome entrapped irinotecan in which the li... | 10/17/2006 |
| 7101848 | Bicyclic oligopeptides The invention relates to a bicyclic oligopeptide or ester thereof having the capability to inhibit the glucagon receptor, comprised of: (a) a first cyclic group, which comprises at least one cysteine group and is formed by an amide bonding of the N-term... | 09/05/2006 |
| 7098024 | Depsipeptide compound This invention relates to a novel compound which has a cytotoxic activity and TGF-β like activity for human cancer cells and is useful as an antitumor agent and to a pharmaceutical composition which contains the same. ... | 08/29/2006 |
| 7074432 | Method of modifying the release profile of sustained release compositions The present invention relates to a method for the sustained release in vivo of a biologically active agent comprising administering to a subject in need of treatment an effective amount of a sustained release composition comprising a biocompatible polymer having the... | 07/11/2006 |
| 7067551 | Deacetylase inhibitors The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties. ... | 06/27/2006 |
| 7064105 | Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents and for other purposes. Methods of making these analogs and methods of... | 06/20/2006 |
| 7056884 | Reduced FK228 and use thereof The present invention relates to reduced FK228 of the formula (I) wherein R1 and R2 are the same or different and each is a hydrogen atom or a thiol-protecting group, or a salt thereof, and ... | 06/06/2006 |
| 7041639 | Depsipeptide and congeners thereof for use as immunosuppressants Depsipeptides and congeners thereof are disclosed having the following structure: wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, ... | 05/09/2006 |
| 7041786 | Guanylate cyclase receptor agonists for the treatment of tissue inflammation and carcinogenesis A method of treatment of inflamed, pre-cancerous or cancerous tissue or polyps in a mammalian subject is disclosed. The treatment involves administration of a composition of at least one peptide agonist of a guanylate cyclase receptor and/or other small molecules th... | 05/09/2006 |
| 7033778 | Methods for determining the acetylation level of a peptide based on sensitivity of the peptide to peptidase The acetylation level of a peptide is determined utilizing the fact that the changes in the acetylation level are reflected in the sensitivity of the substrate peptide to a peptidase. This method can be used for measuring activities of deacetylase and acetylase, and... | 04/25/2006 |
| 7033580 | Hair-growing agent Disclosed is a safe and effective hair-growing agent comprising a protein kinase C-specific inhibitor. ... | 04/25/2006 |
| 7030147 | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease. ... | 04/18/2006 |
| 7029663 | Stable ointment containing acetylsalicylic acid A substantially anhydrous stable ointment containing Aspirin which is characterized in using gelation hydrocarbon and/or vaseline as a base. The ointment is superior in stability and can be stored for a long term. ... | 04/18/2006 |
| 7015208 | C2-substituted indan-1-ols and their derivatives, processes for their preparation and their use as pharmaceuticals Embodiments of the invention relate to C2-substituted indan-1-ols and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention may include compounds of formula I | 03/21/2006 |
| 6979697 | Regulation of substrate activity A method for regulating substrate activity in vivo is useful for the treatment of medical disorders such as inflammation, arteriolosclerosis and angiogenesis. The method involves the administration of an effective amount of a DPP-IV inhibitor to a patient in need of... | 12/27/2005 |
| 6955908 | Organism associated with nongonococcal urethritis The invention features a biologically pure culture of a newly identified single-celled organism Spiky Rotating Cells (SPR), methods to diagnose an SPR infection in a human patient, an instrument for collecting and detecting an SPR infection, and methods for treating... | 10/18/2005 |
