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| Number | Title | Issue Date |
| 6682715 | Nucleosides for imaging and treatment applications Methods of diagnosing and/or of treating tumors by administering a nucleoside analog which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analog compounds, and compositions of same ha... | 01/27/2004 |
| 6680068 | Drug delivery formulations and targeting The invention is based on the discovery that angiogenic vessels have heterogeneous surface charge and that cationic liposomes actually target human tumor blood vessels only in irregularly shaped patches. The invention thus features methods for delivering ... | 01/20/2004 |
| 6677315 | Nucleosides for imaging and treatment applications Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of sam... | 01/13/2004 |
| 6677314 | Nucleosides for imaging and treatment applications Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of sam... | 01/13/2004 |
| 6677299 | Method to increase cerebral blood flow in amyloid angiopathy The present invention provides a method for decreasing cerebral vasoconstriction in a subject suffering from chronic or acute cerebral amyloid angiopathy which comprises administering to the subject an inhibitor of receptor for advanced glycation endprodu... | 01/13/2004 |
| 6677298 | Regulators of PPARĪ“ (ଲ) and their use in the treatment of obesity and insulin resistance Obesity is a common clinical problem in most developed nations and is also rapidly becoming a major health concern in developing nations. Overweight individuals frequently suffer from several metabolic disorders such as insulin resistance, type 2 diabetes... | 01/13/2004 |
| 6676950 | Neurokinin receptor antagonists and methods of use thereof for inhibiting HIV infection Compositions and methods are provided which may be used to advantage for the treatment of HIV infection. More specifically, neurokinin receptor antagonists and methods for administration to inhibit HIV invention are disclosed.... | 01/13/2004 |
| 6677317 | Disaccharide derivatives for treating hyperglycaemia The invention relates to the use of the disaccharide derivatives 3'-aminosucrose, sucrose-C6-acid and palatinose-C6'-acid and/or of an amide or alkyl ester thereof for the prevention or treatment of hyperglycemias.... | 01/13/2004 |
| 6673777 | Guanylhydrazones useful for treating diseases associated with T cell activation There is disclosed a method for treating diseases and disorders involving T cell activation and HIV-infection, using the p38 mitogen activated protein kinase (MAPK) signaling pathway as a target for intervention. There is further disclosed a use for guany... | 01/06/2004 |
| 6673558 | Drug compositions to prevent desensitization of cellular receptors Drug compositions combining antagonists with agonists to prevent desensitization of cellular receptors. An agonist is a substance or drug that produces a maximal or nearly maximal response, whereas an antagonist is a substance or molecule that produces no... | 01/06/2004 |
| 6670332 | Complex cationic lipids having quarternary nitrogens therein Cationic lipids having a derivatized quaternary ammonium head group that provide improved cell targeting ability and enhanced transfective efficacy for introducing molecules into cells are provided.... | 12/30/2003 |
| 6660268 | Proteasome regulation of NF-KB activity Disclosed herein is a method for regulating the activity of NF-.kappa.B in an animal comprising contacting cells of the animal with certain proteasome inhibitors.... | 12/09/2003 |
| 6660720 | Targeted oligonucleotide conjugates The present invention provides improved ingress of therapeutic and other moieties into cellular targets. In accordance with preferred embodiments, complexes are provided which carry primary moieties, chiefly therapeutic moieties, to such target cells. Suc... | 12/09/2003 |
| 6653278 | Selenium-containing pro-drugs for cancer therapy Methods for inhibiting the growth of tumor cells by combination treatment with a selenium-containing prodrug and an enzyme for which it is a substrate are described. The treatment also enhances the effect of anti-tumor agents.... | 11/25/2003 |
| 6652885 | Purification and stabilization of peptide and protein pharmaceutical agents Methods are provided for purifying peptides and proteins by incorporating the peptide or protein into a diketopiperazine or competitive complexing agent to facilitate removal one or more impurities, i.e. undesirable components, from the peptide or protein... | 11/25/2003 |
| 6641811 | Use of angiotensin II inhibitors to prevent malignancies associated with immunosuppression The invention provides a method for reducing formation or progression of neoplasms associated with immunosuppressive therapy in a mammal, the method comprising treating the mammal with an effective amount of an angiotensin II inhibitor. In addition the in... | 11/04/2003 |
| 6638915 | Anti-viral composition The invention relates to antiviral compositions comprising a mixture comprising zinc oxide, aspartic acid, and high fructose corn syrup, and to methods of making and using such compositions.... | 10/28/2003 |
| 6638913 | Concentrated injection and infusion solution for intravenous administration Additives to concentrated injection and infusion solutions that avoid or mitigate acute or delayed hypersensitivity reactions as well as injection and infusion solutions that contain these additives are described.... | 10/28/2003 |
| 6632789 | Methods for modulating T cell responses by manipulating intracellular signal transduction Methods for modulating T cell responses by manipulating intracellular signals associated with T cell costimulation are disclosed. The methods involve inhibiting or stimulating the production of at least one D3-phosphoinositide in a T cell. Production of D... | 10/14/2003 |
| 6624138 | Drug-loaded biological material chemically treated with genipin A method for treating tissue of a patient comprising, in combination, mixing a drug with a solidifiable biological material, chemically treating the drug with the biological material with a crosslinking agent, loading the solidifiable drug-containing biol... | 09/23/2003 |
| 6617305 | Stable aqueous dispersion of nutrients This invention relates to a stable aqueous dispersion of nutrients and more particularly, to an aqueous dispersions of an active nutritional ingredient selected form (a) an isoflavone, (b) lycopene (c) lutein, (d) a Coenzyme Qn where n is an in... | 09/09/2003 |
| 6605299 | Releasable linkage and compositions containing same A compound comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-containing ligand through a dithiobenzyl linkage is described.... | 08/12/2003 |
| 6596262 | Modulated release particles for aerosol delivery A polymeric construct is disclosed. The construct comprises a polymer selected from silica gel, fumed silica gel, silicic acid, disilicic acid, trisilicic acid, metasilicic acid, and orthosilicic acid in their free or salt forms; silicon dioxide in either... | 07/22/2003 |
| 6593301 | Use of steroidal saponins for the prophylaxis or treatment of dementia, and novel steroidal saponin compounds The invention relates to the steroidal saponin compounds for the propylaxis or treatment dementia, the new steroidal saponin compounds and the pharmaceutical composition containing the same. ##STR1##... | 07/15/2003 |
| 6579525 | Pharmaceutical compositions comprising erythropoietin for treatment of cancer Pharmaceutical compositions comprising erythropoietin are provided for treatment of cancer, particularly for treatment of multiple myeloma. Erythropoietin was found to be effective for inhibition of tumor growth, triggering of tumor regression, stimulatio... | 06/17/2003 |
| 6576676 | Means for the modulation of processes mediated by retinold receptors and compounds useful therefor In accordance with the present invention, there are provided methods to modulate processes mediated by retinoid receptors, employing high affinity, high specificity ligands for such receptors. In one aspect of the present invention, there are provided lig... | 06/10/2003 |
| 6576242 | Compositions and methods for reducing or controlling blood cholesterol, lipoproteins, triglycerides and atherosclerosis This invention provides compositions and methods related to the administration of red yeast rice, coenzyme Q10, and chromium, with or without inositol hexanicotinate, selenium, and mixed tocopherols to reduce or control blood cholesterol, trigl... | 06/10/2003 |
| 6572858 | Uses for anti-malarial therapeutic agents A diversity of inflammatory diseases can be treated via local delivery to the patient of a composition containing a therapeutically effective amount of an anti-malarial agent. In a preferred embodiment of the method of the invention, a pulmonary inflammat... | 06/03/2003 |
| 6566324 | Preventing airway mucus production by administration of EGF-R antagonists Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to an... | 05/20/2003 |
| 6566086 | Diagnostic kit for detecting creatine levels Methods for the detection of creatine compound levels in body fluid samples are discussed. Portable kits capable of determining creatine levels using non-invasive and visually detectable methods are also included.... | 05/20/2003 |
| 6562347 | Chemokine-tumor antigen fusion proteins as cancer vaccines The present invention provides a fusion polypeptide comprising a chemokine and either a tumor or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in trea... | 05/13/2003 |
| 6551989 | Preventing airway mucus production by administration of EGF-R antagonists Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to an... | 04/22/2003 |
| 6552007 | Use of somatostatin analogs for the delivery of anti-tumor drugs to tumor cells A conjugate of somatostatin-spacer-drug and a method of making the same. The conjugate can be used to enhance an anti-cancer drug's specificity on the targeted tumor cells, thus increasing its therapeutic efficacy while reducing side-effects.... | 04/22/2003 |
| 6551578 | Modulated release particles for aerosol delivery A modulated release aerosol formulation is disclosed. The formulation comprises a polysaccharide polymer having a selected medicament associated therewith, a fluid carrier for carrying and delivering the construct and a stabilizer.... | 04/22/2003 |
| 6544959 | High affinity nucleic acid ligands to lectins This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin, E-selectin and P-selectin. Also disclosed are the methods for obtain... | 04/08/2003 |
| 6541005 | Compositions and methods for reducing or controlling blood cholesterol, lipoproteins, triglycerides and atherosclerosis This invention provides compositions and methods related to the administration of red yeast rice, coenzyme Q10, and chromium, with or without inositol hexanicotinate, selenium, and mixed tocopherols to reduce or control blood cholesterol, trigl... | 04/01/2003 |
| 6537964 | Reversal of multidrug resistance in human colon carcinoma cells The present invention describes the use of fumitremorgin A, B and C and a series of diketopiperazines of Formula (I) to resensitize multidrug resistant (MDR) cancer cells to the cytotoxic effects of chemotherapeutic drugs.... | 03/25/2003 |
| 6528259 | Methods for detecting human methylenetetrahydrofolate reductase allelic variants Provided herein is a heretofore unknown isolated nucleic acid molecule which encodes human methylenetetrahydrofolate reducatase, along with an amino acid sequence of methylenetetrahydrofolate reductase, and a cDNA probe for human methylenetetrahydrofolate... | 03/04/2003 |
| 6525031 | Targeted Oligonucleotide conjugates The present invention provides improved ingress of therapeutic and other moieties into cellular targets. In accordance with preferred embodiments, complexes are provided which carry primary moieties, chiefly therapeutic moieties, to such target cells. Suc... | 02/25/2003 |
| 6524571 | Methioninase gene therapy for tumor treatment A depletion method to inhibit tumor growth includes introducing a viral expression system capable of expressing methioninase or a fusion protein containing methioninase into a tumor contained in a vertebrate subject or cells thereof. The fusion protein ma... | 02/25/2003 |
