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| Number | Title | Issue Date |
| 8110557 | Gamma secretase inhibitor for treatment of herpesvirus infection This invention relates to methods and compositions for the treatment of malignancies associated with gamma-herpesvirus infection. Specifically, the invention relates to the use of gamma-secretase inhibitors to prevent the production of intracellular Notch1 thereby a... | 02/07/2012 |
| 8106000 | Colonic delivery of adsorbents Orally administrable, site-specific (colonic), particulate delivery systems including adsorbents are disclosed. When delivered specifically to the colon, they can remove various substances present in, or as they reach, the colon. Methods of treatment using the deliv... | 01/31/2012 |
| 8093217 | Methods and compositions for inhibition of multi-drug resistance by hyaluronan oligomers Pharmaceutical compositions and methods for sensitizing multi-drug resistant cancer or radiation resistant cancer cells to chemotherapeutic agents are provided. Compositions include ligands of hyaluronan receptors, including glycosaminoglycans such as hyaluronan oli... | 01/10/2012 |
| 8084413 | Urocortin-III and uses thereof A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology co... | 12/27/2011 |
| 8080515 | Method for prevention of platelet aggregation employing and RGD-enriched gelatine-like protein The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the t... | 12/20/2011 |
| 8071534 | Material for facilitating thermal treatments of biological tissues and method of energy targeting leading to thermal treatment of biological tissues A method includes positioning an effective amount of a thermal target material at a treatment site of a patient. The treatment site, that is, the location of the thermal target material, comprises a location adjacent to biological tissue to be treated. The thermal t... | 12/06/2011 |
| 8071533 | Compositions and methods for modulating store-operated calcium entry Compositions and methods for modulating activity of store-operated calcium entry in cells or tissues are provided. The compositions comprise the P311 protein, fused to a cell-penetrating peptide and formulated for delivery to tissues and cells. This protein has been... | 12/06/2011 |
| 8071532 | Use of C1 inhibitor for the prevention of ischemia-reperfusion injury The present invention relates to the therapeutic and prophylactic use of C1 inhibitor for preventing, reducing and treating ischemia and reperfusion injury. The C1 inhibitor of the present invention is still therapeutically effective when administered after an ische... | 12/06/2011 |
| 8067357 | Annexin derivatives suitable for pretargeting in therapy and diagnosis The present invention provides methods and compositions for the treatment and diagnosis of diseases such as neoplastic diseases, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and inflammatory diseases. The methods are based on the concept... | 11/29/2011 |
| 8067356 | High fibre high calorie liquid or powdered nutritional composition The present invention relates to a nutritional composition which is liquid and shelf-stable or powdered and reconstitutable. The composition has a fiber content of more than 2.5 g/fibber per 100 ml of the composition. Furthermore, it has an energy content of 1.3-1.8... | 11/29/2011 |
| 8067358 | Triple-action remedy for removing toxic oils from skin with simultaneous soothing and healing Disclosed are formulae and methods for the simultaneous relief of a variety of unpleasant symptoms of poison ivy on the skin. The compositions of the present invention remove toxic urushiol, relieve itching of the skin from urushiol, and heal the dermatitis caused b... | 11/29/2011 |
| 8058249 | Immunostimulatory nucleic acid molecules Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atop... | 11/15/2011 |
| 8058225 | Proteins for use in human and animal infections The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and va... | 11/15/2011 |
| 8048844 | Preventing airway mucus production by administration of EGF-R antagonists Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks th... | 11/01/2011 |
| 8030286 | Methods and means for increasing resistance to cell damage Methods are provided to increase resistance to cell damage in a subject. The increase in resistance to cell damage in a subject in the subject is accomplished by decreasing activity of eEF2 kinase in the subject. The eEF2 kinase activity can be decreased by decreasi... | 10/04/2011 |
| 8026212 | Methods of preparing pharmaceutical compositions comprising GPR119 agonists having the effect of glucose-dependent insulinotropic peptide secretatgogues The present invention relates to methods of using GPR119 receptor to identify compounds useful for increasing bone mass in an individual. Agonists of GPR119 receptor are useful as therapeutic agents for treating or preventing a condition characterized by low bone ma... | 09/27/2011 |
| 8017574 | Methods of preparing pharmaceutical compositions comprising GPR119 agonists having the effect of glucose-dependent insulinotropic peptide secretagogues The present invention relates to methods of using GPR119 receptor to identify compounds useful for increasing bone mass in an individual. Agonists of GPR119 receptor are useful as therapeutic agents for treating or preventing a condition characterized by low bone ma... | 09/13/2011 |
| 7998934 | PAI-2 conjugates for the treatment and imaging of cancer A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises PAI-2 or a functional derivative, homologue, analogue, chemical equivalen... | 08/16/2011 |
| 7998922 | Process for treating fibroses with biocompatible polymer A biocompatible polymer constituted by a sequence of identical or different components of the general formula (I): AaXxYy, in which A represents a monomer, X represents a carboxyl group fixed on a monomer A, Y represents a sulfate or... | 08/16/2011 |
| 7994113 | βGBP, compositions comprising βGBP, and related methods and uses thereof The invention relates to β-galactoside binding protein (βGBP) and compositions, including pharmaceutical compositions, comprising βGBP for use in therapy and related applications. In particular, the invention relates to use of βGBP and the manufacture of medicam... | 08/09/2011 |
| 7985726 | ψεRACK peptide composition and method for protection against tissue damage due to ischemia A method of reducing damage to cells and tissue caused by an ischemic or hypoxic event is disclosed. The method includes administering to the cell or tissue, either in vivo or ex vivo, ψεRACK peptide. The peptide can be administered before, during or after the isc... | 07/26/2011 |
| 7981857 | Cerberus/coco derivatives and uses thereof The invention relates to Cerberus/Dan/Gremlin polypeptides or variants thereof for use in treating a variety of disorders associated with myostatin, nodal and GDF-11. Preferred polypeptides are Coco or Cerberus derivatives. ... | 07/19/2011 |
| 7973005 | Alpha-1 antitrypsin for treating exacerbation episodes of pulmonary diseases The present invention relates to methods for the treatment of exacerbation periods of pulmonary diseases, particularly chronic obstructive pulmonary diseases, by administering alpha-1 antitrypsin (AAT) to a subject in need thereof. Particularly, the present inventio... | 07/05/2011 |
| 7964554 | Polypeptide that binds anti-histone H1 antibody The present invention discloses anti-histone H1 monoclonal antibodies, hybridomas for the production thereof, and polypeptides, which are useful for suppressing, predicting, or diagnosing transplant rejection in organ transplantation. ... | 06/21/2011 |
| 7960347 | Matrix protein compositions for induction of apoptosis Enamel matrix, enamel matrix derivatives and/or enamel matrix proteins or peptides may be used as therapeutic or prophylactic agents for inducing programmed cell death (apoptosis), in particular in the treatment or prevention of cancer or malignant or benign neoplas... | 06/14/2011 |
| 7960346 | Tumor cytotoxicity induced by modulators of the CXCR4 receptor The present invention provides a means of selectively killing epithelial cell carcinomas by administering a CXCR4-specific sequence of the Gp120 protein or Nef proteins or the proteins themselves (the modulators) such as that found in strains HIV-1, HIV-2, SIV, or F... | 06/14/2011 |
| 7947652 | Compositions and methods for modulating PGC-1α to treat huntington's disease The present invention provides methods for modulating mitochondrial function, modulating lesion formation in the brain, modulating neurite growth, modulating neuronal degeneration, and treating and preventing neurological diseases or disorders comprising modulating ... | 05/24/2011 |
| 7939489 | Oil absorbent topical compositions and methods for using same There are provided topical compositions and methods for cleaning oil from the skin, nail or hair. The compositions have a vehicle and an effective amount of an oil-absorbing ingredient having an ethylene mixed block copolymer. There is also provided compositions and... | 05/10/2011 |
| 7923429 | Treatment for CD5 B cell lymphoma The present invention provides methods for increasing expression of cell surface molecules of CD5+ B cell lymphoma cells by contacting cells with immune response modifiers. The invention also provides methods for the treatment of CD5+ B cell ly... | 04/12/2011 |
| 7919454 | Methods of treating using conjugates transported by a PEPT2 transporter The invention provides methods of screening agents, conjugates or conjugate moieties, linked or linkable to agents, for capacity to be transported as substrates through the PEPT2 transporter. The invention also provides methods of treatment involving delivery of age... | 04/05/2011 |
| 7919453 | Dosage cap assembly for an applicator A dosage cap assembly is provided for use with an applicator assembly, the dosage cap assembly including a tip including an outer surface, an attachment end, a second end, and an inner surface defining a tip cavity, wherein the attachment end of the tip includes an ... | 04/05/2011 |
| 7897559 | Dermatological composition and kit containing avermectin compound for treating dermatological conditions A dermatological composition and a kit containing the composition for treating dermatological conditions including transient acantholytic dermatitis, acne miliaris necrotica, acne varioliformis, perioral dermatitis, acneiform eruptions, acne vulgaris, and seborrheic... | 03/01/2011 |
| 7888310 | Methods of identifying responders to dopamine agonist therapy The present invention is directed to a method of identifying patients to be treated by dopamine agonist therapy comprising the step of analyzing a plasma or urine sample from said patient for concentrations of norepinephrine (NE), norepinephrine metabolites (NE meta... | 02/15/2011 |
| 7879791 | Regulation of T cell-mediated immunity by tryptophan A mechanism of macrophage-induced T cell suppression is the selective elimination of tryptophan and/or increase in one or more tryptophan metabolites within the local macrophage microenvironment. Studies demonstrate that expression of IDO can serve as a marker of su... | 02/01/2011 |
| 7855174 | Methods of treating vasodilatory shock The invention encompasses methods of decreasing the lumenal diameter of a blood vessel by contacting the vessel with a myosin light chain phosphatase inhibitor. ... | 12/21/2010 |
| 7851431 | Treatment of actinic keratoses with calcium channel blockers The present invention relates to methods and compositions for the treatment and/or prevention of actinic keratoses comprising a calcium channel blocking compound. ... | 12/14/2010 |
| 7851432 | Cytotoxic agents comprising new maytansinoids New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the α-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new may... | 12/14/2010 |
| 7838489 | Methods of treating rheumatoid arthritis with p75 TNF-alpha receptor and methotrexate Methods for treating and/or preventing a TNF-mediated disease in an individual are disclosed. Also disclosed is a composition comprising methotrexate and an anti-tumor necrosis factor antibody. TNF-mediated diseases include rheumatoid arthritis, Crohn's disease, and... | 11/23/2010 |
| 7833962 | Method of reducing hypertension by administering flavanol gylcosides The present invention relates to use of a plant which has been modified to produce increased levels of flavonol glucosides, or an extract thereof containing flavonol glucosides, in reducing hypertension in a mammal. ... | 11/16/2010 |
| 7816315 | Method of isolating a nucleic acid using a material containing an amino group and a carboxyl group and positively charged at a first pH and a solid material for nucleic acid isolation used for the method Provided are a method of isolating a nucleic acid from a sample and a solid material for isolating the nucleic acid which can be used for the above method. The method includes contacting the sample with a bifunctional material containing an amino group and a carboxy... | 10/19/2010 |
