Class 436/94 - Saccharide (e.g., DNA, etc.)

Subclass of Class 436 - Chemistry: analytical and immunological testing
Definition: Subject matter in which the substance subjected to chemical
No. of patents: 914
Last issue date: 05/08/2012

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Number	Title	Issue Date
8173437	Rapid serum sugar biomarker assay of rheumatoid arthritis The present invention includes compositions, methods, kits and diagnostics for biosugar profiling of biological samples from a patient suspected of having a disease associated with changes in the biosugar profile. The biosugar profile from the patient sample is comp...	05/08/2012
8153437	DNA-based molecular switches and uses thereof Disclosed are nucleic acid-based molecular switches that respond to changes in pH. The switches may be used in DNA nanodevices. The switches may also act as sensors for measuring the pH of a sample, including cells, regions thereof, and whole organisms. The switch i...	04/10/2012
8153438	Sequencing nucleic acid polymers with electron microscopy This invention relates to using an electron microscope to sequence by direct inspection of labeled, stretched DNA. This method will have higher accuracy, lower cost, and longer read length than current DNA sequencing methods. ...	04/10/2012
8148159	System and methods for stretching polynucleotides Apparatus and methods are described for achieving uniform stretching of polynucleotides in hybrid electrophoretic-gel, micro-constricting microfluidic channels. Polynucleotides in normally relaxed configurations are driven by an electric field along a microfluidic c...	04/03/2012
8124417	Method for analyzing nucleobases on a single molecular basis A method is herein presented for analyzing nucleobases on a single molecular basis (a single molecule detection), which comprises scanning a molecular tip chemically modified with the complementary nucleobase on the nucleobases, and measuring the tunneling currents ...	02/28/2012
8114591	Sensing apparatus and method A method of observing reaction intermediaries during a chemical reaction and comprising detecting an electrical signal output from an ion sensitive field effect transistor exposed to said reaction, and monitoring the detected electrical signal to discriminate discre...	02/14/2012
8101416	Compositions for detection and analysis of polynucleotides using light harvesting multichromophores Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PNA complementary to the targe...	01/24/2012
8093063	Assay for detecting genetic abnormalities in genomic nucleic acids The present invention provides methods of detecting unamplifed genomic nucleic acid anchored to a solid support. The methods are useful for the detecting genetic abnormalities associated with various diseases, diagnosis, and prognosis. ...	01/10/2012
8076149	Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatog...	12/13/2011
8062897	Diagnostic histopathology using multiplex gene expression FISH The present invention relates to a method for detecting one or more nascent RNAs in a tissue sample using FISH. In the method, a plurality of probes (8 to 82) may be used to detect a single species of nascent RNA. Further, a plurality of nascent RNA species may be d...	11/22/2011
8034747	Photolabile compound, oligomer probe array and substrate for oligomer probe array containing the same, and manufacturing method of the same A photolabile compound, an oligomer probe array, and a substrate for oligomer probe array comprising the same, and a manufacturing method of the same are disclosed. ...	10/11/2011
8021888	Rapid comparative genomic hybridization using acoustic surface waves Disclosed is a method for performing nucleic acid hybridization assays which involve the application of acoustic surface waves. The hybridization assays may be used for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or as...	09/20/2011
7977109	Method for enriching short-chain nucleic acids The present invention relates to a method for enriching nucleic acids with a length of not more than 300 nucleotides. The invention also relates to a kit for enriching nucleic acids with a length of not more than 300 nucleotides, to the use of such a kit, to the use...	07/12/2011
7977108	Method for detecting a mutation in a repetitive nucleic acid sequence The present invention provides methods and probe nucleic acids for detecting mutant forms of target nucleic acids that comprise repetitive nucleotide sequences. In certain embodiments, for example, these approaches and reagents can be used to detect instability in r...	07/12/2011
7972859	Authentication of ingestible products using saccharides as markers A method of determining authenticity of an ingestible product purportedly from a batch of saccharide-marked ingestible product is provided. The ingestible product is a food, beverage, or pharmaceutical, for example. The method includes identifying a sample of the in...	07/05/2011
7972858	Ultra high-throughput opti-nanopore DNA readout platform Described herein are methods for analyzing polymer molecules. These methods are employed for the high throughput readout of DNA and RNA molecules with single molecule sensitivity. The method of the present invention comprises (1) the electrically controlled unzippin...	07/05/2011
7972860	Methods and compositions for the detection and analysis of nucleic acids by signal amplification The present invention relates to a novel integrated PCR-free signal amplification polynucleotide detection system which combines a specific receptor, an optical transducer, and an amplification mechanism. This novel detection system is based on different electrostat...	07/05/2011
7968345	Permethylation of oligosaccharides A solid-phase permethylation procedure is described. For example, solid-phase permethylation can be utilized to prepare permethylated linear and branched, neutral and sialylated oligosaccharides, which can be analyzed by MALDI-MS. ...	06/28/2011
7964410	Method for preparing analysis sample, analysis sample and sugar chain capture agent A method for preparing an analysis sample which involves the sugar chain capture step comprising a reaction of capturing a sugar chain and/or a sugar derivative from a biological sample by using a sugar chain capture agent and the excision step comprising excising a...	06/21/2011
7951604	Mixtures for assaying nucleic acid, novel method of assaying nucleic acid with the use of the same and nucleic acid probe to be used therefor To provide a novel mixture for assaying a target nucleic acid, characterized by enabling a nucleic acid assay while: 1) requiring no step of diluting the target nucleic acid; 2) requiring no procedure of changing a probe concentration depending on a concentration of...	05/31/2011
7951603	Method of mass spectrometric analysis of saccharides with aldehyde groups using labels containing a pyrene ring and a hydrazide group An object of the invention is to provide a method for enabling MSn (n>) analysis of a trace amount of a sample and easily and rapidly obtaining structural information by identifying a bonding position of the labeling compound in a molecule with the MS	05/31/2011
7888127	Methods for reducing adduct formation for mass spectrometry analysis The invention provides a novel additive for improved analysis by mass spectrometry. More specifically, ascorbic acid has been found to reduce or eliminate the presence of adducts commonly present in mass spectra. The improved processes and compositions of the invent...	02/15/2011
7863049	Noninvasive blood sugar level measuring method A noninvasive blood sugar level measurement method includes a process of changing a blood sugar level of a biological body, a process of noninvasively measuring biological feature amounts at plural measurement points that are timewise shifted from each other, a proc...	01/04/2011
7863050	Methods and compositions for purification of nucleic acid from a host cell Methods and compositions are provided for gently lysing and solubilizing cells. Methods and compositions are further provided for quickly purifying high quality low molecular weight nucleic acid from host cells. Target cells are treated with a pre-chilled lysis solu...	01/04/2011
7855080	Fingerprint analysis for a plurality of oligonucleotides The invention provides a method for evaluating the accuracy of an oligonucleotide sample, specifically a sample containing a variety of oligonucleotides of potentially varying size and sequence. The method provides a fingerprint that can be used to evaluate the accu...	12/21/2010
7824917	Method of detecting nucleic acid by using nucleic acid microarray The present invention provides a method of detecting a nucleic acid which is not restricted by the design of the base sequence of a nucleic acid probe. By repeating washing and detection in multiple stages, the present invention can improve the precision of sequence...	11/02/2010
7816144	Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatog...	10/19/2010
7795033	Methods to predict the outcome of treatment with antidepressant medication The invention provides a method for determining the outcome of treatment with an antidepressant medication in a patient. In particular, the invention provides a method of screening patients to identify those patients with a decreased risk of non-response to treatmen...	09/14/2010
7790466	Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatog...	09/07/2010
7759126	Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for amplification (or PCR) analysis Minor groove binder-oligonucleotide probes are provided along with methods for their use wherein the probes have an attached fluorophore which, in an unhybridized form exhibits very low background signal. ...	07/20/2010
7745225	Prognostic tests for development of dermal stretch marks and implications for the preventive treatment thereof Various methods of assessing the regenerative potential of dermal tissue in a patient may be determined and methods to determine the potential development of stretch marks in a patient are provided. Through the analysis of a series of dermal tissue samples, a method...	06/29/2010
7718438	Method for producing a microarray A microarray obtainable by slicing a block comprising a plurality of linear bodies or through-holes which carry an organism-related substance, in a direction intersecting the longitudinal direction of the linear bodies or through-holes, wherein the linear body and/o...	05/18/2010
7687274	Method for determining specific groups constituting heparins or low molecular weight heparins The invention provides methods for analyzing heparins, low-molecular-weight heparins, ultralow-molecular-weight heparins, and oligosaccharides by high performance liquid chromatography a stationary phase dynamically coated with a quaternary ammonium salt. The method...	03/30/2010
7635595	Fluorescent probes for saccharrides The spectroscopic and photophysical properties of fluorescent probes comprising donor-acceptor derivatives comprising the boric acid group or a derivative of boric acid, B(OH)3 (or borate ion, BO(OH)2−1), arsenious acid, H3	12/22/2009
7604998	Fingerprint analysis for a plurality of oligonucleotides The invention provides a method for evaluating the accuracy of an oligonucleotide sample, specifically a sample containing a variety of oligonucleotides of potentially varying size and sequence. The method provides a fingerprint that can be used to evaluate the accu...	10/20/2009
7575930	Method for analyzing oligosaccharides from blood plasma The present invention relates to a method for analyzing oligosaccharides constituting the heparins of low molecular weight and the heparins of very low molecular weight from blood plasma. ...	08/18/2009
7556967	Foldable polymers as probes Disclosed herein are novel probes, which can be used to detect and identify target molecules of interest in a sample. The disclosed probes can be used to monitor conformational changes induced by molecular recognition events in addition to providing signaling the pr...	07/07/2009
7550300	Prediction of bare metal stent restenosis Methods for predicting whether or not a patient is likely to experience restenosis after the placement of a bare metal stent are provided. The methods involve detecting and analyzing gene expression patterns of the cellular components of whole blood, where activatio...	06/23/2009
7534621	Method of producing probe medium and method of immobilizing probe using probe medium When a probe medium is spotted on a substrate, a probe can be effectively and stably immobilized on the substrate. The probe medium includes a probe capable of specifically binding to a target substance, a medium containing an organic solvent, and a substance for so...	05/19/2009
7504261	Method for highly sensitive nucleic acid detection using nanopore and non-specific nucleic acid-binding agent Provided is a method of sensitively detecting nucleic acids in a nucleic acid sample, the method comprising: contacting the sample comprising the nucleic acid with a non-specific nucleic acid binding agent in an electrically conductive fluid medium; contacting the s...	03/17/2009

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Class 436/94 - Saccharide (e.g., DNA, etc.)