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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 8187891 | Methods for detection and determination of vitamin C by luminescence The present invention provides a method for detection or determination of vitamin C by luminescence that employs a redox-responsive fluorogenic probe consisting of porphyrin or phthalocyanine with a nitroxide radical(s), or that employs a liposome preparation compri... | 05/29/2012 |
| 7977107 | Oral detection test for cannabinoid use A method for confirming the active intake of marijuana and its active component Δ9-tetrahydrocannabinol (“Δ9-THC”) by detecting the amount of 11-nor-Δ9-THC carboxylic acid (“THCA”) in oral fluid at the picogram per millili... | 07/12/2011 |
| 7816143 | Oral detection test for cannabinoid use A method for confirming the active intake of marijuana and its active component Δ9-tetrahydrocannabinol (“Δ9-THC”) by detecting the amount of 11-nor-Δ9-THC carboxylic acid (“THCA”) in oral fluid at the picogram per millili... | 10/19/2010 |
| 7465586 | Oral detection test for cannabinoid use A method for confirming the active intake of marijuana and its active component Δ9-tetrahydrocannabinol (“Δ9-THC”) by detecting the amount of 11-nor-Δ9-THC carboxylic acid (“THCA”) in oral fluid at the picogram per millili... | 12/16/2008 |
| 7407811 | System and method for analyte measurement using AC excitation A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the an... | 08/05/2008 |
| 7397026 | Efficient electron transfer dissociation for mass spectrometry The present invention relates to, inter alia, methods and apparatuses for electron transfer dissociation (ETD) that vary the internal energy of precursor ions for ETD. The methods and apparatuses are particularly useful in mass spectrometry. ... | 07/08/2008 |
| 7390667 | System and method for analyte measurement using AC phase angle measurements A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the an... | 06/24/2008 |
| 7385185 | Molecular activation for tandem mass spectroscopy In a tandem mass spectrometer means are provided for molecular activation of ions prior to fragmentation. An embodiment of a tandem mass spectrometer comprises a first collision cell receiving analyte ions having an internal energy and a second collision cell situat... | 06/10/2008 |
| 7335512 | Marker for measuring liver cirrhosis The invention provides methods and kits to detect liver cirrhosis in mammals. The diagnostic test is based on the profiling and identification of diagnostic carbohydrates present in a body fluid such as blood serum. ... | 02/26/2008 |
| 7316899 | Portable sensor array system A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically ... | 01/08/2008 |
| 7303925 | Method of detecting an analyte for lateral flow immunoassay tests A visual perception of a colored site in an immunoassay device comprising a strip for enabling capillary migration of a fluid sample therealong, a labeled reagent disposed on the strip and formulated for suspension in the sample migrating therepast and a captive rea... | 12/04/2007 |
| 7300633 | Specimen collection container The present invention recognizes that sample handling devices, particularly those used for testing for substances of abuse, do not allow for a separation of the bulk sample from a sample thereof to be tested. The present invention provides such a device and methods ... | 11/27/2007 |
| 7270959 | Specimen collection container The present invention recognizes that sample handling devices, particularly those used for testing for substances of abuse, do not allow for a separation of the bulk sample from a sample thereof to be tested. The present invention provides such a device and methods ... | 09/18/2007 |
| 7264971 | Read-head for optical diagnostic device A readhead for a photometric diagnostic instrument includes a housing adapted for incorporation within the photometric diagnostic instrument, and an elongated sample table operatively engaged with the housing. The sample table is configured to support elongated reag... | 09/04/2007 |
| 7255835 | Single pass attenuated total reflection fourier transform infrared microscopy apparatus and method for identifying protein secondary structure, surface charge and binding affinity Apparatus and method for acquiring an infrared spectrum of a sample having or suspected to have an amide I band, an amide II band, an amide III band, an amide A band, an OH stretching region or a combination thereof. A representative method includes providing a samp... | 08/14/2007 |
| 7244619 | Serum marker for measuring liver fibrosis The invention provides methods and kits to detect liver fibrosis or a change in the gradation of liver fibrosis in mammals. The diagnostic marker is based on the profiling and identification of diagnostic carbohydrates present in a body fluid such as blood serum. | 07/17/2007 |
| 7238534 | Capillary active test element having an intermediate layer situated between the support and the covering The invention concerns a device for withdrawing samples of liquid samples for analytical elements. The capillary-device channel is essentially formed by a carrier, a cover and optionally an intermediate layer between the cover and carrier. A notch is located in one ... | 07/03/2007 |
| 7220553 | Use of Russell's viper venom-induced plasma factor Xa activity to monitor the activity of factor Xa inhibitors The invention relates to a method of monitoring the effect of a direct of indirect Factor Xa inhibitors comprising the steps of collecting a plasma sample from a patient, adding a solution of Russell's viper venom to the plasma sample and measuring the clotting time... | 05/22/2007 |
| 7198955 | Method and apparatus for measurement of blood substitutes A method is disclosed whereby the concentration of a blood substitute, such as cross-linked hemoglobin, in a serum or plasma specimen is rapidly and accurately identified and quantified. The method further takes the measured concentration of the blood substitute and... | 04/03/2007 |
| 7189366 | Molecular tag reader Near infrared molecular assays can be used to detect small quantities of a molecule of interest in vivo or in vitro using laser dyes. A hand-held portable device is provided which can rapidly read small quantities of selected molecular tags in tissues of fish or oth... | 03/13/2007 |
| 7169359 | Bioequivalence test for iron-containing formulations A rapid method for assessing the bioequivalence of iron in iron-supplement formulations, particularly iron-sucrose formulations is described, which is based upon the kinetics of reduction of iron (III) to iron (II) in a sample of the formulation. Quality control met... | 01/30/2007 |
| 7150997 | Multiplexed active biologic array A method of addressing and driving an electrode array includes the step of addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect of the method, a value corresponding to a voltage is stored in a local memory assoc... | 12/19/2006 |
| 7126113 | Mass spectrometry system According to the existing mass spectrometric system, whether or not the informations are sufficient for analyzing substances (particularly proteins, sugars, etc.) cannot be judged in the process of measurement. Further, it is difficult to find out isomers having jus... | 10/24/2006 |
| 7102011 | Methods and compositions for the visualization of cellular organelles using tetrazolium salts The invention provides a biochemical method for visualizing cellular organelles (such as centrosome) and/or cytoskeletons (such as microtubules) through the use of crystallizing agents (such as tetrazolium salts), a kit containing crystallizing agents adapted for su... | 09/05/2006 |
| 7101717 | Addressable biologic electrode array An addressable biologic electrode array includes an array of electrodes disposed on a support, the array of electrodes being selectively addressed and driven using a memory associated with each electrode of the array, the driven electrodes being driven at one of a p... | 09/05/2006 |
| 7096714 | Volatile signature detector and associated methods A detector (D) for detecting the volatile signature of one or more substances, e. g. alcohol and/or cannabis, on the breath (MG) of a consumer (P), using several sensors (CT1, CT2, CT3). The sensors can comprise semi-conductors or conductive pol... | 08/29/2006 |
| 7081347 | Method for predicting cardiovascular events A method for assessing aspirin resistance and relative risk of a cardiovascular event in a patient taking aspirin is provided. The concentration of 11-dehydro-thromboxane B2 in a urine sample is measured and compared to a set of standardized quartile concentrations.... | 07/25/2006 |
| 7045097 | Biologic electrode array with integrated optical detector A biologic electrode array is formed on a semiconductor substrate. A matrix of electrode sites is disposed on the semiconductor substrate. A matrix of optical detectors is disposed beneath the electrode sites in the semiconductor substrate, wherein each electrode si... | 05/16/2006 |
| 7008799 | Analytical test element with a capillary channel The invention concerns an analytical test element for the determination of an analyte in a liquid containing an inert carrier, a detection element and a channel capable of capillary liquid transport which has a sample application opening at one end and a vent openin... | 03/07/2006 |
| 6982336 | 1,2-dioxetane derivatives, luminescent reagents, luminescence methods and measuring methods A 1,2-dioxetane derivative of the formula (I): wherein R1–R3 and Ar are defined in the claims is provided. ... | 01/03/2006 |
| 6911342 | Bioequivalence test for iron-containing formulations A rapid method for assessing the bioequivalence of iron in iron-supplement formulations, particularly iron-sucrose formulations is described, which is based upon the kinetics of reduction of iron (III) to iron (II) in a sample of the formulation. Quality control met... | 06/28/2005 |
| 6881579 | Sample processing apparatus and methods Apparatus and methods are disclosed for processing samples on the surface of supports that are contained in support housings. Biopolymer features are attached to the surfaces of the supports. An apparatus comprises an input element, a holding device for holding a pl... | 04/19/2005 |
| 6878552 | Homogeneous detection and/or determination method for a chemical or physico-chemical interaction The invention relates to a homogeneous method for detecting and/or determining by fluorescence a chemical or physicochemical interaction in a measuring medium, in which a rare-earth metal cryptate comprising a substituent is used, characterized in that the variation... | 04/12/2005 |
| 6867048 | Multiplexed active biologic array A method of addressing and driving an electrode array includes the step of addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect of the method, a value corresponding to a voltage is stored in a local memory assoc... | 03/15/2005 |
| 6844198 | Adsorptive method for determining a surface property of a solid A method of determining a surface property of solids in a plurality by contacting the solids with a fluid, measuring the radiation emitted, absorbed, or altered during adsorption of the fluid using a detector, and then determining at least one surface property of th... | 01/18/2005 |
| 6825045 | System and method of infrared matrix-assisted laser desorption/ionization mass spectrometry in polyacrylamide gels A system and method for desorption and ionization of analytes in an ablation medium. In one embodiment, the method includes the steps of preparing a sample having analytes in a medium including at least one component, freezing the sample at a sufficiently low temper... | 11/30/2004 |
| 6821784 | Method of diagnosing colorectal adenomas and cancer using proton magnetic resonance spectroscopy Two dimensional COSY magnetic resonance spectroscopy of human stool can be used in a non-invasive method of detecting the presence of colorectal cancer. The spectrum of a patient's stool is compared with that of stool from non-cancerous subjects, observed difference... | 11/23/2004 |
| 6790668 | Monitoring patient compliance and bioavailability of drugs by deproteinizing body fluids The present invention is a method for drug level detection by using a simplified and effective deproteinizing step from body fluids, such as plasma, blood, urine, saliva, tear fluid, followed by drug extraction and measurement using an accurate technique, such as a ... | 09/14/2004 |
| 6730519 | Method of preparing delta-9-tetrahydrocannabinol A method for the isolation of delta-9-tetrahydrocannibinol (THC) from, Cannabis plant material, wherein delta-9-THC Acid and THC are separately obtained including the steps of extracting the Cannabis plant material, chelating delta-9-THC acid on alumina solid suppor... | 05/04/2004 |
| 6723564 | IR MALDI mass spectrometry of nucleic acids using liquid matrices Mass spectrometry of large nucleic acids by infrared Matrix-Assisted Laser Desorption/Ionization (MALDI) using a liquid matrix is reported. ... | 04/20/2004 |
