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| Number | Title | Issue Date |
| 7399470 | Sandwich immunoassay kits for detecting ciguatoxin CTX3C A sandwich immunoassay kit for detecting ciguatoxins based on a combination of two anti-ciguatoxin CTX3C monoclonal antibodies produced by hybridomas, 3D11 (deposited at IPOD, AIST under accession number FMRM PB-8293) and 10C9 (FMRM PB-8292). In particular, one of t... | 07/15/2008 |
| 7378283 | Reaction monitoring of chiral molecules using fourier transform infrared vibrational circular dichroism spectroscopy A method and apparatus to monitor the enantiomeric excess of chiral molecules participating in a chemical reaction. The method includes real time monitoring of the chemical reaction by obtaining a VCD spectra and an IR spectra of the chemical compounds in the reacti... | 05/27/2008 |
| 7378282 | Method for measuring hypochlorite ion A method for measuring hypochlorite ion, which comprises the steps of: (A) reacting, with hypochlorite ion, a compound represented by the following general formula (I): wherein R1 represe... | 05/27/2008 |
| 7374721 | Chip with measuring reliability and a method thereof A chip with measuring reliability and a method thereof are provided. The present invention serially connects a resistor having a resistance equal to or a little more than a maximum resistance of the chip itself to the resistor Rs of the chip so as to comp... | 05/20/2008 |
| 7368085 | Analyte detector An analyte detector including a device having a surface, wherein the device is capable of detecting a charge adjacent to the surface. The surface includes a plurality of molecules bonded thereto, wherein the molecules have a structure (I): | 05/06/2008 |
| 7267990 | Chelation of charged and uncharged molecules with porphyrin-based compounds Porphyrins containing one or more neutral or negatively-charged, closo- or nido-carborane substituents are useful as chelators. The carbon-carbon bonds linking the boron-containing groups to the porphyrin ring make the compounds highly resistant to hydrolysis. These... | 09/11/2007 |
| 7264777 | Measurement of surface areas by polyvinylpyrrolidone sorption A method of quantitatively determining surface area of a sample uses polyvinylpyrrolidone (PVP) dispersed in a solution containing the sample, and determining the amount of PVP that has deposited on the sample. ... | 09/04/2007 |
| 7255835 | Single pass attenuated total reflection fourier transform infrared microscopy apparatus and method for identifying protein secondary structure, surface charge and binding affinity Apparatus and method for acquiring an infrared spectrum of a sample having or suspected to have an amide I band, an amide II band, an amide III band, an amide A band, an OH stretching region or a combination thereof. A representative method includes providing a samp... | 08/14/2007 |
| 7234365 | Methods and systems for dissolution testing Methods and systems for determining a dissolution profile of a sample material, and for solubilization screening of a library defined by an array comprising multiple sample materials are disclosed. The methods and systems are particularly advantageous for sampling a... | 06/26/2007 |
| 7210336 | Gas link leak evacuation and monitoring system An apparatus and method for evacuating gas from the soil surrounding a leaking gas conduit utilizes non-sparking and static dissipating components to reduce the risk of an explosion. The evacuation of gas from probes in boreholes in the vicinity of the leak is induc... | 05/01/2007 |
| 7198955 | Method and apparatus for measurement of blood substitutes A method is disclosed whereby the concentration of a blood substitute, such as cross-linked hemoglobin, in a serum or plasma specimen is rapidly and accurately identified and quantified. The method further takes the measured concentration of the blood substitute and... | 04/03/2007 |
| 7148069 | Method for analysis of compounds with amino group and analytical reagent therefor The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino... | 12/12/2006 |
| 7132294 | Functionalized small molecules for use in chemical sensors The invention provides a device for selective molecular recognition, the device comprising a sensing portion, wherein said sensing portion includes a substrate having coated thereon a layer comprising a non-volatile, small molecule compound having at least two penda... | 11/07/2006 |
| 7062312 | Combination and method including a visual marker for determining compliance with a medication regimen A method and combination including a visual marker for monitoring a patient to determine compliance with a medication regimen. An orally administrable medication composition is provided in combination with a visual marker. When the combination is orally ingested, th... | 06/13/2006 |
| 7026166 | Fluorogenic dyes The present invention relates to the use of fluorogenic or chromogenic dyes as reporter molecules for detecting cell entry by a specific molecule. ... | 04/11/2006 |
| 7024955 | Methods and systems for dissolution testing Methods and systems for determining a dissolution profile of a sample material, and for solubilization screening of a library defined by an array comprising multiple sample materials are disclosed. The methods and systems are particularly advantageous for sampling a... | 04/11/2006 |
| 7022910 | Photovoltaic cells utilizing mesh electrodes In one aspect, the invention provides photovoltaic cells that utilize a mesh electrode on at least one exposure side of the photovoltaic cell. Preferably, the mesh electrode is a metallic mesh. In one embodiment, the invention provides dye-sensitized solar cells (DS... | 04/04/2006 |
| 7018841 | Compositions and methods for the inhibition of neurotransmitter uptake of synaptic vesicles Compositions and methods for treating neurosynaptic disorder in a subject are described. More specifically, compositions and methods for inhibiting glutamate uptake by synaptic vesicles in a subject are set forth. In one embodiment, the composition is inhibitory pro... | 03/28/2006 |
| 6825045 | System and method of infrared matrix-assisted laser desorption/ionization mass spectrometry in polyacrylamide gels A system and method for desorption and ionization of analytes in an ablation medium. In one embodiment, the method includes the steps of preparing a sample having analytes in a medium including at least one component, freezing the sample at a sufficiently low temper... | 11/30/2004 |
| 6821784 | Method of diagnosing colorectal adenomas and cancer using proton magnetic resonance spectroscopy Two dimensional COSY magnetic resonance spectroscopy of human stool can be used in a non-invasive method of detecting the presence of colorectal cancer. The spectrum of a patient's stool is compared with that of stool from non-cancerous subjects, observed difference... | 11/23/2004 |
| 6723564 | IR MALDI mass spectrometry of nucleic acids using liquid matrices Mass spectrometry of large nucleic acids by infrared Matrix-Assisted Laser Desorption/Ionization (MALDI) using a liquid matrix is reported. ... | 04/20/2004 |
| 6706530 | IR-MALDI mass spectrometry of nucleic acids using liquid matrices Mass spectrometry of large nucleic acids by infrared Matrix-Assisted Laser Desorption/Ionization (MALDI) using a liquid matrix is reported. ... | 03/16/2004 |
| 6699720 | Interference-eliminating membranes, test strips, kits and methods for use in uric acid assay The present invention relates to an interference-eliminating membrane for use in detecting uric acid in a sample, comprising a compound for inhibiting or shading uric acid interfering substances, or derivatives thereof, and a carrier having an absorption ... | 03/02/2004 |
| 6620624 | Mass spectrometry interface, a mass spectrometer and a mass spectrometry With rotating and translating a rotation-translation drum installed in a vacuum chamber of a mass spectrometry interface to constitute a mass spectro-meter, a liquid sample incorporating a dissolved substance to be analyzed in its mass is emitted for the ... | 09/16/2003 |
| 6608178 | 5-hydroxytryptophol (5-HTOL) derivatives, antibodies, immunoassays and detection of recent alcohol consumption Antibody specific for a 5-HTOL compound. A glucuronide with 5-hydroxytryptophol (5-HTOL) characterized in that it comprises the structure of the ଲ-glucuronide between the 5-hydroxy group of 5-HTOL and D-glucopyranosiduronic acid. An immunoassay and ... | 08/19/2003 |
| 6605472 | Microfluidic devices connected to glass capillaries with minimal dead volume A method is provided for joining a microchip device to a capillary tube. The microchip device has a capillary channel opening onto an edge surface of the device. A short hole is drilled into the edge surface, aligned with the capillary channel. The drilli... | 08/12/2003 |
| 6566139 | Method of enhancing the fluorescent signal of a fluorescent oxygen scavenger A method of automatically controlling the addition rate of Fresh Oxygen Scavenger Product and Ultimate Oxygen Scavenger Product to a Boiler System is described and claimed. The method is based on the inherent fluorometric properties of certain Fresh Oxyge... | 05/20/2003 |
| 6558956 | Method and apparatus for detection of a controlled substance Techniques and devices for detecting and analyzing controlled substances and the like are discussed including highly reactive sensor molecules which are coated on a spectroscopic sample surface (4) and which may chemically react with a given analyte to fo... | 05/06/2003 |
| 6416762 | Anti-picornaviral ligands via a combinatorial computational and synthetic approach The present invention provides structure-based combinatorial libraries of compounds containing the functional group minima of picornaviruses including poliovirus and rhinovirus. The libraries can be used to screen for therapeutical antiviral compounds, e.... | 07/09/2002 |
| 6376649 | Methods for the synthesis of - hydroxy-ଲ-amino acid and amide derivatives Methods for the synthesis of -hydroxy-ଲ-amino acid and amide derivatives and -ketoamide derivatives and novel derivatives made by these methods are provided. These methods involve reacting a N-terminally blocked (protected) aminoaldehy... | 04/23/2002 |
| 6333198 | Compound and its use A method of testing the purity or stability to degradation of a sample of lamotrigine or a pharmaceutical dosage form comprising lamotrigine comprises assaying the said sample for the presence of a compound selected from 3-amino-6-(2,3-dichlorophenyl)-1,2... | 12/25/2001 |
| 6210974 | Compositions and methods for promoting nerve regeneration FK506 and geldanamycin promote nerve regeneration by a common mechanism that involves the binding of these compounds to polypeptide components of steroid receptor complexes other than the steroid hormone binding portion of the complex (FKBP52 and hsp90, r... | 04/03/2001 |
| 6210973 | Method for automated flourescent tagged sample detecting An automated DNA sequencing apparatus and method is disclosed in which a laser beam having a predetermined wavelength is sequentially focused on a plurality of lanes of DNA fragments migrating in a polyacrylamide gel and in which the DNA fragments have be... | 04/03/2001 |
| 6077712 | Semiconductor chemical sensor A chemical sensor for detecting a chemical species in a gas comprises a detector element including a porous organic semiconductor comprised of a material on which the chemical species in the gas is adsorbed. The chemical sensor further comprises a power s... | 06/20/2000 |
| 6074881 | Method for the prevention of hemoglobin interference in reagent systems for measuring peroxidase activity The present invention involves an improvement to an assay for the activity of a metal chelate, such as copper II/creatinine, which activity is related to the concentration of the analyte in a fluid test sample. In carrying out the assay, there is combined... | 06/13/2000 |
| 6008054 | Method of measuring a ଲ-glucan For the purpose of improving the accuracy and reproducibility of the measurement of ଲ-glucan by flow injection method using calcofluor, the present invention provides a method in which a gel filtration column having the volume of the interstice outs... | 12/28/1999 |
| 6004536 | Lipophilic cyanine dyes with enchanced aqueous solubilty The present invention relates to a family of cyanine dyes possessing lipophilic alkyl chains and either one or more reactive functional groups, bromo or chloro, or phenyl, sulfophenyl or polysulfophenyl substituents or combinations thereof. The dyes of th... | 12/21/1999 |
| 5994143 | Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment Fluorescent conjugates suitable for use in flow cytometry and other biological applications. The fluorescent conjugates comprise an antibody having a polymeric dye bound thereto. The polymeric dye is preferably enhanced by a hydrophobic and conformational... | 11/30/1999 |
| 5965713 | Dye labeled protein conjugate its preparing method and sensor using the same It is intended to present a sensor capable of labeling with more dyes, applying the labeled protein in immunochromatography making use of antigen-antibody reaction, and having an excellent sensitivity. In a buffer, a protein and a first covalent bonding c... | 10/12/1999 |
| 5872010 | Microscale fluid handling system A microscale fluid handling system that permits the efficient transfer of nanoliter to picoliter quantities of a fluid sample from the spatially concentrated environment of a microfabricated chip to "off-chip" analytical or collection devices for further ... | 02/16/1999 |
