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| Number | Title | Issue Date |
| 6890765 | Particles for immunoassays and methods for treating the same A method of treating particles to be used in immunoassays reduces interference in particle agglutination assays. For particles having covalently bound antibodies and residual NHS-ester or sNHS-ester groups on the surface, the reactive esters are treated with an aque... | 05/10/2005 |
| 6677164 | Multivalent polymers, processes for their preparation, and their use for preparing biologically active compounds The present invention provides biologically active linear polypeptides that possess a plurality of biologically active groups, methods employing such peptides to target molecules to cells, and methods employing such peptides for inhibiting the binding of ... | 01/13/2004 |
| 6436721 | Device and method for obtaining clinically significant analyte ratios Disclosed is a method for determining the concentration of an analyte in a sample of body fluid. The method involves contacting the body fluid sample with a test strip containing mobile, labeled specific binding partner for the analyte, through which stri... | 08/20/2002 |
| 5814521 | Metal ion determination by sandwich aggregation assay The present invention relates to a method for the determination of polyvalent metal ions using a sandwich aggregation assay. One or more chelating agents capable of forming at least 2:1 or higher ratio stoichiometry complexes with polyvalent metal ions ar... | 09/29/1998 |
| 5736341 | Methods and test kits for specific and sensitive diagnosing of periodontal diseases Methods and test kits are described which provide a reliable, sensitive and selective assessment of periodontal disease activity, peri-implantitis or HIV(+)-infection/AIDS-disease related periodontal diseases. The preferred methods and test kits are const... | 04/07/1998 |
| 5716798 | Enhanced detection of microorganisms in samples This invention describes a method for the rapid identification of the presence of microorganisms in a sample. Briefly, in the method of this invention the sample container is divided into a plurality of discrete zones, each of which can be separately moni... | 02/10/1998 |
| 5627080 | Detergent-facilitated immunoassay for the rapid and quantitative assay of pharmacological agents Methods for modulating the rates and dose responses of immunoassays through the incorporation of one or more detergents into the immunoassay reaction are disclosed. The methods are particularly suitable for automated immunoassay formats, especially with f... | 05/06/1997 |
| 5571728 | Method for analyzing particle-enhanced agglutination reactions in centrifugal analyzers by determining the brightening of turbidity The invention relates to a method for determining analytes, in which a sample of a biological material which possibly contains this analyte is incubated with at least one binding partner which is specific for the analyte and which is immobilized on a part... | 11/05/1996 |
| 5508201 | Method for diagnosing the presence or absence of oncological disease The invention pertains to a method for diagnosing oncological diseases wherein an effective small amount of blood is obtained, such as from a finger, and a solution containing blood plasma or serum is exposed to laser radiation and the values of one or mo... | 04/16/1996 |
| 5486479 | Buffer for immunoassay, kit including same and immunoassay method using said buffer The invention relates to immunoassay reagents that are both sensitive and specific and which require no sample pretreatment. The invention reagents are particularly useful for assaying digoxin concentrations in patient sera. More particularly, the inventi... | 01/23/1996 |
| 5449622 | Method and apparatus for analyzing stained particles In a stained particle analyzing method and apparatus for staining a test sample containing suspended particles, shooting an image of the stained sample, and classifying the particles and computing the density from the shot image of the sample, the sample,... | 09/12/1995 |
| 5420042 | Method for the analytical determination of the concentration of a component of a medical sample Method for the analytical determination of the concentration of a component of a medical sample, in which a reaction of the sample with reagents leads to a time-dependent change S(t) in a measured quantity S and the concentration C correlates according to... | 05/30/1995 |
| 5322799 | Observation cell and mixing chamber A device for detecting substances in a liquid film by measuring chemiluminescence, fluorescence or absorption using techniques such as flow-injection analysis schemes, liquid chromatographies, and gas chromatographies. The device can be used as a micro-vo... | 06/21/1994 |
| 5296195 | Automatic immunochemistry analyzing apparatus and method A system for analyzing a chemical reaction provides control of the temperature and volume of the reagents to improve the accuracy and precision in quantitative measurements of specific proteins and other immunochemistries in body fluids. The reaction occu... | 03/22/1994 |
| 5166077 | Latex for immobilization of physiologically active substances for immuno nephelometry A latex for immobilization of a physiologically active substance is prepared by copolymerizing a monomer mixture comprising: (a) 100 parts by weight of an aromatic vinyl monome4r; (b) 0.01 to 5 parts by weight of a vinyl monomer having a sulfonic acid group; (... | 11/24/1992 |
| 5164321 | Process for the removal of non-specific turbidities A process for the removal of non-specific turbidities in the carrying out of determinations according to the immuno-assay principle, wherein an inorganic boron compound is added to the sample solution in combination with a buffer system.... | 11/17/1992 |
| 5162236 | Method of performing nephelometric analysis with independent temperature control of the reaction cuvette and reagent reservior A system for analyzing a chemical reaction provides control of the temperature and volume of the reagents to improve the accuracy and precision in quantitative measurements of specific proteins and other immunochemistries in body fluids. The reaction occu... | 11/10/1992 |
| 5082790 | Apparatus and method for dynamic blanking of non-specific light scattering during rate nephelometric reactions A scatter signal is produced from light scattered by a precipitate formed by a chemical reaction and non-specific scatter sources. A blanking signal is produced from light scattered only by the non-specific scatter sources that contribute to the scatter s... | 01/21/1992 |
| 5034194 | Windowless flow cell and mixing chamber A windowless flow cell for detecting substances in a flowing fluid stream by chemiluminescence, fluorescence or absorption in flow injection analysis schemes, liquid chromatographs, or gas chromatographs is described. Furthermore, the mixing characteristi... | 07/23/1991 |
| 4921915 | Dispersion polymers, biologically active dispersion polymers, a process for their preparation, and their use as diagnostic aids Dispersion polymers composed of latex, which have on the particle surface a copolymer composed of monomers having terminal acetals of the formula I CH2 .dbd.CR1 --CO--NH--(CH2)n --CH(OR2) (OR3) ... | 05/01/1990 |
| 4912051 | Permeation absorption sampler with multiple detection A system for detecting analytes in air or aqueous systems includes a permeation absorption preconcentrator sampler for the analytes and analyte detectors. The preconcentrator has an inner fluid-permeable container into which a charge of analyte-sorbing li... | 03/27/1990 |
| 4889815 | Nephelometric method for determination of an antigen or antibody content in whole blood A method and apparatus for use in quantifying, in a whole blood sample in which the red cells are lysed, a component which will react with a reagent to form an antigen-antibody complex, the method comprising mixing the sample with the reagent to obtain th... | 12/26/1989 |
| 4835110 | Method for enhancing analysis timing in kinetic nephelometry The peak verify time for kinetic nephelometric measurements of reactions between antigens and antibodies is adjusted as a function of the magnitude of the peak rate order to reduce the time required for peak verification. The scatter signal is zeroed foll... | 05/30/1989 |
| 4777141 | Instrument for measuring coagulation parameters and method of use An instrument for measuring coagulation parameters is provided in which plasma and at least one reagent are mixed by spinning in a cuvette with transparent windows and in which measurement is then made of scatter by the mixture of the energy of a light be... | 10/11/1988 |
| 4766080 | Quantitative measurement of lithium A method for the quantitative determination of lithium in a liquid test sample employing turbidimetric or nephelometric techniques to measure the maximum rate of change in the optical density of a reaction mixture containing precipitated lithium. The lith... | 08/23/1988 |
| 4766083 | Method for the photometric determination of biological agglutination A photometric method and apparatus for measuring agglutination in a biological agglutination reaction system test sample using a laser beam source and at least one photodetector for detecting light scattered by the test sample. The method includes the fol... | 08/23/1988 |
| 4760030 | Quantitative opaque particle agglutination assay A method is disclosed for determining the presence of a member of a specific binding pair ("sbp member") consisting of ligand and its homologous receptor in a sample suspected of containing the sbp member. The method comprises combining in an assay medium... | 07/26/1988 |
| 4743561 | Luminescent assay with a reagent to alter transmitive properties of assay solution An improved method and reagents are disclosed for determining a ligand in an assay solution containing the ligand, a reagent system and a luminescent compounds, wherein the intensity of the light emitted by the assay solution is related to the change in t... | 05/10/1988 |
| 4647544 | Immunoassay using optical interference detection Apparatus and method for providing an optical detection of a binding reaction between a ligand and an antiligand, including, a pattern formed by a spatial array of microscopic dimensions of antiligand material, ligand material interacting with the antilig... | 03/03/1987 |
| 4148869 | Immunological reagent and method of using same Immunological assaying methods which require insolubilization of an antigen-antibody complex as an integral step thereof are improved by adding to the test medium in which insolubilization is desired an aqueous reagent solution containing from about 3 to ... | 04/10/1979 |
| 4144030 | Method for improving the rate and measurement accuracy of chemical analysis According to the method of this invention, liquid or solid samples are first measured inaccurately with a pipette or some other measuring instrument and the measured sample quantity is weighed. After the addition of reagents, the samples are measured by t... | 03/13/1979 |
| 4131427 | Chromatography detector A means for detecting the presence of a solute in a flowing fluid stream is disclosed within. The schlieren patterns obtained when a solute present in a flowing fluid stream is directed into a reference fluid stream are utilized to scatter a portion of a ... | 12/26/1978 |
| 4039285 | Single sample method for determination of lipoprotein concentrations in blood A single-sample method for determining concentrations of individual lipoprotein classes and lipids in blood by turbidimetric measurement. The blood serum is mixed with an ionic-strength-sensitive agent for forming an insoluble complex with the chylomicron... | 08/02/1977 |
| 3960493 | Method of measuring the fat and protein content in fluids Nephelometric method for sequential determination of protein and fat in a milk sample. Distinct reagent solutions are added to a milk sample which are effective to sequentially form colloidal dispersions of protein and fat, respectively, while effecting s... | 06/01/1976 |
