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| Number | Title | Issue Date |
| 6677123 | Process for detecting increased risk of fetal chromosomal abnormality An increased risk of a fetal chromosomal abnormality, for example, fetal Down syndrome can be detected by separating or discriminating -fetoproteins present in the body fluid of a pregnant woman, and measuring the proportion of one or more of the &... | 01/13/2004 |
| 6613538 | Detection of HLA-G The present invention relates to the detection of HLA-G. Antibodies to both soluble and membrane bound HLA-G are disclosed. Exemplary antibodies include 2C/C8, 3C/G4, and 4H84. 2C/C8 and 4H84 antibodies bind to the same region of HLA-G, which is a differe... | 09/02/2003 |
| 6465197 | Assay for sperm quality A method for evaluating sperm quality is disclosed. The first step of the method is to obtain a quantity of sample mammalian sperm and a sample of mature mammalian oocytes. The oocytes are fertilized with the sperm and the cumulus cells are removed from t... | 10/15/2002 |
| 6309843 | Glycoprotein for use in determining endometrial receptivity An isolated and purified glycoprotein designated PUP-1 and functional analogs thereof are disclosed and characterized by being a progesterone induced and estradiol inhibited secretory glycoprotein from stromal cells of endometrial origin; having an N-term... | 10/30/2001 |
| 6183975 | Method of detection of congenital disease A method for diagnosing a congenital disease by determining a cell's response to activation of a membrane receptor using a physiological indicator is provided. The method of the invention uses fetal or adult cells in a non-invasive screen for congenital d... | 02/06/2001 |
| 6159159 | Apparatus and method for monitoring ovulation A quantitative process for monitoring female fertility cycle wherein the process involves directing a laser beam, preferably generated by a diode laser, onto an area of a slide containing an air-dried sample of a female body fluid. The diffraction pattern... | 12/12/2000 |
| 6103481 | Assay for sperm quality A method for evaluating sperm quality is disclosed. The first step of the method is to obtain a quantity of sample mammalian sperm and a sample of mature mammalian oocytes. The oocytes are fertilized with the sperm and the cumulus cells are removed from t... | 08/15/2000 |
| 6039923 | Method and kit for monitoring mammalian reproductive cycles A kit for monitoring mammalian reproductive cycles by monitoring variations in the quantity of one or more low molecular weight volatile compound having a molecular weight of less than 50 grams per mole present in a body constituent sample is disclosed. S... | 03/21/2000 |
| 5981291 | Estrogen marker system A method for evaluating the solubility capacity of free unbound estrogens in body fluids of animals is described.... | 11/09/1999 |
| 5935800 | Assays and kits for determining male fertility Assays and kits for identifying fertile sperm samples (e.g. for use in an assisted reproductive technology or as an indication of an ineffective male contraception (vasectomy)) and sub-fertile sperm samples (e.g. as an indication of a potentially infertil... | 08/10/1999 |
| 5932431 | Determination of steroids by competitive immunoassay A method and kit for measurement of a steroid by means of a competitive immunoassay, preferably a competitive enzyme immunoassay. The method and kit involve the use of a steroid analogue conjugated to a label. The steroids that are amenable to detection b... | 08/03/1999 |
| 5922613 | Method for evaluating estrogen dependent physiological conditions A method and apparatus for evaluating estrogen dependent physiological conditions includes a substrate having an anthocyanin pigment applied thereto. The pigment yields a color response indicative of how the body fluid responds to changes in its capacity ... | 07/13/1999 |
| 5895749 | Male fertility and contraception home test kits Kits and assays, incorporating antibodies specific for glutathione peroxidase, for determining the fertilizing ability of a male at home or in a clinical laboratory are disclosed.... | 04/20/1999 |
| 5849713 | Chemotactic factors for human spermatozoa and their use in human assisted fertilization The invention relates to chemotactic factors for human spermatozoa that are purifiable from human follicular fluid. The factors are of peptidic and hydrophilic nature and have, one, a molecular size of about 13 kDa and, the other, an apparent molecular si... | 12/15/1998 |
| 5843673 | Method of screening for endometriosis A glycoprotein having a molecular weight of 28,000 to 32,000 and an isoelectric point of 7.0 to 9.0, both as determined by two-dimensional SDS polyacrylamide gel electrophoresis, is synthesized and secreted specifically by stromal cells of endometriotic o... | 12/01/1998 |
| 5837197 | Positive fertility testing and reproductive health system This Invention relates to a fertility analysis and reproductive health system that is applicable to both female and male mammals. In particular the Invention is a portable, handheld, integrated unit which can be manufactured out of plastic. The unit can b... | 11/17/1998 |
| 5834317 | Method for antenatal risk assessment for fetal abnormalities using gestational age discrepancy A method for antenatal screening for chromosomal and other abnormalities in an unborn child is determined by measuring the gestational age discrepancy of the pregnant mother. This data is determined (a) by reference to the last menstrual period, and (b) a... | 11/10/1998 |
| 5814456 | Sperm antigen corresponding to a sperm zone binding protein autoantigenic epitope The present invention involves DNA encoding a mammalian Sp 17 protein, particularly human Sp17 protein, or antigenic peptides which are fragments thereof, along with said antigenic fragments. These proteins and peptides are useful as immunocontraceptive a... | 09/29/1998 |
| 5801058 | Analytic method to determine the fertilizing capacity of a human semen sample The invention relates to improvements in determining the fertilizing capacity of a human semen sample using a reagent solution which contains 0.1-5% by weight K2 PO4 H/KPO4 H2 to adjust the pH of the solution to... | 09/01/1998 |
| 5721142 | Method for monitoring mammalian reproductive cycles A method for monitoring mammalian reproductive cycles by monitoring variations in the quantity of one or more low molecular weight volatile compound having a molecular weight of less than 50 grams per mole present in a body constituent sample is disclosed... | 02/24/1998 |
| 5693479 | Fertility determination with transforming growth factor ଲ Therapeutic and diagnostic methods of use for the growth factor transforming growth factor ଲ, are provided by this invention. In accordance with preferred embodiments, methods of determining competence of a conceptus toward uterine implantation are ... | 12/02/1997 |
| 5665556 | Complement components and binding ligands in fertility Methods for detecting and isolating acrosome-reacted sperm and complement receptor-bearing oocytes using the complement component C3, fragments, or variants thereof, antibodies to a complement receptor, or antibodies to C3, are disclosed. These methods ha... | 09/09/1997 |
| 5663054 | Determination of steroids by competitive immunoassay A method and kit for measurement of asteroid by means of a competitive immunoassay, preferably a competitive enzyme immunoassay. The method and kit involve the use of asteroid analogue conjugated to a label. The steroids that are amenable to detection by ... | 09/02/1997 |
| 5660997 | Methods for determining antibodies specific for sex associated sperm membrane proteins Substantially pure sex-associated membrane (SAM) proteins are used in methods to detect specific antibodies binding to X- or Y-SAM proteins.... | 08/26/1997 |
| 5639424 | Portable fertility tester A portable fertility tester for identifying days during the menstrual cycle when a woman is most likely to conceive has a circular disc, with transparent regions indexed to each of the days of the cycle, rotatably mounted within a housing and cover. The h... | 06/17/1997 |
| 5602040 | Assays An analytical test device useful for example in pregnancy testing, includes a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with the e... | 02/11/1997 |
| 5599680 | Diagnostic applications of mouse ascites golgi (MAG) manipulation Therapeutic and diagnostic applications by the detection and manipulation of mouse ascites golgi factor produced by endometrium and present in other exocrine tissues and defined by an antibody found in mouse ascites are provided by this invention.... | 02/04/1997 |
| 5575914 | Sperm filter trap having compressed glass wool filter material A filter trap (10) for removing spermatozoa of relatively lower viability from a fluid containing both higher and lower viability spermatozoa includes a conduit (14) which compresses silica glass wool (16) to a density adequate to prevent the passage ther... | 11/19/1996 |
| 5541081 | Process for assessing oocyte and embryo quality Methods and compositions for assessing the quality of an oocyte or pre-implantation embryo are provided. The methods involve comparing the NADH fluorescence of the oocyte or embryo in a control medium to the NADH fluorescence after the oocyte or embryo ha... | 07/30/1996 |
| 5532155 | Spontaneous cycle fertilization method A fertilization method wherein an oocyte puncture is performed and one or more oocytes are inserted into a container containing a culture medium having no added air or CO2 and intended for the fertilization and culture of the oocyte(s), as well... | 07/02/1996 |
| 5514537 | Process and apparatus for sorting spermatozoa A method and apparatus are disclosed for the mechanical sorting of mammalian spermatozoa by sex-type, into a fraction enriched in X-chromosome-bearing spermatozoa, and a fraction enriched in Y-chromosome-bearing spermatozoa. Because of their different DNA... | 05/07/1996 |
| 5474890 | Method for inducing the acrosome reaction in human and animal spermatozoa A method for assessing the fertilization potential of mammalian spermatozoa comprises the steps of incubating a sperm sample with extracellular ATP, determining the level of acrosine secretion from the sperm and comparing with the level of acrosine secret... | 12/12/1995 |
| 5474927 | Complement components and binding ligands in fertility Methods for detecting and isolating acrosome-reacted sperm and complement receptor-bearing oocytes using the complement component C3, fragments, or variants thereof, antibodies to a complement receptor, or antibodies to C3, are disclosed. These methods ha... | 12/12/1995 |
| 5434139 | Detection of heparin-binding seminal plasma proteins A method is disclosed relating to the isolation and purification of certain heparin-binding protein compositions in the seminal plasma of male mammals. The isolated proteins are useful in fertility studies and in enhancing the acrosomal reaction, capacita... | 07/18/1995 |
| 5434057 | Sperm motility assay and devices The present invention provides devices, methods and kits for assessing fertility potential of semen samples. Semen samples may be assayed by the present invention to identify those samples having more than 20×106 motile sperm per milliliter, a... | 07/18/1995 |
| 5389519 | Method of screening for infertility A method for detecting the presence of infertility in mammalian male test subjects based upon failure of sperm to undergo successful capacitation. Sperm samples are given the opportunity to undergo capacitation and subsequently contacted with antibodies t... | 02/14/1995 |
| 5366863 | Total gonadotropal alpha peptide chain assay An assay procedure for predicting the onset of the ovulation in a human subject. Urine samples are obtained on consecutive days and assayed for total gonadotropal alpha peptide chain content. The alpha chain content surges to indicate ovulation and the on... | 11/22/1994 |
| 5250417 | Method for acrosome reaction assay A method is provided for rapidly determining the ability of sperm to undergo the acrosome reaction, using fluorescence microscopy, light microscopy or color change on a dot blot assay to determine the relative percentage of acrosome reacted sperm. Sperm a... | 10/05/1993 |
| 5155045 | Use of male essence to alter female endocrine response A novel method for treating a human female is disclosed comprising the step of exposing the nasal region of said female to at least a portion of the axillary secretions of a human male. This exposure is preferably continued in amounts and for a duration w... | 10/13/1992 |
| 5120660 | Method for canine fertility detection The present invention describes methods and compositions for detecting the fertility of a canine female based on identification of certain characteristic cLH peptides and carrier proteins found in canine urine. More specifically free or complexed metaboli... | 06/09/1992 |
