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| Number | Title | Issue Date |
| 7432105 | Self-calibration system for a magnetic binding assay A self-calibrated, magnetic binding assay (e.g., sandwich, competitive, etc.) for detecting the presence or quantity of an analyte residing in a test sample is provided. The magnetic binding assay includes detection probes capable of generating a detection signal (e... | 10/07/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7070941 | Methods and compositions for tagging via azido substrates The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog substrates. Examples of such analogs are azido farnesyl diphosphate and a... | 07/04/2006 |
| 7022491 | Method for determining molecule—molecule interaction analysis The invention relates to a method for monitoring interactions to a target biomolecule comprising the steps of: providing a biomolecule of interest having specificity for the target biomolecule; binding the biomolecule of interest to at least one type of linker molec... | 04/04/2006 |
| 6855828 | Detection of hypoxia Nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein con... | 02/15/2005 |
| 6613582 | Methods for rapid and efficient protein cross-linking The present application describes novel uses of ruthenium bipyridyls or palladium porphyrins as photo-activatable crosslinking agents. Crosslinking can be between any two molecules including peptides, proteins, or compounds. Crosslinking occurs in the pre... | 09/02/2003 |
| 6346419 | Photolysis system for fast-response NO2 measurements and method therefor An efficient, lightweight, and relatively inexpensive photolysis system based on a short-arc Hg arc lamp provides a simple and accurate method for measurement of ambient NO2. High time resolution is achieved by minimizing inlet and photolysis c... | 02/12/2002 |
| 6277652 | Colorimetric sensor employing polydiacetylene membrane Disclosed is a colorimetric sensor comprising polydiacetylene membrane liposomes, a polydiacetylene membrane film or fine particles coated with a polydiacetylene membrane, in which the polydiacetylene membrane is incorporated with a protein having a reduc... | 08/21/2001 |
| 6100093 | Method and system for determining the quality of a crop The invention relates to a method for determining the quality of a crop, comprising the determination of at least one characteristic parameter of the photosynthesis process of the crop, which parameter serves as a quality indicator for the crop, wherein t... | 08/08/2000 |
| 5976884 | Methods for quantifying photoreactions in light activated materials Systems and methods treat biological fluids carrying contaminants by photoactivating materials mixed with the fluids. The systems and methods quantify the photoreactions that occur in a manner that permits correlation with clinical results.... | 11/02/1999 |
| 5866074 | Systems for quantifying the illumination characteristics of vessels such as blood processing containers with respect to light energy A vessel holds a liquid content for exposure to prescribed light energy. The vessel has a region transparent to the prescribed light energy. The liquid content of the vessel includes a solution comprising a material undergoing reduction oxidation as a res... | 02/02/1999 |
| 5858653 | Reagent and method for attaching target molecules to a surface Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of attracting the target molecule as well as groups capable of covalently b... | 01/12/1999 |
| 5716798 | Enhanced detection of microorganisms in samples This invention describes a method for the rapid identification of the presence of microorganisms in a sample. Briefly, in the method of this invention the sample container is divided into a plurality of discrete zones, each of which can be separately moni... | 02/10/1998 |
| 5618732 | Method of calibration with photoactivatable chemiluminescent matrices Methods for labeling a material are disclosed. The methods comprise combining with the material (a) a photosensitizer capable upon irradiation of generating singlet oxygen and (b) a chemiluminescent compound capable of being activated by singlet oxygen wh... | 04/08/1997 |
| 5616464 | Nucleic acid sequence detection employing amplification probes Methods and compositions are provided for detecting nucleic acid sequences. In particular, pairs of probes are employed, where the pair defines a substantially contiguous sequence on a target nucleic acid. Each of the pairs has a side chain which forms a ... | 04/01/1997 |
| 5610017 | Method for conducting a polymerase chain reaction using an improved electrochemiluminescent label This invention relates to a new electrochemiluminescent (ECL) label for oligonucleotides using phosphoramidite chemistry.... | 03/11/1997 |
| 5595726 | Chromophore probe for detection of nucleic acid The present invention is directed to chromophoric probes for use in detecting nucleic acid sequences. More particularly, the invention is directed to probes that comprise a texaphyrin chromophore molecule covalently coupled or conjugated to a site-directi... | 01/21/1997 |
| 5552134 | Uses of benzochlorins, verdins and porphyrin derivatives and of compositions containing such benzochlorins, verdins and porphyrin derivatives A family of benzochlorins, a family of verdins, a family of porphyrin derivatives and metal complexes thereof are disclosed. The benzochlorins have the formula of FIG. 3 of the attached drawings; their metal complexes have the formula of FIG. 1. The verdi... | 09/03/1996 |
| 5516636 | Assays utilizing sensitizer-induced production of detectable signals Specific binding assays are disclosed which utilize a sensitizer as a label. Such sensitizers include any moiety which, when stimulated by "excitation" with radiation of one or more wavelengths or other chemical or physical stimulus (e.g., electron transf... | 05/14/1996 |
| 5480806 | Method for determining decomposable organic carbon compounds present in a geseous phase The content of decomposable organic carbon compounds present in a gaseous phase is determined down to the parts per billion (10-9) range and in special cases down to the parts per trillion (10-12) range. The gaseous sample material b... | 01/02/1996 |
| 5391463 | Surface modification to create regions resistant to adsorption of biomolecules Irradiating, with ultraviolet light, surfaces which contain thiol groups, epoxy groups, or vicinal diol groups, results in surfaces which exhibit a reduced adsorption of biomolecules. In the case of surfaces having thiol groups such irradiation also resul... | 02/21/1995 |
| 5310687 | Luminescent metal chelate labels and means for detection A chemical moiety is disclosed which comprises a chemical, biochemical, or biological substance attached to one or more electrochemiluminescent organometallic compounds. In a preferred embodiment of the invention the substance is attached to one or more r... | 05/10/1994 |
| 5306624 | Process of quantifying cell number The present invention provides a process of quantifying the number of viable cells in an aqueous suspension of cells using an energy-emitting non-hazardous probe and a probe-trigger. The process provides quantification data in short periods of time withou... | 04/26/1994 |
| 5292665 | Catalyst for preparing polyacrylamide gel which improves the detection of biomaterials by silver staining A polyacrylamide gel comprising acrylamide and diacrylylpiperazine. A method for providing a polyacrylamide gel comprising employing a catalyst system which comprises dimethylpiperazine, sodium thiosulfate or a mixture thereof and ammonium or potassium pe... | 03/08/1994 |
| 5275957 | Instrument and method for measurement of the organic carbon content of water Apparatus and methods for measurement of total organic carbon content of water, particularly of low relative organic content, are described, featuring a single sample cell for exposure of a static sample to ultraviolet radiation and comprising electrodes ... | 01/04/1994 |
| 5266209 | Method and apparatus for analyzing matter in biological fluids using luminescence A method and apparatus is provided for analyzing the leucocytes in a biological fluid. The biological fluid is passed through a filter material having a critical wetting surface tension greater than 53 dynes/cm so that the leucocytes are held in the filte... | 11/30/1993 |
| 5244811 | Method and system for determining organic matter in an aqueous solution A method and system for determining organic matter in an aqueous solution including an oxidizing agent are disclosed. The method includes contacting the solution with a semiconductor which is capable of photocatalytically oxidizing the organic matter, ill... | 09/14/1993 |
| 5223359 | Determination of wet pressure sensitivity of a film Wet pressure sensitivity of a film having a silver halide coating is indirectly determined by measurement of a difference in density of a coating area which has increased pressure applied thereto compared to a coating area without such increased pressure.... | 06/29/1993 |
| 5064768 | Silver staining technique and kit An improved silver staining technique is disclosd for the detection of a biocomponent contained in a support medium. The technique includes fixing the support medium with a fixing agent, pretreating the thus-fixed support medium with a sensitizer, treatin... | 11/12/1991 |
| 5004565 | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes A method and compositions including a 1,2-dioxetane and a fluorescent compound is described. In particular, enzymatic triggering of a triggerable 1,2-dioxetane admixed with a surfactant and the fluorescent compound attached to a hydrocarbon to provide a c... | 04/02/1991 |
| 5001051 | Dose critical in-vivo detection of anti-cancer drug levels in blood A method and apparatus are disclosed for the in vivo and in vitro detection and measurement of dose critical levels of DNA-binding anti-cancer drug levels in biological fluids. The apparatus comprises a laser based fiber optic sensor (optrode) which utili... | 03/19/1991 |
| 4973493 | Method of improving the biocompatibility of solid surfaces A method for modifying the solid surface to improve its biocompatibility is disclosed. The method employs molecules of a biocompatible agent and a chemical linking moiety possessing a photochemically reactive group capable upon activation of covalently bo... | 11/27/1990 |
| 4945063 | Method for detecting organic compounds by photoacoustic conversion A method is provided for detecting the presence of organic materials in an aqueous sample. The materials are decomposed by simultaneous exposure to ultraviolet radiation and acoustic energy to decompose the materials to simple decomposition products. The ... | 07/31/1990 |
| 4917503 | Photoactivatable leuco base time-temperature indicator A photoactivated time-temperature indicator is based on a leuco base system. A thermally insensitive, white ("inactive") leuco base (or a mixture of such leuco bases) is mixed, preferably in a polymeric matrix, with a material that generates acid upon exp... | 04/17/1990 |
| 4804631 | Method and apparatus for measuring cyanide A system for measuring cyanides in a sample employs a photoillumination component for producing ultraviolet radiation to dissociate cyanides contained in an alkaline sample. The system includes filtering components interposed between the photoillumination... | 02/14/1989 |
| 4782027 | Protein detection by negative staining A polypeptide is located in a gel matrix by treating the matrix with a negative staining agent (i.e. an agent that stains the gel more intensely in regions devoid of polypeptides, so that gel areas exhibiting reduced staining intensity are indicative of t... | 11/01/1988 |
| 4749657 | Organic spill monitor A sample aqueous stream including one or more organic compounds capable of partial oxidation to acid form are flowed continuously through an ultraviolet light reactor in which the sample is exposed to ultraviolet light in the presence of oxygen under cond... | 06/07/1988 |
| 4737463 | Photoactivatable time-temperature indicator A photoactivated time-temperature indicator is based on diacetylenic salts. A thermally unreactive ("inactive") diacetylenic salt (or a mixture of such salts) is mixed, in a polymeric matrix, with a material that generates acid upon exposure to light. Pho... | 04/12/1988 |
| 4716122 | Carrier material for use in immune determinations The present invention provides a carrier such as polyethylene having covalently bound to it a reaction component such as an antibody, for use for immune determinations. The reaction component is covalently bound via heterobifunctional photoactivatable com... | 12/29/1987 |
| 4703016 | Silver stain for rapid, quantitative detection of polypeptides and nucleic acids A simple, positive image forming silver stain which takes less than 15 minutes to perform is disclosed for the detection of nanogram quantities of proteins and DNA on membranes and thin layer plates. This stain demonstrates a reproducible curvilinear rela... | 10/27/1987 |
