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| Number | Title | Issue Date |
| 7833798 | Method for analysis of albumin in sample solution The present invention provides a method of analyzing albumin in a sample solution, which is characterized by pretreating a sample solution before subjecting the sample solution to mass spectrometry or liquid chromatography. The present invention further provides a m... | 11/16/2010 |
| 7473559 | Method for measuring the content of a toxin in a formulation A method of measuring the concentration of a bioactive agent is disclosed. ... | 01/06/2009 |
| 7291476 | O-acetyltranferases A post-translational modification of a predetermined protein expressed by a cell is detected by specifically detecting an O-acetylation of a serine, threonine or tyrosine residue of the protein as an indication of the post-translational modification. The detection m... | 11/06/2007 |
| 7282368 | Method for diagnosing and monitoring hemostatic dysfunction, severe infection and systematic inflammatory response syndrome A method for diagnosing and monitoring subjects for hemostatic dysfunction, severe infection and systematic inflammatory response syndrome is provided whereby lipoproteins are examined for abnormalities, particularly for prothrominase enhancement, through quantitati... | 10/16/2007 |
| 7229835 | Amine detection method and materials A compound linked to a solid support (R) through a divalent linker moiety (X) and which is represented by the following formula: is disclosed. In particular, the 1-hydroxybenzotriazole-6-carboxylic acid is direct... | 06/12/2007 |
| 7198955 | Method and apparatus for measurement of blood substitutes A method is disclosed whereby the concentration of a blood substitute, such as cross-linked hemoglobin, in a serum or plasma specimen is rapidly and accurately identified and quantified. The method further takes the measured concentration of the blood substitute and... | 04/03/2007 |
| 7195923 | Ratiometric determination of glycated protein The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the glycosylated protein, or the glycoprotein. The method incorporates lateral f... | 03/27/2007 |
| 7070937 | Marker useful for detection and measurement of free radical damage and method The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presenc... | 07/04/2006 |
| 7002670 | Optical sensor and method for measuring concentration of a chemical constituent using its intrinsic optical absorbance An improved optical sensor and method for measuring concentration of a chemical constituent where measurement interference from other chemical compounds is present in the solution is provided. More specifically, the invention relates to a system for measuring the am... | 02/21/2006 |
| 6955921 | Trypsin substrate and diagnostic device, and method of using same A compound of the formula (I) wherein R1 is a protecting group for Nα, R2 is a protecting group for NG, and R3 is aryl, and wherein the compound of formula (I) is a trypsin ... | 10/18/2005 |
| 6825045 | System and method of infrared matrix-assisted laser desorption/ionization mass spectrometry in polyacrylamide gels A system and method for desorption and ionization of analytes in an ablation medium. In one embodiment, the method includes the steps of preparing a sample having analytes in a medium including at least one component, freezing the sample at a sufficiently low temper... | 11/30/2004 |
| 6756230 | Quantitative analysis Amounts of components in a specimen can be analyzed with excellent quantitativity. The analysis includes: measuring an amount of a component to be analyzed in a specimen; measuring an amount of a standard component present originally and homeostatically in the speci... | 06/29/2004 |
| 6642055 | Method for the prediction of preeclampsia and other diseases The invention disclosed is a process for determining the cytoprotective activity of plasma that prevents the destruction of endothelial cells and forestalls the development of a number of diseases such as atherosclerosis, preeclampsia, edema, nephrotic sy... | 11/04/2003 |
| 6620624 | Mass spectrometry interface, a mass spectrometer and a mass spectrometry With rotating and translating a rotation-translation drum installed in a vacuum chamber of a mass spectrometry interface to constitute a mass spectro-meter, a liquid sample incorporating a dissolved substance to be analyzed in its mass is emitted for the ... | 09/16/2003 |
| 6605472 | Microfluidic devices connected to glass capillaries with minimal dead volume A method is provided for joining a microchip device to a capillary tube. The microchip device has a capillary channel opening onto an edge surface of the device. A short hole is drilled into the edge surface, aligned with the capillary channel. The drilli... | 08/12/2003 |
| 6589748 | Method for kidney disease detection and treatment A method is disclosed for diagnosing early stage of a disease in which an intact protein found in urine is an indicator of the disease. The method includes assaying urine sample to detect the presence of modified protein using either immunological or non-... | 07/08/2003 |
| 6579718 | Carbazolylvinyl dye protein stains The present invention describes a variety of substituted and unsubstituted carbazolylvinyl dyes and their use for detecting and quantifying poly(amino acids), including peptides, polypeptides and proteins. The labeled proteins or peptides are highly color... | 06/17/2003 |
| 6498039 | Sample presentation apparatus for mass spectrometry A sample presentation device, with a surface-bound complex including at least one molecule which chemically modifies a biomolecule, is prepared and exposed to a biomolecule. The molecular weights of the chemically modified biomolecule is then determined b... | 12/24/2002 |
| 6492179 | Test for rapid evaluation of ischemic states and kit The present invention relates to a rapid method for the detection of ischemic states and to a kit for use in such a method. Provided for is a rapid method of testing for the existence of and quantifying ischemia based upon method of detecting and quantify... | 12/10/2002 |
| 6475743 | Marker useful for detection and measurement of free radical damage and method The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in ... | 11/05/2002 |
| 6451543 | Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polype... | 09/17/2002 |
| 6447989 | Kidney disease detection and treatment A method is disclosed for diagnosing early stage of a disease in which an intact protein found in urine is an indicator of the disease. The method includes assaying urine sample to detect the presence of modified protein using either immunological or non-... | 09/10/2002 |
| 6436649 | Method for detecting and/or quantifying a hapten in a homogeneous phase and device for implementation thereof The invention discloses a method for detecting and/or quantifying a hapten in a homogeneous phase, comprising the following steps: adding a known quantity of a hapten inhibitor complex to the solution containing the hapten to be detected and/or quantified... | 08/20/2002 |
| 6432716 | Method to identify a surface-bound molecule The present invention relates to a method of identifying a molecule of a molecule-substrate complex, wherein the molecule is covalently attached directly to a substrate or indirectly by means of a linking moiety, comprising: (a) bombarding the molecule-su... | 08/13/2002 |
| 6429294 | Peritoneal dialysis fluid and method for a continuous recirculating peritoneal dialysis using the same A peritoneal dialysis fluid used for a continuous recirculating peritoneal dialysis wherein the peritoneal dialysis fluid is infused into a peritoneal cavity of a patient and then, typically on a continuous process basis a portion of the dialysis fluid is... | 08/06/2002 |
| 6391650 | Protein sample preparation for electrophoresis The present invention provides an integrated, fully automated, high-throughput system for two-dimensional electrophoresis comprised of gel-making machines, gel processing machines, gel compositions and geometries, gel handling systems, sample preparation ... | 05/21/2002 |
| 6372510 | Method for removing unconventional transmissible agents from a protein solution The present invention is drawn to method for removing unconventional transmissible agents (UCTA) from aqueous protein solution. This method involves treating the aqueous protein solution with simultaneous electrostatic adsorption and hydrophobic chromatog... | 04/16/2002 |
| 6316267 | Luminescent protein stains an their method of use The invention relates to the staining of poly(amino acids), including peptides, polypeptides and proteins in gels and on solid supports, using neutral or anionic complexes of transition metals.... | 11/13/2001 |
| 6316266 | Sample presentation apparatus for mass spectrometry A sample presentation device, with a surface-bound complex including at least one molecule which chemically modifies a biomolecule, is prepared and exposed to a biomolecule. The molecular weights of the chemically modified biomolecule is then determined b... | 11/13/2001 |
| 6306660 | Method for improving the accuracy of the semi-quantitative determination of analyte in fluid samples Disclosed is an improved method for determining the concentration of a first analyte in a fluid test sample as a function of a second analyte also present in the sample whose concentration in the fluid sample is clinically related to that of the first ana... | 10/23/2001 |
| 6300142 | Device and apparatus for conducting an assay A apparatus for assaying glycated proteins and other analytes in biological samples such as blood, in which a sample is presented to the apparatus, includes an inlet port between moveable between first and second inlets, such that the inlet can be brought... | 10/09/2001 |
| 6287758 | Methods of registering trans-membrane electric potentials Sensitive methods for identifying compounds having biological activity comprising combining living cells with two fluorescent membrane permeable ionic dyes having the same charge sign, the first of which has an emission spectrum which overlaps the excitat... | 09/11/2001 |
| 6289229 | Readable probe array for in vivo use A disposable high density optically readable polydeoxynucleotide array with integral fluorescence excitation and fluorescence emission channels is described. The compact array size allows integration into several types of interventional devices such as ca... | 09/11/2001 |
| 6277643 | Method for detection of protein on polyacrylamide gels using a counter-dye composition and counter-dye composition for the same The present invention relates to a method for detection of protein using a counter-dye composition, on polyaciylamide gels, and the counter-dye composition for detection of protein on polyacrylamide gels. More specifically, the present invention relates t... | 08/21/2001 |
| 6241946 | Solventless protein assay standard A method for preparing a solventless protein standard is disclosed in which a solventless dye indicator and a predetermined amount of solventless protein are placed in an appropriate receptacle such as the well of a multiwell plate. This results in a solv... | 06/05/2001 |
| 6207459 | Method for the analysis of medical samples containing haemoglobin The invention concerns a method for the determination of an analyte in a sample containing free haemoglobin in which the determination is carried out by an optical measurement and the value measured for the analyte concentration is mathematically correcte... | 03/27/2001 |
| 6090789 | Synthesis of the breast tumor-associated antigen defined by monoclonal antibody MBr1 and uses thereof The present invention provides a process for synthesizing a compound having the structure: ##STR1## wherein R is H, as well as related oligosaccharides useful as a vaccine for inducing antibodies to human breast cancer cells in an adjuvant thera... | 07/18/2000 |
| 6004770 | Sample presentation apparatus for mass spectrometry A sample presentation device, with a surface-bound complex including at least one molecule which chemically modifies a biomolecule, is prepared and exposed to a biomolecule. The molecular weights of the chemically modified biomolecule is then determined b... | 12/21/1999 |
| 5942187 | Protein assay kit The invention provides a kit for use in assaying protein, which comprises: an alkaline copper solution containing a tartrate; and a solution of Folin reagent. An alkaline copper solution containing tartrate has surprisingly been found to remain stable for several m... | 08/24/1999 |
| 5876944 | Method for amplification of the response signal in a sandwich immunoassay Disclosed is an improvement to a sandwich type immunoassay in which there is immobilized to a solid support an antibody which is specific to an epitope of the analyte whose presence or concentration is being sought and a first labeled antibody which is sp... | 03/02/1999 |
