Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 8158436 | Methods for characterizing heparin-like glycosaminoglycan mixtures The invention provides methods and apparatus for characterizing complex polymeric mixture of interest. Candidate solutions are eliminated from a solution space using one or more experimental measurements of a polymeric mixture of interest. The elimination step can b... | 04/17/2012 |
| 8062896 | Cardiac hormones for assessing cardiovascular risk The present invention relates to the use of cardiac hormones, particularly natriuretic peptides, for diagnosing the cardiovascular risk of a patient who is a candidate for administration of a cox-2-inhibiting compound, in particular an NSAID, selective cox-2 inhibit... | 11/22/2011 |
| 8030085 | Method for discriminating between prostatic cancer and benign prostatic hyperplasia The present invention provides a method for accurately discriminating between prostate carcinoma and benign prostatic hyperplasia based on a glycan structure of prostate specific antigen (PSA). The method of the present invention includes the steps of: purifying PSA... | 10/04/2011 |
| 7981684 | Methods and biomarkers for diagnosing and monitoring psychotic disorders A method of diagnosing or monitoring a psychotic disorder, or predisposition thereto, comprises measuring, in a sample taken from a subject, the level of a biomarker selected from clusterin precursor, inter α-trypsin inhibitor, IgM, apolipoprotein A2 and α2 H5 gly... | 07/19/2011 |
| 7811827 | Methods and apparatus for characterizing heparin-like glycosaminoglycan mixtures The invention provides methods and apparatus for characterizing complex polymeric mixture of interest. Candidate solutions are eliminated from a solution space using one or more experimental measurements of a polymeric mixture of interest. The elimination step can b... | 10/12/2010 |
| 7807472 | Methods for separation and detection of ketosteroids and other carbonyl-containing compounds Methods for enhancing detection by mass spectroscopy (MS) and/or chromatographic separability of carbonyl-containing compounds such as steroids are disclosed. Reaction of a carbonyl compound with a sulfonhydrazide compound provides a sulfonhydrazone with enhanced io... | 10/05/2010 |
| 7695973 | Determination of glycated protein The present invention provides methods for quantitation of glycated protein in a biological sample using a solid support matrix by making a first bound protein measurement total bound protein under conditions where both glycated and non-glycated protein bind to the ... | 04/13/2010 |
| 7439071 | Method of employing elevation of marinobufagenin in determining the presence of preeclampsia and related apparatus A method of determining the presence of preeclampsia is provided wherein a determination is made as to whether there has been a substantial elevation in marinobufagenin which may be a blood-derived or urine-derived and if such elevation does exist concluding that pr... | 10/21/2008 |
| 7435384 | Diagnostic instrument with movable electrode mounting member and methods for detecting analytes An instrument (A) detects in a sample the presence of an analyte. The sample includes electrically readable particles (126) with an agent attached thereto that binds with the analyte or is an analog of the analyte. The instrument includes a port for the sampl... | 10/14/2008 |
| 7432107 | Cardiac hormones for assessing cardiovascular risk The present invention relates to the use of cardiac hormones, particularly natriuretic peptides, for diagnosing the cardiovascular risk of a patient who is a candidate for adminitstration of a cox-2-inhibiting compound, in particular an NSAID, selective cox-2 inhibi... | 10/07/2008 |
| 7407810 | Methods and apparatus for characterizing polymeric mixtures The invention provides methods and apparatus for characterizing complex polymeric mixture of interest. Candidate solutions are eliminated from a solution space using one or more experimental measurements of a polymeric mixture of interest. The elimination step can b... | 08/05/2008 |
| 7331920 | Glycopeptide antibiotics, combinational libraries of glycopeptide antibiotics and methods of producing same Methods for preparing a glycopeptide are disclosed. The methods comprise the steps of selecting a protected glycopeptide of the formula A1-A2-A3-A4-A5-A6-A7, wherein the groups A1 | 02/19/2008 |
| 7315767 | Impedance spectroscopy based systems and methods One aspect of the invention provides a device that non-invasively determines the concentration of a substance in a target. The device includes a first electrode, a measuring circuit, and a data processor. In one embodiment of the device, the first electrode can be e... | 01/01/2008 |
| 7314760 | Biochemical test for identifying pregnancies with Down's syndrome fetus The invention provides prenatal screening methods for Down's syndrome. Specifically, the methods of the invention comprise determining the amount of hyperglycosylated human chorionic gonadotropin (hCG) charge isoforms in a biological sample from a pregnant woman and... | 01/01/2008 |
| 7285646 | Ultrapure transferrin for pharmaceutical compositions The present invention relates to an ultrapure human transferrin, and to methods for manufacturing the ultrapure transferrin. The transferrin may be holo-, apo- or at any desired degree of iron saturation. The invention further relates to the use of ultrapure transfe... | 10/23/2007 |
| 7285391 | Methods for predicting pregnancy outcome in a subject by hCG assay The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early ... | 10/23/2007 |
| 7273711 | Diagnosis of human glycosylation disorders This invention provides methods and kits for use in diagnosing genetically transmitted diseases that are associated with deficiencies in glycosylation of glycoconjugates such as glycoproteins, glycolipids, and proteoglycans. The methods and kits are also useful for ... | 09/25/2007 |
| RE39789 | Tumor therapy Neoplasia is treated by administering to a mammalian host a composition comprising ligands for the NKG2D receptor. In addition, other NKG2D ligands, proteins specific for the neoplastic cells and cytokines may be included to enhance the immune response. The composit... | 08/21/2007 |
| 7255835 | Single pass attenuated total reflection fourier transform infrared microscopy apparatus and method for identifying protein secondary structure, surface charge and binding affinity Apparatus and method for acquiring an infrared spectrum of a sample having or suspected to have an amide I band, an amide II band, an amide III band, an amide A band, an OH stretching region or a combination thereof. A representative method includes providing a samp... | 08/14/2007 |
| 7255998 | High sensitivity immunoassay method A method for detecting a cytokine in a biological fluid sample with a high sensitivity is provided. A time-resolved fluoroimmunoassay (TR-FIA) method including a step of forming on a solid phase a composite in which a cytokine is captured and which includes a fluore... | 08/14/2007 |
| 7241576 | Uses of THANK, a TNF homologue that activates apoptosis The present invention is directed to the applications of a novel cytokine, named THANK, for TNF homologue that activates apoptosis, NF-κB and c-jun N-terminal kinase. Such applications include using THANK inhibitors to inhibit the activation of NF-κB and to treat ... | 07/10/2007 |
| 7229835 | Amine detection method and materials A compound linked to a solid support (R) through a divalent linker moiety (X) and which is represented by the following formula: is disclosed. In particular, the 1-hydroxybenzotriazole-6-carboxylic acid is direct... | 06/12/2007 |
| 7223552 | Myeloperoxidase, a risk indicator for cardiovascular disease Diagnostic tests for characterizing an individual's risk of developing or having a cardiovascular disease. In one embodiment the present diagnostic test comprises determining the level of myeloperoxidase (MPO) activity in a bodily sample obtained from the individual... | 05/29/2007 |
| 7217739 | Method for inducing cell death with carbonyl scavengers Carbonyl scavengers, which have been recognized for their ability to react with reactive carbonyl species, have been implicated as agents that can accelerate or induce the death of abnormal cells without having a parallel effect on normal cells. As such, they are us... | 05/15/2007 |
| 7211376 | Polypeptide fingerprinting methods The invention provides methods, compositions, apparatus, and a computer data retrieval system for conducting proteomics. ... | 05/01/2007 |
| 7198955 | Method and apparatus for measurement of blood substitutes A method is disclosed whereby the concentration of a blood substitute, such as cross-linked hemoglobin, in a serum or plasma specimen is rapidly and accurately identified and quantified. The method further takes the measured concentration of the blood substitute and... | 04/03/2007 |
| 7198954 | Methods for predicting pregnancy outcome in a subject by hCG assay The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early ... | 04/03/2007 |
| 7195923 | Ratiometric determination of glycated protein The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the glycosylated protein, or the glycoprotein. The method incorporates lateral f... | 03/27/2007 |
| 7192779 | Diagnosis of Smith-Lemli-Optiz syndrome The invention provides a non-invasive assay for the detection of a SLOS affected individual by determining the ratio of at least one of the specific SLOS steroid analytes, dehydro-estriol (8-DHE3) and a dehydro-pregnanetriol (7-DHPT) to their normal steroid counterp... | 03/20/2007 |
| 7179616 | Method for detecting phosphatidylserine on the surface of cells The present invention relates generally to a method and compound for sensing the presence of anionic phospholipids, especially phosphatidylserine, on the surface of vesicles and cells. Upon introducing a compound having the structure below to a sample of cells or ve... | 02/20/2007 |
| 7173107 | Glycopeptide and preparation thereof The stereospecific synthesis of a glycopeptide using a triply orthogonal protection scheme is described, in particular, the synthesis of N-acetylglucosaminyl-β-[1,4]-N-acetylmuramylmonopeptide and derivatives thereof. The glycopeptide is useful for the preparation ... | 02/06/2007 |
| 7166473 | Transferrin assay The invention relates to an assay method for assessing a transferrin variant or combination of transferrin variants for the diagnosis and monitoring of alcoholism, and to kits for performing the assay. In particular, the invention provides a method of producing an a... | 01/23/2007 |
| 7160689 | Pretreatment instrument of saliva and pretreatment method of saliva In a pretreatment instrument and a pretreatment method of saliva, used for identification and quantitation of Streptococcus mutans in saliva by the immunochromatographic method utilizing an antigen-antibody reaction, the instrument includes a swab and a mixin... | 01/09/2007 |
| 7144704 | Methods and reagents for preparing and using immunological agents specific for P-glycoprotein This invention relates to immunological reagents and methods specific for a mammalian, transmembrane protein termed Pgp, having a non-specific efflux pump activity established in the art as being a component of clinically-important multidrug resistance in cancer pat... | 12/05/2006 |
| 7122322 | Endometriosis-specific secretory protein A method and kit of diagnosing endometriosis in a female patient suspected of having endometriosis. The method includes obtaining a sample from the patient. The sample is analyzed to detect the presence of a purified and isolated endometriotic haptoglobin designated... | 10/17/2006 |
| 7052833 | Absorptive hypercalciuria locus on human chromosome 1 Disclosed is a region on human chromosome 1 that provides a genetic basis for absorptive hypercalciuria. The genes, proteins, and other biological materials provided are envisioned for use in diagnostic and therapeutic methods related to absorptive hypercalciuria an... | 05/30/2006 |
| 7015048 | Methods and kits for diagnosing or monitoring synovial or osteoarticular disease, comprising the use of a specific marker for synovial tissue degradation Disclosed are specific markers for synovial tissue degradation and methods of using the markers in diagnosing, monitoring or determining a prognosis of synovial disease. ... | 03/21/2006 |
| 7011977 | Quantification of carnitine levels in dialysis patients Disclosed herein are methods for diagnosing carnitine deficiency in patients and quantifying that deficiency such that carnitine concentrations can be easily and accurately tracked within a given patient over time. Particular embodiments disclosed herein pertain to ... | 03/14/2006 |
| 6995018 | Complex formed by N-linked glycoproteins (SIBLINGS)and Factor H The invention provides methods and compositions for exploiting the discovery that members of the small integrin-binding ligand, n-linked glycoproteins family termed SIBLINGS bind to complement Factor H, and moreover that SIBLINGS proteins, such as BSP, exist in rela... | 02/07/2006 |
| 6986995 | Methods of diagnosing liver fibrosis The present invention provides a method of diagnosing the presence or severity of liver fibrosis in an individual by detecting α2-macroglobulin (α2-MG) in a sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissu... | 01/17/2006 |
