Did You Know...
...that Robert Adler has the dubious distinction of being the Father of the Couch Potato? Back in 1955 Adler was employed by what was then Zenith Radio Corp., where he was charged to invent something that would allow viewers to turn down the TV volume without leaving their chairs. After a series of flops (such as a wired contraption that people tripped over), Adler hit on the idea of using sound waves. Thus the Remote Control was born...
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| Number | Title | Issue Date |
| 7033746 | NES-1 polypeptides, DNA, and related molecules and methods Disclosed is substantially pure NES1 polypeptide and purified DNA, vectors, and cells encoding that polypeptide. Also disclosed are methods for carcinoma detection and treatment using the NES1 sequence. ... | 04/25/2006 |
| 7030210 | Materials and methods for detection and quantitation of an analyte The subject invention pertains to methods and materials for accurately assessing the presence or absence of analytes of interest in samples, particularly in physiological samples. The subject invention involves utilizing a ligand binding domain (LBD) of a receptor t... | 04/18/2006 |
| 7030211 | Antigenic peptides derived from telomerase This invention relates to proteins or peptides that elicit T cell mediated immunity, and to cancer vaccines and compositions for anti-cancer treatment comprising such proteins or peptide fragments. This invention also relates to pharmaceutical compositions comprisin... | 04/18/2006 |
| 7026167 | Systems and methods for the analysis of protein phosphorylation The present invention relates to a method of applying mass spectrometry to analyzing peptides or proteins, especially in the proteome setting. More particularly, the invention relates to a mass spectrometry-based method for detection of protein/peptide phosphorylati... | 04/11/2006 |
| 7026129 | IG lambda biopolymer markers predictive of Alzheimers disease The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopoly... | 04/11/2006 |
| 7022288 | Chemical detection sensor system A chemical detection sensor system comprises a support structure; multiple SERS chemical detection sensors supported by the support structure; multiple chemical reaction sensors, wherein each of the chemical reaction sensors is disposed for undergoing a state change... | 04/04/2006 |
| 7022490 | Myc-binding zinc finger proteins, their preparation and their use The present invention provides assays for determining transcription-modulating substances. The transcription-modulating activity of test compounds is assessed on the basis of their ability to suppress or enhance complex formation between Myc and a novel zinc finger ... | 04/04/2006 |
| 7022289 | Chemical and biological sampling device and kit and method of use thereof A self-contained, leak-proof sampling device and kit employing said device for collecting chemical and biological samples from various surfaces. The invention provides a sampling device and kit that may be employed to easily collect chemical and biological samples, ... | 04/04/2006 |
| 7018842 | Reading dry chemical arrays through the substrate A method of interrogating an addressable array unit having a transparent substrate with a back surface, and an array with a plurality of different chemical features on a front surface. The method may include illuminating the features while the array is dry, with an ... | 03/28/2006 |
| 7018841 | Compositions and methods for the inhibition of neurotransmitter uptake of synaptic vesicles Compositions and methods for treating neurosynaptic disorder in a subject are described. More specifically, compositions and methods for inhibiting glutamate uptake by synaptic vesicles in a subject are set forth. In one embodiment, the composition is inhibitory pro... | 03/28/2006 |
| 7015006 | Diagnostic test An assay for detecting type IV cytosolic phospholipase A2(cPLA2) or a protein immunologically homologous to type IV cPLA2, the assay comprising use of red blood cells, particularly for use in the diagnosis of a disease in which dysfu... | 03/21/2006 |
| 7015004 | Inter-alpha trypsin inhibitor biopolymer marker indicative of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopoly... | 03/21/2006 |
| 7015041 | Automated method for setting up multiple crystallization experiments in submicroliter volumes A method is provided for performing array microcrystallizations to determine suitable crystallization conditions for a molecule, the method comprising: forming an array of microcrystallizations, each microcrystallization comprising a drop comprising a mother liquor ... | 03/21/2006 |
| 7011977 | Quantification of carnitine levels in dialysis patients Disclosed herein are methods for diagnosing carnitine deficiency in patients and quantifying that deficiency such that carnitine concentrations can be easily and accurately tracked within a given patient over time. Particular embodiments disclosed herein pertain to ... | 03/14/2006 |
| 7012427 | Methods and devices for analysis of sealed containers This invention provides methods, NMR probes, and NMR systems for the analysis of the contents of sealed food and beverage containers and the like. ... | 03/14/2006 |
| 7008800 | Biopolymer marker indicative of disease state having a molecular weight of 1077 daltons The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopoly... | 03/07/2006 |
| 7005255 | Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for pred... | 02/28/2006 |
| 7001438 | Method for performing submicroliter crystallization experiments with high experiment to experiment precision A method is provided for forming crystallization experiments for a molecule, the method comprising forming a plurality of crystallization experiments that comprise a molecule to be crystallized and a composition that varies among the plurality of crystallization exp... | 02/21/2006 |
| 6995363 | Reduction of matrix interference for MALDI mass spectrometry analysis A MALDI plate suitable for MS or MS-MS analysis provided with a composite coating that comprises a hydrophobic coating and a thin layer coating of a mixture of a MALDI matrix material and an intercalating agent such as a polymer is disclosed. A MALDI plate produced ... | 02/07/2006 |
| 6995023 | Labeling proteins with dyes that are insoluble or only sparingly soluble in water The proteins in a biological sample that is sought to be analyzed for its protein composition by an electrophoretic or chromatographic procedure are coupled to a dye in an unusually efficient manner by combining the sample with a solid dry composition containing the... | 02/07/2006 |
| 6991937 | Urine cystine quantitation and supersaturation assay A method for measuring cystine supersaturation of a patient urine sample as an indicator of the patient's risk for cystine stone formation has been found. A method for collecting a patient urine sample for assessment of cystine concentration and cystine supersaturat... | 01/31/2006 |
| 6991916 | Compounds for the treatment of sexual dysfunction Polynucleotide and polypeptide sequences are described. The polypeptide sequences comprise one or more of: (a) a polypeptide having the deduced amino acid sequence translated from the polynucleotide sequence in SEQ ID NO: 1 or SEQ ID NO: 5 and variants, fragments, h... | 01/31/2006 |
| 6989274 | Polyaspartic acid concentration determination by fluorometry The present invention relates to a method of performing concentration determinations of aqueous solutions of polyaspartic acid and/or salts thereof. ... | 01/24/2006 |
| 6989239 | Methods for diagnosis and treatment of chronic immune diseases Methods are provided for diagnosing/characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to have a chronic immune disease. The sample is then assayed for the presence an... | 01/24/2006 |
| 6986995 | Methods of diagnosing liver fibrosis The present invention provides a method of diagnosing the presence or severity of liver fibrosis in an individual by detecting α2-macroglobulin (α2-MG) in a sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissu... | 01/17/2006 |
| 6982084 | Prevention and treatment of amyloidogenic disease The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylac... | 01/03/2006 |
| 6980674 | Reference database Data acquisition and cataloging are used to classify polypeptides into a reference index or database. The database can be used to identify previously unidentified samples. New polypeptides are characterized and added to the database. ... | 12/27/2005 |
| 6977370 | Off-resonance mid-IR laser desorption ionization Methods for producing a preponderance of gas phase ions having higher order charge states during laser desorption ionization of an analyte are presented, the methods comprising irradiating the analyte in the presence of energy absorbing molecules at a mid-IR wavelen... | 12/20/2005 |
| 6974798 | Treatment of balance impairments Compositions and methods are provided for prophylactic or therapeutic treatment of balance impairments involving neuronal damage, loss, or degeneration, preferably of vestibular ganglion neurons, in an animal by administration of an effective amount of a trkB or trk... | 12/13/2005 |
| 6974702 | Fourier transform mass spectrometry of complex biological samples The present invention relates to methods for high information content (HIC) analysis or screening of complex biological systems using Fourier transform mass spectrometry (FTMS). The present methods are useful for analyzing complex biological mixtures containing both... | 12/13/2005 |
| 6972326 | Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes The invention describes methods for labeling or detecting of immobilized poly(amino acids), including peptides, polypeptides and proteins, on membranes and other solid supports, using fluorescent dipyrrometheneboron difluoride dyes. Such immobilized poly(amino acids... | 12/06/2005 |
| 6972127 | Prevention and treatment of amyloidogenic disease The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylac... | 12/06/2005 |
| 6969614 | Methods for the isolation and analysis of cellular protein content The present invention describes devices and methods for performing protein analysis on laser capture microdissected cells, which permits proteomic analysis on cells of different populations. Particular disclosed examples are analysis of normal versus malignant cells... | 11/29/2005 |
| 6969757 | Differential labeling for quantitative analysis of complex protein mixtures The present invention relates to a method of simultaneously identifying and determining the levels of expression of cysteine-containing proteins in normal and perturbed cells, a method for proteomic analysis, a process for preparing fusion proteins, and compounds of... | 11/29/2005 |
| 6969612 | Reagent and method for measuring a concentration of protein The object of the present invention is to measure a concentration of protein stably at a temperature not higher than 25° C., which is a possible ambient temperature at home, and further to expand the measurable concentration range while preventing an obstruction du... | 11/29/2005 |
| 6966693 | Thermal characterization chip A thermal characterization chip comprising a substrate having overlying electronics, the electronics including semiconductor circuitry and thin film circuitry overlying the semiconductor circuitry; wherein the electronics define a plurality of thermal domains, each ... | 11/22/2005 |
| 6967251 | Reagents for labeling biomolecules having aldehyde or ketone moieties Novel fluorescent derivitization reagents are described that are suitable for coupling to biomolecules that contain aldehyde or ketone functional groups. In one embodiment is provided reagents that have the following formula: | 11/22/2005 |
| 6964851 | Compositions and methods for detecting stress-inducible proteins Compositions and methods for detection of the stress-inducible Hsp70B′ protein are disclosed. These include antibodies directed against particular amino acid regions of Hsp70B′ and various peptides corresponding, or antigenically equivalent, to the regions. The ... | 11/15/2005 |
| 6963807 | Automated identification of peptides A fully automated, user-independent method is described for computer-mediated interpretation of data derived by mass spectrometry of an experimental peptide to identify and characterize a corresponding peptide sequence in a peptide database. The method identifies th... | 11/08/2005 |
| 6962707 | Prevention and treatment of amyloidogenic disease The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylac... | 11/08/2005 |
