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| Number | Title | Issue Date |
| 8183050 | Detection of lysophosphatidylcholine for prognosis or diagnosis of a systemic inflammatory condition The present invention provides methods and compositions useful for the diagnosis or prognosis of a systemic inflammatory condition such as sepsis. ... | 05/22/2012 |
| 8178056 | Biochemical reaction cartridge and biochemical treatment equipment system There is provided a biochemical reaction cartridge comprising at least one chemical reaction chamber that accommodates a solution for biochemically treating a sample, a reaction chamber for performing detection reaction of a target substance in the biochemically tre... | 05/15/2012 |
| 8173436 | Biosensor utilizing a resonator having a functionalized surface Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a ... | 05/08/2012 |
| 8168436 | Method for determining quantity of peptide compound having phenylalanine residue at N-terminus The present invention provides a method for quantifying a peptide compound having a phenylalanine residue at the N-terminal, comprising measuring the content of heat generated by mixing 1) a peptide compound having a phenylalanine residue at the N-terminal, 2) cucur... | 05/01/2012 |
| 8143067 | Hydrophilic, high protein binding, low fluorescence, western blotting membrane Hydrophilic membrane particularly suited for blotting applications, preferably Western blotting. A pre-wet hydrophobic membrane substrate, preferably made of PVDF, is contacted with a monomer solution and subjected to a UV-initiated free radical polymerization step ... | 03/27/2012 |
| 8143066 | Methods and apparatus for performing retention-time matching A method (100) for analyzing chemicals includes fractionating a complex sample into at least two sample portions that each includes portions of two polypeptides though in different concentration ratios, digesting and performing LC/MS on each of the sample por... | 03/27/2012 |
| 8129191 | Monitoring method and apparatus A device for remote management of patients suffering from heart failure and hypertension can measure one or more biomarker. The device aids in monitoring the efficacy and safety of treatment in such patients. ... | 03/06/2012 |
| 8119410 | Apoptosis modulator Bcl-B and methods for making and using same A novel human member of the Bcl-2 family Bcl-B has been identified, which is closest in amino-acid sequence homology to the Boo (Diva) protein. The Bcl-B protein is widely expressed in adult human tissues. The Bcl-B protein modulates apoptosis. Bcl-B also binds Bcl-... | 02/21/2012 |
| 8114674 | Method for determining whether or not a mammal is affected with a lung cancer The present invention relates to a method for determining whether or not a mammal is affected with a lung cancer. The method for determining whether or not a mammal is affected with a lung cancer of the present invention includes the steps of: ... | 02/14/2012 |
| 8105839 | Diagnostic kit for Alzheimer's disease, diagnostic marker, and detection method for indicator of pathological state thereof While the differential diagnosis of Alzheimer's disease as distinguished from other types of dementia and the diagnosis of Alzheimer's disease at an early stage where neuronal apoptosis has not proceeded yet are important for the treatment of Alzheimer's disease, it... | 01/31/2012 |
| 8105840 | Urine pretreatment agent for urinary protein quantitation, urine pretreatment method, and urinary protein quantitation method Described are a urine pretreatment agent, a urine pretreatment method, and a urinary protein quantitation method which reduce or cancel the influences of urine pH variations, cancel the influences of precipitates of urinary inorganic salts, and solubilize membrane p... | 01/31/2012 |
| 8105838 | Generation and use of a catalog of polypeptide-related information for chemical analyses A method (100) for performing chemical analyses includes digesting a reference sample to obtain precursors associated with a peptide in the sample (110), separating the precursors to determine values associated with retention times of the separated pre... | 01/31/2012 |
| 8097463 | Use of arylboronic acids in protein labelling Tagging of Histidine in polypeptides with arylboronic acid tagging reagents for identifying proteins in a sample by isolating and identifying Histidine-comprising peptides from one protein sample or a pool of protein samples. Databases of Histidine-including peptide... | 01/17/2012 |
| 8097464 | Chemical and biological detection arrays Device comprising: a first substrate; a plurality of first raised elements on the first substrate, the first raised elements mutually spaced apart by first channel regions on the first substrate, each of the first raised elements having a first distal end, the first... | 01/17/2012 |
| 8093061 | Methods of determining potency of chemically-synthesized oligonucleotides Provided herein are methods for determining potency of RNAi agents. Such methods include, but are not limited to, cell-based and cell-free assays that measure binding of an RNAi agent with Ago2 or that measure Ago2 activity in the presence of such RNAi agents. Also ... | 01/10/2012 |
| 8093062 | Enzymatic assays using umbelliferone substrates with cyclodextrins in droplets in oil The invention is directed to droplet actuator devices and assay methods. The method may include, among other things, a method of conducting enzymatic assays using umbelliferone substrates with cyclodextrins in droplets in oil, the method including incubating a dropl... | 01/10/2012 |
| 8093060 | Multisite phosphorylated peptide (protein) recognizing compound and detection method, imaging method, alzheimer's disease diagnosing method and reagent kit using the same A compound which captures a multisite phosphorylated peptide or protein specifically to a phosphorylation site and a method for detecting the peptide or protein using the compound. Particularly, a compound which specifically detects an excessively phosphorylated tau... | 01/10/2012 |
| 8088626 | Chiral selectors for separating enantiomers of a compound The invention relates to the use of compounds as new chiral selectors for separating the optical or enantiomeric isomers of a compound, wherein the chiral selector comprises at least one compound of formula (I): and at least one metal ion, for example Cu2+ | 01/03/2012 |
| 8076148 | Cytochrome c protein and assay The present invention relates to a cytochrome c-reporter fusion protein construct comprising a modified cytochrome c protein which targets the mitochondria and has a reduced ability to induce apoptosis in a living cell. The invention also relates to nucleic acid con... | 12/13/2011 |
| 8071388 | Compositions and methods for biodetection by nucleic acid-templated chemistry The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid-templated chemistry, for example, by generating fluorescent polymethine dyes. ... | 12/06/2011 |
| 8067241 | Method and apparatus for antigen retrieval process The invention provides a method for antigen retrieval of a formaldehyde-fixed tissue sample comprising incubating a formaldehyde-fixed tissue sample in a first antigen retrieval solution at a temperature of greater than 90° C., transferring the tissue sample to a s... | 11/29/2011 |
| 8062894 | Generation of fluorescent microbead cellular surrogate standards A method of producing microbead populations that mimics the fluorescence intensity profile distribution of fluorescent biological cells so that they may be used a standard for flow cytometry. ... | 11/22/2011 |
| 8062895 | Misfolded protein sensor method A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes the transformation of the p... | 11/22/2011 |
| 8053242 | Crystallization of chemical species/polymorphs and microfluidic apparatus and screening methodology therefor The crystallization of chemical species/polymorphs comprises forming droplets of a solution of a substance with optionally different concentrations of said substance in an inert phase; producing and storing the droplets in at least one storage microchannel (1... | 11/08/2011 |
| 8039264 | Compositions, methods and kits for biarsenical fluorophore labeling Methods, compositions, and kits for labeling tetracysteine-tagged proteins with biarsenical fluorophores with increased specificity, including compositions, methods and kits particularly adapted for labeling of tetracysteine-tagged proteins to be resolved within an ... | 10/18/2011 |
| 8030084 | Thyroglobulin quantitation by mass spectrometry Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifyi... | 10/04/2011 |
| 8030083 | Method of analyzing protein structural affinity relationship A method for analyzing a structural affinity relationship between plural kinds of proteins and a compound, comprising the steps of (a) using a compound-immobilized carrier to purify plural kinds of proteins bound to the compound on the carrier, from a group of isoto... | 10/04/2011 |
| 8003395 | Non-signal imidazole reagents for mass spectrometry analysis of phosphomonoesters Analytical chemical reagents termed non-signal imidazoles and a method for their use that provide a host of advantages for analysis of phosphomonoesters are described. The method and compounds of the invention provide a host of advantages for the analysis of phospho... | 08/23/2011 |
| 8003396 | NT-proBNP/troponin ratio for assessing myocardial dysfunction The present invention relates to a method of diagnosing if a subject which has suffered from an acute myocardial infarction is also suffering from a pre-existing myocardial dysfunction, the method comprising a) determining the amount of a natriuretic peptide in a sa... | 08/23/2011 |
| 7998743 | Panel of biomarkers for peripheral arterial disease The invention provides biomarkers including β-2-microglobulin, Cystatin C, hsCRP and glucose as well as methods for using the biomarkers for diagnosing and/or assessing the risk of peripheral artery disease in a subject. In some embodiments, the subject being teste... | 08/16/2011 |
| 7998744 | Methods for determining dysregulation of methylation of brain expressed genes on the X chromosome to diagnose autism spectrum disorders The discovery that alterations in methylation, which can cause one or more genes on the single X chromosome in males to be partially silenced or overexpressed, constitute a predisposition to autism spectrum disorders is generally disclosed herein. These alterations ... | 08/16/2011 |
| 7993929 | Method for determination of presence or absence of peptide compound PYY The present invention provides a method for determining in a pharmaceutical test formulation the presence or absence of a peptide compound PYY3-36 represented by the following amino acid sequence: H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-... | 08/09/2011 |
| 7989210 | IL1RL-1 as a cardiovascular disease marker and therapeutic target Methods for evaluating the likelihood that a subject will benefit from treatment with an agent for reducing the risk of a cardiovascular condition, by evaluating levels of Interleukin 1 Receptor-Like 1 (IL1RL-1) polypeptides in a sample comprising serum from the sub... | 08/02/2011 |
| 7985591 | Parasitic helminth cuticlin proteins and uses thereof The present invention relates to: parasitic helminth cuticlin proteins; parasitic helminth cuticlin nucleic acid molecules, including those that encode such cuticlin proteins; antibodies raised against such cuticlin proteins; and compounds that inhibit parasitic hel... | 07/26/2011 |
| 7968344 | Automated protein analyzer A protein analysis kit is disclosed. The kit includes a sample cup for mixing a protein sample with a dye-binding solution and a filter holder for being positioned in the sample cup. The filter holder includes a filter media and a depending spout below the filter me... | 06/28/2011 |
| 7960179 | Analytical method for protein mapping using hydrogen/deuterium exchange Analytical methods using hydrogen/deuterium exchange are provided which reduce or eliminate the back-exchange of deuterium for hydrogen. The methods, which are useful in protein and peptide mapping, include the steps of (a) providing a peptide or protein comprising ... | 06/14/2011 |
| 7955854 | Assessing heart failure in patients with atrial fibrillation using GDF-15 and natriuretic peptides Disclosed are a method, device, and test kit for diagnosing heart failure in a patient exhibiting atrial fibrillation. The method includes determining an amount of growth differentiation factor-15 (GDF -15) in a sample from the patient and comparing the amount of GD... | 06/07/2011 |
| 7951601 | Oxide layers on silicon substrates for effective confocal laser microscopy Methods of performing confocal laser microscopy on a polymer array disposed on a silicon wafer substrate, the method comprising the steps of providing a silicon wafer substrate having a top side and a bottom side, coating the top side of the silicon wafer with an ox... | 05/31/2011 |
| 7951602 | Mass defect labeling and methods of use thereof Mass defect labeled peptides and methods of identifying peptides are provided. In particular, embodiments of the present disclosure include mass defect labels for polypeptides that include at least one cysteine and/or at least one tryptophan and methods of using the... | 05/31/2011 |
| 7947506 | Protein detection and quantitation using hydroxyquinolone dyes A hydroxyquinolone compound formulated as a fluorescent dye for protein detection, assay, quantitation, etc. The hydroxyquinolone compound may be modified, for example, by adding or removing sulfate groups, changing hydrocarbon chain lengths, etc. to result in more ... | 05/24/2011 |
