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| Number | Title | Issue Date |
| 4761288 | Multiphase liposomal drug delivery system The present invention provides a novel multiphase drug delivery system which comprises: (a) lipid vesicles with a biologically active compound captured therein; (b) a saturated solution of the biologically active compound; and (c) the biologically active compound i... | 08/02/1988 |
| 4753788 | Method for preparing small vesicles using microemulsification A method is provided for preparing small (less than 2000 Å) lipid vesicles in commercial quantities by microemulsifying lipid compositions using very high shear forces generated in a homogenizing apparatus operated at high pressures at a selected tempera... | 06/28/1988 |
| 4752425 | High-encapsulation liposome processing method A method of preparing a suspension of liposomes containing a water-soluble compound predominantly in liposome-encapsulated form. A solution of vesicle-forming lipids in a chlorofluorocarbon solvent is infused under selected conditions into an aqueous medi... | 06/21/1988 |
| 4752572 | Lipid vesicles containing labeled species and their analytical uses Vesicles comprising a matrix of lipid membranes prepared from lipid materials are useful in biomedical studies and immunoassays. A labeled species is encapsulated within the vesicles and released when the vesicles are lysed with a surface active agent. Th... | 06/21/1988 |
| 4748129 | Assay method employing fluorescent cell incorporative dye A method is provided for determining the presence in a sample of a member of a specific binding pair ("sbp member") consisting of ligand and its homologous receptor. The sample is combined in an aqueous medium with (1) a complementary sbp member wherein a... | 05/31/1988 |
| 4745074 | Blood-fluid composition for cell lysis system A blood fluid composition for use in a complement-mediated cell lysis system. The composition includes a blood fluid, which may be either a serum source of complement, analyte-containing serum, or both, and lipid vesicles capable of reducing the extent of... | 05/17/1988 |
| 4743560 | Solid phase assay Solid phase assay for an analyte wherein binder is supported on a solid support, such as nitrocellulose, and the tracer is comprised of ligand labeled with a particulate label, such as a liposome, including a detectable marker which is not visible.... | 05/10/1988 |
| 4737323 | Liposome extrusion method A suspension of liposomes whose sizes are predominantly greater than about 1 micron is passed through an asymmetric ceramic filter whose inner-surface pore size is about 1 micron. The processed liposomes have a selected average size of about 0.4 microns o... | 04/12/1988 |
| 4731324 | Viral lysis assay A viral lysis immunoassay system and method. The system includes hemolytic particles carrying non-viral, anti-analyte molecules, lysable target cells which are devoid of surface molecules capable of binding to endogenous viral surface molecules, and forei... | 03/15/1988 |
| 4731210 | Process for the preparation of liposomal medicaments Associates of at least one amphiphilic bilayer-forming substance and a solubilizing agent are formed in an aqueous phase. The bilayer-forming substance itself can be a pharmaceutical substance, or pharmaceutical substances and/or pharmaceutical auxiliarie... | 03/15/1988 |
| 4721612 | Steroidal liposomes Methods and compositions are described for the preparation of lipid vesicles, the bilayers of which comprise a salt form of an organic acid derivative of a sterol such as the tris-salt form of a sterol hemisuccinate. The method is rapid, efficient, and do... | 01/26/1988 |
| 4717676 | Vesicles and use thereof in an assay Sacs comprising a compound having a hydrophilic peptide radical are prepared and are believed to have improved stability as a result of hydrogen bonding. The sacs, including a detectable marker and derivatized with a ligand may be used as a tracer in an a... | 01/05/1988 |
| 4714672 | Immunoassays involving complement lysing of chromophore containing microcapsules An immunoassay of the type which utilizes the hemolysis of microcapsules such as red blood cells. Microcapsules which can be lysed by complement activity, which contain an optically determinable substance, on whose surfaces an antibody to be quantified is... | 12/22/1987 |
| 4713324 | Inverted latency specific binding assay A specific binding assay composition and method for determining a ligand in a sample are disclosed. The composition comprises (a) a binding partner for the ligand; (b) a detection system which has at least two components; (c) a selectively accessible vesi... | 12/15/1987 |
| 4708933 | Immunoliposome assay-methods and products This invention is directed to a new membrane lytic immunoassay. In one embodiment of this assay, an antigen is first covalently coupled with lipids and this antigen-lipid complex is mixed with a hexagonal phase forming lipid to form bilayer liposome vesic... | 11/24/1987 |
| 4707441 | Binding assays in automated apparatus with liposome compatible surfactants Disclosed is a specific binding assay composition and method for determining a ligand in a sample. The composition comprises (a) a binding partner for the ligand; (b) a detection system which has at least two components; (c) a selectively accessible vesic... | 11/17/1987 |
| 4707453 | Vesicle including a metal marker for use in an assay Vesicles are formed, in part, from an amphiphilic chelating agent whereby a detectable metal marker can be complexed to the vesicle. A portion of the vesicle may also be formed from an amphiphilic compound derivatized with a ligand, whereby the vesicle ma... | 11/17/1987 |
| 4704355 | Assay utilizing ATP encapsulated within liposome particles An assay utilizing receptor or antibody sensitized liposome particles which have ATP encapsulated therein. The ATP is released by lysing the liposomes, and detected by means of luciferin-luciferase reagent and a luminometer. The assay provides a very sens... | 11/03/1987 |
| 4703017 | Solid phase assay with visual readout Solid phase assay for an analyte wherein binder is supported on a solid support, such as nitrocellulose, and the tracer is comprised of ligand labeled with a colored particulate label, such as a liposome including a dye. The assay has a high sensitivity, ... | 10/27/1987 |
| 4698263 | Sac having a marker linked thereto Vesicles are formed having a detectable marker and ligand conjugated to compounds forming the vesicle wall. The vesicles are dried, and reformed by addition of water for use in an assay.... | 10/06/1987 |
| 4695554 | Sac or liposome containing dye (sulforhodamine) for immunoassay A sac, in particular a vesicle, including as a detectable marker an absorbing dye having an extinction coefficient of at least 100,000 and a solubility in water of at least 0.1M; in particular, sulforhodamine B or salt thereof. The sacs have improved stab... | 09/22/1987 |
| 4671954 | Microspheres for incorporation of therapeutic substances and methods of preparation thereof Novel hydrophilic protein or polypeptide microspheres prepared by dispersing an aqueous solution or dispersion of protein or polypeptide in an organic solvent solution of a high molecular weight polymer to form a stabilized dispersion of microspheres and ... | 06/09/1987 |
| 4668638 | Liposome composition for lupus assay An immunoassay utilizing a novel liposome composition in which there is incorporated a stabilizing or destabilizing component and an antigen. The presence of cognate antibodies in test samples is detected by the alteration of the supramolecular structure ... | 05/26/1987 |
| 4666830 | Assay employing sacs and sac lysing agent In an assay for an analyte, the tracer is comprised of a sac lysing agent, which lyses sacs containing detectable marker and sac lysing agent in inactive form which is activated when released from the sacs to provide a cascade effect which increases sensi... | 05/19/1987 |
| 4663161 | Liposome methods and compositions The present disclosure relates to novel liposome compositions and methods for their preparation. Utilization of the present invention provides an efficient reconstitution of membrane proteins into large (0.1 to 2 micron diameter) phospholipid vesicles wit... | 05/05/1987 |
| 4656129 | Assay for a ligand by use of supported binder and sac lysing agent In a homogeneous assay, binder supported on a solid support, having a sac lysing agent conjugated thereto, is contacted with analyte and tracer comprised of sacs containing a detectable marker. The sacs of the bound tracer portion are lysed to release mar... | 04/07/1987 |
| 4650769 | Microcapsules for immune response Microcapsules for effecting an immune response, especially through agglutination reaction, comprise an antigen or antibody bound to functional groups, such as amino groups, carboxy groups, etc., on a wall surface of the microcapsules via cross linking age... | 03/17/1987 |
| 4640898 | Homogeneous fluorescence ligang binding assay based upon preferential alteration of the respective intensities of bound and free label by solvent components Fluorescence ligand binding assay of a sample containing an unknown amount of ligand may be performed by making direct intensity measurements. In an immunoassay, for example, the sample may be added to a solution containing fluorescein labeled analyte and... | 02/03/1987 |
| 4636479 | Enhanced agglutination method and kit An enhanced agglutination assay method for determination of a multivalent analyte is disclosed. Analyte is added to agglutinatable particles coated with anti-analyte molecules to produce particle agglutination. The extent of agglutination is enhanced by m... | 01/13/1987 |
| 4634681 | Diagnostic method of determining the presence or absence of select proteins in a liquid sample An emulsion (in which an aqueous medium contains small liquid droplets coated with a protein that will interact specifically with a select protein) is mixed with a liquid sample, time is allowed for interaction to occur and the mixture is then exposed to ... | 01/06/1987 |
| 4623618 | Simultaneous quantitative immunoassay for different antigens or antibodies An immunoassay by which a plurality of kinds of antigens or antibodies in one test sample may be simultaneously quantified. Each of a plurality of kinds of microcapsules is first provided for each kind of a plurality of antigens or antibodies to be quanti... | 11/18/1986 |
| 4622294 | Liposome immunoassay reagent and method A liposome assay reagent for determination of an analyte in a homogeneous immunoassay. The reagent includes a suspension of oligolamellar lipid vesicles containing encapsulated glucose-6-phosphate dehydrogenase (G6PD), at a specific activity of between ab... | 11/11/1986 |
| 4622188 | Method for manufacturing liposomes A method and apparatus for manufacturing liposomes is characterized by optically monitoring the light transmission of a liposome precursor solution and controlling the flow rate and/or temperature of the precursor solution and/or a dialysis buffer solutio... | 11/11/1986 |
| 4619795 | Method for preparing lipid vesicles A method for forming vesicles is described, wherein a lipid coating is formed onto a deformable surface. During hydration, the lipid coating is fragmented by deformation of the surface. The resulting fragments of the lipid coating are dispersed in the hyd... | 10/28/1986 |
| 4619904 | Agglutinating immunoassay using protein-coated liquid droplets Small liquid droplets, coated with protein, the protein coating containing molecules of protein that will interact specifically with a select protein, are contacted with a liquid sample to determine the presence or absence of the select protein therein de... | 10/28/1986 |
| 4619794 | Spontaneous preparation of small unilamellar liposomes The present invention relates to a novel advantageous process for the preparation of unilamellar liposomes in aqueous phase by converting a suitable lipid component, e.g. phosphatidic acid, into the ionic form by subjecting the lipid dispersion to a chang... | 10/28/1986 |
| 4608211 | Process for preparing lipid vesicles by vaporisation of solvents A process for preparing large unilamellar lipid vesicles is disclosed which process comprises preparing unilamellar lipid vesicles having an average diameter of at least 1,000 Å, each of these vesicles consisting of a spheroidal lipid lamella containing ... | 08/26/1986 |
| 4605630 | Large-liposome agglutination reagent and method An agglutination assay reagent and method. The reagent is composed of liposomes predominantly in the 1 to 20 micron diameter size range. Each liposome has a surface array of laterally mobile ligand molecules, at a surface concentration adapted to produce ... | 08/12/1986 |
| 4603044 | Hepatocyte Directed Vesicle delivery system A targeted drug delivery system which has specificity for hepatobiliary receptors, which are the specialized metabolic cells of the liver. Hereinafter, this will be referred to as a Hepatocyte Directed Vesicle, or abbreviated as HDV. This preferred direct... | 07/29/1986 |
| 4598051 | Liposome conjugates and diagnostic methods therewith A number of naturally occurring antibodies to human erythrocyte surface antigens are capable of combining with their specific antigens (for example, Rhesus factor), but are not capable of producing visible hemagglutination. Also, the sensitivity of many d... | 07/01/1986 |
