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| Number | Title | Issue Date |
| 4590170 | Process for preparing microcapsule reagents for immunological response A process for producing a microcapsule diagnostic material utilizing passive agglutination which comprises binding an antigen or antibody onto a microcapsule wall negatively charged, in an acidic solution is provided. The microcapsule diagnostic material ... | 05/20/1986 |
| 4590169 | Direct particle agglutination immunoassays avoiding false negatives at high antigen concentrations A direct particle agglutination immunoassay for assaying an antigenic substance (Ag) in a fluid. The immunoassay is the type which comprises: (a) contacting the fluid with an antibody (Ab) coated particle (P) to agglutinate the Ab coated particles; and (b) det... | 05/20/1986 |
| 4588578 | Lipid vesicles prepared in a monophase A process for the preparation in a monophasic solvent system of a new type of lipid vesicles, called monophasic lipid vesicles (MPVs). MPVs can be made to encapsulate one or more bioactive agents. MPVs are stable during storage and can be used in vivo in ... | 05/13/1986 |
| 4588698 | Encapsulated scintillators for measuring the concentration of tritiated solutes Microencapsulation of solid phase scintillators in gels selectively permeable to diffusible radioactive label. These encapsulated scintillators are used to monitor the concentration of radioactive-tagged subtances in fluid systems.... | 05/13/1986 |
| 4564599 | Liposome composition for lupus assay An assay for detecting SLE antibodies utilizing a novel liposome composition in which there is entrapped a divalent cation responsive indicator. The presence of such antibodies is detected by their stabilization of the supermolecular structure of the lipo... | 01/14/1986 |
| 4560665 | Method of measuring membrane fusion This method of measuring membrane fusions between liposomes made of phospholipid is characterized by the combination of ionophores, fluorescent dyes sensitive to the membrane potential (interior negative) and porins which are the pore-forming membrane pro... | 12/24/1985 |
| 4551288 | Processes for the preparation of liposome drug delivery systems Process and apparatus for the production of medicament containing liposomes, comprising an aliphatic lipid-sterol-water lamellae, wherein a clear, mixed micellar medicament-detergent-aliphatic lipid-sterol sample is applied to a gel filtration column. The... | 11/05/1985 |
| 4532089 | Method of preparing giant size liposomes Large size liposomes are produced from small unilamellar vesicles by incorporating a polar compound in an aqueous dispersion of the vesicles, subjecting the dispersion to repeated freeze-thaw cycles, and thereafter dialyzing the vesicles against a hypoosm... | 07/30/1985 |
| 4529561 | Method for producing liposomes in selected size range Liposomes of uniform size are produced by forming liposomes in relatively random sizes, and extruding the liposomes under pressure through a uniform-pore-size membrane to force at least some of the liposomes into smaller sizes. Extrusion may be repeated t... | 07/16/1985 |
| 4522803 | Stable plurilamellar vesicles, their preparation and use A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds... | 06/11/1985 |
| 4517303 | Specific binding assays utilizing analyte-cytolysin conjugates A novel analyte-cytolysin conjugate and its use in a lipid vesicle mediated measurement process is described for a wide variety of analytes present at very low concentration. The method involves forming a reaction system consisting of analyte, analyte spe... | 05/14/1985 |
| 4515736 | Method for encapsulating materials into liposomes A novel encapsulation method is provided in which liposome dispersions are dried in the presence of a material to be encapsulated. As drying occurs, the individual liposomes fuse to form multilamellar structures which capture the material between lipid la... | 05/07/1985 |
| 4508703 | Production of pulverulent mixtures of lipidic and hydrophobic constituents The invention relates to a method for preparing a pulverulent mixture of amphiphilic lipidic constituents and possibly of hydrophobic constituents, as well as to a method for producing hydrated lipidic lamellar phases from the pulverulent mixture. The met... | 04/02/1985 |
| 4501728 | Masking of liposomes from RES recognition A biochemical membrane covered with sialic residues thereby provides a coating that masks the surface membrane from recognition and removal by the scavenging RES cells of the body.... | 02/26/1985 |
| 4485054 | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) This invention provides an improved procedure for producing large multilamellar lipid vesicles (MLV), which may be used to encapsulate a biologically active material, particularly lipophilic substances. According to this invention, a lipid film is formed ... | 11/27/1984 |
| 4483929 | Liposomes with glycolipid-linked antibodies Lipid vesicles, labelled with encapsulated reporter compositions and bound to antibodies comprise a new class of immunoreagent, useful in immunoassays for ligands.... | 11/20/1984 |
| 4483928 | Microcapsules sensitized with antibody and a method for measurement of lymphocyte using the same based on cell-mediated immunity Microcapsules are sensitized with antibody to antigen of lymphocyte. Using such microcapsules, B cells and/or T cells can be selectively measured separately or simultaneously, in a simple manner, based on cell-mediated immunity which comprises applying th... | 11/20/1984 |
| 4483921 | Immunoassay with antigen or antibody labeled liposomes sequestering enzyme An immunoassay method utilizes antigen tagged, enzyme encapsulating liposomes which are immunospecifically ruptured in the presence of cognate antibody and active complement. A homogeneous phase reaction occurs with the antibody and complement acting to r... | 11/20/1984 |
| 4480041 | Use of phosphotriester intermediates for preparation of functionalized liposomes A method of forming an analyte-functionalized liposome for use in immunoassay techniques employs a phosphotriester intermediate of a phospholipid derivatized with the desired analyte in a process of forming a liposome which is functionalized on its outer ... | 10/30/1984 |
| 4463090 | Cascade amplification enzyme immunoassay The invention provides enzyme immunoassays whose sensitivity is increased by cascade amplification. The coupled ligand (enzyme or an activator) catalytically activates a second enzyme which acts on a substrate or can act on a third enzyme to produce a cas... | 07/31/1984 |
| 4452747 | Method of and arrangement for producing lipid vesicles In accordance with a method of and an arrangement for producing lipid vesicles from biological membranes or lipid suspensions, a lipid suspension or lipid particles in a dispersion fluid are accommodated in a treatment container, ultrasonic treatment of t... | 06/05/1984 |
| 4448765 | Liposomes and their use in treating human or other mammalian patients Microvesicles are stabilized by the incorporation of a polymer having aliphatic lipophilic groups with a chain of at least six atoms attached to the backbone thereof. Such microvesicles may incorporate a physiologically active substance such as an antigen... | 05/15/1984 |
| 4438052 | Process and device for producing bilayer vesicles A process for producing bilayer vesicles from a colloidal solution comprising mixed micelles of a bilayer-forming substance and a detergent, comprises removing the detergent from the micelle-containing colloidal solution by means of flow-through dialysis ... | 03/20/1984 |
| 4436826 | Tagged immunoassay An immunoassay method for measurement of the content of a target antigen or antibody in a fluid or tissue specimen comprises reacting the target with reagent antibody or antigen which forms a complex with the target and is tagged with tagging elements whi... | 03/13/1984 |
| 4429008 | Thiol reactive liposomes Liposomes are provided which have a plurality of thiol reactive groups extending outward of the liposomal bilayer. The liposomes form stable covalent bonds with ligands having thiol groups, such as Fab' fragments. Particularly preferred liposomes include ... | 01/31/1984 |
| 4343895 | Encapsulated antigenic tumor specific substances and methods for detecting cancer using said substances The present invention provides encapsulated antigenic tumor-specific substances prepared by extracting said antigenic tumor-specific substances in an aqueous phase and then encapsulating said aqueous phase. Said encapsulated substances are characterized b... | 08/10/1982 |
| 4342826 | Immunoassay products and methods An immunoassay method utilizes antigen tagged, enzyme encapsulating liposomes which are immunospecifically ruptured in the presence of cognate antibody and active complement. A homogeneous phase reaction occurs with the antibody and complement acting to r... | 08/03/1982 |
| 4342739 | Novel material for immunological assay of biochemical components and a process for the determination of said components Antigen- or antibody-bound microcapsules are employed for immunological assay of biochemical components having immunological activity. The microcapsule system provides high detection sensitivity, high accuracy and excellent reproducibility in immunologica... | 08/03/1982 |
| 4311690 | Test set and method for the determination of free hormones Disclosed is a process for determining the concentration of unbound hormone, e.g., thyroxine, cortisol, or testosterone, in a liquid sample containing hormone and protein capable of binding the hormone. The sample is incubated with antibody specific to th... | 01/19/1982 |
| 4255411 | Process of determining an immunogenic substance by competition with an antibody in a microcapsule A process for determining an immunogenic substance present in a sample wherein the immunogenic substance in the sample competes with a distinguishable analog of such substance for available binding sites on an antibody which is highly specific for the imm... | 03/10/1981 |
| 4235792 | Immunological materials Immune lysis of sensitized liposomes containing a marker is employed in an assay method wherein an antigenic material to be determined is reacted with a specific antiserum and the degree of inhibition of the antiserum is detected by the extent of release ... | 11/25/1980 |
| 4193983 | Labeled liposome particle compositions and immunoassays therewith The subject invention concerns novel compositions for use in immunoassays, as well as immunoassays employing such novel compositions. The compositions comprise discrete charged colloidal particles comprised of small molecules which particles are capable o... | 03/18/1980 |
| 4078052 | Large unilamellar vesicles (LUV) and method of preparing same A process and resulting product for producing large unilamellar phosphatidylserine vesicles (LUV) in the diameter of about 2,000-12,000 A which may additionally encapsulate a drug. The large vesicles are prepared from an initial phosphatidylserine aqueous... | 03/07/1978 |
| 4066568 | Method of producing microcapsules Microcapsules are produced by dispersing and emulsifying hydrophobic material such as water insoluble material, color forming material, color forming assistant, oil and mixture of oil and various medicines dissolved therein in gelatin aqueous solution so ... | 01/03/1978 |
| 4062799 | Method of forming microcapsule films having low porosity A method of forming low porosity microcapsule films which comprises chemically or ionically binding a water soluble or water dispersible heterocyclic amine to a microcapsule film forming material, or depositing the heterocyclic amine alone or a water inso... | 12/13/1977 |
| 3937668 | Method for incorporating substances into protein microspheres The subject matter of this invention is a process for solid albumin particles so that such spheric particles may act as a carrier for radioactivity, drugs, insecticides, dyes, metal salts, etc. In order to prepare such spheric particles, the substance to ... | 02/10/1976 |
