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| Number | Title | Issue Date |
| 7405054 | Signal amplification method for surface plasmon resonance-based chemical detection The present invention provides methods and compositions for amplifying the detection signal in surface plasmon resonance (SPR)-based flow systems. The signal amplification methods comprise the use of well established marker systems that provide a precipitate. The ma... | 07/29/2008 |
| 7329739 | Use of lectin library for distinguishing glycoproteins or cells, diagnosing serum or cells, or fractionating glycoproteins or cells It is intended to provide lectins and a lectin library comprising these lectins which are useful in recognizing differences in carbohydrates on cell surface (for example, sugar chains and cell surface glycoproteins) reflecting extremely subtle differences among cell... | 02/12/2008 |
| 7273711 | Diagnosis of human glycosylation disorders This invention provides methods and kits for use in diagnosing genetically transmitted diseases that are associated with deficiencies in glycosylation of glycoconjugates such as glycoproteins, glycolipids, and proteoglycans. The methods and kits are also useful for ... | 09/25/2007 |
| 7179660 | Carriers coated with polysaccharides, their preparation and use A polysaccharide coated carrier having a coating of at least two successive layers of polysaccharide. The first polysaccharide layer spontaneously associates with a second polysaccharide layer and, optionally, the carrier. Each successive layer of polysaccharide spo... | 02/20/2007 |
| 7129096 | Sensor for use in testing biological, biochemical, chemical or environmental samples Disclosed are sensors for use in testing biological, biochemical, chemical or environmental samples, and methods of making and using the same. ... | 10/31/2006 |
| 7064191 | Process for purifying antibody The present invention relates to a process for purifying an antibody having a desired property, which comprises using a substance having an affinity to a carbohydrate binding to the antibody; a medicament comprising, as an active ingredient, the antibody purified by... | 06/20/2006 |
| 7056657 | Apparatus and methods for magnetic separation Separation apparatus and method for separating magnetic and/or magnetically-labeled particles from a test medium. Test medium within a reaction chamber is caused to flow past a collecting surface, and a high-gradient magnetic field is applied to the surface t... | 06/06/2006 |
| 7049130 | Diagnostic sanitary test strip An improved multi-layered diagnostic sanitary test strip for receiving a heterogenous fluid, such as whole blood, to test for presence and/or amount of a suspected analyte in the fluid by facilitating a color change in the strip corresponding to the amount of the an... | 05/23/2006 |
| 6991940 | Diagnostic sanitary test strip An improved multi-layered diagnostic sanitary test strip for receiving a heterogenous fluid, such as whole blood, to test for presence and/or amount of a suspected analyte in the fluid by facilitating a color change in the strip corresponding to the amount of the an... | 01/31/2006 |
| 6867052 | Biological material detecting articles of manufacture The present invention relates to articles of manufacture inclusive of or in combination with a biological assay material, formed from a material capable of detecting and identifying the presence of one or more particular toxic substances, wherein said toxic substanc... | 03/15/2005 |
| 6844166 | Recombinant reduced valency carbohydrate binding ligands The invention is based on the discovery of reduced valency carbohydrate binding ligands (CBLs) that can be used to to detect or quantitate (i.e., evaluate) carbohydrates in a sample. CBLs can be used with fluorescence resonance energy transfer (FRET) to evaluate fre... | 01/18/2005 |
| 6762032 | Compositions, assay kits, and methods for use related to a disease condition comprising multiple sclerosis and/or a pro-MS immune response Provided are methods, and assay kits, and compositions useful for generating an indicator of a disease condition selected from the group consisting of multiple sclerosis (MS), a pro-MS immune response, and a combination thereof. A method for assaying a sample of an ... | 07/13/2004 |
| 6692923 | Tapasin-like protein The invention provides a cDNA which encodes tapasin-like protein. It also provides for the use of the cDNA, protein, and antibody in the diagnosis, prognosis, treatment and evaluation of therapies for cancer. The invention further provides vectors and hos... | 02/17/2004 |
| 6692973 | Surface binding of an immunoglobulin to a flexible polymer using a water soluble varnish matrix The present invention relates to bioassay materials useful for the detection of toxic substances and, more particularly, to packaging materials for food and other products, along with methods for their manufacture and use. The invention provides a unique ... | 02/17/2004 |
| 6689615 | Methods and devices for processing blood samples Approaches are described for separating plasma from whole blood samples and include the use of magnetically attractable particles associated with an agglutinating agent. The magnetically attractable particles bind the cellular components in a whole blood ... | 02/10/2004 |
| 6677123 | Process for detecting increased risk of fetal chromosomal abnormality An increased risk of a fetal chromosomal abnormality, for example, fetal Down syndrome can be detected by separating or discriminating -fetoproteins present in the body fluid of a pregnant woman, and measuring the proportion of one or more of the &... | 01/13/2004 |
| 6677164 | Multivalent polymers, processes for their preparation, and their use for preparing biologically active compounds The present invention provides biologically active linear polypeptides that possess a plurality of biologically active groups, methods employing such peptides to target molecules to cells, and methods employing such peptides for inhibiting the binding of ... | 01/13/2004 |
| 6514716 | Detection of the end-position sialic acid groups of the human transferrin molecule The subject matter of this invention is a method of determining terminal sialic acid residues in human transferrin according to a sandwich principle, which is characterized in that the sample fluid containing the human transferrin is incubated with a firs... | 02/04/2003 |
| 6468807 | Mixing method The invention relates to a method for carrying out mixing in a thin liquid layer, which is arranged between essentially parallel walls at a capillary distance from each other. The mixing is carried out by subjecting the walls to a motion essentially in th... | 10/22/2002 |
| 6303325 | Method for detecting analytes The invention relates to methods of determining the presence or amount of an analyte in a sample suspected of containing the analyte, said method comprising the steps of: (a) bringing together in an aqueous medium to form a mixture: (i) the sample; (ii) a... | 10/16/2001 |
| 6284550 | Diagnostic sanitary test strip An improved multi-layered diagnostic sanitary test strip for receiving a heterogenous fluid, such as whole blood, to test for presence and/or amount of a suspected analyte in the fluid by facilitating a color change in the strip corresponding to the amoun... | 09/04/2001 |
| 6271044 | Method and kit for detecting an analyte The present invention provides a viscometric method of detecting the presence or absence of an analyte in a solution. The method utilizes a dispersion of a conjugate and a receptor. The conjugate functions as an analog of the analyte, and the receptor can... | 08/07/2001 |
| 6235488 | Surface preparation for chemical-specific binding A mass biosensor uses an intermediate avidin layer to facilitate binding of a biotinylated antibody to a measurement surface of the biosensor. The avidin layer can be added by the manufacturer of the biosensor, while the biotinylated layer can be added by... | 05/22/2001 |
| 6232130 | Method for detecting or quantifying carbohydrate containing compounds A method of evaluating a carbohydrate in a sample. The method includes providing a low valency carbohydrate binding ligand, providing a glycoconjugate which includes a label, and a carbohydrate moiety, contacting the low valency carbohydrate binding ligan... | 05/15/2001 |
| 6231733 | Immobilized carbohydrate biosensor A biosensor in which a carbohydrate or a derivative of a carbohydrate is used to generate a detectable signal by way of the specific binding to a protein, a virus or a cell.... | 05/15/2001 |
| 6165710 | Method for immobilizing viral glycoproteins for use in solid-phase immunoassays A process for selectively immobilizing viral glycoproteins on lectin-coated surfaces for use in solid phase immunoassays is disclosed. This method does not require that the virus or antigen be purified prior to immobilization. This method provides an inex... | 12/26/2000 |
| 6150123 | Affinity biotinylation The present invention relates to a method for biotinylating a desired subset of a larger population of proteins, wherein the subset of proteins is first selectively bound to a solid phase, thereby separating it from undesired proteins of the population, a... | 11/21/2000 |
| 6130101 | Sulfonated xanthene derivatives The present invention describes xanthene dyes, including rhodamines, rhodols and fluoresceins that are substituted one or more times by a sulfonic acid or a salt of a sulfonic acid. The dyes of the invention, including chemically reactive dyes and dye-con... | 10/10/2000 |
| 6117836 | Glycosylation-mediated inhibition of factor X Reagents that specifically bind a carbohydrate target wherein sialic acid is linked at the nonreducing terminus of a glycoside to a galactose or galactosamine residue through an 댒-6 linkage are able to inhibit the conversion of human Factor X to hu... | 09/12/2000 |
| 6084072 | Purified lectin and methods of use Amaranthin, a new lectin isolated from the seeds of Amaranthus caudatus, is purified and characterized. Amaranthin, designated ACA (Amaranthus caudatus agglutinin), has a high affinity for the T-antigen glycoconjugate and variants thereof expressed by pro... | 07/04/2000 |
| 6074643 | Site-directed chemotherapy of metastases Provided for use in site-directed chemotherapy are compositions comprising chemotherapeutic agents targeted to either arrested metastatic cells via a cell-surface marker associated with metastasis; or are targeted to type 1 endothelial cells of the tissue... | 06/13/2000 |
| 6040195 | Diagnostic sanitary test strip An improved multi-layered diagnostic sanitary test strip for receiving a heterogenous fluid, such as whole blood, to test for presence and/or amount of a suspected analyte in the fluid by facilitating a color change in the strip corresponding to the amoun... | 03/21/2000 |
| 5876954 | Cytotoxic factor as is associated with multiple sclerosis, its detection and its quantification Gliotoxic factor in the isolated or purified state, characterized in that it possesses toxic activity with respect to human or animal astrocytic cells, having the effect of a cytomorphological disorganization of their network of intermediate filaments and... | 03/02/1999 |
| 5846748 | Method for diagnosing visceral leishmaniasis in a patient by identification of a new key marker namely 9-O-acetylated sialoglycoconjugate This invention relates to identification of a new key marker namely 9-O-Acetylated sialoglycoconjugate with the help of a known 9-O acetylsialic acid binding lectin, Achatinin-H useful for the diagnosis of visceral leishmaniasis, by a rapid, accurate haem... | 12/08/1998 |
| 5801002 | Galactoside-binding-protein useful in the diagnosis and inhibition of of metastasis Disclosed are novel polypeptides possessing part or all of the amino acid sequence or primary structural conformation and one or more of the biological properties of certain galactoside-binding-proteins with apparent molecular weights of 34,000 and 31,000... | 09/01/1998 |
| 5786221 | Diagnostic test for measuring islet cell autoantibodies and reagents relating thereto An in vitro diagnostic test for analyzing body fluid so as to obtain an indication of the risk of developing insulin dependent diabetes-mellitus (IDDM) is provided. A solid phase containing immobilized pancreatic antigens is contacted with a test sample. ... | 07/28/1998 |
| 5780247 | Process for separating and measuring trace components Two or more analytes having the same action, or having different actions in spite of their similar structures, or two or more analytes having the same action and the same detectable chemical characteristics, in samples derived from living bodies, etc., ca... | 07/14/1998 |
| 5773222 | Solid phase immunological assay A solid phase method of detection or assay of the presence or amount in a serum or plasma sample of a target antibody specific to a cell surface antigen. The sample is contacted with an immobilised preparation of cells bearing the antigen and antibody bou... | 06/30/1998 |
| 5766552 | Apparatus for red blood cell separation Red blood cells are removed from whole blood or a fraction thereof by agglutinating whole blood with a mixture of a free agglutinating agent and nucleating particles having agglutinating agent intimately associated therewith to form clusters of red blood ... | 06/16/1998 |
| 5738984 | Kits and methods of detection using cellulose binding domain fusion proteins A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production thereof. Fusion products comprising the CBD and a second protein are likewis... | 04/14/1998 |
