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| Number | Title | Issue Date |
| 6951727 | Methods and reagents for quantitation of cell-surface molecule expression on peripheral blood cells Improved methods, reagents, and kits for quantitation of HLA-DR and/or CD11b expression on peripheral blood cells are presented. Inclusion of a lysosomotropic amine, such as chloroquine, during staining stabilizes HLA-DR and CD11b expression. Use of a novel anti-CD1... | 10/04/2005 |
| 6927071 | Method for reducing non-specific aggregation of latex microparticles in the presence of serum or plasma A particle-enhanced assay for determining an analyte in a test sample in which an additive for reducing non-specific particle aggregation is added in an amount to substantially reduce non-specific aggregation. The additive is selected form the group consisting of tr... | 08/09/2005 |
| 6905886 | Preservative solutions This invention relates to preservative solutions for peptides, for example, parathyroid hormone, insulin-like growth factor binding protein 3 (IGFBP3), adrenocorticotropic hormone (ACTH) and mixtures thereof. Preferably, the peptides preserved by the solutions are n... | 06/14/2005 |
| 6890765 | Particles for immunoassays and methods for treating the same A method of treating particles to be used in immunoassays reduces interference in particle agglutination assays. For particles having covalently bound antibodies and residual NHS-ester or sNHS-ester groups on the surface, the reactive esters are treated with an aque... | 05/10/2005 |
| 6777246 | Tertiary amine compounds for use in immunoassays A reagent for use in immunoassays reduces interference in particle agglutination assays. The reagent contains particles having covalently bound antibodies and a tertiary amine compound of formula (I): N(R1—X)(R2—Y)(R3 | 08/17/2004 |
| 6767708 | Stabilized aqueous steroid immunoassay standards Aqueous solutions of steroid compounds which have biological activity and have a tendency to oxidative degradation at temperatures between 2 and 8° C. on storage in excess of several months are stabilized by the addition of chelators. Aqueous solutions of particula... | 07/27/2004 |
| 6740527 | Methods and reagents for cyanide-free determination of hemoglobin and leukocytes in whole blood Cyanide-free reagents for the determination of hemoglobin and leukocytes present in a blood sample comprise an aqueous solutions of at least one quaternary ammonium salt, preferably selected from the group of alkyltrimethylammonium salts, alkyldimethylbenzylammonium... | 05/25/2004 |
| 6706486 | Method for the quantitative release of natural or recombinant proteins, polypeptides or peptides The present invention relates to a method for the quantitative release of natural or recombinant proteins, polypeptides (thermostable immunoligands) able to bind to the Fc-part of immunoglobulins (antibodies, in particular of the IgG class and primarily becoming bou... | 03/16/2004 |
| 6620628 | Analytical elements having a surface charge An assay element for analyzing a charged analyte employs an immobilized receptor and a material having a net charge which is the same as that of the analyte. In a preferred embodiment, the analyte is an aminoglycoside and the material is a polymer having ... | 09/16/2003 |
| 6579688 | Stabilizing diluent for polypeptides and antigens Compositions for stabilizing polypeptides or antigens are described. These compositions are useful for stabilizing polypeptides or antigens stored in aqueous formulations. Such formulations can be used for various analytical or other methods.... | 06/17/2003 |
| 6500629 | Materials and methods for detection and quantitation of an analyte The subject invention pertains to methods and materials for accurately assessing the presence or absence of analytes of interest in samples, particularly in physiological samples. The subject invention involves utilizing a ligand binding domain (LBD) of a... | 12/31/2002 |
| 6338960 | Histamine measuring apparatus and a histamine measuring method Histamine may be quantitatively measured by performing the following steps. First, an oocyte that expresses histamine receptors is held in a recess formed at the bottom of a vessel. Then, first and second electrodes are inserted into the oocyte. Subsequen... | 01/15/2002 |
| 6337178 | Histamine measuring apparatus and a histamine measuring method Histamine may be quantitatively measured by performing the following steps. First, an oocyte that expresses histamine receptors is held in a recess formed at the bottom of a vessel. Then, first and second electrodes are inserted into the oocyte. Subsequen... | 01/08/2002 |
| 6277559 | Histamine measuring apparatus and a histamine measuring method Histamine may be quantitatively measured by performing the following steps. First, an oocyte that expresses histamine receptors is held in a recess formed at the bottom of a vessel. Then, first and second electrodes are inserted into the oocyte. Subsequen... | 08/21/2001 |
| 6177283 | Diagnostic assay For blood or other physiological fluid sample collection kits that use filter paper to collect the sample, the performance of the kit and associated analytical method can be improved by using a material having properties which are superior to those of sta... | 01/23/2001 |
| 6143537 | Method for stabilizing analyte structure using antibodies or antibody fragments thereof A method for stabilizing analyses with antibodies and antibody fragments comprises dissolving the analyte in a liquid to form a solution, adding analyte-specific antibodies, fragments of such antibodies, or both to the solution, heating the solution, and ... | 11/07/2000 |
| 6103538 | Colloidal gold immunoassay method Disclosed herein is a method for the detection of a target substance by a colloidal gold immunoassay, which comprises dissolving in an immunoreaction system a metal salt selected from the group consisting of sodium, potassium and lithium fluorides, sodium... | 08/15/2000 |
| 6096508 | Method of reducing background in biotin-based assays This invention relates to an improvement in a method for detecting labeled molecules and especially biotinylated molecules and particularly relates to a method for reducing background signal problems in such detection methods.... | 08/01/2000 |
| 6083530 | High drug:lipid formulations of liposomal-antineoplastic agents A method for encapsulation of antineoplastic agents in liposomes is provided, having preferably a high drug:lipid ratio. Liposomes may be made by a process that loads the drug by an active mechanism using a transmembrane ion gradient, preferably a transme... | 07/04/2000 |
| 6080385 | Oxidative metabolism in smooth muscle cells: methods and materials relating thereto Disclosed are methods for measuring non-contractile oxidative metabolism in smooth muscle cells comprising providing a medium suitable for the support of oxidative metabolism, incubating a cell or tissue sample with a specimen from a patient, measuring a ... | 06/27/2000 |
| 6077518 | Cloning of mite allergens Isolated allergens of Dermatophagoides (house dust mites) particularly of the species and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In addition, the or peptides enco... | 06/20/2000 |
| 5858805 | Assay for aminoglycoside antibiotics This invention is directed to the use of polycarboxylic acid polymers to enhance the performance of immunochemical assays for the quantitation of aminoglycoside antibiotics in biological samples. This invention is also concerned with the improved homogene... | 01/12/1999 |
| 5837474 | Immunological method for the detection of malignant tumors and kit for performing the method A method of detecting malignant tumors and determining their mass includes withdrawing fresh blood and/or serum samples from the patient. The blood or serum sample is then stabilized. The tumor determination is obtained from a shift in the ratio of at lea... | 11/17/1998 |
| 5795589 | Liposomal antineoplastic agent compositions A method for encapsulation of antineoplastic agents in liposomes is provided, having preferably a high drug:lipid ratio. Liposomes may be made by a process that loads the drug by an active mechanism using a transmembrane ion gradient, preferably a traname... | 08/18/1998 |
| 5773304 | Method for quantitatively determining cholesterol A method for quantitatively determining cholesterol in high density lipoproteins, in which, prior to the determination of cholesterol by an enzymatic method, a surfactant and a substance which forms a complex with lipoproteins other than high density lipo... | 06/30/1998 |
| 5731157 | Two-site allergen immunoassay An allergen immunoassay method features the use of a combination of a) closely controlled 1) elevated temperatures for assay reactions, 2) low temperatures for reagents and samples, 3) times for assay steps and especially assay reaction times, 4) reagent ... | 03/24/1998 |
| 5691150 | Immunoassay for insulin-like growth factors Described are immunoassay of insulin-like growth factors in a biological sample, which comprises prior to the immunoassay, treating the biological sample with an acid solution to liberate the insulin-like growth factors from insulin-like growth factor bin... | 11/25/1997 |
| 5686316 | Methods and reagents for the rapid determination of glycated hemoglobin The invention is a rapid, continuous test for glycated hemoglobin using a non-equilibrium affinity binding method. Agarose beads derivatized with 3-aminophenylboronic acid specifically bind glycated hemoglobin. This solid phase is incorporated into a samp... | 11/11/1997 |
| 5679536 | Chemiluminescent analytical method A chemiluminescent method is provided for the analysis of a target. A peroxidase is first bound as a labelling substance to the target by using a target specific binding reagent. The target so labelled is isolated and then reacted with luminol, hydrogen p... | 10/21/1997 |
| 5660978 | Stabilization of analytes A method for stabilizing analytes with antibodies and antibody fragments comprises dissolving the analyte in a liquid to form a solution, adding analyte-specific antibodies, fragments of such antibodies, or both to the solution, heating the solution, and ... | 08/26/1997 |
| 5658737 | Compositions and methods for the simultaneous detection and quantification of multiple specific nucleic acid sequences The invention relates to methods for simultaneously or sequentially detecting multiple nucleic acid analytes in a single medium utilizing oligonucleotide hybridization probes coupled to different chemiluminescent labeling reagents. The methods may be used... | 08/19/1997 |
| 5648222 | Method for preserving cells, and uses of said method This invention provides a method for preserving cells which comprises the steps of (a) suspending cells in a physiologically-acceptable, isotonic medium; and (b) fixing the cells so suspended at a temperature of less than about 10° C. under sufficiently ... | 07/15/1997 |
| 5641637 | Method of preparing lyophilized and frozen cell standards A method is disclosed for preparing lyophilized and frozen cells as cytometry standards.... | 06/24/1997 |
| 5637509 | Modulated homogeneous fluorescence biospecific affinity assay employing fluorescing lanthanide chelates as covalent labels Method for a homogeneous biospecific affinity assay for determining the content of a substance (analyte) in a biological sample. The assay is carried out in an aqueous reaction medium by means of time-resolved fluorescence spectroscopy and with a biospeci... | 06/10/1997 |
| 5627080 | Detergent-facilitated immunoassay for the rapid and quantitative assay of pharmacological agents Methods for modulating the rates and dose responses of immunoassays through the incorporation of one or more detergents into the immunoassay reaction are disclosed. The methods are particularly suitable for automated immunoassay formats, especially with f... | 05/06/1997 |
| 5616460 | Buffer composition for reagents for immunoassay An aqueous composition suitable for use when performing immunological procedures. The composition includes at least one biological buffer, dithiothreitol (alternatively referred to herein as "DTT"), and ethylene glycol. The composition can also include at... | 04/01/1997 |
| 5589393 | Method for preparing a glycated hemoglobin solution The invention is a rapid, continuous test for glycated hemoglobin using a non-equilibrium affinity binding method. Agarose beads derivatized with 3-aminophenylboronic acid specifically bind glycated hemoglobin. This solid phase is incorporated into a samp... | 12/31/1996 |
| 5585246 | Method for preparing a sample in a scan capillary for immunofluorescent interrogation An assay and sample mixture for the enumeration of fluorescently stained target components of a whole blood sample by an imaging instrument. The sample preparation method ensures that the amount of target components per unit of volume of the whole blood s... | 12/17/1996 |
| 5558996 | Fungus extraction method, kit, and extraction solution A method and kit for extracting fungus from a plant. An extraction solution is combined with tissue from a plant and the combination is agitated, preferably by shaking, to extract a detectable amount of the fungus from the plant. The extraction solution i... | 09/24/1996 |
| 5552142 | Cloning and sequencing of allergens of dermatophagoides (house dust mite) The present invention features isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least o... | 09/03/1996 |
