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| Number | Title | Issue Date |
| 7387897 | Tetrameric antibody complexes for blocking non-specific labeling of antigens A method for preventing or inhibiting non-specific binding reactions between a detection reagent and an antigen in an immunological assay is described. The method involves using tetrameric antibody complexes that can bind to the antigen and are comprised of two mono... | 06/17/2008 |
| 7368542 | Method of altering the binding specificity of plasma proteins by oxidation-reduction reactions The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium is altered by exposing the protein to an oxidizing agent or an electric current sufficient to alter its binding specificity. A masked protein such as an autoantibody can... | 05/06/2008 |
| 7300761 | Methods and device for detecting prostate specific antigen (PSA) An immunoassay device and assay to detect an antigen, such as PSA, in a biological sample. The device comprises a solid support having multiple reaction zones containing capture antibodies directed to the antigen. Exposure of a test sample to a mixture of incubation... | 11/27/2007 |
| 7285218 | Method for the extra-corporeal qualitative and/or quantitative recording of neurotoxic substances in the blood plasma of an individual The invention relates to a method for the extra-corporeal qualitative and/or quantitative recording of neuro-toxic substances in the blood plasma of an individual. According to said method, a system containing neurones or neuronal networks, which have been cultivate... | 10/23/2007 |
| 7279136 | Metering technique for lateral flow assay devices A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. A sample membrane is utilized having a collection region and a detection region, the collection region having a known saturation volume for the intended test ... | 10/09/2007 |
| 7252961 | Competitive immunoassay using complexed analyte derivatives The invention relates to a method for the detection of an analyte in a competitive immunoassay in the presence of an analyte derivative and first and second receptor molecules, and to a kit for carrying out this detection method. ... | 08/07/2007 |
| RE39664 | Lateral flow chromatographic binding assay device The present invention relates to improved specific binding assay devices comprising a chromatographic medium including a reaction site at which a specific binding reagent is immobilized, a sample application well located adjacent to the chromatographic medium and of... | 05/29/2007 |
| 7195923 | Ratiometric determination of glycated protein The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the glycosylated protein, or the glycoprotein. The method incorporates lateral f... | 03/27/2007 |
| 7192786 | Biospecific assay method This invention relates to a biospecific assay method, in which microparticles coated with the bioaffinity reactant A binding the analyte to be assayed; the sample to be analyzed, and the labelled bioaffinity reactant B are mixed. After the binding reaction the signa... | 03/20/2007 |
| 7186518 | Method and composition useful for determining FK 506 New derivatives of FK 506 are disclosed. These new derivatives and other derivatives that are useful for determining the levels of FK 506 in a sample are also provided as are assay procedures and kits for use in determining the levels of FK 506 or other macrophilin ... | 03/06/2007 |
| 7135340 | Tetrameric antibody complexes for blocking non-specific labeling of antigens A method for preventing or inhibiting non-specific binding reactions between a detection reagent and an antigen in an immunological assay is described. The method involves using tetrameric antibody complexes that can bind to the antigen and are comprised of two mono... | 11/14/2006 |
| 7115422 | Separation apparatus including porous silicon column A sample separation apparatus including a porous, or rough, capillary column. The porous capillary column includes a matrix which defines pores, and may be formed rough surface of hemispherical grain silicon. The capillary column is defined in a surface of a substra... | 10/03/2006 |
| 7112453 | Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d... | 09/26/2006 |
| 7108993 | Use of dual conjugated labels in the elimination of serum interference in immunochromatographic assays A method and device for carrying out immunoassays in which non analyte specific binding of heterophilic antibodies to a labeled antibody in a capture region produces an incorrect measure of the amount of an analyte attached to the antibody. Immunoglobulin from the s... | 09/19/2006 |
| 7026132 | Method of monitoring the effect of Cathepsin S inhibitors The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant chain (Ii), in particular the p10 Ii fragment, in blood of dosed sub... | 04/11/2006 |
| 6995018 | Complex formed by N-linked glycoproteins (SIBLINGS)and Factor H The invention provides methods and compositions for exploiting the discovery that members of the small integrin-binding ligand, n-linked glycoproteins family termed SIBLINGS bind to complement Factor H, and moreover that SIBLINGS proteins, such as BSP, exist in rela... | 02/07/2006 |
| 6949344 | Hair analysis method A method the direct analysis of an analyte in keratinized structures, e.g., hair and fingernails, which comprises preparing a mixture containing a low redox potential activator compound such as dithiothreitol or dithioerythritol, an enzyme suitable for the digestion... | 09/27/2005 |
| 6939681 | Method of detecting an antibody in a liquid sample The invention relates to a method of evaluating the immunological status of a subject comprising the steps of 1) determining the content of an antibody in a liquid sample from the subject using an immunoassay, wherein the reaction between the antibody of the sample ... | 09/06/2005 |
| 6927071 | Method for reducing non-specific aggregation of latex microparticles in the presence of serum or plasma A particle-enhanced assay for determining an analyte in a test sample in which an additive for reducing non-specific particle aggregation is added in an amount to substantially reduce non-specific aggregation. The additive is selected form the group consisting of tr... | 08/09/2005 |
| 6900023 | Method for classifying and counting leukocytes A method for classifying and counting leukocytes comprises the steps of: (1) adding to a hematological sample the following fluorescence-labeled antibodies labeled with fluorescent dyes which emit fluorescences distinguishable from each other; (a) a first fluorescen... | 05/31/2005 |
| 6893875 | Method for assay of analyte by adjustment of chemiluminescence A method for assay of an analyte by use of a material labeled with a chemiluminescent substance, which comprises adding a quencher and/or decreasing the specific activity of a chemiluminescent substance labeled probe, thereby decreasing the quantity of chemiluminesc... | 05/17/2005 |
| 6890765 | Particles for immunoassays and methods for treating the same A method of treating particles to be used in immunoassays reduces interference in particle agglutination assays. For particles having covalently bound antibodies and residual NHS-ester or sNHS-ester groups on the surface, the reactive esters are treated with an aque... | 05/10/2005 |
| 6887669 | Reagents for assays for ligands The present invention relates to a method for releasing a ligand from a complex of the ligand with an endogenous protein using a releasing agent. ... | 05/03/2005 |
| 6881821 | Hepatitis-C virus type 4, 5, and 6 Newly elucidated sequences of hepatitis C virus type 4 and type 5 are described, together with those of a newly discovered type 6. Unique type-specific sequences in the NS4, NS5 and core regions enable HCV detection and genotyping into types 1 to 6. Antigenic peptid... | 04/19/2005 |
| 6867002 | Sample treating kit and sample treating method using the same for analysis with a biosensor A sample solution treating instrument is provided for facilitating rapid and simplified adjustment of the condition of a sample solution proper for analysis with a biosensor before supplying the solution to the biosensor. The sample solution treating instrument incl... | 03/15/2005 |
| 6824985 | Formulation for reducing urea effect for immunochromatography assays using urine samples Disclosed is an improvement in the analysis for an analyte in a urine test sample in which the urine is contacted with a labeled antibody specific to the analyte and the concentration of the analyte is determined by measuring the response from the label. The improve... | 11/30/2004 |
| 6783947 | Protecting groups for biological labeling Alpha-haloketones are useful alkylating agents for coupling to sulfhydryl-containing biomolecules. However, they react spontaneously with water, alkali and organic bases and therefore cannot be stored for extended periods of time in aqueous solutions, particularly i... | 08/31/2004 |
| 6777246 | Tertiary amine compounds for use in immunoassays A reagent for use in immunoassays reduces interference in particle agglutination assays. The reagent contains particles having covalently bound antibodies and a tertiary amine compound of formula (I): N(R1—X)(R2—Y)(R3 | 08/17/2004 |
| 6764825 | Methods and device for detecting prostate specific antigen (PSA) An immunoassay device and assay to detect an antigen, such as PSA, in a biological sample. The device comprises a solid support having multiple reaction zones containing capture antibodies directed to the antigen. Exposure of a test sample to a mixture of incubation... | 07/20/2004 |
| 6762062 | Method of determining cholesterol and sensor applicable to the same The present disclosure relates to a method for determining cholesterol in low density lipoprotein comprising the steps of (a) measuring total cholesterol level in a sample containing at least high density lipoprotein, low density lipoprotein, very low density lipopr... | 07/13/2004 |
| 6737278 | Ligand binding assay and kit with a separation zone for disturbing analytes The invention relates to a method for determining an analyte by means of binding reactions, which method comprises: i) applying the sample to an application zone for sample (ASZ) on a flow matrix in which transport of components present in the sample can take place ... | 05/18/2004 |
| 6706486 | Method for the quantitative release of natural or recombinant proteins, polypeptides or peptides The present invention relates to a method for the quantitative release of natural or recombinant proteins, polypeptides (thermostable immunoligands) able to bind to the Fc-part of immunoglobulins (antibodies, in particular of the IgG class and primarily becoming bou... | 03/16/2004 |
| 6673629 | Neutralization of polycations in a chromatographic device for whole blood use A chromatography assay device and method for use with whole blood samples utilizing a red blood cell separating agent to aggregate red blood cells and permit plasma or serum to flow by capillary action and a neutralizing agent to neutralize any effects th... | 01/06/2004 |
| 6653066 | Device and method for detecting polyvalent substances Disclosed is a device and method of use for detecting polyvalent analytes such as antibody to the AIDS virus, utilizing an inverse sandwich method. The test device comprises a first substance having an epitope, bound to a label and capable of moving withi... | 11/25/2003 |
| 6607891 | Method of assaying insulin-like growth factor A pretreatment method for assaying a substance which comprises mixing a biological specimen with at least one pretreating agent selected from among surfactants and alkali agents, thus releasing binding proteins in the biological specimen from the substanc... | 08/19/2003 |
| 6596502 | Kit and method for detecting fecal parasites The invention concerns a home kit and a method for detection of the presence of a fecal parasite in a stool.... | 07/22/2003 |
| 6579685 | Method and apparatus for screening microscopic cells utilizing light scatter techniques A method for performing screening of one or more cell groups of interest obscured by a cell population such as one or more subsets of interest of a WBC population utilizing at least one light sensing parameter. The cell group of interest is enumerated by ... | 06/17/2003 |
| 6548309 | Procedure for assay of liquids containing undissolved solids, semisolids or colloids In qualitative or quantitative assays which employ a test device comprising a test strip pretreated for detection of a specified target analyte dissolved in a liquid medium, the presence of solid, semisolid and/or colloidal materials in the liquid medium ... | 04/15/2003 |
| 6503702 | Rapid immunoassay for detection of antibodies or antigens incorporating simultaneous sample extraction and immunogenic reaction The present invention is drawn to an immunoassay capable of the rapid detection of a variety of test substances that may be present in a test sample. One feature of the invention is that extraction or isolation of the test substance occurs simultaneously ... | 01/07/2003 |
| 6492127 | Lateral flow testing device with on-board chemical reactant A lateral flow testing device is provided for testing a biological fluid for the presence of methamphetamines. The device includes a substrate element such as a nitrocellulose strip, including an antibody zone and an immobilized drug conjugate zone for de... | 12/10/2002 |
