Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 7402398 | Measuring receptor homodimerization The invention provides methods and kits for detecting and/or measuring receptor homodimers on a cell surface membrane. In one aspect, the methods employ pairs of probes comprising binding compounds and a cleaving probe, such that at least one binding compound binds ... | 07/22/2008 |
| 7402397 | Detecting and profiling molecular complexes Methods are provided for detecting the formation of complexes of molecules, especially proteins, in a sample, such as a cell or tissue lysate. In one aspect, a cleaving probe specific for a first protein in a complex and one or more binding compounds specific for on... | 07/22/2008 |
| 7371584 | Multi-functional and configurable assay Novel magnetic assay methods and systems. According to a preferred embodiment, a chromatographic medium is provided that is designed to be contacted with a test solution having activated magnetic particles such that the solution flows bilaterally thereacross. A magn... | 05/13/2008 |
| 7368277 | Method for assay of antibodies and antibody assay device The invention relates to a technology by which antibodies directed to sources of infection in body fluids can be assayed with high accuracy, expediency and specificity. More particularly, the invention provides an antibody immunoassay method in which the antigen-ant... | 05/06/2008 |
| 7364921 | Method and apparatus for separating biological materials and other substances A method for separating biological materials and other substances is disclosed, wherein a mixture containing desired and undesired components are exposed to magnetic particles having ligands capable of binding to the desired and/or the undesired components to form a... | 04/29/2008 |
| 7358096 | Immobilisation of proteins The immobilization of proteins at solid surfaces facilitated by incorporation of a polypeptide segment which is capable of adopting a folded structure is described. Materials comprising proteins so immobilized and uses thereof are also described. ... | 04/15/2008 |
| 7316932 | Method for separating cells The present invention is related to a method for separating a first population of cells from a second population of cells in a sample by discontinuous density gradient separation using dense particles to target the first population of cells and a density separation ... | 01/08/2008 |
| 7285424 | Membrane-based assay devices A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a self-calibrated magnetic binding assay format (e.g., sandwich, competitive, etc.) that includes detection probes capable o... | 10/23/2007 |
| 7252961 | Competitive immunoassay using complexed analyte derivatives The invention relates to a method for the detection of an analyte in a competitive immunoassay in the presence of an analyte derivative and first and second receptor molecules, and to a kit for carrying out this detection method. ... | 08/07/2007 |
| 7223546 | Method for measuring the amount of constituent contained in a specific lipoprotein There is provided a method and kit for measuring the amount of an objective constituent contained in a specific lipoprotein in a biological sample such as serum and plasma, specifically for measuring the amount of cholesterol contained in high density lipoprotein, w... | 05/29/2007 |
| 7205157 | Method of separating cells from a sample Rare cells are separated from a sample fluid by a positive selection or negative selection antibody by centrifuging in a tube containing a harvesting float. The harvesting float has an axial passage and a density to settle in the sample fluid and expand the layer of... | 04/17/2007 |
| 7183119 | Method for sensitive detection of multiple biological analytes The present invention relates to a method of detecting biological analytes comprising suspending a target analyte in a suspending solution containing polymeric particles marked with a probe, wherein the probe has an affinity for said target analyte; adding recogniti... | 02/27/2007 |
| 7166423 | Direct selection of cells by secretion product Cells can be labeled with products which they secrete and release in an efficient manner by coupling the cells at their surface to a specific binding partner for the product and allowing the product to be captured by the specific binding partner as it is secreted an... | 01/23/2007 |
| 7160735 | Tagged microparticle compositions and methods Compositions and methods are disclosed for detecting multiple target analytes in a sample using microparticles having molecular tags attached by cleavable linkages. Generally, an assay mixture is formed comprising a sample and a reagent comprising multiple such micr... | 01/09/2007 |
| 7122382 | Method for detecting proteins under mutual interaction A method for detecting proteins under mutual interaction which comprises mixing a protein having a label for detection synthesized by a cell-free protein synthesis method with another protein having a modification for separation, or synthesizing a protein having a l... | 10/17/2006 |
| 7108985 | Methods and kits useful for the simplification of complex peptide mixtures Methods and reagents for obtaining simplified mixtures of peptides from a sample containing a number of peptides are disclosed. The simplified sample can be easier to analyze than the original peptide sample yet it is representative of all or nearly all of the prote... | 09/19/2006 |
| 7074622 | Method and system for sorting and separating particles The present invention relates to a method of particle separation comprising preparing a suspension of particles containing at least one recognizable target particle in a suspending solution, labeling the target particle with a conjugate marker, wherein the conjugate... | 07/11/2006 |
| 7064191 | Process for purifying antibody The present invention relates to a process for purifying an antibody having a desired property, which comprises using a substance having an affinity to a carbohydrate binding to the antibody; a medicament comprising, as an active ingredient, the antibody purified by... | 06/20/2006 |
| 7056657 | Apparatus and methods for magnetic separation Separation apparatus and method for separating magnetic and/or magnetically-labeled particles from a test medium. Test medium within a reaction chamber is caused to flow past a collecting surface, and a high-gradient magnetic field is applied to the surface t... | 06/06/2006 |
| 7045363 | Nucleic acid-bound polypeptide method of producing nucleic acid-bound polypeptide and immunoassay using the polypeptide A nucleic acid-bound polypeptide produced by binding a nucleic acid to a polypeptide, a method of producing the nucleic acid-bound polypeptide, and applications of the nucleic acid-bound polypeptide, including immunoassays for an antigen or antibody, such as an aggl... | 05/16/2006 |
| 7022491 | Method for determining molecule—molecule interaction analysis The invention relates to a method for monitoring interactions to a target biomolecule comprising the steps of: providing a biomolecule of interest having specificity for the target biomolecule; binding the biomolecule of interest to at least one type of linker molec... | 04/04/2006 |
| 7001775 | Assays for autoantibodies A method and kit for screening a sample of body fluid for at least one autoantibody to at least one antigen. A source of at least one antigen to the autoantibody is provided. A substrate having immobilized thereto at least one antibody to the antigen is also provide... | 02/21/2006 |
| 6991912 | Systems and methods for performing magnetic chromatography assays Novel magnetic assay methods and systems. According to a preferred embodiment, a chromatographic medium, which preferably comprises a test strip, is provided that is designed to be contacted with a test solution having activated magnetic particles such that the solu... | 01/31/2006 |
| 6972327 | Regeneration of chromatography material The invention provides improved methods of regenerating and using affinity chromatography material, in particular Protein A affinity chromatography resins. ... | 12/06/2005 |
| 6939681 | Method of detecting an antibody in a liquid sample The invention relates to a method of evaluating the immunological status of a subject comprising the steps of 1) determining the content of an antibody in a liquid sample from the subject using an immunoassay, wherein the reaction between the antibody of the sample ... | 09/06/2005 |
| 6932969 | Ig fractions having immunomodulatory activity The invention concerns a method for preparing Ig fractions from human polyvalent intravenous Immunoglobulins (IV Ig) which are in particular likely to be responsible for the immunomodulatory effect observed during the treatment of certain autoimmune diseases. The in... | 08/23/2005 |
| 6933109 | Rapid particle detection Methods and reagents for rapid purification and/or identification of particles in a liquid sample are described. The technique uses centrifugation to concentrate particles against a slanted surface having an agent specifically binding to the particles. This method i... | 08/23/2005 |
| 6900023 | Method for classifying and counting leukocytes A method for classifying and counting leukocytes comprises the steps of: (1) adding to a hematological sample the following fluorescence-labeled antibodies labeled with fluorescent dyes which emit fluorescences distinguishable from each other; (a) a first fluorescen... | 05/31/2005 |
| 6893832 | Method for quantifying cholesterol in high density lipoprotein Disclosed is a method for quantifying cholesterol in HDL, which does not require complex fragmentation and separation operations, and by which the HDL cholesterol in test samples containing HDL and other lipoproteins such as low density lipoprotein (LDL), very low d... | 05/17/2005 |
| 6893881 | Method for detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations The invention relates to a method for detecting specific target-cells in a simple and time saving way, using paramagnetic particles, antibodies recognizing the Fc portions of target-cell associating antibodies and target-cell associating antibodies directed to speci... | 05/17/2005 |
| 6870034 | Protein purification A method for purifying proteins by Protein A chromatography is described which comprises removing contaminants by washing the solid phase with various intermediate wash buffers. ... | 03/22/2005 |
| 6866846 | Patient-specific immunoadsorbers for the extracorporeal apheresis and methods for their preparation A process for preparing a patient-specific immunoadsorber, which comprises (i) extracting a body fluid from a patient having an immunopathological condition, the fluid containing immune complexes that are relevant to that immunopathological condition, (ii) contactin... | 03/15/2005 |
| 6828157 | Products and methods for single parameter and multiparameter phenotyping of cells A method of single parameter and multiparameter characterizing of cells, particularly immunophenotyping of cells, is provided. The method preferably uses antibody coated microspheres which are adapted to bind to specific types of cells. One or more sets of coated mi... | 12/07/2004 |
| 6811969 | Retentate chromatography—profiling with biospecific interaction adsorbents This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d... | 11/02/2004 |
| 6797814 | Protein purification A method for purifying proteins by Protein A chromatography is described which comprises the steps of: (a) adsorbing the protein to Protein A immobilized on a solid phase comprising silica or glass; (b) removing contaminants bound to the solid phase by washing the s... | 09/28/2004 |
| 6794153 | Helicobacter pylori antigens in blood The present invention relates to the finding and detection of Helicobacter pylori (H. pylori) antigens in blood of infected individuals. The H. pylori antigens are components of H. pylori cells which include, but not limited to DNA, RNA, ... | 09/21/2004 |
| 6770490 | Membrane immunobead assay for the detection of ciguatoxin and related polyether marine toxins An immunological test kit suitable for the rapid detection of ciguatoxin and related low molecular weight lipid polyether marine toxins in fish tissues in the field, home or laboratory. The test procedure utilizes a synthetic membrane laminated onto one end of a sol... | 08/03/2004 |
| 6764860 | Ultrasonic force differentiation assay An ultrasonic energy source is used to provide a variable force for measuring the binding forces between molecular entities and for sensing the presence of an analyte in a test sample. The device includes a surface that has a first binding member attached thereto an... | 07/20/2004 |
| 6762062 | Method of determining cholesterol and sensor applicable to the same The present disclosure relates to a method for determining cholesterol in low density lipoprotein comprising the steps of (a) measuring total cholesterol level in a sample containing at least high density lipoprotein, low density lipoprotein, very low density lipopr... | 07/13/2004 |
| 6753189 | Detection apparatus and method for the same A catcher, having an immunological epitope, is fixed to a detection zone of a spreading layer. A marker, capable of easy detection, has an inmmunological epitope. The marker and bispecific antibodies are soluble so that they can move on the spreading layer. The bisp... | 06/22/2004 |
