Bizarre Patents
A coffin, for allowing inclination for display of a deceased person in a natural position.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7390631 | Diagnosis and monitoring of systemic lupus erythematosus and of scleroderma Methods for diagnosing and monitoring systemic lupus erythematosus (SLE) or scleroderma by determining, in a blood sample from the individual being diagnosed or monitored, complement component C4d deposited on surfaces of red blood cells in the sample, and optionall... | 06/24/2008 |
| 7279158 | Methods for the treatment of inflammatory joint disease The use of compounds that block complement component C5 or its active fragments C5a and/or C5b (such compounds collectively referred to as “C5 blockers”) to treat established joint inflammation (arthritis) is disclosed. Administration of such C5 bl... | 10/09/2007 |
| 7041458 | Methods and reagents for determining protein S The present invention relates to an assay for free protein S comprising the addition of a ligand specific for free protein S to a biological fluid sample to form a protein S/ligand complex, and subsequent determination of the amount of the complex formed in the samp... | 05/09/2006 |
| 6995018 | Complex formed by N-linked glycoproteins (SIBLINGS)and Factor H The invention provides methods and compositions for exploiting the discovery that members of the small integrin-binding ligand, n-linked glycoproteins family termed SIBLINGS bind to complement Factor H, and moreover that SIBLINGS proteins, such as BSP, exist in rela... | 02/07/2006 |
| 6824975 | Incorporation of selective binding substances in a solid phase assay device This invention discloses a method and composition for detecting the presence of class specific antibodies reactive with analytes such as bacteria, allergens, autoimmune antigens, viral proteins, and carbohydrates by lateral flow techniques. In one embodiment of the ... | 11/30/2004 |
| 6379975 | Methods and reagents for determining protein S The present invention is concerned with an assay for free protein S comprising addition of a ligand specific for free protein S to a biological fluid sample to form a protein S/ligand complex, and subsequent determination of the amount of said complex for... | 04/30/2002 |
| 6303325 | Method for detecting analytes The invention relates to methods of determining the presence or amount of an analyte in a sample suspected of containing the analyte, said method comprising the steps of: (a) bringing together in an aqueous medium to form a mixture: (i) the sample; (ii) a... | 10/16/2001 |
| 6274328 | Method for quantifying LBP in body fluids The present invention provides a method for quantifying the presence of extracellular LBP in body fluids including blood in a subject comprising conducting an LBP immunoassay on plasma obtained from said subject.... | 08/14/2001 |
| 6242265 | Use of doubly or triply charged cations in immunochemical assays The use of calcium salts, magnesium salts or combination thereof in immunochemical methods for the determination of an analyte in a sample. These salts increase the specificity of such determinations, in particular, the background signal being reduced by ... | 06/05/2001 |
| 6221621 | Methods of screening for colorectal cancers in which a complement Factor I or related protein is associated Methods of screening for cancers or treating cancers or autoimmune disorders are disclosed. In an aspect of the present invention, the screening methods are based on the detection of complement C3 or C3 related protein, or a nucleic acid molecule encoding... | 04/24/2001 |
| 6087188 | Two-site immunoassay for an antibody with chemiluminescent label and biotin bound ligand A method of detecting an antibody in a sample using a labelling compound and comprising the steps of mixing a ligand antigen, antibody or hapten bound to biotin with the sample; an antibody directed against the antibody to be detected bound to paramagneti... | 07/11/2000 |
| 6048684 | Method for the determination of "soluble" fibrin A method for the determination of soluble fibrin in a body fluid of a species is described, entailing use of a binding partner which is bound to a solid phase, and of a labeled bioaffinity binding partner, for fibrin.... | 04/11/2000 |
| 6015679 | Process for measuring complement activity and reagent used therefor A reagent composition comprising (a) liposomes encapsulating a marker therein, immobilizing a hapten on liposome membranes and having a size in the range of 100 to 500 nm in terms of mean particle size plus twice the standard derivation, and (b) an antibo... | 01/18/2000 |
| 5972632 | Anticomplement activity assays Immunoassays for complement components, complement activation products or, preferably both, can be used to determine an acceptable level of anticomplement activity (AC) in plasma derived biologically active products intended for infusion into a mammal. In... | 10/26/1999 |
| 5942405 | Therapeutic and screening methods using C3a receptor and C3a Human C3a Receptor polypeptides and DNA (RNA) encoding such C3a Receptor and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such C3a Receptor for the treatment of inflammatory a... | 08/24/1999 |
| 5854082 | Process for measuring complement activity and reagent used therefor A reagent composition comprising (a) liposomes encapsulating a marker therein, immobilizing a hapten on liposome membranes and having a size in the range of 100 to 500 nm in terms of mean particle size plus twice the standard derivation, and (b) an antibo... | 12/29/1998 |
| 5843794 | Technique for the prevention of false positive reactions in immunological testing due to C1 and C1q components of the complement and method for screening for rheumatic factor A novel technique is disclosed for the prevention of false positive reactions in immunological testing which are caused by interference of C1 and C1q. The method is based on heating a sample of a body fluid at a temperature of 59°-6... | 12/01/1998 |
| 5778895 | Method of discriminating bacterial from aseptic meningitis The present invention provides a method for the differential diagnosis of bacterial meningitis in an individual in need of such diagnosis, comprising the steps of: measuring the levels of complement C3 and complement factor B in the cerebrospinal fluid of... | 07/14/1998 |
| 5763156 | Inhibition of complement mediated inflammatory response A composition and methods for use thereof relating to polypeptides having the ability to act as an inhibitor of complement C5b-9 complex activity. The compositions contain an 18 kDa protein found on the surface of human erythrocytes, a 37 kDa protein foun... | 06/09/1998 |
| 5753445 | Test for the detection of anti-heparin antibodies This invention pertains to a method of detecting, in a sample obtained from an individual, anti-heparin antibodies which inhibit the formation of the heparin accelerated antithrombin III-thrombin complex. In the present method, the presence of such anti-h... | 05/19/1998 |
| 5681750 | Process for preparing a C1-esterase inhibitor concentrate (C1-INH), and concentrate obtained, for therapeutic use Disclosed is a process for preparing a C1-esterase inhibitor concentrate, of human plasma origin, comprising 2 separations by chromatography on ion exchanger gels of tentacular type.... | 10/28/1997 |
| 5665556 | Complement components and binding ligands in fertility Methods for detecting and isolating acrosome-reacted sperm and complement receptor-bearing oocytes using the complement component C3, fragments, or variants thereof, antibodies to a complement receptor, or antibodies to C3, are disclosed. These methods ha... | 09/09/1997 |
| 5654156 | Immunoassay using liposomes Complement immunoassay using liposomes is improved by pretreatment of a sample solution before determination of analyte comprising acidifying or alkalinizing the sample solution, followed by changing the pH to about neutral so as to remove influences caus... | 08/05/1997 |
| 5633132 | Determination of the presence of an antigen, particularly HLA-B27 antigen, at the surface of a cell, particularly lymphocytes, by cytotoxicity test combined with fluorescent staining The present invention relates to a method of determining the presence of an antigen, particularly the HLA-B27 antigen, at the surface of cells, particularly lymphocytes, by combining the sensitivity of a cytotoxicity test, particularly a lympho... | 05/27/1997 |
| 5627036 | Use of an anticoagulant as a diagnostic agent Detectably labelled annexines and compositions thereof are disclosed. Also disclosed are methods for diagnosing a disruption or activation of the hemostatic system or a prothrombotic state in an individual suspected of having a hemostatic disorder, by con... | 05/06/1997 |
| 5486452 | Devices and kits for immunological analysis New devices and kits for solid-phase immuno-assays comprising a solid porous support, preferably in the form of a sheet, where antigens or immuno-globulins or both of them are bound by direct application in any suitable geometry, e.g. as an assay of dots ... | 01/23/1996 |
| 5474927 | Complement components and binding ligands in fertility Methods for detecting and isolating acrosome-reacted sperm and complement receptor-bearing oocytes using the complement component C3, fragments, or variants thereof, antibodies to a complement receptor, or antibodies to C3, are disclosed. These methods ha... | 12/12/1995 |
| 5472850 | Quantitative clotting assay for activated factor VII An assay for activated factor VII (factor VIIa) has been developed using truncated tissue factor (tTF), a soluble mutant form of (tTF) that retains the cofactor function of TF toward factor VIIa. Unlike full-length TF, however, tTF appears not to support ... | 12/05/1995 |
| 5385826 | Diagnostic assay for lyme disease A method of performing an assay to determine whether a patient has been exposed to or infected by Borrelia burgdorferi is disclosed which comprises collecting serum from the patient; preparing a sample mixture comprising a portion of the patient's serum a... | 01/31/1995 |
| 5369010 | Monoclonal antibody to polymorphic HLA determinant -B27 Novel cell lines, receptors and monoclonal antibodies prepared therefrom that are specific for the human HLA-B27 antigen are provided. The monoclonal antibodies are useful in diagnosis and therapy, particularly with respect to certain rheumatoid disorders... | 11/29/1994 |
| 5356778 | Method for detection of gram-negative bacterial liposaccharides in biological fluids The invention relates to a method of detecting gram-negative bacterial endotoxin using antibody capture combined with amoebocyte lysate chromogenic detection. The method is highly sensitive and rapid and may be used for detection of specific endotoxin. In... | 10/18/1994 |
| 5221613 | Immunoassay process and liquid reagents used therefor A combination of reagents including (i) a first liquid containing (a) first microcapsules having an analyte immobilized on surfaces thereof and containing a marker therein and (b) microcapsules encapsulating an antibody and having different capsule walls ... | 06/22/1993 |
| 5219926 | Method of covalently bonding biopolymer to a solid hydrophilic organic polymer A process for covalently bonding biopolymer, such as protein, to an organic polymer surface coated with hydrophilic nonionic polymer having groups reactive with the biopolymer and having a cloud point in the reaction medium that is at least 5° C. above ... | 06/15/1993 |
| 5213963 | Procedure for finding and identifying red cell antibodies by means of the solid phase method A procedure for finding and identifying red cell antibodies by means of the solid-phase method, comprising contacting erythrocytes having selected antigen patterns with sera or plasmas that are to be tested for antibodies and transferred along with a poly... | 05/25/1993 |
| 5200323 | In vitro method to determine the safety of modified hemoglobin blood substitutes for human prior to clinical use The present invention relates to an in vitro method to determine the safety of modified hemoglobin blood substitutes for human subjects prior to their clinical usages, wherein the method is based on complement activation reaction from adding modified hemo... | 04/06/1993 |
| 5198339 | Method for detection of gram-negative bacterial lipopolysaccharides in biological fluids The invention relates to a method of detecting gram-negative bacterial endotoxin using antibody capture combined with amoebocyte lysate chromogenic detection. The method is highly sensitive and rapid and may be used for detection of specific endotoxin. In... | 03/30/1993 |
| 5196308 | Methods for identifying the DQw3.2 allele associated with increased risk of insulin-dependent diabetes mellitus Methods for identifying individuals at increased risk of diabetes are disclosed. The methods disclosed utilize the discovery of the DQw3.2 variant, which identifies a specific allelic polymorphism at a sinle gene locus. One preferred method utilizes a lab... | 03/23/1993 |
| 5187067 | Immunological determination of free human protein S and C4bp-protein S complex A method of immunologically determining free human protein S in an assay sample, which comprises contacting a primary antibody fixed to an insoluble solid carrier and a labelled secondary antibody with the assay sample, the primary and secondary antibodie... | 02/16/1993 |
| 5175083 | Immunoassay for the quantitation of human C4 gene products Utilizing mouse monoclonal antibodies which recognize Rodgers 1 and Chido 1 epitopes carried on the C4A and C4B molecules, and heat aggregated IgG to activate C1, an immunoassay was developed for the quantitation of complement components, including total ... | 12/29/1992 |
| 5173406 | Liposome immunoassay method and kit therefor A liposome immunoassay comprising the steps of reacting an analyte antigen, a liposome bearing antibody comprising a first antibody to the analyte antigen and a liposome encapsulating a marker therein linked to the antibody, and a second antibody to the a... | 12/22/1992 |
