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| Number | Title | Issue Date |
| 7410768 | Test methods and devices A method and test device for differentiating between states of an analyte that can exist in different forms, such as follicle stimulating hormone (FSH). The method or test device uses a pair of specific binding agents, especially monoclonal antibodies, in two assays... | 08/12/2008 |
| 7332350 | Diagnostic device for distinguishing between normal and ectopic pregnancy and method for preparing the same A one-step diagnostic device for simultaneously detecting and distinguishing between a normal pregnancy and an ectopic pregnancy and methods for preparing the device are disclosed. Utilizing the device and principles of the present invention, normal pregnancy and ec... | 02/19/2008 |
| 7285391 | Methods for predicting pregnancy outcome in a subject by hCG assay The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early ... | 10/23/2007 |
| 7238538 | Chromatographic assay device and methods A chromatographic assay device for the analysis of an analyte in a liquid sample has a proximal sample application zone and a distal test zone. The test zone contains a first ligand capable of binding with the analyte to form an analyte-ligand complex. The device al... | 07/03/2007 |
| 7238537 | Assays An analytical test device incorporating a dry porous carrier to which a liquid sample, eg. urine, suspected of containing an analyte such as HCG or LH can be applied indirectly, the device also incorporating a labelled specific binding reagent which is freely mobile... | 07/03/2007 |
| 7192786 | Biospecific assay method This invention relates to a biospecific assay method, in which microparticles coated with the bioaffinity reactant A binding the analyte to be assayed; the sample to be analyzed, and the labelled bioaffinity reactant B are mixed. After the binding reaction the signa... | 03/20/2007 |
| 7109042 | Assays An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with t... | 09/19/2006 |
| 6927034 | Methods for detecting trophoblast malignancy by HCG assay The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early ... | 08/09/2005 |
| RE38688 | Sheet-like diagnostic device A solid diagnostic device for the quantitative determination of substances of biological affinity in biological fluids is described. A process is also described in which the biological fluid is brought into contact with a specific functional sector of the device, th... | 01/18/2005 |
| 6818455 | Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as; plastics materials, containing a dry porous carrier (510) which communicates indirectly with ... | 11/16/2004 |
| 6689615 | Methods and devices for processing blood samples Approaches are described for separating plasma from whole blood samples and include the use of magnetically attractable particles associated with an agglutinating agent. The magnetically attractable particles bind the cellular components in a whole blood ... | 02/10/2004 |
| 6677123 | Process for detecting increased risk of fetal chromosomal abnormality An increased risk of a fetal chromosomal abnormality, for example, fetal Down syndrome can be detected by separating or discriminating -fetoproteins present in the body fluid of a pregnant woman, and measuring the proportion of one or more of the &... | 01/13/2004 |
| 6627457 | Methods for detecting pregnancy Methods for detecting pregnancy in a woman comprise screening a biological sample of the woman for pregnancy markers. The methods of the invention include chemiluminescent assays for the pregnancy markers. The methods of the invention also comprise utiliz... | 09/30/2003 |
| 6582970 | Simple immunochemical semi-quantitative assay method and apparatus The present invention relates to a simple immunochemical semi-quantitative assay method according to chromatography, which comprises trapping a certain amount of an analyte in a sample with a predetermined amount of a fixed antibody for the analyte before... | 06/24/2003 |
| 6573103 | Antenatal screening for Down's syndrome A method of screening for fetal Down's syndrome is described. Screening marker levels are measured. These may be measurements of a biochemical marker in a maternal sample or measurements of a marker from an ultrasound scan. The marker levels are used to c... | 06/03/2003 |
| 6548309 | Procedure for assay of liquids containing undissolved solids, semisolids or colloids In qualitative or quantitative assays which employ a test device comprising a test strip pretreated for detection of a specified target analyte dissolved in a liquid medium, the presence of solid, semisolid and/or colloidal materials in the liquid medium ... | 04/15/2003 |
| 6500629 | Materials and methods for detection and quantitation of an analyte The subject invention pertains to methods and materials for accurately assessing the presence or absence of analytes of interest in samples, particularly in physiological samples. The subject invention involves utilizing a ligand binding domain (LBD) of a... | 12/31/2002 |
| 6500627 | Methods for predicting pregnancy outcome in a subject by HCG assay The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amoun... | 12/31/2002 |
| 6492178 | Methods of determining an increased risk of a woman carrying a downs syndrome affected fetus by measuring an analyte in a biological sample There are provided methods for assaying biological specimens for one or more of leptin, prorenin or renin in order to provide predictive information about the likelihood of a woman carrying a Downs Syndrome affected fetus.... | 12/10/2002 |
| 6485982 | Test device and method for colored particle immunoassay Disclosed is a test cell and a method for detection of a preselected ligand in a liquid sample such as a body fluid. The test cell includes an elongate outer casing which houses an interior permeable material capable of transporting an aqueous solution an... | 11/26/2002 |
| 6448022 | Protein with human choriogonadotropin inhibitory effect A substance having an inhibitory effect on the production of human choriogonadotropin (hCG) is described, which comprises a protein isolated from human decidual cells with a preliminary amino acid analysis and a molecular weight of about 7,000 to about 10... | 09/10/2002 |
| 6429018 | Prenatal screening for Down's syndrome using hyperglycosylated gonadotropin A prenatal screening method for Down's syndrome involves assaying for hyperglycosylated gonadotropin in biological test samples such as urine, plasma or serum obtained from pregnant women. Hyperglycosylated gonadotropin comprises a variant population of c... | 08/06/2002 |
| 6395503 | Chemiluminescent reagents and chemiluminescence analysis methods with the use of the same The present invention provides a novel chemiluminescent reagent producing chemiluminescence in the presence of hydrogen peroxide, extent of which depends on peroxidase concentration, chemiluminescent analysis method using the same, in particular useful fo... | 05/28/2002 |
| 6368876 | One step immunochromatographic device and method of use This invention relates to a lateral flow immunochromatographic assay device without a plastic housing. The assay includes a sample receiving region, analyte detection region and end region all made of porous material and capable of lateral flow. The analy... | 04/09/2002 |
| 6352862 | Analytical test device for imuno assays and methods of using same An analytical test device incorporating a dry porous carrier to which a liquid sample, eg. urine, suspected of containing an analyte such as HCG or LH can be applied indirectly, the device also incorporating a labelled specific binding reagent which is fr... | 03/05/2002 |
| 6251688 | Method and apparatus for measurement of binding between a protein and a nucleotide A method and apparatus for measuring binding between a plurality of molecules of a first type and a plurality of molecules of a second type is presented. Apparatus utilizes a sensor possessing a waveguide to which have been attached in close proximity to ... | 06/26/2001 |
| 6228660 | Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with the ... | 05/08/2001 |
| 6204002 | Gangliosides having fluorescent-tagged ceramide moieties The invention provides a compound represented by the following formula (I) ##STR1## wherein m is an integer of 2-15; n is an integer of 0-12; R represents a sugar chain or a derivative thereof; R' represents a general formula (II) ##STR2## (wherein p is a... | 03/20/2001 |
| 6194222 | Methods for monitoring the status of assays and immunoassays The invention relates in part to the use of independent assay controls (IACs) for the optical communication between an assay device and an instrument in monitoring and performing assays, preferably immunoassays.... | 02/27/2001 |
| 6187598 | Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with the ... | 02/13/2001 |
| 6143576 | Non-porous diagnostic devices for the controlled movement of reagents The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount r... | 11/07/2000 |
| 6127186 | Methods of determining an increased risk of a woman carrying a downs syndrome affected fetus by measuring an analyte in a biological sample There are provided methods for assaying biological specimens for one or more of leptin, prorenin or renin in order to provide predictive information about the likelihood of a woman carrying a Downs Syndrome affected fetus.... | 10/03/2000 |
| 6046057 | Analyte assaying device The invention is an improved single-step test device for detecting the presence of a pre-selected analyte in a urine stream. The device includes a hollow rectangular outer casing and an assay material disposed within co-joined upper and lower sections of ... | 04/04/2000 |
| 6010912 | Antenatal screening for chromosomal abnormalities A method for antenatal screening for chromosomal abnormalities in which maternal blood from a pregnant woman is measured for levels of free beta hCG and at least a second serum marker and/or precursors and metabolites of these markers and the measured lev... | 01/04/2000 |
| 5965458 | Test strip, its production and use A test strip for a rapid immunoassay containing specific immunochemical reagent zones (7, 8, 9) is described. The test strip (10) has a backing sheet (1) and attached thereto a receiving end pad (3) and at a distance therefrom a finishing end pad (5). A t... | 10/12/1999 |
| 5958789 | Reduction in positive bias in wet assays due to splashing A method of preventing false detection of signal due to splashing of reagent liquid used to produce such signal, when dispensing at least one such liquid from a metering tip into a second liquid, comprising the steps of: a) positioning the metering tip a ... | 09/28/1999 |
| 5763164 | Immunogenic cancer proteins and peptides and methods of use The present invention relates to tumor specific antigens and functional proteins of a tumor cell preparable by identifying protein presents in the tumor cell that are selectively immunogenic for tumor patients. The present invention still further provides... | 06/09/1998 |
| 5714389 | Test device and method for colored particle immunoassay Disclosed is a test cell and a method for detection of a preselected ligand in a liquid sample such as a body fluid. The test cell includes an elongate outer casing which houses an interior permeable material capable of transporting an aqueous solution an... | 02/03/1998 |
| 5712172 | One step immunochromatographic device and method of use This invention relates to a lateral flow immunochromatographic assay device without a plastic housing. The assay includes a sample receiving region, analyte detection region and end region all made of porous material and capable of lateral flow. The analy... | 01/27/1998 |
| 5686315 | Assay device for one step detection of analyte A "one step" device for the detection of analytein clinical assays is disclosed. A visible label comprising a visible moiety and a ligand that binds to or competes with analyte is contained in a fluid conducting membrane or prefilter; and the analyte and ... | 11/11/1997 |
