Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 5492807 | Method of obtaining diagnostic reagents, assays and therapeutics based on clinical manifestations of a disease Antibodies are recovered and isolated from the sera of a number "n" of patients each of which have or have had the same given disease so that each of the "n" patients has, within a large number of different antibodies, some antibodies uniquely associated ... | 02/20/1996 |
| 5492812 | Diagnostic method for Alzheimer's disease by screening for tau-peptides in the blood of a patient The present invention is directed to methods and kits for diagnosing, Alzheimer's disease. The invention is based, in part, on the discovery that proteolytic fragments of the amino and carboxy terminal amino acid residues of tau-proteins are released from... | 02/20/1996 |
| 5487973 | Methods for detecting and assaying nucleic acid sequences A novel class of reagents for assaying nucleic acid sequences comprise successive layers of polynucleotides of a specific structure, including a double-stranded waist and single-stranded, free arms at the molecule ends, formed by hybridization of the arms... | 01/30/1996 |
| 5486460 | Method and test kits for identifying Alzheimer's disease by testing cerebrospinal fluid A method for aid in diagnosing Alzheimer's disease in patients exhibiting the Alzheimer's characteristic dementia is described. Cerebrospinal fluid (CSF) suspected of containing amyloid particles is removed from a patient, living or deceased, concentrated... | 01/23/1996 |
| 5484705 | Method for quantifying lipopolysaccharide binding protein The present invention provides a method for quantifying the presence of extracellular LBP in body fluids including blood in a subject comprising conducting an LBP immunoassay on plasma obtained from said subject.... | 01/16/1996 |
| 5484703 | Assay using recombinant histidyl-tRNA synthetase Recombinant Histidyl tRNA synthetase produced by non-mammalian host cells is used in a sensitive assay to determine the presence of autoimmune diseases in mammals. Methods for isolating, cloning and expressing rHRS are described. In addition, a kit for de... | 01/16/1996 |
| 5474893 | Spectrophotometry of amyloid degrading activity in serum or tissue A method for spectrophotometric measurement of amyloid degrading activity in serum or tissue is disclosed. The method involves first binding a dye to a purified amyloid protein. Preferably, the dye and the amyloid bind stably, yet reversibly, so that the ... | 12/12/1995 |
| 5472884 | Detection of collagen degradation in vivo Compositions useful in quantitating collagen peptides to determine the rate of bone resorption are prepared by treating bone with a protease, such as collagenase, and purifying the compositions so as to enrich them with peptides capable of binding to the ... | 12/05/1995 |
| 5472848 | Methods to aid in the diagnosis of multiple sclerosis Disclosed are methods and kits useful in the differential diagnosis of multiple sclerosis. The method involves the use of an immunochemical reagent containing one or more prosomal antigens. Such a method typically involves: obtaining serum from a patient ... | 12/05/1995 |
| 5470751 | Reagent for detecting malaria infected cells and a detecting method for malaria infected cells using the same A reagent for staining malaria infected cells and a method for detecting malaria infected cells using the same, wherein the regent is a staining solution comprising at least one first dye of an Auramine analogue having the formula (I): ##STR1## ... | 11/28/1995 |
| 5466582 | Thrombocytopenia determination The present invention relates to the determination of thrombocytopenia induced by an inductor drug such as heparin. According to the invention, a sample is mixed with a complex of an antigenic substance such as platelet factor 4 (pF4) and heparin to deter... | 11/14/1995 |
| 5462859 | Method of diagnosing irregularities in bile salt absorption via brush border membrane proteins An isolated associated complex of bile acid salts and brush border membrane protein and a method of diagnosing irregularities in bile salt absorption via brush border membrane proteins is presented. In addition a method for detecting specific binding of b... | 10/31/1995 |
| 5460977 | Peptide having allergenicity According to the present invention, a peptide which causes the blast formation of lymphocytes sensitized by mites is provided, and mite allergy is diagnosed by using the peptide. The present invention relates to a peptide, that is, pentadecapeptide and tr... | 10/24/1995 |
| 5459035 | Method of detecting the tumors using ring shaped particles as a tumor marker A method is described for identifying and localizing tumors in a patient. The method comprises assaying extracellular fluids, isolated from a patient, for the presence of elevated levels of ring shaped particles (RSP). The assay employs binding labeled RS... | 10/17/1995 |
| 5455160 | Diagnostic test and kit for disease or disorders in the digestive system This study describes method for extraction and quantification of calprotectin (L1 protein) in feces by enzyme immunoassay. This protein is a prominent antimicrobial component of neutrophils, monocytes, macrophages and squamous epithelia. Calprotectin was ... | 10/03/1995 |
| 5445937 | Detection of Alzheimer's disease and other diseases using an improved photoaffinity labeling method An improved method for diagnosing a disease comprising detecting a disease-specific biochemical marker macromolecule within a sample of extracted cerebral spinal fluid or serum is disclosed. In particular, a radioactively labeled photoaffinity probe is us... | 08/29/1995 |
| 5443952 | Autoantibodies and their targets in the diagnosis of peripheral neuropathies The present invention relates to methods of aiding in the diagnosis of peripheral neuropathies that comprise determining the titer of autoantibodies directed toward particular nervous system antigens. It also provides for substantially purified preparatio... | 08/22/1995 |
| 5441870 | Methods for monitoring cellular processing of ଲ-amyloid precursor protein Processing of ଲ-amyloid precursor protein (댪PP) is monitored by detecting the secretion of a soluble 댪PP fragment resulting from cleavage of 댪PP at the amino-terminus of ଲ-amyloid peptide. In vivo monitoring of secretion o... | 08/15/1995 |
| 5439801 | Test composition for the rapid detection of helicobacter pylori in gastric biopsy tissue An improved test composition for the diagnosis of gastric disease by detecting the presence of urease associated with H. pylori in a biopsy specimen is described in which the hydrolysis of urea by urease is detected by a combination of at least two dye in... | 08/08/1995 |
| 5437987 | Triple gradient process with antibody panning to recover nucleated fetal cells from maternal blood A method for separating nucleated fetal red blood cells and nucleated fetal cells and maternal granular sites from maternal blood is achieved by applying maternal blood to a triple gradient gel, isolating nucleated fetal cells from the gel and binding the... | 08/01/1995 |
| 5436169 | Protein associated with acute pancreatitis agents for the screening of acute pancreatitis The invention relates to the family of the protein (PAP) associated with acute pancreatitis in man and in the rat. It also relates to the nucleotide fragments coding for the above proteins. Also included in the framework of the invention are antibodies which ... | 07/25/1995 |
| 5434050 | Labelled ଲ-amyloid peptide and methods of screening for Alzheimer's disease The present invention provides: a labelled ଲ-amyloid peptide of active fragment; a composition including the labelled ଲ-amyloid peptide or active fragment thereof and a pharmaceutical carrier; a method for labelling the ଲ-amyloid peptide... | 07/18/1995 |
| 5432059 | Assay for glycosylation deficiency disorders A method is provided for detecting carbohydrate-deficient glycoproteins in samples taken from subjects with metabolic disorders, such as alcohol abuse and subjects who display a syndrome of carrying abnormal levels of carbohydrate deficient glycoproteins.... | 07/11/1995 |
| 5429947 | Diagnosing Alzheimer's disease and schizophrenia A method for detecting elevated levels of the middle isoform of -2 haptoglobin, -2FS haptoglobin in bodily fluids of subjects with Alzheimer's disease and schizophrenia as compared with the -2FS haptoglobin level in normal subjects. F... | 07/04/1995 |
| 5429929 | Method for detecting antibodies to a neuroblastoma antigen in mental illness The subject invention provides an antigen characterized as having a molecular weight of approximately 68 kD, being reactive with autoantibodies associated with mental illness especially schizophrenia, being located in neuronal cells, and co-migrating with... | 07/04/1995 |
| 5427956 | Quantitative analysis for diabetic condition predictor An enhanced quantitative assay for chiro-inositol concentration can be used to determine insulin-resistance, or a predisposition to the development of insulin-resistance, in type I and type II diabetics. Spot urine or serum samples reflecting concentratio... | 06/27/1995 |
| 5422244 | Detection of brain 댑-antichymotrypsin The present invention is related generally to methods and compositions for identifying and quantitating particular 댑-antichymotrypsin species in a biological sample. More particularly, the present invention is related to methods and compositions fo... | 06/06/1995 |
| 5418139 | Method for screening for cardiomyopathy Disclosed herein are methods for screening for primary cardiomyopathy. The methods are preferably immunological methods in which the level of binding of a monoclonal or polyclonal antibody to a 50 kD glycoprotein component of a mammalian muscle tissue is ... | 05/23/1995 |
| 5413910 | Measuring non-dystrophin proteins and diagnosing muscular dystrophy The invention pertains to the dystrophin-glycoprotein complex of mammalian skeletal muscle and a method of isolating said complex. The components of the complex and methods of separating and isolating said components also pertain to the invention. In addi... | 05/09/1995 |
| 5410028 | Test agent composition for dentistry A test agent composition for dentistry comprises from 5 to 45% by weight of Hydrogenated Maltose Syrup, from 5 to 30% by weight of sorbitol, from 10 to 40% by weight of paratinose, from 5 to 20% by weight of water, from 5 to 37% by weight of a component s... | 04/25/1995 |
| 5407821 | Genetic diagnosis of torsion dystonia Methods are provided for detecting the presence of a gene for torsion dystonia in a human subject. Furthermore, a haplotype which is associated with torsion dystonia is disclosed. Methods and kits for the detection of torsion dystonia in a subject are add... | 04/18/1995 |
| 5407802 | Method of accessing the risks of developing type I diabetes Two subsets of Islet Cell Autoantibodies (ICA), termed restricted and non-restricted, have been identified. The expression of non-restricted ICA correlates with progression to type I diabetes, indicating that these individuals are at much greater risk tha... | 04/18/1995 |
| 5399501 | Covalent attachment of specific binding members to a solid phase with two bifunctional reagents and a dithio compound A specific binding member such as an antigen or antibody is immobilized by covalent attachment to a solid phase such as a latex microparticle. The solid phase is reacted with a heterobifunctional or homobifunctional coupling agent to form a complex that i... | 03/21/1995 |
| 5399485 | Methods and compositions for diagnosing cat scratch disease and bacillary angiomatosis caused by Rochalimaea henselae The present invention relates to a method of diagnosing cat scratch disease and a method of diagnosing bacillary angiomatosis in a subject by detecting the presence of Rochalimaea henselae or an immunogenically specific determinant thereof in the subject.... | 03/21/1995 |
| 5397712 | Method to aid in the diagnosis of alzheimer's disease A method to aid in the diagnosis of Alzheimer's disease in a living patient is disclosed which tests cerebrospinal fluid (CSF) obtained from the patient. The CSF is tested using a Western blot analysis to determine the presence of an antigen present in so... | 03/14/1995 |
| 5385826 | Diagnostic assay for lyme disease A method of performing an assay to determine whether a patient has been exposed to or infected by Borrelia burgdorferi is disclosed which comprises collecting serum from the patient; preparing a sample mixture comprising a portion of the patient's serum a... | 01/31/1995 |
| 5384244 | Detection of schistosomiasis antibodies The present disclosure is directed to a peptide having active binding sites in a protein wherein the binding sites attract and hold antibodies for schistosomiasis in humans. A test reagent is set forth. Separate binding sites in the complex protein have b... | 01/24/1995 |
| 5382522 | Immunoassay for creatine kinase-MB and creatine kinase-BB isoforms and reagents Methods and reagents for determining the lapse of time since an acute disease event, such as the occurrence of a myocardial infarction, are presented. A serum or plasma sample is assayed to determine the concentration of two different analytes selected fr... | 01/17/1995 |
| 5382515 | Creative kinase-MB immunoassay for myocardial infarction and reagents Methods and reagents for determining the lapse of time since an acute disease event, such as the occurrence of a myocardial infarction, are presented. A serum or plasma sample is assayed to determine the concentration of two different analytes selected fr... | 01/17/1995 |
| 5376533 | Methods and compositions for the detection of Addison's disease An epitope of 21-hydroxylase has been identified which specifically reacts with autoantibodies to 21-hydroxylase. This epitope immunoreacts with anti-adrenocortical autoantibodies characteristically present in patients having autoimmune Addison's disease.... | 12/27/1994 |
