Did You Know...
...that the Band-Aid Bandage was invented by a Johnson & Johnson employee whose wife had cut herself? Earl Dickson's wife was rather accident prone, so he set out to develop a bandage that she could apply without help. He placed a small piece of gauze in the center of a small piece of surgical tape, and what we know today as the Band Aid bandage was born!
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| Number | Title | Issue Date |
| 5288463 | Positive flow control in an unvented container A containment device, such as a cuvette, for use in amplifying and detecting nucleic acid material at a contained detection site. A waste compartment provided downstream from the detection site is provided with fold lines that give the compartment a bi-st... | 02/22/1994 |
| 5283342 | Biotinylated small molecules Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related com... | 02/01/1994 |
| 5272260 | Reagents and methods for the determination of glycohydrolytic enzymes Novel pyrene-trisulfonate derivatives and the use thereof in a method for the determination of glycohydrolytic enzyme activity are provided. The method comprises the steps of (a) forming a test solution comprising a test sample containing the glycohydroly... | 12/21/1993 |
| 5270210 | Capacitive sensing system and wash/alignment station for a chemical analyzer The automatic chemical analyzer includes a turntable adapted to hold a plurality of disposable cuvettes. An optical system adjacent to the turntable can perform tests on the contents of each cuvette as they are rotated on the turntable. A sample/reagent t... | 12/14/1993 |
| 5254315 | Carrier device An analytical carrier device permits the holding of a sample, reaction vessel with reagents for the sample, and a container for receiving a processed sample. The container facilitates transfer to an analytical device for analysis.... | 10/19/1993 |
| 5254459 | Nucleotide and amino acid sequences of protein MTP40 of M. tuberculosis and synthetic peptides derived therefrom The present invention relates to novel chemically synthesized nucleotides and novel chemically synthesized peptides which have been found to be effective in assaying for the presence of M. tuberculosis.... | 10/19/1993 |
| 5252459 | Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles An indicator reagent, assay method and test kit for determining the presence or amount of an analyte in a test sample, in which the indicator reagent is formed by attaching an organic polymer latex particle, preferably a colored particle, to a specific bi... | 10/12/1993 |
| 5248590 | Surface modified liposomes A liposome reagent encapsulating a molecule to be targeted to a body site or used as an assay reporter has a ligand and a sulfonate-containing group on the liposome surface. Preferred ligands are antibodies or antibody fragments and preferred encapsulants... | 09/28/1993 |
| 5234813 | Method and device for metering of fluid samples and detection of analytes therein An analytical device for fluid samples includes a fluid sample well means connected to a sample initiation area in such a fashion that the assay will not commence unless sufficient sample is introduced into the sample well means to conduct the assay. Once... | 08/10/1993 |
| 5225326 | One step in situ hybridization assay A quantitative, sensitive, One-Step In Situ hybridization assay is provided which will detect as few as 1-5 copies of target biopolymer per cell and may be accomplished in 5 minutes to 4 hours. There is provided a simultaneous assay for detecting multiple... | 07/06/1993 |
| 5221628 | Binding of aggregated immunoglobulin or immune complexes by serum amyloid P component A method of binding aggregated immunoglobulin or immune complexes comprising contacting them with serum amyloid P component ("SAP"). The invention also comprises methods of using SAP to detect or quantitate immune complexes and to deplete fluids of aggreg... | 06/22/1993 |
| 5221613 | Immunoassay process and liquid reagents used therefor A combination of reagents including (i) a first liquid containing (a) first microcapsules having an analyte immobilized on surfaces thereof and containing a marker therein and (b) microcapsules encapsulating an antibody and having different capsule walls ... | 06/22/1993 |
| 5215882 | Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays Methods of immobilizing nucleic acid on a solid surface for us in nucleic acid hybridization assays is disclosed. The methods of the invention comprise reacting a modified nucleic acid strand comprising a variable portion and an anchor portion wherein the... | 06/01/1993 |
| 5212065 | Rapid assay device A rapid immunoassay device comprising a single porous membrane that serves as both a reagent support and a spent reagent reservoir is disclosed. The immunoassay device directs the flow of sample and reagents within the device in a manner that eliminates b... | 05/18/1993 |
| 5212060 | Dry test strip comprising a dextran barrier for excluding erythrocytes A dry test strip for the detection of an analyte in a test fluid is disclosed. The test strip comprises a porous detection zone containing a reactant system that can generate a signal in the presence of an analyte. The detection zone further comprises dex... | 05/18/1993 |
| 5208166 | Reactive chitosan coated articles and test kit for immunoassay A reagent coating material has been developed to modify the surface of articles used in assay procedures. Polymers of chitosan solubilized with an organic acid form into thin films when contacted to glass, plastic, metal or cellulose articles. The coated ... | 05/04/1993 |
| 5207918 | Column analyzer system An analyzer system for automatic column chromatography, and method for its use, includes an array of chromatograph columns and multi-cell cuvettes associated with each column. Chromatographic separation takes place under a constant, low fluid pressure. A ... | 05/04/1993 |
| 5200321 | Microassay on a card A microassay card for a includes an upper layer containing wells for receiving a liquid sample. A second layer of the card, beneath the first layer, includes a supporting surface bound to a reactive species. A third layer includes a superabsorbent support... | 04/06/1993 |
| 5200313 | Nucleic acid hybridization assay employing detectable anti-hybrid antibodies A nucleic acid hybridization assay employing an immobilized or immobilizable polynucleotide probe selected to form DNA.RNA or RNA.RNA hybrids with the particular polynucleotide sequence to be determined. Resulting hybrids are detected by binding of an ant... | 04/06/1993 |
| 5192694 | Anti-PCI monoclonal antibody A monoclonal antibody specific to a human placenta-derived coagulation inhibitor is disclosed. The antibody is produced by culturing a hybridoma which secretes it. A human placenta-derived coagulation inhibitor can be purified by using the monoclonal anti... | 03/09/1993 |
| 5185128 | Test kit containing labeled receptor and wash solution for determination of an immunological ligand A test kit useful for the determination of an immunological ligand includes a labeled receptor for that ligand, a specific wash solution and a test device. The wash solution is buffered to a pH of from about 5 to about 9 and contains at least 0.01 weight ... | 02/09/1993 |
| 5182264 | Angiotensin II receptor blockers as antiglaucoma agents A method and composition for reducing and/or controlling elevated intraocular pressure, especially the elevated intraocular pressure associated with glaucoma, are disclosed in which an angiotensin II antagonist is administered to the eye.... | 01/26/1993 |
| 5182191 | Occult blood sampling device and assay The invention provides a disposable device for collecting, transporting and storing semi-solid or liquid specimens prior to analysis. A sample of the collected specimen is removed from the device for analysis by means of a detachable transferring stick, o... | 01/26/1993 |
| 5173433 | Method for chemical analysis A chemical analysis test device for detection of a selected chemical in a biological fluid is disclosed wherein the test is preformed on a rigid base containing a detection well for holding a reagent and a specimen well for holding a sample of the biologi... | 12/22/1992 |
| 5171695 | Determination of analyte concentration using two labelling markers In order to measure the concentration of an analyte in a liquid sample the sample is contacted with a receptor molecule having binding sites for the analyte and labelled with a first marker, whereby a fraction of the binding sites on the receptor molecule... | 12/15/1992 |
| 5169599 | Method and apparatus for optically detecting presence of immunological components An optical immunosensing device for detecting the presence of an analyte in a liquid sample is fabricated by coating iron phosphate onto a silicon substrate and then etching the iron phosphate layer to obtain steps of varying thickness. Then, a first mip,... | 12/08/1992 |
| 5167925 | Precipitation of multivalent antiligands with affinity surfactants Surfactants bound to a ligand and dissolved in a single phase aqueous solution form a precipitate when a multivalent antiligand is added to the solution. This invention can be used in an affinity precipitation test procedure (and kit) for detecting the pr... | 12/01/1992 |
| 5162236 | Method of performing nephelometric analysis with independent temperature control of the reaction cuvette and reagent reservior A system for analyzing a chemical reaction provides control of the temperature and volume of the reagents to improve the accuracy and precision in quantitative measurements of specific proteins and other immunochemistries in body fluids. The reaction occu... | 11/10/1992 |
| 5162202 | Rectal mucus test and kit for detecting cancerous and precancerous conditions An improved rectal mucus screening test method and kit for cancerous and precancerous conditions which is rapid, employs reagents which can be provided in kit form and which does not give false negatives due to sampling error, immobilizes the mucus sample... | 11/10/1992 |
| 5162237 | Reaction cassette for preforming sequential analytical assays by noncentrifugal and noncapillary manipulations Analytical reaction cassette and method for performing sequential analytical assay procedures to determine the amount of an analyte in a liquid test mixture. The reaction cassette can be in the form of a substantially square container having a substantial... | 11/10/1992 |
| 5160723 | Method of imaging colorectal carcinoma lesion and composition for use therein This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface antigen associated with the coloretal carcinoma lesion and... | 11/03/1992 |
| 5156948 | Method and kit for diagnosis of diseases An improved simplified enzyme-linked immunosorbent assay (ELISA) for the diagnosis of viral, fungal, bacterial and parasitic diseases. The diagnostic test is designed for use in non-laboratory settings where the usual equipment and supplies, including run... | 10/20/1992 |
| 5155022 | Assay for lyme disease Diagnosis of Lyme disease by immunoassay for anti-Borrelia burgdorferi antibodies in the serum of a patient includes adsorption of crossreactive antibodies in the serum with antigen of Acinetobacter calcoaceticus or Treponema phagedensis prior to binding ... | 10/13/1992 |
| 5154888 | Automatic sealing closure means for closing off a passage in a flexible cuvette There are described a cuvette and a method for sealing off flow such as flow in a passageway from an access port in the cuvette with a closure, that ensures a complete seal merely by applying the closure. The cuvette is improved in that it has the closure... | 10/13/1992 |
| 5149630 | Methods of assay An electrochemical specific binding assay of a ligand (e.g., antigen, hapten or antibody) wherein at least one of the components is enzyme-labelled, and which includes the step of determining the extent to which the transfer of electrons between the enzym... | 09/22/1992 |
| 5149625 | Multiplex analysis of DNA This invention features vectors and a method for sequencing DNA. The method includes the steps of: a) ligating the DNA into a vector comprising a tag sequence, the tag sequence includes at least 15 bases, wherein the tag sequence will not hybridize to the... | 09/22/1992 |
| 5149505 | Diagnostic testing device A diagnostic testing device is disclosed. The testing device includes a base member and a cover member which defines an opening for the reception of a liquid specimen. A distribution wheel delivers portions of the specimen to antibiotic units which are ci... | 09/22/1992 |
| 5149501 | Multichambered container and instrument for performing diagnostic tests An instrument (50) automatically determines the concentrations of HDL cholesterol, LDL cholesterol, total cholesterol and triglycerides for a sample (80) of whole, anticoagulated blood placed in a doughnut shaped container (10). The sample (80) is first s... | 09/22/1992 |
| 5147609 | Assay element There is described an assay element suitable for use in an automated analytical test instrument for assaying a fluid sample. The element includes a thin porous member possessing a high degree of capillarity such as a fibrous mesh pad supported within a gu... | 09/15/1992 |
| 5147607 | Reaction vessel with a rocking base A reaction vessel for microassay is provided. The reaction vessel has a body structure having provided therein at least one reaction unit having a channel having at least one fluid inlet and at least one reagent-immobilized area in the downstream of the f... | 09/15/1992 |
