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| Number | Title | Issue Date |
| 4166102 | Immobilized immunoadsorbent An immobilized immunoadsorbent for use in immunoassay and radioimmunoassay procedures includes, in a preferred form, a mass of superficially porous refractory particles having a water insoluble polymer, such as dextran, bonded thereto. The polymer in turn... | 08/28/1979 |
| 4163643 | Automation of discrete analysis systems The invention concerns the use, in discrete sample analysis apparatus, of vibratory conveyor to convey samples, and there is provided an automated discrete analysis system in which the means for conveying samples through the system comprises vibratory con... | 08/07/1979 |
| 4155711 | Method and apparatus for determining thyroid function of multiple samples A method and apparatus for measuring thyroid function by means of measuring the up-take of a radioactive tracer on a resin involves causing the mixing of resin with tracer for predetermined periods and preferably by a means which causes agitation of the r... | 05/22/1979 |
| 4150949 | Immunoassay for gentamicin Aminoglycoside antibiotics, especially gentamicin, in biological fluid samples are assayed fluorimetrically by mixing the sample with a fluorescent-labelled compound and with antibodies. The fluorescence of the compound is reduced when the compound binds ... | 04/24/1979 |
| 4150149 | Method and means for the early detection and diagnosis of certain types of cancers This invention is directed to a method and means for the early detection of a wide variety of cancers, in humans, which method and means consists of the assay and development of a pattern or fingerprint of severally biologically inert, or inactive polypep... | 04/17/1979 |
| 4148607 | Apparatus and analysis for agglutination reaction Analysis of and apparatus for studying simple or complex agglutination reactions, such as for blood analysis and in particular blood groupings in which the specimen is mixed with at least one reagent in a vessel of predetermined shape and this mixture is ... | 04/10/1979 |
| 4141687 | Automatic apparatus and method for the assay of fluid samples Method and apparatus suitable for automatic assay of fluid samples, particularly immunoassays, in which a reaction product of the assay is bound to a magnetically attractable particle and separated from the reaction mixture by use of a magnetic trap. The ... | 02/27/1979 |
| 4138213 | Agglutination immunoassay of immune complex with RF or Clq A method of determining Ab:Ag complex in a biological fluid sample comprising adding to the sample a solution of RF or Clq and a known quantity of a material, such as immunoglobulin-coated polystyrene particles, which is caused to agglutinate on contact w... | 02/06/1979 |
| 4136159 | Radioassay of folates Novel folic acid derivatives useful in processes for analysis of biological fluids for folic acid or its metabolites comprising components of the formula: ##STR1## wherein R is hydrogen or radioactive iodine.... | 01/23/1979 |
| 4132769 | Cancer antigen, cancer therapy, and cancer diagnosis A novel human cancer associated protein, termed C1 IAC, having C1 inactivator-like function, diagnostic tests based on demonstrating the presence of C1 IAC, antibodies and antisera with specificity against C1 IAC, matrix-immobilized antibodies, and the th... | 01/02/1979 |
| 4130471 | Microelectrophoretic apparatus and process New gel tray and lid assemblies designed for use in conjunction with slotted electrophoretic membranes have been developed to take advantage of recently improved microelectrophoretic accessories which include a multisample applicator capable of applying u... | 12/19/1978 |
| 4130395 | Process and apparatus for detection of specific biological factors by means of osmotic hemolysis The extent of lysis or red blood cells treated with a test solution containing a known or suspected agglutinating factor, and preferably with a lipid, serves for blood typing and cross matching, and, in addition for the detection and semi-quantitation of ... | 12/19/1978 |
| 4128628 | Automated immunoassay An automated immunoassay apparatus which provides: time controlled incubation of a multiplicity of sample solutions, each of which comprise a mixture of (a) a sample, possibly containing an antigen or antibody intended to be assayed; (b) a solution of a k... | 12/05/1978 |
| 4125375 | Separation of solid and liquid components of mixtures A method of separating solid and liquid components of mixtures comprises delivering to the mixture a second liquid, having a density intermediate between those of the solid and liquid components of the mixture, to form a discrete layer above or below the ... | 11/14/1978 |
| 4124470 | Method and apparatus for electrophoresis A method and apparatus for zone electrophoresis which is completely automatic and which requires no manual handling of the electrophoretic medium or the serum sample to be tested. In a preferred embodiment, prefabricated (empty) electrophoresis tubes are ... | 11/07/1978 |
| 4123224 | Diagnostic test device A simple, sensitive method and device for detecting pregnancy. The test involves concentration by ultrafiltration of a sample of urine or serum from a subject; followed by determining the presence of human chorionic gonadotropin or of its ଲ-subunit ... | 10/31/1978 |
| 4115538 | Assay kit for cAMP and/or cGMP and method of using the same An assay kit for assaying adenosine-3',5'-cyclic monophosphate, which is herein referred to as cAMP, guanosine-3',5'-cyclic monophosphate, which is herein referred to as a cGMP, or both; and said assay kit comprising, A container of Reagent 1 comprising succin... | 09/19/1978 |
| 4108972 | Immunological reagent employing radioactive and other tracers A broad new class of reagents permits extremely sensitive and specific assay for, or chemical separation of, a broad range of biological and nonbiological substances. Each reagent consists of a suspension of microscopic carrier material particles, each pa... | 08/22/1978 |
| 4108975 | Radioimmunoassay system An improved radioimmunoassey procedure involves the use of an improved reusable immunoadsorbent through which a sample of an antigen and radioactive labelled antigen is flowed to form a bound and unbound fraction. The bound fraction is releasably coupled ... | 08/22/1978 |
| 4108976 | Automated direct serum radioimmunoassay Automated radioimmunoassay directly from serum, for those antigens present in serum in relatively small amounts, is accomplished by use of an immobilized immunoadsorbent having an excess of antibodies, specific to the antigen, covalently bonded to a parti... | 08/22/1978 |
| 4104026 | Immunoassay separation technique In a method for effecting immunoassay of a multiplicity of samples, each possibly containing an antigen or an antibody to be assayed, wherein each sample is incubated with a solution containing a detectable antigen or antibody to form a multiplicity of mi... | 08/01/1978 |
| 4094963 | Means for testing for pregnancy Disclosed is a method for the determination of the hormone human chorionic gonadotropin (HCG), luteinizing hormone (LH), prolactin (PRL) and HCG-like material in an aqueous sample comprising contacting a highly specific receptor for these hormones with an... | 06/13/1978 |
| 4092408 | Method for solid phase immunological assay of antigen An improved solid-phase radioimmunological assay method for assay of an antigen in a biological fluid, e.g., blood plasma, by use of a solid phase polymeric substrate on which is adsorbed in solid phase an antibody composite layer, comprising a solid phas... | 05/30/1978 |
| 4087248 | Multiple assay machine and method Method and apparatus are provided for carrying out simultaneous multiple manipulations. The method and apparatus are particularly directed toward heterogeneous (two phases) immunoassays, particularly radioimmunoassay (RIA) and immunoradiometricassays (IRM... | 05/02/1978 |
| 4071315 | Analytical tape medium A method and apparatus is provided for the continuous immunological analysis of a plurality of samples of serum, which consists in detecting, in each sample, the possible presence of antibodies or antigens by fixation of the said antibodies or antigens po... | 01/31/1978 |
| 4062733 | Radio-assay of oestrogen A method for the radio-assay of an oestrogen in a biological fluid which method comprises causing the oestrogen to compete with a radio-iodine derivative, selected from the group consisting of the 2-iodo-, 4-iodo- and 2,4-di-iodo- derivatives of the oestr... | 12/13/1977 |
| 4057148 | Multiple sample support assembly and apparatus for facilitating radioimmunoassays and the like An improved multiple sample handling system, including a fully machine-compatible multiple sample support assembly, sample vortexing apparatus, and sample radioactivity sensing apparatus, is disclosed which enables performance of a complete radioimmunoass... | 11/08/1977 |
| 4034071 | Immunoassay procedures The technique of separating a tagged bound material from the same unbound material in immunoassay procedures is improved by utilizing a clathrate sorbent to carry out the separation. A clathrate sorbent, for example, comprises a mixture of hydrate zinc su... | 07/05/1977 |
| 4032626 | Reagent and method for TBG assay The concentration of thyroxine binding globulin (TBG) in a fluid sample can be determined via radioassay technique with an immunochemical composite comprising anti-TBG antibodies immobilized on a water-insoluble carrier. The composite is incubated with th... | 06/28/1977 |
| 4030886 | Saturation analysis The invention provides a method and a kit for the saturation analysis of a steroid characterized by the use of a selenium-75 labelled version of the steroid to be assayed. Selenium-75 derivatives of steroids are quite simple to prepare and have practical ... | 06/21/1977 |
| 4022577 | Automated radioimmunoassay An automated radioimmunoassay apparatus which comprises: Means for time controlled incubation of a multiplicity of sample solutions, each of which comprise a mixture of (a) a sample, possibly containing an antigen, intended to be assayed, (b) a solution of a k... | 05/10/1977 |
| 4017597 | Unitized solid phase immunoassay kit and method A unitized solid phase kit for radioimmunoassay is disclosed. All of the necessary assay reagents are incorporated in a single tube wherein all phases of the assay procedure are performed, requiring only the addition of the patient's sample. Antibody is b... | 04/12/1977 |
| 4011350 | Method of making microscope slide system A microscope slide assembly and a method of preparing such which includes an optically clear glass slide having a controlled thickness fluorocarbon layer coated on one planar surface. The layer is provided with a multiplicity of openings to form wells on ... | 03/08/1977 |
| 4001583 | Covalently bound biological substances to plastic materials and use in radioassay Covalently bound biological substances to plastic materials whose inside surfaces have been coated with glutaraldehyde, with or without prior treatment with an aliphatic amine or diamine, useful in radioimmunoassay procedures.... | 01/04/1977 |
| 3997657 | Dry slide reagent employed in immunofluorescent test for detection of human antinuclear factor A dry diagnostic reagent composed of specially prepared, fixed and stabilized fetal calf thymocytes on microscope slides ready for use in an immunofluorescent test for the detection of human anti-nuclear factor in human serum or plasma in the diagnosis of... | 12/14/1976 |
| 3966896 | Radioimmunoassay for plasma renin activity A radioimmunoassay method for the in vitro determination of the renin activity of an unknown plasma sample. In this method an unknown generation sample is provided by mixing the unknown plasma sample with a generation buffer solution and an inhibitor for ... | 06/29/1976 |
| 3954411 | Preparation of reagents on-line in automated sample analysis Method and apparatus in an automated sample analysis system for on-line preparation from plural constituents of a reagent for combination with a sample, which includes purification of the reagent prior to exposure of the reagent in a flowing stream to a f... | 05/04/1976 |
| 3951605 | Instrument for automated immunochemical analysis An instrument for quantitative analysis to measure a minute quantity of antigens or antibodies in a sample. There is a defined travel path for holding sample container holding means thereon, moving means coupled to said travel path to move a plurality of ... | 04/20/1976 |
