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"I watched his countenance closely, to see if he was not deranged ... and I was assured by other senators after he left the room that they had no confidence in it."
U.S. Senator Smith of Indiana ; After seeing Samuel Morse demonstrate the telegraph.
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| Number | Title | Issue Date |
| 5068089 | Kit for testing human males for fertility The potential fertility of a semen sample is evaluated using a kit comprising a collection tube with volume gradients on its side; a funnel which is fitted into the collection tube for guiding an ejaculate into the collection tube; a pipet containing a st... | 11/26/1991 |
| 5068177 | Anti-idiotype antibodies induced by synthetic polypeptides Chemically synthesized polypeptides containing about 6 to 40 amino acid residues and having amino acid residue sequences that substantially correspond to the primary amino acid residue sequences of particular variable or hypervariable regions of immunoglo... | 11/26/1991 |
| 5068176 | Method for the simultaneous determination of DNA sequence variations at a large number of sites, and a kit suitable therefor This invention relates to a method of simultaneously determining DNA sequence variations on a large number of loci, and a kit suitable therefor. The method comprises an electrophoretic separation of restriction fragments in two dimensions on the basis of ... | 11/26/1991 |
| 5063024 | Method and apparatus for immunological determinations The invention concerns an immunological assay system, wherein the inner face of the cuvettes is used as the solid phase. The equipment includes a displaceable carriage (8) for the cuvette set as well as, above the carriage, a dosage head (9), to which the... | 11/05/1991 |
| 5059521 | Monoclonal antibodies against prosumal proteins The invention relates to monoclonal antibodies against prosomal proteins of a prosome, said prosome having a sedimentation coefficient of approximately 19S, and to a method for detecting cancer using monoclonal antibodies specifically directed against sai... | 10/22/1991 |
| 5055258 | Device for ascertaining the presence of an antigen or of an antibody in a liquid sample A device for performing immunoassays which has an external housing, a sample container provided with reagents that can be inserted into the external housing, a material container for an absorbent material and membrane-bound antibody or antigen that can be... | 10/08/1991 |
| 5055396 | Diagnostic methods and systems for quantifying APO AI The present invention describes a monoclonal antibody that is directed against an Apo AI/HLD epitope whose expression is substantially unaffected by deamidation. Also disclosed is a polypeptide capable of immunologically mimicking an Apo AI/HLD epitope wh... | 10/08/1991 |
| 5055395 | Latex agglutination method for the detection of anti-streptococcal deoxyribonuclease B An agglutination method for the detection of antibodies against streptococcal deoxyribonuclease B is described, in which carrier-bound antibodies against streptococcal DNase B are mixed with a solution of streptococcal DNase which contains a protease inhi... | 10/08/1991 |
| 5051356 | Specific binding composition comprising a low pI protein or carbohydrate and a diagnostic test kit and method of use A specific binding composition comprises a specific binding species and one or more water-soluble proteins or carbohydrates, substantially none of which has a pI greater than about 5. This composition provides improved sensitivity with lower background in... | 09/24/1991 |
| 5050735 | Specimen strip package A specimen kit for collection, preservation and dispatch of smear specimens collected on a glass slide makes use of a single sheet of package material having short fold-over panels at opposite end edges and long fold-over overlapping panels at the side ed... | 09/24/1991 |
| 5039604 | Test device and method of preparing same, assay kit and method for the simultaneous detection of two HTLV or HIV antibodies A kit and method have been developed which can be used to simultaneously detect antibodies to two HTLV or HIV antigens. The kit includes a solid carrier material, such as a microtest plate, having immobilized thereon a mixture of first and second viral an... | 08/13/1991 |
| 5039615 | Method for chemically analyzing a test piece An apparatus for chemically analyzing a sample on a test piece that includes a reagent layer, comprises a test piece table for positioning a test piece thereon, and an applying station wherein a sample may be applied to the reagent layer. The test table m... | 08/13/1991 |
| 5030559 | Methods and compositions for the identification of metastatic human tumors Disclosed are monoclonal antibodies which react with human tumor cells, particularly metastatic human tumor cells, but not with normal human tissues tested. The monoclonal antibodies are prepared against a 580 kilodalton glycoprotein antigen, designated g... | 07/09/1991 |
| 5030417 | Method and kit to assay for steroid receptor functionality in cancerous cells A method and a test kit for rapidly determining the presence of functional cellular steroid receptors by assaying a tissue sample for nuclear steroid or antisteroid binding is disclosed which comprises treating the tissue with collagenase, incubating the ... | 07/09/1991 |
| 5030421 | Integral centrifuge tube and specimen slide A generally tubular container integrally formed and communicating with a microscope slide member having an enclosed specimen chamber. The container is adapted to serve as a centrifugation tube and a permanent handle for manipulation of the microscope slid... | 07/09/1991 |
| 5030555 | Membrane-strip reagent serodiagnostic apparatus and method For the serodiagnosis of a fluid sample, it is particularly advantageous to use a device comprising (A) a supported, porous membrane wherein a first immunoreagent is bound so as to be capable of binding a foreign analyte and forming a complex when the for... | 07/09/1991 |
| 5024935 | Dye-providing composition, diagnostic test kit and their use in method for ligand determination using peroxidase labeled-receptor A dye-providing composition comprises a water-soluble or -dispersible polymer, such as a vinylpyrrolidone polymer, and an imidazole leuco dye capable of providing a dye in the presence of hydrogen peroxide and a peroxidative substance. The weight ratio of... | 06/18/1991 |
| 5019497 | Human squamous lung carcinoma cell specific antigens and antibodies Methods and compositions are provided for detecting antigens having a specific epitope associated with squamous lung carcinoma. The antigen may be found at lesion sites or in the blood as indicative of the squamous lung carcinoma. Specific antibodies may ... | 05/28/1991 |
| 5019498 | Method of assaying high molecular hyaluronic acid and kit of reagents for such assay A high molecular hyaluronic acid which is an important factor in the diagnosis of inflammations such as rheumatism or diseases such as cancer is assayed as a complex of sandwich structure in which a hyaluronic acid binding protein is coupled to the hyalur... | 05/28/1991 |
| 5017472 | Microflotation devices used for immunoassays and cell/molecular fractionation This invention relates to a flotation immunoassay employing a novel buoyant matrix to which an antigen or antibody is coupled and which separates the bound and free products of the assay by floating to the surface of the reaction liquid. The novel flotati... | 05/21/1991 |
| 5017474 | Wash solution, test kit and method for the determination of an immunological ligand An aqueous wash solution is buffered to a pH of from about 5 to about 9 and contains at least about 0.01 weight percent of a compound comprising a dodecyl sulfate anion and an alkali metal or ammonium cation, such as sodium dodecyl sulfate. This wash solu... | 05/21/1991 |
| 5017473 | Homogeneous chemiluminescence immunoassay using a light absorbing material A method for separation-free solid phase immunoassay of an analyte includes contacting an antianalyte attached to the surface of a solid support with the analyte, a light absorbing material and a tracer for the analyte which includes a label. The resultin... | 05/21/1991 |
| 5013645 | Immunological methods and materials for detection of tumor associated antigens Disclosed are immunological methods and materials for detection of antigens associated with breast or prostate cancer disease states. Presently preferred antibody preparations (e.g., PR92 monoclonal antibodies produced by hybridoma cell line ATCC HB 9390)... | 05/07/1991 |
| 5011771 | Multiepitopic immunometric assay The invention relates to an immunometric assay for a multivalent antigen in a sample which comprises forming a complex of the antigen together with multiple immobilized monoclonal antibodies against different epitopes of the antigen and with a detectably ... | 04/30/1991 |
| 5009997 | Two site cross-reaction immunometric sandwich assay method A two site cross-reaction immunometric sandwich assay method for the detection and measurement of an analyte, such as creatine phospho-kinase-MB, in serum comprising the selection of two different antibodies each of which is specific to a different analyt... | 04/23/1991 |
| 5006474 | Bi-directional lateral chromatographic test device A chromatic test device for the performance of immuno- or chemical assays wherein a unitary planar fibrous filter body incorporates a sample application zone, a separation zone and a reaction zone and the application zone is in fluid communication with a ... | 04/09/1991 |
| 5006464 | Directed flow diagnostic device and method Am improved device and method for analyte assay in liquid samples, wherein a porous membrane with an immobilized receptor which is capable of directly or indirectly binding to the analyte is separated from a body of absorbent material capable of absorbing... | 04/09/1991 |
| 5006463 | Immunoassays for discriminating between brucellosis infections and vaccinations A method is disclosed for discriminating between cattle vaccinated against and those infected with Brucella spp. The method involves immunoassay using a purified polysaccharide containing 4,6-dideoxy-4-acylamido-D-mannopyranosyl units obtained from B. abo... | 04/09/1991 |
| 5002867 | Nucleic acid sequence determination by multiple mixed oligonucleotide probes A method is provided for sequencing nucleic acids without the need to separate similarly sized DNAs or RNAs by gel electrophoresis. The method relies on the separate hybridization of multiple mixed oligonucleotide probes to a target sequence. The mixed ol... | 03/26/1991 |
| 4997771 | Method for measuring the BZ-1 receptor binding activity in a test sample or test compound The invention describes a method for determining the BZ-1 receptor activity of a test sample or a potential anxiolytic drug.... | 03/05/1991 |
| 4992364 | Probe for DNA and a process for the detection of "Shigellae" and entero-invasive strains of Escherichia coli The invention concerns a probe for the detection of shigellae and entero-invasive E. coli, containing a nucleic acid sequence originating from the 140 Mdal virulence plasmid of the M 90 T strain of Shigella flexneri; having a maximum size of around 27 kb ... | 02/12/1991 |
| 4992366 | Process for producing a receptor preparation for a radioreceptor assay and kit-correct radioreceptor assay according to the process A receptor preparation of biologically active receptor material is produced in which a cell membrane preparation is lyophilized accompanied by the addition of sugars and/or amino acids and/or proteins. A radioreceptor assay can be produced therefrom, whic... | 02/12/1991 |
| 4992377 | Article for carrying out biological or chemical procedures containing magnetically responsive material A biologically or chemically active substance is incorporated in a unitary body with a magnetically responsive material for carrying out a specific biological or chemical procedure. This may be microbiological, immunological, serological or other biochemi... | 02/12/1991 |
| 4988627 | Test device with dried reagent drops on inclined wall An immunoassay test device is disclosed with dried reagent drops applied to a sloping side wall of a reaction wall. A method of applying them as liquid drops is also described, wherein the slope of the side wall, and the composition and volume of the liqu... | 01/29/1991 |
| 4988618 | Magnetic separation device and methods for use in heterogeneous assays Magnetic separation devices are described for use in immunoassay or hybridization assay procedures. The most preferred embodiments comprise a defined relationship between microtube and microtiter plate receiving orifices and rare earth cobalt magnets havi... | 01/29/1991 |
| 4987086 | Method for analysis of subpopulations of cells A method and kit for determination of subsets of leukocytes utilizing flow cytometry analysis techniques.... | 01/22/1991 |
| 4985542 | Kit for the determination and diagnosis of non-goodpasture glomerulonephritis Purified glomerular proteoglycans are used as a basis for a diagnostic test for glomerulonephritis in humans involving an immunological reaction between the purified proteoglycans and patient area. A new method for purification of glomeruli proteoglycan a... | 01/15/1991 |
| 4983359 | Apparatus for measuring lymphocyte subclasses A blood sample is prepared by combining a fluorescently tagged monoclonal antibody with blood cells. The sample is then passed through a flow cytometer and light scattered by each blood cell in two directions is sensed simultaneously by a single sensor. L... | 01/08/1991 |
| 4978502 | Immunoassay or diagnostic device and method of manufacture Liquid containers or receptacles are disclosed with cooperating means for rupturing the receptacles to release contained fluid to rain upon test specimens. Structure is disclosed for rupturing receptacles in response to relative motion occurring between r... | 12/18/1990 |
| 4978625 | Fluorescence immunoassay using water insoluble dyes In a method for fluorescence immunoassay of an analyte, an antianalyte attached to the surface of a solid support is contacted with the analyte and a tracer which includes a substantially water insoluble fluorescent dye occluded in the nonaqueous portion ... | 12/18/1990 |
