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| Number | Title | Issue Date |
| 6284197 | Optical amplification of molecular interactions using liquid crystals Interactions between molecules which are components of self-assembled monolayers and other molecules can be amplified and transduced into an optical signal through the use of a mesogenic layer. The invention provides a device and methods for detecting ana... | 09/04/2001 |
| 6280960 | Optical detection and analysis of sub-micron particles Method and apparatus for the single particle detection of submicron structures such as biological molecules and viruses utilises and optically transparent substrate coated with a thin film of metal illuminated with an optical beam incident at or close to ... | 08/28/2001 |
| 6277653 | Optical assaying method and system having movable sensor with multiple sensing regions An optical assaying method and system having a movable sensor is described. In one aspect, the present invention is a sensing system having a rotating sensor disk coated with indicator dyes sensitized to a variety of substances. In this configuration the ... | 08/21/2001 |
| 6277652 | Colorimetric sensor employing polydiacetylene membrane Disclosed is a colorimetric sensor comprising polydiacetylene membrane liposomes, a polydiacetylene membrane film or fine particles coated with a polydiacetylene membrane, in which the polydiacetylene membrane is incorporated with a protein having a reduc... | 08/21/2001 |
| 6277650 | Analyte assaying device The invention is an improved single-step test device for detecting the presence of a pre-selected analyte in a urine stream. The device includes a hollow rectangular outer casing and an assay material disposed within co-joined upper and lower sections of ... | 08/21/2001 |
| 6277627 | Biosensor The present invention relates to a glucose biosensor comprising a genetically engineered Glucose Binding Protein (GBP). In a specific embodiment, the invention relates to a GBP engineered to include mutations that allow site specific introduction of envir... | 08/21/2001 |
| 6277559 | Histamine measuring apparatus and a histamine measuring method Histamine may be quantitatively measured by performing the following steps. First, an oocyte that expresses histamine receptors is held in a recess formed at the bottom of a vessel. Then, first and second electrodes are inserted into the oocyte. Subsequen... | 08/21/2001 |
| 6274384 | Method for specific substance and molecule detection A system for detecting a specific substance or analyte of interest is provided that includes one or more sensing units and an instrument for analyzing the sensing units. Each sensing unit preferably includes a substrate, an attachment layer and at least o... | 08/14/2001 |
| 6274326 | Method and apparatus for detecting proper strip insertion into an optical reflectance meter A method and apparatus for detecting proper strip insertion into an optical reflectance meter. An electrical or electromagnetic device within the optical reflectance meter launches a signal when a test strip is inserted therein. The test strip which is de... | 08/14/2001 |
| 6271045 | Device for determination of an analyte in a body fluid A strip for testing for the presence of an analyte generally comprises a support member which contains a spreading layer and a reagent layer, and a capillary tube in communication with the support layer and spreading layer for transporting a sample of bod... | 08/07/2001 |
| 6271041 | Electrochemiluminescent reaction utilizing amine-derived reductant A composition suitable for use in an ECL assay and kits therefor wherein electromagnetic radiation emitted by said composition is detected, which composition comprises (a) a metal-containing ECL moiety which, when oxidized by exposure to an effective amou... | 08/07/2001 |
| 6268125 | Analytical apparatus A surface plasmon resonance apparatus for detecting a soluble analyte (e.g. a protein) or a particulate analyte (e.g. a cell), the apparatus comprising: (a) a sensor block adapted to receive a sensor, said sensor, for example a sensor slide, having a meta... | 07/31/2001 |
| 6258548 | Single or multiple analyte semi-quantitative/quantitative rapid diagnostic lateral flow test system for large molecules Lateral flow device and method are provided for performing semi-quantitative visual or instrument-based detection in a test sample of a large molecule analyte that contains two binding domains, and ଲ. The device contains two reagents, a cont... | 07/10/2001 |
| 6255053 | Dry biochemical assay plate and method for making the same An assay plate for detecting the presence of a mobile reactant that binds to a immobilized reactant and the methods of making and using the same. An assay plate according to the present invention includes a substrate and at least one dried aliquot of the ... | 07/03/2001 |
| 6254830 | Magnetic focusing immunosensor for the detection of pathogens A magnetic focusing immunosensor for the detection of pathogens comprising a laser, an exciting fiber and a collecting fiber, a fiber optic magnetic probe in communication with the collecting and exciting fibers and means for detecting, collecting and mea... | 07/03/2001 |
| 6251690 | Electrical excitation of label substances at insulating film-coated conductors The excitation of label molecules usable in chemical and biochemical analysis by electrical pulses at electrodes covered with a thin insulating film, and the use of such electrodes in chemical, clinical and biochemical analysis. The electrodes include a c... | 06/26/2001 |
| 6251688 | Method and apparatus for measurement of binding between a protein and a nucleotide A method and apparatus for measuring binding between a plurality of molecules of a first type and a plurality of molecules of a second type is presented. Apparatus utilizes a sensor possessing a waveguide to which have been attached in close proximity to ... | 06/26/2001 |
| 6248596 | Liposome-enhanced immunoassay and test device A test device for detecting or determining an analyte in a test solution includes an absorbent material having separate contact, competitive binding, and measurement portions. The contact portion is positioned for contact with and uptake of the test solut... | 06/19/2001 |
| 6248542 | Optoelectronic sensor A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase ... | 06/19/2001 |
| 6248539 | Porous semiconductor-based optical interferometric sensor The measurement of the wavelength shifts in the reflectometric interference spectra of a porous semiconductor substrate such as silicon, make possible the highly sensitive detection, identification and quantification of small analyte molecules. The sensor... | 06/19/2001 |
| 6245578 | Analytical apparatus An analytical apparatus comprises a biosensor device (3) which forms the base of a sample chamber. A stirrer (8) extends into the sample chamber and moves within the chamber so as to homogenize a sample contained within the chamber in contact with the bio... | 06/12/2001 |
| 6245577 | IgG antibody testing method A method of determining the concentration of IgG antibodies in the biological fluids of mammals. The assay may be performed in a lateral flow cassette or dipstick format where dehydrated immobilized reagents are spaced along a membrane. A sample of a mamm... | 06/12/2001 |
| 6243980 | Protease inhibitor assay Heterogenous and homogenous assays are provided for the detection of protease inhibitory activity in a sample or target compound, taking advantage of the chemiluminescent characteristics of 1,2-dioxetanes. In the heterogenous assay, a peptide bearing a cl... | 06/12/2001 |
| 6235536 | Analysis of quiescent anticoagulated whole blood samples Formed constituents of a quiescent anticoagulated whole blood sample are optically or visually analyzed in a sample chamber which has a varying through plane thickness due to convergent opposing sample chamber walls. At least one of the convergent walls o... | 05/22/2001 |
| 6235535 | Fluorescent energy transfer ligand interaction assay on a lipid film This invention relates to a fluorescence-based immunoassay method for the detection of an analyte, or for the measurement of its concentration in a biological sample. The method is based on the ability of a multivalent analyte to induce aggregation of rec... | 05/22/2001 |
| 6232130 | Method for detecting or quantifying carbohydrate containing compounds A method of evaluating a carbohydrate in a sample. The method includes providing a low valency carbohydrate binding ligand, providing a glycoconjugate which includes a label, and a carbohydrate moiety, contacting the low valency carbohydrate binding ligan... | 05/15/2001 |
| 6231733 | Immobilized carbohydrate biosensor A biosensor in which a carbohydrate or a derivative of a carbohydrate is used to generate a detectable signal by way of the specific binding to a protein, a virus or a cell.... | 05/15/2001 |
| 6225068 | Process for sequencing an individual DNA molecule An extended fibre point (1) is coated with photbiotin and irradiated with U.V. light, causing the photobiotin to bind with the fibre pint. The fibre point is then brounght into contact with streptavidin and submerged in a solution containing dyed copies o... | 05/01/2001 |
| 6224831 | Microassay device and methods The subject invention relates to a rapid, field-portable, modular, versatile and highly reliable assay device for substances, particularly drugs of abuse, which provides a positive signal in the presence of a specific substance for which the device has be... | 05/01/2001 |
| 6221678 | Apparatus and method for analyte detection Disclosed is a testing device and methods for the identification of an analyte of interest in a sample. In a preferred embodiment, the testing device includes a front panel having at least one sample application aperture; a rear panel having at least one ... | 04/24/2001 |
| 6221620 | Monoclonal antibodies specific for human thymidylate synthase The present invention relates to monoclonal antibodies that are specific for the protein thymidylate synthase, and hybridomas producing these monoclonal antibodies. The invention further relates to methods of detection and diagnostic kits to test for the ... | 04/24/2001 |
| 6219137 | Nanoprobe for surface-enhanced Raman spectroscopy in medical diagnostic and drug screening A probe for a surface-enhanced Raman scattering spectrometer is provided for injection into a cell in order to detect trace amounts of a compound within that cell. The probe has a spherical shape with a diameter less than one micrometer and preferably in ... | 04/17/2001 |
| 6218194 | Analytical methods and apparatus employing an optical sensor device with refractive index modulation A method for monitoring the interaction of molecular species utilizes a sensor device comprising a substrate (1) with a waveguide (2) formed on the surface thereof. A grating (3) is formed in one of the surfaces of the waveguide (2). A beam of light (6) i... | 04/17/2001 |
| 6218135 | 1,2-dioxetane derivative The present invention has its objects to provide a compound not only which is easy to handle, thermally stable, and high in emission efficiency, but also which can show high emission efficiency without coexisting enhancer in the system even in a protic so... | 04/17/2001 |
| 6210977 | Measuring device and method for making same A measuring device for measuring or examining physiological parameters on biocomponents includes an FET sensor 5 whose electrical protective layer 12 is roughened or has a structured coating 15. The structuring of the active sensor contact surface 12 is a... | 04/03/2001 |
| 6210910 | Optical fiber biosensor array comprising cell populations confined to microcavities A biosensor, sensor array, sensing method and sensing apparatus are provided in which individual cells or randomly mixed populations of cells, having unique response characteristics to chemical and biological materials, are deployed in a plurality of micr... | 04/03/2001 |
| 6207369 | Multi-array, multi-specific electrochemiluminescence testing Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for nov... | 03/27/2001 |
| 6205263 | Distributed optical fiber sensor with controlled response Distributed fiber optic chemical and physical sensors provide a relatively highly uniform response over the length of the fiber by, for example, varying such properties as the core/cladding index of refraction ratio to compensate for the non-linearity in ... | 03/20/2001 |
| 6197594 | White trigger preparations for improving the signal detection in bioluminescent and chemiluminescent reactions The present invention concerns a method for the detection of an analyte in a sample liquid by luminescence measurement according to the principle of a ligand-receptor assay, e.g. an immunoassay or a hybridization assay or a combination thereof, wherein a ... | 03/06/2001 |
| 6194224 | Diagnostic membrane containing fatty acid sarcosinate surfactant for testing oral fluid A diagnostic test strip for determining the presence of a specified analyte in a fluid sample is described. The test strip has a test membrane sandwiched between two layers of a plastic sheath. The upper layer of the sheath has a sample well into which a ... | 02/27/2001 |
