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...Daniel Webster invented a "bull plow" to pull out tree stumps. It didn't catch on because it was huge and required four oxen to pull it!
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| Number | Title | Issue Date |
| 4092116 | Method for binding antibodies to a surface such that they remain active In carrying out an immunological reaction or diagnostic test, an immunologically inert organic compound of sufficient quantity is added to an aqueous medium containing an immunologically reactive antigen. A substrate is then treated with the aqueous mediu... | 05/30/1978 |
| 4080264 | Immunoassay by light scattering spectroscopy This inventin provides a means for determining the concentration of any of a wide range of antibody or antigen molecules with a high degree of specificity, accuracy and sensitivity. Antigen or antibody concentration is determined by effecting an agglutina... | 03/21/1978 |
| 4071315 | Analytical tape medium A method and apparatus is provided for the continuous immunological analysis of a plurality of samples of serum, which consists in detecting, in each sample, the possible presence of antibodies or antigens by fixation of the said antibodies or antigens po... | 01/31/1978 |
| 4065354 | Lysozyme conjugates for enzyme immunoassays Novel conjugated enzyme compositions are provided for use in homogeneous immunoassays. A wide variety of haptenic compounds, such as drugs of abuse, therapeutic drugs, naturally occurring hormones, and the like, are conjugated to the enzyme lysozyme for u... | 12/27/1977 |
| 4054646 | Method and apparatus for detection of antibodies and antigens Method and apparatus for the detection of antibodies and antigens based upon the effect that any arbitrary antigen will adsorb onto a substrate in a monomolecular layer only, but that a corresponding specific antibody for such arbitrary antigen will bond ... | 10/18/1977 |
| 4050895 | Optical analytical device, waveguide and method A device for detecting a first material comprising (a) a waveguide having on a peripheral surface of the waveguide a second material which on contacting the first material selectively combines with the first material to measurably change the light transmi... | 09/27/1977 |
| 4038485 | Test composition, device, and method A test device, test composition, and method are disclosed for determining the presence of a component in a sample. The device comprises a carrier matrix incorporated with a reactant system which produces a detectable response upon contact with the sample ... | 07/26/1977 |
| 4018886 | Diagnostic method and device employing protein-coated magnetic particles Small magnetic particles are used to provide large and widely-distributed surface area for separating a select protein from a solution to enable detection thereof when present in low concentrations. The particles are coated with a protein that will intera... | 04/19/1977 |
| 4011044 | Use of laser speckle patterns for measurement of electrophoretic mobilities Reduction in electrophoretic mobility of antigen-coated microscopic polystyrene spheres due to an antigen-antibody reaction is detected by observing changes in oscillation amplitude of speckle patterns (i.e., regions of light and dark) produced by laser l... | 03/08/1977 |
| 3999948 | Diagnostic reagent holder and method A diagnostic reagent holder specifically adapted for the detection of an unknown quantity of a biologically derived sample suitably by radioimmunoassay, fluorometric detection or by spectrophotometry. The holder comprises an elongate shaft with a support ... | 12/28/1976 |
| 3992096 | Detecting system A method is disclosed for detecting the formation of or presence of light-interacting domains, e.g. particles or clumps of particles, in a supporting medium which comprises: disposing the supporting medium between a source of multipoint illumination and a... | 11/16/1976 |
| 3990851 | Process and device for measuring antigen-antibody reactions Antigen-antibody reactions are measured by passing laser light through the mixture of the antigen solution with the corresponding antibody and measuring the light scattered in the forward direction and determining its intensity. The device used comprises ... | 11/09/1976 |
| 3985867 | Immunoassays employing a colored second antibody In some radioimmunoassays, the antigen competes with labelled antigen for reaction with a first antibody and the antigen-antibody complex is precipitated by reaction with an aqueous solution of a second antibody to the first antibody. The invention consis... | 10/12/1976 |
| 3984533 | Electrophoretic method of detecting antigen-antibody reaction A method of rapidly detecting presence of antibodies in a solution comprises depositing, on each of a plurality of microscopic particles, an antigen specific to the antibodies sought, and forming a dilute suspension of the particles in the solution to be ... | 10/05/1976 |
| 3979509 | Opaque layer method for detecting biological particles A monomolecular layer of first biological particles is adsorbed on the surface of a substrate fabricated of virtually any nonreactive solid material, the coated substrate is then exposed to a solution suspected of containing second biological particles sp... | 09/07/1976 |
| 3973129 | Fluorimetric apparatus and method for analysis of body fluid Fluorimetric assay procedures indicative of the presence of antigens or other abnormal conditions in body fluids permit rapid, accurate screening. Extra-clinical testing is facilitated by a fluorimeter design providing for optical excitation of a totally ... | 08/03/1976 |
| 3967901 | Nephelometer having means semiautomatically cancelling components from scattering by particles smaller or larger than those of interest An improved nephelometer for immunochemical complex assay measures forward light scatter in samples. The angle of forward scatter, about 30°, is small enough to result in a large amount of forward scatter from the immunochemical complex particles which a... | 07/06/1976 |
| 3966897 | Medium for use in bioassay and method of using same A hydratable or hydrated gel medium for use in bioassay of a test substance contains fixed in a localized zone a reagent for the test substance. Assays are conducted rapidly by diffusing the test substance followed by an indicator substance also reactive ... | 06/29/1976 |
| 3962413 | Plate methods for diagnosing Brucella canis infection This invention relates to the use of Brucella ovis antigens to diagnose the presence of Brucella canis in an animal. B. canis is the causative agent of canine brucellosis. Further, this invention relates to a plate test where B. ovis antigens are employed... | 06/08/1976 |
| 3960488 | Method and apparatus for quantitative surface inhibition test A metallized slide has adsorbed thereon a first monomolecular layer of particular first immunologically reactive biological particles and is covered with a suitable moisture holding medium. A test solution is then applied along a first edge of the slide, ... | 06/01/1976 |
| 3960489 | Method and apparatus for determination of concentration of immunologically reactive biological particles The area of a bimolecular layer formed on a metallized slide is related to the concentration of second immunologically reactive biological particles forming the second layer. The slide initially has adsorbed thereon a first monomolecular layer of first im... | 06/01/1976 |
| 3960490 | Method and apparatus for detecting immunologic reactions by diffusion in gel A thin layer of gel on a metallized solid surface has two or more wells formed through the gel which are subsequently filled with specimens of first and second solutions suspected of respectively containing first and second immunologically reactive biolog... | 06/01/1976 |
| 3960491 | Method and apparatus for detecting immunologically reactive biological particles A metallized solid substrate is covered with a moistened porous paper, and specimens of first and second solutions suspected of respectively containing first and second immunologically reactive biological particles specific to each other are applied to se... | 06/01/1976 |
| 3959650 | Method for detecting and identifying allergy A method is described for determining the presence of an antigen-specific antibody in a vertebrate. Effluvial tissue is exposed to antigens from known sources and is subsequently examined to detect the presence or absence of a conjugate compound formed be... | 05/25/1976 |
| 3957436 | Resultant color step indicator A resultant color step indicator for use in various diagnostic or analytic test procedures particularly useful in those involving qualitative and quantitative analysis, such as radioimmunoassay, where a number of steps must be accomplished consecutively i... | 05/18/1976 |
| 3955923 | Serologic reaction method A method for detecting the end point in immunochemical and serodiagnostic tests involving agglutination is described wherein the test is carried out on a curved slide having a curvature sufficient to produce a discernible pattern at the end point.... | 05/11/1976 |
| 3951748 | Sensitized matrix for detection of disease A specific sensitized matrix for diagnosing both infectious and non-infectious disease is disclosed comprised of an insoluble, inert, pliable and wettable matrix having a network of pores, and a protein polymer network immobilized in the network of pores ... | 04/20/1976 |
| 3949065 | Composition and method for the detection of syphilis An antigen preparation for use in the detection of syphilis and other treponemal diseases comprising (1) V.D.R.L. or U.S.R., antigen reagent and (2) A. a compound having the formula ##SPC1## B. a compound having the formula ##SPC2## C. a compound hav... | 04/06/1976 |
| 3939350 | Fluorescent immunoassay employing total reflection for activation Receptors are employed to which one or more fluroescent molecules are bound. When the receptors are bound to the epitopic sites on the surface and light of predetermined wave length is directed toward the surface, the fluorescing molecules are activated a... | 02/17/1976 |
| 3932221 | Immunological isozyme determination method This invention relates to a process, to a diagnostic agent employed therein and to the use thereof, for the organ-specific and/or disease-specific diagnosis of the isozyme pattern of an enzyme occurring in multiple molecular configurations in a sample of ... | 01/13/1976 |
