Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 7300803 | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices. ... | 11/27/2007 |
| 7288415 | Compositions and methods for capturing, isolating, detecting, analyzing and quantifying macromolecules The present invention provides imprint compositions useful for capturing, isolating, detecting and/or quantifying macromolecules in a sample, methods of making and using the same. Generally, the imprint compositions comprise a matrix material defining an imprint of ... | 10/30/2007 |
| 7285426 | Bulking materials containing starch reagent for use in test devices The present invention provides methods, compositions, and kits for rapid detection of analytes in a sample. Surprisingly, it has been found that bulking materials having starch reagents effectively enhance chromatographic detection methods by providing component sta... | 10/23/2007 |
| 7282373 | Ultra-high specificity fluorescent labeling A self-assembled relay probe for detecting a target material is provided including: a first peptide tag bound to the target material; and a first fluorescent conjugate including a first fluorochrome and a first tag binding group; wherein the first fluorescent conjug... | 10/16/2007 |
| 7276368 | Enhanced waveguide and method The present invention provides an optical assay apparatus that includes a light source module and an optical sensor. The light source module produces light having a range of propagation angles. The sensor includes a light adjusting portion and an assay sensing porti... | 10/02/2007 |
| 7270995 | Analyzing device The present invention is an analytical device which comprises a porous piece assembly consisting of a liquid reagent-receiving porous piece (1), a labeled substance-retaining piece (2), a test piece (3) comprising a detection site (4) and... | 09/18/2007 |
| 7264973 | Label-free methods for performing assays using a colorimetric resonant optical biosensor The instant invention provides compositions and methods for determining cell interactions that are faster than conventional methods and that require the use of fewer reagents than conventional methods. ... | 09/04/2007 |
| 7262017 | Diagnostic markers for ischemia This invention relates to the diagnosis and monitoring of ischemia, including but not limited to myocardial and cerebral ischemia, by measuring the concentration of molecules that do not originate from the ischemic tissue but whose concentration in the blood and oth... | 08/28/2007 |
| 7241569 | Method and a device for the evaluation of biopolymer fitness A Method for identifying one or a small number of molecules, especially in a dilution of ≦1 μM, using laser excited FCS with measuring times ≦500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume ... | 07/10/2007 |
| 7236812 | System, device and method for determining the concentration of an analyte There are many inventions described and illustrated herein. In one aspect, the present invention is a system, a device and a method for sensing the concentration of an analyte in a fluid (for example, a fluid sample) or matrix. The analyte may be glucose or other ch... | 06/26/2007 |
| 7229839 | Bidirectional lateral flow test strip and method A test strip adapted to receive a sample and detect an analyte therein is provided. The test strip comprises a sample addition zone to which a sample may be added; an absorbent zone proximal to the sample addition zone; one or more test zones distal to the sample ad... | 06/12/2007 |
| 7223534 | Diffraction-based diagnostic devices A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive material are defined in the receptive material layer by a ... | 05/29/2007 |
| 7217574 | Method and apparatus for biosensor spectral shift detection Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guide... | 05/15/2007 |
| 7214546 | Dendritic chemiluminescent substrates Chemiluminescent substrate delivery systems comprising a conjugate of a dendrimer and at least one chemiluminescent substrate are provided. The substrate delivery systems can also include a chemiluminescence enhancer. The dendrimer/chemiluminescent substrate conjuga... | 05/08/2007 |
| 7211444 | Waveguide and assay A fluidic waveguide comprising a container and a fluid that fills said container, wherein said fluid has a refractive index greater than the refractive index of the wall of said container and wherein said fluid can act as a waveguide for electromagnetic radiation wh... | 05/01/2007 |
| 7208286 | Bioluminescent bioreporter integrated circuit devices and methods for detecting ammonia Monolithic bioelectronic devices for the detection of ammonia includes a microorganism that metabolizes ammonia and which harbors a lux gene fused with a heterologous promoter gene stably incorporated into the chromosome of the microorganism and an Optical Applicati... | 04/24/2007 |
| 7205155 | Method for the determination of substances using the evanescence field method This invention relates to a method for the determination of substances using the evanescence field method. A cuvette, a microtiter well, a solution and a kit for application in a method according to the invention are disclosed. This method can in particular be used ... | 04/17/2007 |
| 7202093 | Method for labeling phosphorylated peptides, method for selectively adsorbing phosphorylated peptides, complex compounds used in the methods, process for producing the complex compounds, and raw material compounds for the complex compounds Provided are a method for easily detecting phosphorylated peptides, namely, proteins, in samples derived from living organisms or the like, a method for selectively adsorbing the phosphorylated peptides, and compounds that are highly coordinated to the phosphorylate... | 04/10/2007 |
| 7202041 | Immunoreaction measurement method The present invention relates to an immunoreaction measuring method for measuring an antigen or antibody contained as a subject substance in a sample, wherein the sample was mixed with at least one compound selected from the group consisting of dicarboxylic acids ha... | 04/10/2007 |
| 7202076 | Label-free high-throughput optical technique for detecting biomolecular interactions Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. ... | 04/10/2007 |
| 7195909 | Measurement and use of molecular interactions The subject invention pertains to a method for determining the affinity between binding partners, or a property of one of the binding partners dependent on the affinity, comprising the steps of: (i) contacting the binding partners,... | 03/27/2007 |
| 7195923 | Ratiometric determination of glycated protein The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the glycosylated protein, or the glycoprotein. The method incorporates lateral f... | 03/27/2007 |
| 7195922 | Allergen detection A method of determining allergen activity in dust comprises: providing a dust sample; extracting from the dust sample at least one breakdown component or proteins or peptides; reacting the extracted at least one breakdown component with a colorimetric amine detectio... | 03/27/2007 |
| 7193711 | Imaging method and apparatus An imaging method and apparatus are provided, including a light source emitting a polarized light beam, and an optical assembly including a control layer and/or a light reflection surface. The control layer advantageously allows for control over the properties of a ... | 03/20/2007 |
| 7186568 | Electrochemiluminescence from acridan compounds Methods are disclosed for producing electrochemiluminescence by electrochemically oxidizing an acridan compound at an electrode in the presence of a peroxide. Maintaining a sufficiently positive potential results in continuous oxidation of the acridan compound to an... | 03/06/2007 |
| 7176036 | Electroactive microspheres and methods Methods and devices for electrochemical detection of a specific binding pair member utilizing a microsphere with an incorporated electroactive marker, wherein a member of the specific binding pair to be detected is bound, directly or through one or more intermediate... | 02/13/2007 |
| 7169550 | Diffraction-based diagnostic devices A biosensor includes a substrate with a receptive material layer of radiation-absorbing member (RAM)-tagged biomolecules disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive mater... | 01/30/2007 |
| 7153702 | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices. ... | 12/26/2006 |
| 7144742 | Quantitative lateral flow assays and devices This invention provides solid phase specific binding lateral flow assay methods, devices and kits for quantitating high and low molecular weight analytes. The methods and devices of the invention employ labelled reagents which are either analyte analogs or complemen... | 12/05/2006 |
| 7141431 | Microparticles with multiple fluorescent signals and methods of using same This invention provides a novel fluorescent particle including a core or carrier particle having on its surface a plurality of smaller polymeric particles or nanoparticles, which are stained with different fluorescent dyes. When excited by a light source they are ca... | 11/28/2006 |
| 7141437 | Solid-state colorimetric biosensors comprised of dendritic polymer networks Solid-state colorimetric biosensors having sensory groups and interdendritic cross-linking segments of alternating conjugated double and triple bonds are prepared by intermolecular polymerization of diacetylene-functionalized dendritic polymer precursors. The polyme... | 11/28/2006 |
| 7135143 | Detecting compounds with liquid crystals A device for detecting a compound in a sample includes a substrate and a self-assembled monolayer. The substrate includes a support with a metallized top surface, and the self-assembled monolayer includes an alkanethiol attached to the metallized top surface of the ... | 11/14/2006 |
| 7129096 | Sensor for use in testing biological, biochemical, chemical or environmental samples Disclosed are sensors for use in testing biological, biochemical, chemical or environmental samples, and methods of making and using the same. ... | 10/31/2006 |
| 7125592 | Detecting interactions at biomimetic interfaces with liquid crystals A method of forming a liquid crystal device, includes: contacting an aqueous solution comprising a surfactant and a receptor molecule with a top surface of a liquid crystal. The liquid crystal is in a holding compartment of a substrate, and the receptor molecule is ... | 10/24/2006 |
| 7118899 | Detection of transmembrane potentials by optical methods Methods and compositions are provided for detecting changes in membrane potential in membranes biological systems. In one aspect, the method comprises; a) providing a living cell with a first reagent comprising a charged hydrophobi... | 10/10/2006 |
| 7115401 | Detection of transmembrane potentials by optical methods Methods and compositions are provided for determining the potential of a membrane. In one aspect, the method comprises: (a) introducing a first reagent comprising a hydrophobic fluorescent ion capable of redistributing from a first face of the membrane ... | 10/03/2006 |
| 7115362 | Electrochemical test device and related methods An electrochemical test device is provided for determining the presence or concentration of an analyte in an aqueous fluid sample. The electrochemical test device includes a working electrode and a counter electrode made of an amorphous semiconductor material. The w... | 10/03/2006 |
| 7109023 | Immunossay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients An immunochemical assay device for determining the presence of NT-proBNP alone or conjunctively with Cardiac Troponin I comprising a base member, an array disposed on the base member, and at least one assay indicia zone. The array comprises (i) a reservoir pad to re... | 09/19/2006 |
| 7109042 | Assays An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with t... | 09/19/2006 |
| 7105358 | Apparatus and method for visually identifying micro-forces with a palette of cantilever array blocks An apparatus to measure micro-forces includes a cantilever palette with a set of cantilever array blocks. Each cantilever array block includes a set of cantilevers, with each cantilever including a set of cantilever fingers surrounded by a frame with frame fingers. ... | 09/12/2006 |
