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| Number | Title | Issue Date |
| 7344892 | Screening for gestational disorders The invention relates to methods and compositions for identifying subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the ... | 03/18/2008 |
| 7288415 | Compositions and methods for capturing, isolating, detecting, analyzing and quantifying macromolecules The present invention provides imprint compositions useful for capturing, isolating, detecting and/or quantifying macromolecules in a sample, methods of making and using the same. Generally, the imprint compositions comprise a matrix material defining an imprint of ... | 10/30/2007 |
| 7241630 | Paramagnetic particle detection A method of determining the number of magnetic particles within a sample using a tuned circuit having a capacitor and a coil. The method comprises: a. determining the difference in the resonant frequency of the tuned circuit when t... | 07/10/2007 |
| 7205403 | 8-Heteroaryl xanthine adenosine Areceptor antagonists The present invention relates generally to compounds of the formula (I): wherein: X is a five or six-membered heteroaromatic ring, containing one to four heteroatoms, selected f... | 04/17/2007 |
| 7081347 | Method for predicting cardiovascular events A method for assessing aspirin resistance and relative risk of a cardiovascular event in a patient taking aspirin is provided. The concentration of 11-dehydro-thromboxane B2 in a urine sample is measured and compared to a set of standardized quartile concentrations.... | 07/25/2006 |
| 7067263 | High throughput screening assay systems in microscale fluidic devices The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effe... | 06/27/2006 |
| 7029856 | Methods for determination of an analyte The invention relates to analytical methods in which the partition of a labeled substance between a liquid and a solid phase is determined. The assays include solid-phase reagents which can be particulate or monolithic such as, for example, a coated tube. Assays of ... | 04/18/2006 |
| 6989240 | Method for detecting hemolysis This invention provides a method for determining the presence of hemolyzed erythrocytes in blood by detecting erythrocyte adenylate kinase in a serum sample from the blood. This invention also provides a method for diagnosing a hemolytic condition in a subject suspe... | 01/24/2006 |
| 6958219 | Method for detecting a gram-negative bacterial autoinducer molecule The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria. The immunogenic conjugate, when combined with a pharmaceutically acceptable carrier, forms a suitable vaccine for mammals t... | 10/25/2005 |
| 6946260 | Allergen/inflammatory testing and diagnosis The invention relates to the use of a secretor variant cell-line expressing the alpha moiety of human IgE binding protein to determine the allergic status of a given individual. Moreover, the cell-line is also used to provide an assay system for determining the alle... | 09/20/2005 |
| 6939681 | Method of detecting an antibody in a liquid sample The invention relates to a method of evaluating the immunological status of a subject comprising the steps of 1) determining the content of an antibody in a liquid sample from the subject using an immunoassay, wherein the reaction between the antibody of the sample ... | 09/06/2005 |
| 6933109 | Rapid particle detection Methods and reagents for rapid purification and/or identification of particles in a liquid sample are described. The technique uses centrifugation to concentrate particles against a slanted surface having an agent specifically binding to the particles. This method i... | 08/23/2005 |
| 6905886 | Preservative solutions This invention relates to preservative solutions for peptides, for example, parathyroid hormone, insulin-like growth factor binding protein 3 (IGFBP3), adrenocorticotropic hormone (ACTH) and mixtures thereof. Preferably, the peptides preserved by the solutions are n... | 06/14/2005 |
| 6844162 | Assays for TSH receptor autoantibodies A method and kit for monitoring autoantibodies to thyroid stimulating hormone (TSH) receptor in a sample of body fluid, which employs the steps of: (i) incubating TSH receptor with a sample of body fluid; (ii) reac... | 01/18/2005 |
| 6844199 | Direct detection of bacteria-antibody complexes via UV resonance Raman spectroscopy A system for the detection of bacteria based on bacteria-antibody complexes. Bacteria attached to antibody are detected with resonance Raman spectroscopy. The bacteria are detected directly in a great numerical excess, e.g. 100 to 10,000 of antibody molecules. A sam... | 01/18/2005 |
| 6815214 | Pharmaceutical uses and synthesis of diketopiperazines The synthesis of novel diketopiperazines, their use in inhibiting cellular events such as those involving NFK-α, NFK-β and in the treatment of inflammation events, a combinatorial library of diverse diketopiperazines and process for their synthesis as a library an... | 11/09/2004 |
| 6803238 | Methods for multiplexed biochemical analysis The invention provides methods for detecting a labeled sample molecule bound to an immobilized probe by electrochemiluminescence. The method comprises providing a multiplexed molecular analysis system comprising a reaction chamber comprising a reaction substrate com... | 10/12/2004 |
| 6783751 | Method for labeling biopolymers using isotopes The invention relates to a novel method for the in-vivo labeling of biopolymers such as proteins, nucleic acids, lipids, carbohydrates and biodegradable plastic using isotopes, especially stabile isotopes. The invention also relates to the use of chemolithotrophic b... | 08/31/2004 |
| 6756233 | Method for measuring free ligands in biological fluids, and assay kits for measuring same A method for measuring free ligands in biological fluids in the presence of bound ligand and endogenous binding proteins, without disturbing the equilibrium between the free ligand and the protein-bound ligand, comprised of the following steps: (a) incubating a samp... | 06/29/2004 |
| 6713256 | Fluorescent energy transfer mediated chemical activation (fetma) for the elucidation of the three-dimensional structure of biomacromolecules The present invention relates to a method for the selected chemical activation of photo-activatable cross-linker molecules around ligand binding pockets and fluorescent groups in macromolecules, especially biological macromolecules, by using fluorescent ligands of t... | 03/30/2004 |
| 6706490 | Method for detecting rheumatoid arthritis employing the CB10 peptide of mammalian type II collagen as an antigen A predictive test for rheumatoid arthritis comprises the detection of antibodies to collagen in a biological sample from a patient by contacting the biological sample with an antigen comprising the CB10 peptide of mammalian type II collagen, or an antibody-binding f... | 03/16/2004 |
| 6692923 | Tapasin-like protein The invention provides a cDNA which encodes tapasin-like protein. It also provides for the use of the cDNA, protein, and antibody in the diagnosis, prognosis, treatment and evaluation of therapies for cancer. The invention further provides vectors and hos... | 02/17/2004 |
| 6682897 | Peptides derived from human heat protein 60 for treatment of diabetes, compositions, methods and kits Novel peptides which are epitopes of the human 60 kDa heat shock protein (hsp60) may be used for the diagnosis and treatment of insulin-dependent diabetes mellitus (IDDM). Pharmaceutical compositions containing such peptides and kits for use in diagnosis ... | 01/27/2004 |
| 6627457 | Methods for detecting pregnancy Methods for detecting pregnancy in a woman comprise screening a biological sample of the woman for pregnancy markers. The methods of the invention include chemiluminescent assays for the pregnancy markers. The methods of the invention also comprise utiliz... | 09/30/2003 |
| 6602989 | Synthesis, characterization, and application of pyridylazo bioconjugates as diagnostic and therapeutic agents The detection of gallium in biological samples is required due to its role in the diagnosis of tumor and for possible treatment of malignancies. However, the use of purely instrumental techniques is unsuitable for detection of low levels of gallium in bio... | 08/05/2003 |
| 6515113 | Phthalamide lanthanide complexes for use as luminescent markers The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the... | 02/04/2003 |
| 6492181 | Atpase assay The present invention uses the principle that phosphomolybdate binds to hydrophobic surfaces to isolate the phosphomolybdate complex from other phosphate-containing molecules and further uses the SPA concept to bring a radiolabeled phosphomolybdate comple... | 12/10/2002 |
| 6472222 | Method of estimating rate of nicotine metabolism in individuals A simple screening method is provided for determining biological variations among individuals in a smoking cessation program so that a therapy regimen can be adjusted appropriately for each individual. The method includes the steps of having an individual... | 10/29/2002 |
| 6455322 | Competition binding assay for detecting P2YADP receptor ligands The invention provides a competition binding assay for detecting P2YADP receptor ligands.... | 09/24/2002 |
| 6387711 | Liquid intact parathyroid hormone (PTH) standards A solution of a non-reconstituted hormone and a preservative having a useful shelf life of at least six months, and, in some circumstances, at least a year. A series of solution of varying levels of the non-reconstituted hormone may be in a test kit and u... | 05/14/2002 |
| 6379909 | Method of detecting an antibody in a liquid sample The invention relates to a method of evaluating the immunological status of a subject comprising the steps of 1) determining the content of an antibody in a liquid sample from the subject using an immunoassay, wherein the reaction between the antibody of ... | 04/30/2002 |
| 6350582 | Hair analysis method A method for the direct analysis of the presence of an analyte which becomes embedded in keratinized structures, e.g., hair, fingernails and toenails, from the bloodstream of a subject which comprises preparing a mixture containing dithiothreitol or dithi... | 02/26/2002 |
| 6342265 | Apparatus and method for in-situ thickness and stoichiometry measurement of thin films An apparatus and method for using -particle energy loss to measure the thickness and stoichiometry of films grown by molecular beam epitaxy and other methods. The apparatus for measuring the thickness of films grown on a substrate in a growth chamb... | 01/29/2002 |
| 6326159 | Receptors for immune complexes Receptors are disclosed that are antibodies that exhibit a binding affinity for an immune complex of a monoepitopic antigen and an antibody for such antigen that is substantially greater than the binding affinity for the monoepitopic antigen or the antibo... | 12/04/2001 |
| 6313274 | Photoactivation of proteins for conjugation purposes A protein containing one or more disulfide bonds, e.g., an antibody, is subjected to ultraviolet radiation to reduce one or more such bonds to reactive sulfhydryl groups; the resulting photoactivated protein is reacted with other chemical entity which is ... | 11/06/2001 |
| 6294340 | Method of binding material to the ଲ-amyloid peptide The present invention relates to the finding that antibodies bind to the ଲ-amyloid peptide, and that ଲ-amyloid peptide binds the hinge region of the immunoglobulin heavy chain, thereby preserving the ability of the immunoglobulin to bind antig... | 09/25/2001 |
| 6284473 | P-cresol sulfate, a component of urinary myelin basic protein-like material, as a correlate of multiple sclerosis status The present invention provides a method of determining the status of a multiple sclerosis patient, i.e., predicting the transition from a status of relapsing-remitting to a progressive phase of multiple sclerosis, comprising the step of measuring the amou... | 09/04/2001 |
| 6284475 | Assays for diagnosis of thrombophilic disease The present invention provides methods for diagnosing and/or monitoring thrombophilic disease in a patient that can result from the antiphospholipid antibody syndrome (aPL syndrome). The methods of the invention are premised on the inhibition of binding o... | 09/04/2001 |
| 6251617 | Glycine transporter Provided are, among other things, nucleic acid sequences encoding the GlyT1d form of glycine transporter, vectors, methods of producing the transporter, and methods for identifying bioactive agents.... | 06/26/2001 |
| 6248538 | Immunologically active PC proteins from Borrelia burgdorferi Various immunologically active proteins from Borrelia burgdorferi have been prepared by genetic manipulation in microorganisms. To do this, the specific DNA sequences were selected from a B. burgdorferi gene bank using suitable screening methods, or were ... | 06/19/2001 |
