Class 436/803 - STABE FREE RADICALS (E.G., SPIN IMMUNOASSAY, ETC.)

Subclass of Class 436 - Chemistry: analytical and immunological testing
Definition: Art collection of patents utilizing stable free radicals
No. of patents: 24
Last issue date: 10/29/2002

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Number	Title	Issue Date
6472143	Complex of human kallikrein 2 (hK2) and protease inhibitor-6 (PI-6) in prostate tumor tissue and methods of using the complex and its constituents The present invention provides a novel complex of hK2 and PI-6 and methods of using the novel complex and its constituents. The novel complexes of hK2 and PI-6 of the present invention and the PI-6 exist at an elevated level in prostate cancer tissues. PI...	10/29/2002
6010845	Leukocyte adhesion assay This invention provides a method of assaying leukocyte binding to vascular tissue which comprises contacting a suspension of a monocyte-like cell line in a suitable medium with a human vascular tissue sample at a temperature of at least 10° C., and quant...	01/04/2000
5854000	Methods for measurement predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts Methods are disclosed for measuring the accumulation of advanced glycosylation endproducts (AGEs), which are predicated on the discovery that such AGEs are present in tobacco and its byproducts. More particularly, the methods focus on the observation that...	12/29/1998
5804368	Method for screening for prostate cancer by measuring apolipoprotein D levels in body fluid The invention is directed to a method for screening for possible prostate cancer presence. The method calls for assaying apolipoprotein D ("ApoD") levels in body fluids, such as serum. Assays for ApoD can be used prognostically, as well as diagnostically....	09/08/1998
5766838	Leukocyte adhesion assay A method of assaying leukocyte binding to a tissue sample, which comprises contacting a arterial tissue sample at a temperature of at least 10° C. with a suspension of monocytes or a cell line having adhesion to arterial tissue similar to monocytes, and ...	06/16/1998
5693539	Methods for coating metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same Improvements in the existing procedures and materials for conduct of high gradient magnetic separation (HGMS) are disclosed. Superior superparamagnetic particles, optionally coated with a polysaccharide or other, usually organic, materials can be prepared...	12/02/1997
5567411	Dendritic amplifier molecules having multiple terminal active groups stemming from a benzyl core group Dendritic derivatives of 3,5-bis(aminomethyl)benzene and aminomethyl benzene core groups are disclosed. In each derivative, termed an "amplifier" because the dendritic structure on each molecule terminates with multiple termini to each of which an "active...	10/22/1996
5412148	Amplifier molecules derived from diethylene triaminepentaacetic acid for enhancement of diagnosis and therapy Disclosed are amplifier molecules: various organic compounds having branched structures terminating with amine groups to which pharmacologically active groups can be chemically attached. A number of MRI contrast-enhancing agents were synthesized, each com...	05/02/1995
5275801	13,17-propionic acid and propionic acid derivative substituted porphyrin complex compounds, process for their production and pharmaceutical agents containing them Porphyrin complex compounds consisting of at least one porphyrin ligand, optionally at least one ion of an element of atomic numbers 5, 13, 21-32, 37-39, 42-44, 49, 50 or 57-83 as well as optionally cations of inorganic and/or organic bases, amino acids o...	01/04/1994
5002868	DNA sequencing process using stable isotopes A DNA sequencing process using specific stable isotopes associated with specific terminators for labels. The process includes a step of incorporating a stable isotope in at least one of the deoxynucleoside triphosphates and/or the dideoxynucleoside tripho...	03/26/1991
4863717	Methods for circumventing the problem of free radial reduction associated with the use of stable nitroxide free radicals as contrast agents for magnetic reasonance imaging Nitroxide contrast agents for MRI have a long useful life and can be administered in low concentration doses. Such agents include nitroxide-doped liposomes that encapsulate an oxidant and large molecules having surfaces covered with persistent nitroxide f...	09/05/1989
4849346	Method for determining thioredoxin reductase activity The present invention provides a method for measuring the activity of thioredoxin reductase in mammalian cells by contacting the cells in vivo or in vitro with a quaternary ammonium salt spin-labelled with a stable nitroxide free radical, and measuring th...	07/18/1989
4788138	Method to achieve a linear standard curve in a sandwich immunoassay A method for obtaining an actual linear standard curve in a sandwich type of immunoassay where a first antibody bound to an insoluble support and a second unbound labelled antibody complex with the antigen contained in a test sample to form an insoluble a...	11/29/1988
4656026	Magnetic resonance (MR) image enhancement compounds for specific areas of the brain An improved imaging technique involving nuclear magnetic resonance. Known drug or neurotransmitter receptor ligands are covalently bound to magnetic resonance image enhancing spin label compounds, such as sterically hindered free radical nitroxide compoun...	04/07/1987
4652532	Free radical based biochemical method for detecting substances in fluids A biochemical method of assaying for ligand molecules in fluids based on the specific interaction of a ligand and a ligand-recognition molecule that binds the ligand wherein a free radical forming group is covalently coupled to label either a ligand sough...	03/24/1987
4517303	Specific binding assays utilizing analyte-cytolysin conjugates A novel analyte-cytolysin conjugate and its use in a lipid vesicle mediated measurement process is described for a wide variety of analytes present at very low concentration. The method involves forming a reaction system consisting of analyte, analyte spe...	05/14/1985
4483929	Liposomes with glycolipid-linked antibodies Lipid vesicles, labelled with encapsulated reporter compositions and bound to antibodies comprise a new class of immunoreagent, useful in immunoassays for ligands....	11/20/1984
4160645	Catalyst mediated competitive protein binding assay Method and compositions are provided for competitive protein binding assays wherein a non-enzymic catalytically mediated reaction is sterically inhibited by receptors binding to a ligand to which the reaction intermediary is bound. The method employs firs...	07/10/1979
4130462	Receptor steric hindrance immunoassay for receptor determination A method is provided for the determination of receptors, particularly antibodies, where a polyepitopic reagent is employed, at least one of the epitopes being specific for the receptor of interest. The epitopic sites are situated on the reagent, so that t...	12/19/1978
4123431	Non-oxo-carbonyl containing benzoyl ecgonine and cocaine compounds and derivatives thereof Non-oxo-carbonyl substituted derivatives of cocaine are provided for conjugation with other compounds to provide reagents for use in a diversity of immunoassay techniques. Specifically, carboxy or imidoyl derivatives are provided which may be conjugated w...	10/31/1978
4045420	Non-oxo-carbonyl containing benzoyl ecgonine and cocaine compounds polypeptide and derivatives thereof Non-oxo-carbonyl substituted derivatives of cocaine are provided for conjugation with other compounds to provide reagents for use in a diversity of immunoassay techniques. Specifically, carboxy or imidoyl derivatives are provided which may be conjugated w...	08/30/1977
4016146	Phenethylamine antigenic conjugates, their preparation, antibodies, and use Antigenic phenethylamine conjugates are produced by blocking the amine of the phenethylamine hapten with a group, coupling of the phenethylamine to a carrier, and removal of the blocking group. Specific phenethylamines useful in this invention are ampheta...	04/05/1977
3959287	Ligand determination of spin labeled compounds by receptor displacement Compounds are provided for use in assays of organic compounds, where organic compounds of biological interest are determined at extremely low concentrations by combining in a medium, the composition to be determined, hereinafter referred to as ligand, a h...	05/25/1976
3935074	Antibody steric hindrance immunoassay with two antibodies A novel immunoassay is provided, as well as particular reagents, for determining the presence of a ligand. A Reagent is employed having at least two epitopes, one of the epitopes being common with the ligand, and the other epitopes being foreign to the li...	01/27/1976

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Class 436/803 - STABE FREE RADICALS (E.G., SPIN IMMUNOASSAY, ETC.)