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| Number | Title | Issue Date |
| 7419833 | Method for nucleic acid sequencing A method for determining the sequence of at least a portion of a single-stranded nucleic acid molecule by base-specifically labeling the exposed bases of the nucleic acid molecule using heavy element-substituted nucleotide bases which form Watson-Crick type base-pai... | 09/02/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7176036 | Electroactive microspheres and methods Methods and devices for electrochemical detection of a specific binding pair member utilizing a microsphere with an incorporated electroactive marker, wherein a member of the specific binding pair to be detected is bound, directly or through one or more intermediate... | 02/13/2007 |
| 6750065 | Immunoassays involving surface enhanced Raman scattering Immunoassay displacement methods for detecting (preferably identifying) the presence or amount of a target analyte (e.g. drug) in a sample comprising the steps of: (a) exposing the sample to a complex comprising an immobilized antibody capable of specifically bindin... | 06/15/2004 |
| 6387614 | Methods for using redox liposome biosensors The present invention provides methods and compositions for detecting the presence of biologically-important analytes by using redox liposome biosensors. In particular, the present invention provides liposome/sol-gel electrodes suitable for the detection ... | 05/14/2002 |
| 6342396 | Method for isolating, in particular for detecting or quantifying an analyte in a medium The present invention relates to a method for at least one of detecting, quantifying or isolating at least one analyte from a liquid medium in which the analyte is distributed and comprises providing a reagent comprised of particles having a receptor for ... | 01/29/2002 |
| 6284475 | Assays for diagnosis of thrombophilic disease The present invention provides methods for diagnosing and/or monitoring thrombophilic disease in a patient that can result from the antiphospholipid antibody syndrome (aPL syndrome). The methods of the invention are premised on the inhibition of binding o... | 09/04/2001 |
| 6219137 | Nanoprobe for surface-enhanced Raman spectroscopy in medical diagnostic and drug screening A probe for a surface-enhanced Raman scattering spectrometer is provided for injection into a cell in order to detect trace amounts of a compound within that cell. The probe has a spherical shape with a diameter less than one micrometer and preferably in ... | 04/17/2001 |
| 5872013 | Universally applicable detection system based on ultra small colloidal metal particles An aggregate for qualitatively or quantitatively determining bindable substances. Said aggregate comprises an ultra small colloidal particle and a specific binding agent characterized in that the mean diameter of the colloidal particle is below 2 nm. Pref... | 02/16/1999 |
| 5792622 | Assay for chemicals A microbiological assay for chemicals, which uses a cell and a reducing dye to quantitatively measure inhibition of electron transport in the cell membrane as a function of chemicals in the substance being tested, is disclosed. This assay and method is re... | 08/11/1998 |
| 5710011 | Mediators to oxidoreductase enzymes Half-sandwich complexes of transition metals having a single π-ligand with delocalised π bonding are of use in mediating electron transfer between an electrode and a redox protein, for example an oxidoreductase enzyme such as in an amperometric enzyme s... | 01/20/1998 |
| 5686244 | Method for detecting a nucleic acid analyte using an improved electrochemiluminescent label This invention relates to a new electrochemiluminescent (ECL) label for oligonucleotides using phosphoramidite chemistry.... | 11/11/1997 |
| 5627036 | Use of an anticoagulant as a diagnostic agent Detectably labelled annexines and compositions thereof are disclosed. Also disclosed are methods for diagnosing a disruption or activation of the hemostatic system or a prothrombotic state in an individual suspected of having a hemostatic disorder, by con... | 05/06/1997 |
| 5597910 | Electrochemiluminescent label for DNA probe assays This invention relates to a new electrochemiluminescent (ECL) label for oligonucleotides using phosphoramidite chemistry.... | 01/28/1997 |
| 5587292 | Diagnosis of fungal infections with a chitinase A novel method for detecting chitin, and for diagnosing fungal infections (including yeast infections), with a chitinase or other chitin-specific binding protein. This method should allow the convenient, broad spectrum diagnosis of fungal infections in ti... | 12/24/1996 |
| 5567628 | Surface-enhanced raman spectroscopy immunoassay method, composition and kit A method, composition, device, apparatus, and kit for the determination of the presence or amount of an analyte by monitoring an analyte-mediated ligand binding event in a test mixture which contains the analyte to be assayed, a specific binding member, a... | 10/22/1996 |
| 5516697 | Biosensor for detecting iron A simple, cost effective assay of iron is accomplished by using lactoferrin as part of a biosensor to detect iron in a sample. The lactoferrin releases protons when the iron is sequestered by the lactoferrin and the change in potential caused by the relea... | 05/14/1996 |
| 5272061 | Assay for serum cholinesterase activity A dry analytical element for the determination of serum cholinesterase (CHE) activity is disclosed. The element analyses undiluted body fluids and employs butyrylthiocholine as the substrate for CHE. Butyrylthiocholine is hydrolyzed by serum cholinesteras... | 12/21/1993 |
| 5266498 | Ligand binding assay for an analyte using surface-enhanced scattering (SERS) signal An assay for an analyte in a test sample that uses a ligand binding reaction between the analyte and a specific binding member or a binding member pair that includes one binding member having a Raman active reporter. The analyte can be assayed by measurem... | 11/30/1993 |
| 5248589 | Separation of cells and biological macromolecules by ferritin conjugates An Fc receptor protein conjugated with Ferritin binds to an exposed Fc region of an antibody to form a cell/Ferritin complex. Magnetic particles are added to the medium and bind to the complex. The magnetic particles when bound to the complex significantl... | 09/28/1993 |
| 5120643 | Process for immunochromatography with colloidal particles The present invention relates to improved specific binding assay methods, kits and devices utilizing chromatographically mobile specific binding reagents labelled with colloidal particles. Specific binding reagents labelled with colloidal particles such a... | 06/09/1992 |
| 5079172 | Method for detecting the presence of antibodies using gold-labeled antibodies and test kit A method and test kit for detecting a first antibody using a gold particle labeled secondary antibody is described. Microspheres coated with an antigen reactive with the first antibody is reacted with the first antibody from serum or other sources. The go... | 01/07/1992 |
| 5068178 | Method of enhancing direct immunofluorescence staining of cells A method of identifying and enumerating specific cell types in a heterogeneous population of cells by enhancing the specific staining of desired cells, comprising contacting a sample from the heterogeneous population of cells with a labeled primary antibo... | 11/26/1991 |
| 4962023 | Single incubation immuno sorbent assay method using particle labels to detect test antigen specific antibodies in presence of other antibodies An immunoassay method for one-step detection of specific antibodies which includes incubation of a solid phase support or matrix having a spot of the antigen bound thereto with a sample of the clinical fluid to be tested in the presence of a signal develo... | 10/09/1990 |
| 4900660 | Streptococcal fc rc Proteinaceous, antigenic factor derived from a group C Streptococcus which is receptor for the Fc region of IgG, a method for its preparation and immunoassay and antigen detection methods employing the receptor.... | 02/13/1990 |
| 4882270 | Monoclonal antibodies to placental isoferritin for use in detecting oncofetal ferritin associated with breast cancer and Hodgkins disease There are provided monoclonal antibodies which react with human oncofetal ferritin and which do not react with human spleen ferritin or with liver ferritin; there are also provided monoclonal antibodies which react both with human placenta oncofetal ferri... | 11/21/1989 |
| 4855226 | Novel competitive assay for theophylline and reagent for use therein A novel competitive assay for theophylline wherein caffeine-like (7-substituted) labeled conjugates are used to detect the presence and/or amount of theophylline present in a test sample. The use of such conjugates in a competitive assay for theophylline ... | 08/08/1989 |
| 4788138 | Method to achieve a linear standard curve in a sandwich immunoassay A method for obtaining an actual linear standard curve in a sandwich type of immunoassay where a first antibody bound to an insoluble support and a second unbound labelled antibody complex with the antigen contained in a test sample to form an insoluble a... | 11/29/1988 |
| 4742000 | Antibody to human progesterone receptor and diagnostic materials and methods Methods and procedures are described for the isolation of human progestin receptors and for the use of human progestin receptors as immunogens in producing both monoclonal and polyclonal antibodies. These antibodies are used for the detection of progestin... | 05/03/1988 |
| 4687732 | Visualization polymers and their application to diagnostic medicine A method for detecting a minute quantity of an inorganic or organic target molecule by combining it with a composition of a detecting agent for the target molecule which carries, by direct or indirect means, a visualization polymer. The visualization poly... | 08/18/1987 |
| 4668620 | Reducing background interference activity in enzyme-label immunoassays Background interference which disrupts the measurement of an analyte in enzyme immunoassays with samples is substantially diminished. In accordance with one embodiment of the invention, the serum sample is treated with a sufficient amount of a peracid com... | 05/26/1987 |
| 4578350 | Immunoassays employing protected labels An improved immunoassay for determining the presence of an analyte in a serum sample and conjugates therefor are described. The known method comprises combining the sample with a conjugate of the analyte and an enzyme and with a receptor for analyte, and ... | 03/25/1986 |
| 4560648 | Homogeneous enzyme immunoassay for ferritin Composition and method are provided for enzyme immunoassays for high molecular weight proteins, such as ferritin. An enzyme is conjugated to the high molecular weight protein through a specific linking group. Usually, on the average, about 2 to 10 enzyme ... | 12/24/1985 |
| 4469787 | Immunoassay involving soluble complex of second antibody and labeled binding protein A method and kit for determining the presence of a polyvalent ligand in an aqueous fluid. The method involves incubating the fluid with an immobilized antibody to the ligand to form an immobilized ligand-antibody complex, then incubating the immobilized l... | 09/04/1984 |
| 4456690 | Non-centrifugation method for immunoassay of materials The present invention relates to a method which eliminates centrifugation and decantation steps, to be performed in an automatic manner for carrying out specific binding assay tests, wherein liquid and solid phases are present. According to the invention,... | 06/26/1984 |
| 4454231 | Method and device for mass transfer operation in immunoassays and other applications The present invention relates to a new technique and device for mass transfer of one or more components from one liquid phase to another liquid phase, involving a physical separation of said two phases. According to the new technique, the mass transfer and phy... | 06/12/1984 |
| 4446238 | Bright field light microscopic method of localizing tissue antigens The use of colloidal gold as a bright field light microscopic marker for the immunocytochemical localization of antigens in histological sections, namely the two step or the bridge immuno gold staining method.... | 05/01/1984 |
| 4332785 | Immunoassay for measurement of reticulocytes, and immunoreactive reagents for use therein The reticulocyte content present in a specimen of red blood cells is quantitatively measured based upon the selective immunoreactivity of the reticulocyte portion of the specimen with a reticulocyte-specific antibody which is immunoreactive with proteinac... | 06/01/1982 |
| 4302536 | Colorimetric immunoassay process Quantitative and qualitative measurement of antigenic materials present in blood serum or other biological fluids or cells is effected by an extremely precise and sensitive colorimetric immunoassay process. This process comprises adding to the sample to b... | 11/24/1981 |
| 4278652 | Process for determining ferritin A process for the determination of ferritin in serum or in plasma is disclosed, which comprises incubating an antibody directed against an organ-specific isoferritin, which is covalently bound to nylon(polyamide 6,6), on the one hand with ferritin standar... | 07/14/1981 |
