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| Number | Title | Issue Date |
| 8062893 | Fluorescent sensor for mercury The present invention provides a sensor for detecting mercury, comprising: a first polynucleotide, comprising a first region, and a second region, a second polynucleotide, a third polynucleotide, a fluorophore, and a quencher, wherein the third polynucleotide is opt... | 11/22/2011 |
| 7695972 | Methods and kits for the in vitro diagnostic or for the monitoring of a disease involving an inflammatory reaction Method for the in vitro diagnostic or for the monitoring of a disease involving an inflammatory reaction within a patient, which comprises the steps of: a) providing a biological sample from the patient; b) measuring the amount of selenoprotein P which is contained ... | 04/13/2010 |
| 7651858 | Ion-detecting microspheres This invention provides methods of using ion-detecting microspheres containing an ionphore and a chromoionphore in clinical laboratory instrumentation such as flow cytometry for sample analysis. In one embodiment, the microspheres are contacted with a flowing stream... | 01/26/2010 |
| 7399639 | Sensors, and methods of making and using the same The present invention is directed, in part, to sensors for detecting metal ions, and methods of making and using the same. ... | 07/15/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7326573 | Assay procedures and apparatus In cytometry and like procedures, particles containing signal dyes are exposed to a laser, and the resulting fluorescence is assessed in two different wavelength bands. When the particle is a single-assay particle, or when the particle carries only a single dye, the... | 02/05/2008 |
| 7312083 | Control value assignment method A method of assigning expected recovery values to control substances used in analytical testing is disclosed. ... | 12/25/2007 |
| 7300465 | Intervertebral allograft spacer An allogenic intervertebral implant for fusing vertebrae is disclosed. The implant is a piece of allogenic bone conforming in size and shape with a portion of an end plate of a vertebra. The implant has a wedge-shaped profile to restore disc height and the natural c... | 11/27/2007 |
| 7288414 | Use of phosphonazo III for the measurement of calcium, magnesium and sodium in analytical samples Novel reagent formulations and methods are described for the use of phosphonazo III to measure calcium, magnesium and sodium in biological fluids. ... | 10/30/2007 |
| 7282369 | Tests for the rapid evaluation of ischemic states and kits The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an altera... | 10/16/2007 |
| 7247489 | Ion-detecting microspheres and methods of use thereof This invention provides methods of using ion-detecting microspheres containing an ionphore and a chromoionphore in clinical laboratory instrumentation such as flow cytometry for sample analysis. In one embodiment, the microspheres are contacted with a flowing stream... | 07/24/2007 |
| 7244620 | Method for quantitatively determining a reducing substance and a reagent for quantitative determination The present invention provides a method for quantitatively determining a reducing substance, which comprises reacting a reducing substance in a test specimen with iron (III) ions, reacting iron (II) ions formed by reduction of the iron (III) ions or residual iron (I... | 07/17/2007 |
| 7226563 | Ion-detecting sensors comprising plasticizer-free copolymers Plasticizer-free ion-detecting sensors for detecting a target ion in a sample are provided. The sensor comprises a plasticizer-free copolymer comprised of polymerized units of methacrylate monomers and a polymerizable ion exchanger, wherein the methacrylated monomer... | 06/05/2007 |
| 7208121 | Plasticizer-free-ion-detective sensors A plasticizer-free ion detective sensor for detecting a target ion in a sample is provided. The sensor comprises a copolymer of methacrylate monomers with pendant alkyl groups of different length, and an ionophore for detecting the target ion. The copolymer matrix o... | 04/24/2007 |
| 7201876 | Ion-detecting sensors comprising plasticizer-free copolymers Ion-detecting sensors for detecting a target ion in a sample are provided. The sensor comprises a plasticizer-free copolymer comprised of polymerized units of methacrylate monomers having pendent alkyl groups of different length and a functionalized ionophore of sai... | 04/10/2007 |
| 7179939 | Sodium ferric gluconate complexes and method of manufacture thereof A process is provided for preparing a sodium ferric gluconate complex, substantially free of excipients, for providing a sodium ferric gluconate complex co-precipitated with sucrose, and for providing sodium ferric gluconate complexes in aqueous solution. ... | 02/20/2007 |
| 7160732 | Fluorescein-based metal sensors, and methods of making and using the same The present invention is directed, in part, to fluorescein-based ligands for detection of metal ions, and methods of making and using the same. ... | 01/09/2007 |
| 7148068 | Method of trivalent chromium concentration determination by atomic spectrometry A method is disclosed for determining the concentration of trivalent chromium Cr(III) in a sample. The addition of perchloric acid has been found to increase the atomic chromium spectrometric signal due to Cr(III), while leaving the signal due to hexavalent chromium... | 12/12/2006 |
| 7090995 | Molecules and methods using same for measuring non-transferrin bound iron A molecule suitable for use as an indicator of free iron levels in a biological sample, the molecule including an iron binding moeity and a signal generating moeity, wherein an intensity of the signal generated by the signal generating moeity is related to an amount... | 08/15/2006 |
| 7070937 | Marker useful for detection and measurement of free radical damage and method The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presenc... | 07/04/2006 |
| 7067320 | Sensor for luminescense-optical determination of an analyte The invention relates to an optochemical sensor functioning in accordance with the FRET-principle and exhibiting an acceptor (chromophore or luminophore) responsive to an analyte contained in a sample medium as well as a donor (luminophore), characterized in that ac... | 06/27/2006 |
| 7045098 | Apparatus and method for removing interfering substances from a urine sample using a chemical oxidant Urine samples are made free of potentially interfering substances, such as alkaloids or pharmaceuticals, by contacting the urine sample with an amount of a chemical oxidizing agent in a disposable oxidation bag, while retaining the physical indicia characteristic of... | 05/16/2006 |
| 7029840 | Method for preservation of cells and nucleic acid targets The present invention provides a method for preserving cells and nucleic acids in a sample by exposing the sample to a composition that causes an inhibitory affect on proteolytic agents and/or nucleic acid degradative agents in the sample. Such compositions that are... | 04/18/2006 |
| 6994973 | Method and agent for determining total water hardness The invention relates to a dry chemical method and a test strip for determining calcium and magnesium in aqueous samples. Said test strip contains o-cresolphthalein complex (o-CPC; CAS Registry No. 2411-89-4) as a colour-causing reagent in a buffer system with a pH ... | 02/07/2006 |
| 6962968 | Purification of macrocyclic oligoesters Acid impurities, such as carboxylic acid-terminated polymers, are removed from macrocyclic oligoesters with ion exchange resins, resulting in macrocyclic oligoesters that are substantially free of acid impurities. The ion exchange resins can be regenerated anew and ... | 11/08/2005 |
| 6925392 | Method for measuring fluid chemistry in drilling and production operations A method for chemical analysis of fluids utilized in hydrocarbon exploration and production in which microfluidic systems designed to react to specific characteristics of a fluid are introduced into fluid samples or during operations. The microfluidic systems are th... | 08/02/2005 |
| 6911007 | Method for determining concentration; a dialyser A method for determining the concentration of an ion, atom or molecule bound in a complex. A reliable determination of the concentration of the ion, atom or molecule to be determined is possible in accordance with the invention in that the complexing of the ion, ato... | 06/28/2005 |
| 6905655 | Modification of selectivity for sensing for nanostructure device arrays An electronic system for selectively detecting and identifying a plurality of chemical species, which comprises an array of nanostructure sensing devices, is disclosed. Within the array, there are at least two different selectivities for sensing among the nanostruct... | 06/14/2005 |
| 6858440 | Tapered tubular optical waveguide probe for magnetic focusing immunosensors A waveguide probe for the detection of pathogens in a sample which comprises a laser, a first and a second tubes that converge at a point to form a proximal end. A magnet is positioned in the end to configure to focus paramagnetic microspheres attached to antigen/an... | 02/22/2005 |
| 6846299 | Method for continuous recirculating peritoneal dialysis Method for a continuous recirculating peritoneal dialysis wherein the peritoneal dialysis fluid is infused into a peritoneal cavity of a patient and then, typically on a continuous process basis a portion of the dialysis fluid is sequentially drained from the cavity... | 01/25/2005 |
| 6821786 | Diagnostic test for elemental imbalances A self-diagnostic test, a self-diagnostic test apparatus, and method of manufacturing a self-diagnostic test for screening for elemental mineral imbalances in a patient utilizing an analysis of the reaction of mineral specific reagents to a sample from a patient are... | 11/23/2004 |
| 6806089 | Low frequency modulation sensors using nanosecond fluorophores Described is a new approach to fluorescence sensing based on a mixture of fluorophores, one of which is sensitive to the desired analyte. If a long lifetime analyte-insensitive fluorophore is mixed with a short lifetime analyte-sensitive fluorophore, the modulation ... | 10/19/2004 |
| 6800489 | Electrospray tandem mass spectrometry of transition metal diimine complexes of amino acids, α-hydroxyketones and hexose phosphates for newborn screening Tandem mass spectrometry (MS/MS) has been used extensively for solving various biological problems, such as structure identification of oligopeptides, nucleic acids, and nucleotides. One of the main advances of MS/MS is that it lends itself to the quantitative and q... | 10/05/2004 |
| 6790673 | Speciated isotope dilution mass spectrometry of reactive species and related methods A method of speciated isotope dilution mass spectrometry (SIDMS) which will permit determination of concentrations of one or more species from a sample even if the sample has been subjected to species conversion prior to species separation or degradation or incomple... | 09/14/2004 |
| 6756230 | Quantitative analysis Amounts of components in a specimen can be analyzed with excellent quantitativity. The analysis includes: measuring an amount of a component to be analyzed in a specimen; measuring an amount of a standard component present originally and homeostatically in the speci... | 06/29/2004 |
| 6740527 | Methods and reagents for cyanide-free determination of hemoglobin and leukocytes in whole blood Cyanide-free reagents for the determination of hemoglobin and leukocytes present in a blood sample comprise an aqueous solutions of at least one quaternary ammonium salt, preferably selected from the group of alkyltrimethylammonium salts, alkyldimethylbenzylammonium... | 05/25/2004 |
| 6645768 | Reagent and kit for determining global coagulability and hemostatic potential A reagent and kit are disclosed for determining if a patient is hypercoagulable, hypocoagulable or normal. The test involves providing a test sample from the patient and initiating coagulation in the sample in the presence of an activator, which is added ... | 11/11/2003 |
| 6645777 | Tapered tubular optical waveguide probe for magnetic focusing immunosensors A waveguide probe for the detection of pathogens in a sample which comprises a laser, a first and a second tubes that converge at a point to form a proximal end. A magnet is positioned in the end to configure to focus paramagnetic microspheres attached to... | 11/11/2003 |
| 6627448 | Analyte-binding assay Analyte-binding assays, such as iron binding assays, are disclosed. The assays can provide information relating to the serum iron content and/or total iron binding capacity of a sample.... | 09/30/2003 |
| 6602989 | Synthesis, characterization, and application of pyridylazo bioconjugates as diagnostic and therapeutic agents The detection of gallium in biological samples is required due to its role in the diagnosis of tumor and for possible treatment of malignancies. However, the use of purely instrumental techniques is unsuitable for detection of low levels of gallium in bio... | 08/05/2003 |
