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| Number | Title | Issue Date |
| 5733734 | Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments Substantially purified antibodies, including substantially purified monoclonal antibodies, which are specifically reactive with ͌ that has an abnormally phosphorylated serine in the sequence LysSerProVal SEQ ID NO:3 are disclosed. Methods of screening pe... | 03/31/1998 |
| 5716790 | Method for estimating the lysine content of seed by elongation factor (EF) complex immunoassay Seed lysine is detected by an immunoassay in which anti-EF antibody binds seed protein. Seed EF concentration is highly correlated with seed lysine content.... | 02/10/1998 |
| 5716793 | Method for diagnosing a patient for chlamydia A method of detecting chlamydia in a extracellular sample is provided which comprises contacting the sample with an idiotypic antibody to GLXA to form an immunocomplex and detecting the immunocomplex.... | 02/10/1998 |
| 5714365 | Sucrose phosphate synthetase isolated from maize A protein having sucrose phosphate synthetase (SPS) activity is isolated from plants, preferably maize. The protein has a molecular weight of 110-130 dK and contains at least one peptide selected from Thv Trp Ile Lys, Try Val Val Glu Leu Ala Arg, Ser Met ... | 02/03/1998 |
| 5707632 | Receptors for fibroblast growth factors A fibroblast growth factor (FGF) receptor including a basic fibroblast growth factor receptor has been purified. Various forms have been identified including soluble forms lacking any transmembrane segment. DNA sequences encoding full-length fibroblast gr... | 01/13/1998 |
| 5702909 | Methods of detecting collagen type II degradation in vivo In a method of analyzing a body fluid sample for the presence of an analyte indicative of a physiological condition, comprising the steps of contacting the body fluid sample with an immunological binding partner which binds to the analyte, detecting bindi... | 12/30/1997 |
| 5702910 | Method of sandwich immunoassay for N-peptide The present invention relates to a sandwich immunoassay for rapidly and readily measuring N-peptide using two kinds of monoclonal antibodies recognizing different portions of the N-peptide. The method for measuring N-peptide or a precursor thereof include... | 12/30/1997 |
| 5702904 | Immunoassay for identifying alcoholics and monitoring alcohol consumption The invention provides an antibody which reacts selectively with a transferrin homolog found in alcoholics but not in non-alcoholics. The invention also provides methods of making the antibody and hybridomas producing the antibody. Finally, the invention ... | 12/30/1997 |
| 5693479 | Fertility determination with transforming growth factor ଲ Therapeutic and diagnostic methods of use for the growth factor transforming growth factor ଲ, are provided by this invention. In accordance with preferred embodiments, methods of determining competence of a conceptus toward uterine implantation are ... | 12/02/1997 |
| 5691157 | Method for detecting a mammal's prior exposure to radiation or radiomimetic chemicals The present invention is directed to a method for detecting a mammal's prior exposure to radiation or radiomimetic agents. Labeled antibodies are employed to determine the quantity of transferrin receptors on the red blood cells of the mammal. The quantit... | 11/25/1997 |
| 5688659 | Streptolysin O peptide antigens and methods for the determination of streptolysin antibodies SLO peptide antigens are described. These peptide antigens are suitable for the determination of SLO antibodies, as immunogens for the production of antibodies against SLO and as vaccines for the production of vaccines against SLO.... | 11/18/1997 |
| 5684133 | Neurite growth regulatory factors, antibodies thereto, and pharmaceutical compositions The CNS myelin associated proteins inhibit neurite outgrowth in nerve cells and neuroblastoma cells, and can also inhibit fibroblast spreading. Such inhibitory proteins include a 35,000 dalton and a 250,000 dalton molecular weight protein and analogs, der... | 11/04/1997 |
| 5681754 | Method for improving the performance of an immunoreagent in an immunoassay A method for increasing the binding activity of specific binding members bound to a solid phase material, e.g., a particle, that has been sterically stabilized. This increase in binding activity is brought about by degrading a steric stabilizer on the sur... | 10/28/1997 |
| 5681707 | Method of immunological assaying human osteocalcin, reagent and kit therefor, antibody to human osteocalcin, hybridoma producing said antibody, and method of producing it A method of immunologically assaying intact human osteocalcin in a human assay sample is provided by using an antibody having an epitope in a region of an amino acid sequence 1 to 20 on the N-terminal side of human osteocalcinand an antibody having an epi... | 10/28/1997 |
| 5679583 | Monoclonal antibodies for the selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids It is possible with the aid of a monoclonal antibody which is specifically directed against an epitope of amino-terminal procollagen peptide (type III) which is not present on the fragment Col 1, and of a second monoclonal or polyclonal antibody against a... | 10/21/1997 |
| 5674983 | Natural human chorionic gonadotropin ଲ-core molecule The present invention relates to the purification of the human chorionic gonadotropin ଲ-core molecule which can then be used as the antigen in the preparation of antibodies to the ଲ-core molecule. The combination of the purified ଲ-core m... | 10/07/1997 |
| 5672692 | Purification of human myelomonocyte interferon gamma with an immobilized antibody A human myelomonocyte interferon-gamma having a novel polypeptide and carbohydrate chain structure is produced by propagation of an established human myelomonocyte in vitro or after being implanted in a non-human warm-blooded animal or in a diffusion cham... | 09/30/1997 |
| 5669819 | Chemiluminescent phenanthridinium Acridinium sulfonylamides and isomers, such as phenanthridinium sulfonylamides, may be employed in applications including chemiluminmescent immunoassays. Methods for synthesis of these compounds include contacting an amine with a sulfonylhalide to form a ... | 09/23/1997 |
| 5670328 | Monoclonal antibodies to human pulmonary surfactant apoprotein D and use thereof A monoclonal antibody which is capable of specifically binding with human pulmonary surfactant apoprotein D has been successfully obtained. Using the monoclonal antibody, human pulmonary surfactant apoprotein D can be specifically detected and assayed, wh... | 09/23/1997 |
| 5665552 | Antibodies to plasmodium falciparum Antibodies which recognize and bind to histidine rich protein II of Plasmodium falciparum. These antibodies exhibit improved specificity and affinity for the antigen which provides enhanced sensitivity in immunoassays. Peptides useful for generation of th... | 09/09/1997 |
| 5660994 | Method of detecting tissue-specific, insoluble cytoskeletal proteins The invention relates to the identification of insoluble cytoskeletal proteins, or fragments thereof, which are characteristic of the origin of the tissue. The invention relates as well to the method for detecting such proteins by breaking down and solubi... | 08/26/1997 |
| 5658741 | Anti-CD3 antibody-aminodextran conjugates for induction of T-cell activation and proliferation The invention describes the use of novel aminodextran compounds containing about 5-20% by weight amine groups to bind a plurality of monoclonal antibodies. The resulting antibody-aminodextran compounds may be used to induce the activation and proliferatio... | 08/19/1997 |
| 5658803 | Monoclonal antibodies reactive with cachectin Cell lines are provided that produce improved neutralizing monoclonal antibodies reactive with human cachectin. The antibodies have various therapeutic and diagnostic uses.... | 08/19/1997 |
| 5658745 | Cell enumeration immunoassay This invention relates to a cell enumeration immunoassay which uses a calibrated standard, i.e., a substance which behaves like the sample under study and the concentration of which can be correlated to the concentration of the cells. This immunoassay is ... | 08/19/1997 |
| 5656442 | Characterization of platelet aggregation disorders Methods are described for characterizing platelet aggregation defects. The defects are characterized as activation, ligand binding, or post-occupancy defects. In one embodiment of the invention a Cam variant of Glanzmann's thrombasthenia is characterized ... | 08/12/1997 |
| 5656434 | Monoclonal antibody against cardiac glycoside and utilization thereof The present invention provides monoclonal antibodies that specifically recognize a specific structural portion of cardiac glycoside. The monoclonal antibodies of the present invention recognize an integrated structure in the steroid structure of cardiac glycos... | 08/12/1997 |
| 5656435 | Antibodies to peptides having NGF-like activity, said antibodies having no substantial cross-reactivity with NGF, and use thereof Disclosed are (A) an antibody to a peptide including at least 8 successive amino acids of an amino acid sequence represented by formula TyrAlaGluHisLysSerHisArgGlyGluTyrSerValCys AspSerGluSerLeuTrpValThrAspLysSerSerAlaIle AspIleArgGlyHisGlnValThrValLeuGly... | 08/12/1997 |
| 5654158 | Methods for detection of nephropathy-related immunoglobulin G using monoclonal antibodies specific for nephropathy-related immunoglobulin G A novel immunoglobulin-like glycoprotein is described which has been found to occur in high concentrations in the urine of patients with glomerulosclerosis of end-stage renal disease. This nephropathy-related protein is also found at a high frequency in t... | 08/05/1997 |
| 5650324 | Inhibitor and anti-inhibitor monoclonal antibodies specific for horseradish peroxidase Monoclonal antibodies have been prepared which are of the IgG isotype and are highly specific for horseradish peroxidase. One group of antibodies inhibits at least about 95% of the normal activity of horseradish peroxidase when bound to the enzyme. A seco... | 07/22/1997 |
| 5648225 | Method of using a multi-purpose beagent for subclassification of nucleated blood cells A multipurpose reagent system for rapid analysis of a whole blood sample allowing the determination of at least five classes of peripheral white blood cells, nucleated red blood cells, and lymphocyte immunophenotyping on automated hematology instrumentati... | 07/15/1997 |
| 5648220 | Methods for labeling intracytoplasmic molecules The invention features a method of labeling a cell containing an intracytoplasmic target molecule involving (1) permeabilizing the plasma membrane of the cell so that (a) a reagent capable of detectably labeling the intracytoplasmic target molecule can tr... | 07/15/1997 |
| 5645983 | Core antigen protein of hepatitis C virus, and diagnostic method and kit using the same The invention relates to a DNA molecule, a polypeptide expressed by the molecule, their use in diagnosis and their methods of production. More particularly, the invention relates to a diagnostic DNA molecule, a diagnostic protein, diagnostic antibodies an... | 07/08/1997 |
| 5645997 | Assay and treatment for demyelinating diseases such as multiple sclerosis, related hybridomas and monoclonal antibodies The present invention relates to the diagnosis of multiple sclerosis. More specifically, this invention relates to an assay for detecting antigen(s) associated with multiple sclerosis. The present invention also relates to the generation of hybridomas whi... | 07/08/1997 |
| 5643550 | Method of treating colorectal carcinoma lesion and composition for use therein This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface antigen associated with the colorectal carcinoma lesion an... | 07/01/1997 |
| 5644033 | Monoclonal antibodies that define a unique antigen of human B cell antigen receptor complex and methods of using same for diagnosis and treatment Three monoclonal antibodies defining extracellular epitopes of a unique heterodimeric glycoprotein complex consisting of the human mb-1 protein and the human B29 protein which react with one or more leukemia lymphoma cell specimens selected from the group... | 07/01/1997 |
| 5641865 | Interaction system comprising a surfactant-stabilized disperse aqueous phase containing an antibody or antibody fragment An interaction system, including an antibody or, antibody fragment having functional capability, which comprises a surfactant-stabilized microheterogeneous dispersion of aqueous phase in a water-immiscible medium, said aqueous phase containing an amount o... | 06/24/1997 |
| 5641690 | Method of determining haptens, use of method and components useful in method A method is described for determining a hapten which method comprises (i) contacting the hapten with a binding partner of the hapten, whereby the hapten becomes bound to some of the binding partner, (ii) contacting the unbound binding partner with a secon... | 06/24/1997 |
| 5641638 | Monoclonal antibodies against Mycoplasma pneumoniae, hybridomas producing these, methods for the preparation thereof, and the use thereof The invention relates to monoclonal antibodies and fragments thereof which are specific for Mycoplasma pneumoniae P2 protein and have a cross-reactivity of 1% or less with five other species of the genus Mycoplasma and other pathogen species of the concom... | 06/24/1997 |
| 5639624 | Monoclonal antibodies specific for metallic cations and method therefor The invention is directed to monoclonal antibodies, their fragments, single chains and polypeptide mimics of their hypervariable regions which immunoreact with bare small moieties such as metallic cations the hybridomas for production of the monoclonal an... | 06/17/1997 |
| 5629194 | Isolated porcine pancreatic cells for use in treatment of diseases characterized by insufficient insulin activity Isolated porcine pancreatic cells, isolated populations of such cells and methods for isolating and using the cells to treat subjects with diseases characterized by insufficient insulin activity are described. The porcine pancreatic cells are preferably n... | 05/13/1997 |
