William F. Semple, a dentist, was awarded the first US Patent on chewing gum in 1869. His recipe contained powdered chalk.
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| Number | Title | Issue Date |
| 4364932 | Monoclonal antibody to human cytotoxic and suppressor T cells and methods of preparing same Hybrid cell line for production of monoclonal antibody to an antigen found on normal human cytotoxic and suppressor T cells. The hybrid is formed by fusing splenocytes from immunized CAF1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and thera... | 12/21/1982 |
| 4363799 | Monoclonal antibody to human T cells, and methods for preparing same Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells. The hybrid is formed by fusing splenocytes from immunized Balb/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal... | 12/14/1982 |
| 4361509 | Ultrapurification of factor VIII using monoclonal antibodies A method of preparing high purity procoagulant protein comprising the steps of (a) adsorbing a VIII:C/VIII:RP complex from a plasma or commercial concentrate source of factor VIII onto agarose beads bound to a monoclonal antibody specific to VIII:RP, (b) ... | 11/30/1982 |
| 4361550 | Complement-fixing monoclonal antibody to human suppressor T cells and methods of preparing same Hybrid cell line for production of monoclonal antibody to an antigen found on normal human suppressor T cells. The hybrid is formed by fusing splenocytes from immunized CAF1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of... | 11/30/1982 |
| 4361549 | Complement-fixing monoclonal antibody to human T cells, and methods of preparing same Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells and cutaneous T lymphoma cells. The hybrid is formed by fusing splenocytes from immunized CAF1 mice with P3X63Ag8Ul myeloma cells. Diagnostic... | 11/30/1982 |
| 4359457 | Anti Thy 1.2 monoclonal antibody-ricin hybrid utilized as a tumor suppressant A tumor suppressive composition active against lymphoma consisting of an injection of hybrid protein anti Thy 1.2 monoclonal antibody-ricin and hyperosmotic lactose. The inoculation i.v. of murine tissues in vivo by lymphoma is made at -20 to -25 days and... | 11/16/1982 |
| 4357311 | Substrate for immunoassay and means of preparing same A method is disclosed for preparing an activated microporous substrate to which antibody may be covalently bonded through trichloro-triazine to yield an activated substrate which is very useful for many immunochemical reactions utilizing a flow-through pr... | 11/02/1982 |
| 4349528 | Monocolonal hybridoma antibody specific for high molecular weight carcinoembryonic antigen It has been determined that 180,000 dalton molecular weight carcinoembryonic antigen has an antigen site which is not shared by other molecular weight carcinoembryonic antigens, which are released by colorectal carcinoma. A hybridoma antibody specific for... | 09/14/1982 |
| 4322274 | Method of diagnosing cystic fibrosis patients and asymptomatic carrier of the cystic fibrosis gene An immunologic method has been devised enabling diagnosis of patients with cystic fibrosis, as well as asymptomatic carriers of the cystic fibrosis gene. Mono-specific antibody to Cystic Fibrosis Protein (CFP) is inserted into a first position on an elect... | 03/30/1982 |
| 4284412 | Method and apparatus for automated identification and enumeration of specified blood cell subclasses Specified subclasses of blood cells, such as of lymphocytes, are automatically identified based on utilization of antigenic determinants on the cell surface, their reactivity with antibodies which fluoresce under known circumstances, and utilization of pr... | 08/18/1981 |
| 4196265 | Method of producing antibodies Continuous cell lines of genetically stable fused cell hybrids capable of producing large amounts of monoclonal antibodies against specific viruses and their antigenic determinants have been developed. The cell lines are fused cell hybrids between viral a... | 04/01/1980 |
| 4172124 | Method of producing tumor antibodies Antibodies demonstrating a specificity for malignant tumors are produced by somatic cell hybrids between hypoxanthine phosphoribosyltransferase deficient myeloma cells and spleen or lymph cells derived from an animal previously primed with tumor cells.... | 10/23/1979 |