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| Number | Title | Issue Date |
| 6905882 | Diagnostic devices and apparatus for the controlled movement of reagents without membranes The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount related to t... | 06/14/2005 |
| 6897030 | Immunoassays for human brain natriuretic peptide Immunoassays and antibodies useful in conducting them for human and canine brain natriuretic peptide are described. ... | 05/24/2005 |
| 6893831 | Immunoassay of PIVKA-II The present invention provides an immunoassay for specifically measuring with high sensitivity PIVKA-II in serum or plasma through antigen-antibody reaction by adding an animal serum containing thrombin and/or an antibody reacting with human fibrin-like related subs... | 05/17/2005 |
| 6884417 | Monoclonal antibodies immunoreactive with lipopolysaccharide binding protein (LBP) and methods of their use The present invention concerns a method of treating LBP-mediated LPS-induced myeloid cell activation comprising administering a therapeutically effective amount of an anti-LBP monoclonal antibody molecule. A therapeutic composition comprising anti-LBP antibody molec... | 04/26/2005 |
| 6875580 | Antibodies specific for plasmacytoid dendritic cells The invention provides immunological reagents (antibodies) capable of binding to plasmacytoid dendritic cells (pDC), to cell lines which express such antibodies and to a process for identifying and purifying plasmacytoid dendriticcells from tissues containing pDC us... | 04/05/2005 |
| 6855508 | ELISA for VEGF The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions, and other pathologies. Antibody-sandwich ELISA method and kits for VEG... | 02/15/2005 |
| 6849720 | Monoclonal antibodies to the human LDL receptor, their production and use There are provided monoclonal antibodies to the LDL receptor which are useful for the identification and purification of LDL and in treatment of e.g. hepatitis C infection. ... | 02/01/2005 |
| 6844162 | Assays for TSH receptor autoantibodies A method and kit for monitoring autoantibodies to thyroid stimulating hormone (TSH) receptor in a sample of body fluid, which employs the steps of: (i) incubating TSH receptor with a sample of body fluid; (ii) reac... | 01/18/2005 |
| 6838250 | Immunoassay for C-reactive protein The present invention relates to new CRP immunoassay compositions. The compositions include a low affinity anti-human CRP monoclonal antibody, and an antiidiotypic antibody raised against it. The invention further provides a method for obtaining antiidiotypic monocl... | 01/04/2005 |
| 6830937 | Method for generating and identifying antibodies directed against a B7 The invention provides a method for generating and identifying antibodies directed against a B7 antigen having SEQ ID NO. 8 or a fragment of SEQ ID NO. 8, which antibodies inhibit B cells from binding CD28, comprising immunizing an animal with the B7 antigen so as t... | 12/14/2004 |
| 6828114 | Monoclonal antibody against apolipoprotein A-I The present invention is drawn to a monoclonal antibody reacting specfically with (1) apoA-I occurring in HDL containing no apoA-II and having a molecular weight of 150,000 or less; and (2) apoA-I not binding to a lipid; a hybridoma producing this antibody; a method... | 12/07/2004 |
| 6825000 | Immunoassay reagent and immunoassay method An immunoassay reagent is obtained whereby a microscale substance such as an antigen or antibody can be assayed at a high sensitivity, and whereby a need to separate a reacted substance, e.g., an immunoreacted substance, from an unreacted substance can be eliminated... | 11/30/2004 |
| 6824986 | Methods for measuring in vivo cytokine production The present invention involves techniques for evaluating in vivo cytokine production through the in vivo capture of secreting cytokines by labeled cytokine-binding reagents, followed by in vitro measurement of serum levels of captured cytokine. The methods of the pr... | 11/30/2004 |
| 6815169 | Identification and expression of a novel kinesin motor protein The invention provides isolated nucleic acid and amino acid sequences of TL-γ, antibodies to TL-γ, methods of screening for TL-γ modulators using biologically active TL-γ, and kits for screening for TL-γ modulators. ... | 11/09/2004 |
| 6806056 | Fluorescent capture assay for kinase activity employing an anti-phosphotyrosine antibody as both the capture agent and detecting agent A method for determining the level of tyrosine kinase activity in a biological sample is disclosed. The method employs an anti-phosphotyrosine antibody as both the capture agent and the detecting agent. The detecting antibody is labeled with a fluorescent label, for... | 10/19/2004 |
| 6803209 | Preparation for use in cell culture in which an interfering compound is absent or depleted A cell culture preparation and methods are provided which are suitable for production in cells of a first protein in a class of proteins where the medium is deficient in a second protein in a related class, where the second protein is normally present in the serum a... | 10/12/2004 |
| 6800462 | Production of recombinant proteins in vivo and use for generating antibodies The invention is directed to methods of producing a protein by administering a nucleic acid encoding the protein to an animal. Following the administration of the nucleic acid to the animal, the protein is produced in vivo and is isolated by removing a biological sa... | 10/05/2004 |
| 6797814 | Protein purification A method for purifying proteins by Protein A chromatography is described which comprises the steps of: (a) adsorbing the protein to Protein A immobilized on a solid phase comprising silica or glass; (b) removing contaminants bound to the solid phase by washing the s... | 09/28/2004 |
| 6790662 | Method of isolating CD8+ cells, and related hybridoma cells antibodies and polypeptides This invention provides a method of isolating CD8+ cells which employs an antibody which specifically binds to CD8 molecules present on the surface of CD8+ cells but does not activate the CD8+ cells once bound. This invention also pr... | 09/14/2004 |
| 6790625 | Antibodies to placental protein 13 A monoclonal antibody (Mab) capable of binding Placental Protein 13 (pp-13) is disclosed. Also disclosed are hybridoma clone producing the Mab, an immunoassay using the Mab for measuring the level of PP-13 in a biological fluid, and a kit for measuring the level of ... | 09/14/2004 |
| 6787320 | In vitro methods for determining in vivo thrombotic events Diagnostic systems, methods, polypeptides and antibodies for detecting the presence of C-terminal hGPIIb fragment of the platelet receptor GPIIb-IIIa in a body fluid sample are disclosed. ... | 09/07/2004 |
| 6777193 | Methods for diagnostic and/or treatment of antiphospholipids antibodies-related diseases, and devices Methods for detecting anti-lipidic particles antibodies and lipidic particles in cellular membranes for the diagnosis of diseases associated to the antiphospholipid syndrome are disclosed. Kits or sets to put these methods of diagnosis into practice are also disclos... | 08/17/2004 |
| 6764827 | Anti-human medullasin monoclonal antibody process for producing the same and immunoassay using the same A monoclonal antibody by which medullasin that is a kind of serine proteases existing in granulocytes, production process thereof and an immunoassay of human medullasin using the antibody are disclosed. The monoclonal antibody specifically recognizes human medullasi... | 07/20/2004 |
| 6756234 | Stabilization of particles and reduction of sample discordance in immunoassays using casein coating of particles It has been found that casein and salts of casein are useful as replacements for, or in addition to, BSA as materials for coating solid phases, particularly magnetic particles, used for immunoassays and other binding assays for separation of the desired analyte. By ... | 06/29/2004 |
| 6753153 | Markers for identification and isolation of pancreatic islet α and β progenitors The differential expression of marker proteins in a targeted population provides a means of identifying and isolating cells. A population of cells associated with the regeneration of pancreatic islets is shown to express certain proteins, including the cell surface ... | 06/22/2004 |
| 6750328 | Antibodies for detection of water treatment polymers The invention provides an antibody having an affinity to water treatment polymers. The antibodies of the invention are used in assays to determine the presence or concentration of a water treatment polymer in a fluid or aqueous system. ... | 06/15/2004 |
| 6743595 | Method and diagnostic kit for diagnosis of endometriosis The invention relates to a method and a kit for the diagnosis of endometriosis using blood and endometrial leukocyte markers or a combination thereof. The marker is a surface antigen from endometrial or blood leukocytes. ... | 06/01/2004 |
| 6727102 | Assays, antibodies, and standards for detection of oxidized and MDA-modified low density lipoproteins Immunoassays for malondialdehyde-modified low density lipprotein (MDA-modified LDL) and oxidized low density lipprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the assays, and a storage-stable standard (which may be used as a calibrat... | 04/27/2004 |
| 6722062 | Capsular polysaccharides from enterococci The present invention is directed to a method for purifying polysaccharides capable of inducing the production of high titers of opsonic antibodies that kill strains of enterococcal bacteria. In addition, the invention is directed to the antigens produced by this pu... | 04/20/2004 |
| 6719975 | Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin A method of making antibodies to hirudin by immunizing with an immunogenic composition containing polymerized hirudin monomers in the absence of carrier protein is taught. ... | 04/13/2004 |
| 6716410 | Reagents and methods for diagnosing, imaging and treating atherosclerotic disease The invention provides a novel human Mab Fab, cloned by phage display, and its use in diagnostic and therapeutic methods. In particular the invention provides a method for analyzing the OxLDL components of atherosclerotic plaques in vivo and a means to determine the... | 04/06/2004 |
| 6716640 | Stabilization and amplification of electrochemiluminescence signals The invention concerns the stabilization and amplification of electrochemiluminescence signals in detection methods. ... | 04/06/2004 |
| 6716594 | Monoclonal antibody The invention relates to monoclonal antibody capable of specific binding to the molecular weight of 20 kDa variant of human growth hormone. This monoclonal antibody has no substantial binding to hGH of molecular weight 22 kDa. The invention also relates to th... | 04/06/2004 |
| 6709873 | Method for production of antibodies to specific sites of rapamycin This invention relates to the production of polyclonal and monoclonal antibodies to specific sites of rapamycin (Sirolimus). The reactivity of these poly and monoclonal antibodies make them particularly useful for immunoassays for therapeutic drug monitoring (TDM). ... | 03/23/2004 |
| 6709833 | Monoclonal antibody recognizing phosphatidylinositol-3,4-diphosphate A novel monoclonal antibody that specifically recognizes phosphatidylinositol-3,4-biphosphate (PI-3,4-P2) but does not cross-react with structurally similar phospholipid antigens is advantageous for PI-3,4-P2-specific immunoassay. The gene in the variable regions of... | 03/23/2004 |
| 6696060 | Methods for sterilizing preparations of monoclonal immunoglobulins Methods are disclosed for sterilizing preparation of monoclonal immunoglobulins to reduce the level of active biological contaminants such as viruses, bacteria, yeasts, molds, mycoplasmas, prions and parasites.... | 02/24/2004 |
| 6692920 | Antibodies to a chemokine expressed in inflamed adenoid The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which enco... | 02/17/2004 |
| 6692930 | Monoclonal antibodies specific to cooked meats Monoclonal antibodies are provided which bind to heat-treated proteins of meats. The antibodies are useful in detecting the presence of an exogenous meat in a cooked or raw meat sample. Furthermore, the antibodies can be used to determine the end point te... | 02/17/2004 |
| 6689566 | Methods, kits, and antibodies for detecting parathyroid hormone The present invention relates to novel methods and devices for detecting whole or non-fragmented parathyroid hormone (wPTH) in a biological sample. In particular, a novel monoclonal or polyclonal antibody or antibody fragment is used that is specific for ... | 02/10/2004 |
| 6673561 | Diagnostic test for thrombotic or thromboembolic disease Thrombotic or thromboembolic disease is detected or monitored by determining the presence or amount B in a urine sample.... | 01/06/2004 |
