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Class 436/548 - Monoclonal antibody


Subclass of Class 436 - Chemistry: analytical and immunological testing
Definition: Subject matter in which includes the production of antibodies
No. of patents: 1215
Last issue date: 06/29/2010


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NumberTitleIssue Date
5532137Anti-FR-900506 substance antibodies and highly-sensitive enzyme immunoassay method
Monoclonal or polyclonal antibodies capable of recognizing at least one antigenic determinant located on the FR-900506 compound, are disclosed. FR-900506 is a compound having pharmacological activities such as immunosuppressive activity and antimicrobial ...
07/02/1996
5529902Direct fluorescence-conjugated immunoassay for platelet activation
A method is provided to measure the extent of platelet activation by fluorometrically determining the extent of expression of P-selectin in a platelet sample in vitro, using a maximally activated platelet sample as a reference standard....
06/25/1996
5527713Anti-CD3 antibody-aminodextran conjugates for induction of T-cell activation and proliferation
The invention describes the use of novel aminodextran compounds containing about 5-20% by weight amine groups to bind a plurality of monoclonal antibodies. The resulting antibody-aminodextran compounds may be used to induce the activation and proliferatio...
06/18/1996
5525476Immunoassay, monoclonal antibody, and hybridoma
The present invention relates to a method for determining a lipophilic compound, comprising using an antibody tolerant to one or more organic solvents, and carrying out an antigen-antibody reaction in the presence of one or more organic solvents. By the p...
06/11/1996
5525473Assay for bone alkaline phosphatase
Monoclonal antibodies highly specific for human bone alkaline phosphatase, especially in the presence of human liver alkaline phosphatase, and their use in assays for human bone alkaline phosphatase are disclosed. A kit using the antibodies in an assay fo...
06/11/1996
5523210Bispecific antibody determinants
A homogenous sample of identical bispecific antibody determinants, each determinant being composed of two L-H half-molecules linked by disulfide bonds, each L-H half-molecule being specific for a different antigenic determinant and including at least the ...
06/04/1996
5521289Small organometallic probes
Small organometallic probes comprise a core of metal atoms bonded to organic moieties. The metal atoms are gold, silver, platinum, palladium, or combinations thereof. In one embodiment, a multifunctional organometallic probe comprises a core of metal atom...
05/28/1996
5518889Immunoassay methods using single polypeptide chain binding molecules
The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and heavy chain aggregate variable region of an antibody, to geneti...
05/21/1996
5516640Method of determination of pivka
To provide a simple immunochemical assay of a PIVKA of every kind (PIVKA-VII, -IX, -X, -C, -S or -Z: protein induced by vitamin K absence) corresponding to a vitamin K-dependent protein. It has been confirmed that a PIVKA of every kind can be determined a...
05/14/1996
5516639Antibodies specific for human prostate glandular kallkrein
The present invention provides an isolated preparation of monoclonal or polyclonal antibodies which react specifically with human prostate-specific glandular kallikrein (hK2), but which do not cross-react with human prostate-specific antigen (PSA), as wel...
05/14/1996
5512443Second generation monoclonal antibodies having binding specificity to TAG-72 and human carcinomas and methods for employing the same
The present invention relates to second generation monoclonal antibodies having binding specificity to a tumor associated glycoprotein having an approximate molecular weight of >106 d ("TAG-72") and human carcinomas and methods for employing th...
04/30/1996
5506111Method of immunological assaying of human osteocalcin, reagent and kit therefor, antibody to human osteocalcin, hybridoma producing said antibody, and method of producing it
A method of immunologically assaying intact human osteocalcin in a human assay sample is provided by using an antibody having an epitope in a region of an amino acid sequence 1 to 20 on the N-terminal side of human osteocalcin and an antibody having an ep...
04/09/1996
5503981Isolation of fetal cells from maternal blood to enable prenatal diagnosis
This invention relates to a method for the isolation of trophoblast (placental) cells from the blood of a pregnant mammal so as to provide the essential starting material, namely cells derived from the fetus, to enable genetic and/or biochemical informati...
04/02/1996
5501988Anti hCG-ଲ core monoclonal antibody, its production and use
A hybridoma capable of producing monoclonal antibody for recognizing hCG-ଲ core region and hCG-ଲ subunit, which is obtained by cell fusion of an antibody producing cell of a mammal immunized with hCG-ଲ subunit and a lymphoid cell line, a...
03/26/1996
5500348Basophil-binding monoclonal antibody, method for separation of basophils, method for chemical mediator release from basophils, and method for testing release of basophil-derived chemical mediators
The monoclonal antibodies of the present invention makes it possible to separate basophils suitable for the IgE-mediated specific chemical mediator release test, because it retains its reactivity with basophils even after being immobilized onto a solid ca...
03/19/1996
5500347Method for the purification of cytokeratin 20 and its use for the production of antibodies
In a process for the purification of cytokeratin 20 (CK 20), a cytoskeletal fraction of cells containing CK 20 is produced, the proteins present therein are separated by gel electrophoresis or/and by chromatography and the CK 20 is isolated from the gel o...
03/19/1996
5500345Hybridomas producing monoclonal antibodies specific for C-reactive protein and methods for detection of C-reactive protein
Monoclonal antibodies specifically reacting with the side face of a C-reactive protein (CRP), i.e., monoclonal antibodies specifically reacting with the side face of a disk-like subunit of a C-reactive protein (CRP), hybridoma producing the monoclonal ant...
03/19/1996
5496705Monoclonal antibody specific for rat synaptophysin
An object of this invention is to provide a monoclonal antibody which can quantitatively analyze a very small amount of synaptophysin present in tissues using a small amount of the antibody in accordance with a complement fixation test. Disclosed is a mon...
03/05/1996
5494791Monoclonal antibodies against glycated low density lipoprotein
An antibody specifically immunoreactive with glycated LDL and methods for using the antibody are provided. The antibody can be used for quantitating amounts of glycated LDL in a sample, for monitoring glycemic control in diabetic patients, for diagnosing ...
02/27/1996
5491066Anti-human ceruloplasmin monoclonal antibody
Disclosed is a monoclonal antibody which specifically reacts with active human ceruloplasmin as well as a method for diagnosing Wilson's disease using the same. The monoclonal antibody of the present invention specifically reacts with active human cerulop...
02/13/1996
5486453Antibodies to human papillomavirus latent proteins, diagnostic systems and methods
The present invention relates to polypeptides that immunologically mimic papillomavirus latent proteins and to antibodies and monoclonal antibodies that immunoreact with papillomavirus latent proteins. Systems and methods for detecting the presence and ty...
01/23/1996
5484735Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids
An immunoassay for a protein that is non-enzymatically glycosylated on the alpha amino group of its N-terminal amino acid, the immunoassay comprising: providing a sample containing the glycosylated protein; reacting the glycosylated protein with a reducin...
01/16/1996
5480895Method of producing antibodies to a restricted population of T lymphocytes, antibodies produced therefrom and methods of use thereof
This invention relates to a method of obtaining antibodies specific to a population of T-lymphocytes (T cells) restricted by Vଲ gene usage. The invention also relates to the antibodies obtained and to methods of using them. According to the inventio...
01/02/1996
5480775Method for measuring a specimen by the use of fluorescent light
A method of and an apparatus for measuring a specimen by the use of fluorescence light which has the step of dyeing the specimen with a fluorescence dye, the step of applying light to the dyed specimen and exciting the fluorescence dye, and the step of de...
01/02/1996
5478926Monoclonal antibody against human IgE
The present invention provides novel monoclonal antibodies HE-22A, HE-35A, HE-39E, and HE-69B against human IgE, a mixture thereof, hybridomas producing the antibodies, and immunoassays of human IgE employing the antibodies, which are useful for clinical ...
12/26/1995
5478741Antibodies to the HRPII protein of plasmodium falciparum
Antibodies which recognize and bind to histidine rich protein II of Plasmodium falciparum. These antibodies exhibit improved specificity and affinity for the antigen which provides enhanced sensitivity in immunoassays. Peptides useful for generation of th...
12/26/1995
5478725v3 integrin as a predictor of endometriosis
Methods of screening for endometriosis comprise obtaining a sample of endometrium selected from menstrual cycle day 20 to 24, identifying the endometrial sample as nulliparous, contacting the endometrium with a monoclonal antibody for 댣 ...
12/26/1995
5474905Antibodies specific for streptococcus pneumoniae hemin/hemoglobin-binding antigens
The present invention relates to the isolation of newly discovered hemin/hemoglobin-binding proteins of Streptococcus pneumoniae with approximate molecular weights of 18, 43, 55, 66 and 76 kDa, respectively, thereby providing bacterial-derived antigens an...
12/12/1995
5472884Detection of collagen degradation in vivo
Compositions useful in quantitating collagen peptides to determine the rate of bone resorption are prepared by treating bone with a protease, such as collagenase, and purifying the compositions so as to enrich them with peptides capable of binding to the ...
12/05/1995
5472849Method for detecting inflammation
A method for the detection of the presence of inflammation in a patient by measuring the amount of circulating intercellular adhesion molecule (cICAM-1) in a sample of one or more bodily fluids of the patient and then comparing the amount of cICAM-1 in th...
12/05/1995
5468846Monoclonal antibodies and method for the determination of human G-CSF
The present invention relates to a high affinity monoclonal antibody and to an enzyme immunoassay of human G-CSF using the antibody. The trace amount of human G-CSF in samples such as body fluids from patients with hematological disorders can be measured witho...
11/21/1995
5468651Method for determining haptens, use of method and components useful in method
A method is described for determining a hapten which method comprises (i) contacting the hapten with a binding partner of the hapten, whereby the hapten becomes bound to some of the binding partner, (ii) contacting the unbound binding partner with a secon...
11/21/1995
5468646Chemiluminescent acridinium salts
Acridinium sulfonylamides and isomers, such as phenanthridinium sulfonylamides, may be employed in applications including chemiluminmescent immunoassays. Methods for synthesis of these compounds include contacting an amine with a sulfonylhalide to form a ...
11/21/1995
5468622Salt stabilization of antibody-enzyme conjugates heat-dried into paper
New and useful methods of producing stabilized enzyme antibody conjugates are disclosed which are particularly useful in forming multi-layer immunoassay test devices. In particular, the invention concerns the formation of a manganese ion and enzyme-antibo...
11/21/1995
5468616Method and apparatus for rapid mixing of small volumes for enhancing biological reactions
A method and apparatus for accelerating at least one definitive biological reaction including increasing the accuracy of determinations made therefrom. The reaction involves selected viable biological cells which are prepared in a small sample volume and ...
11/21/1995
5466610Immunoassays for insulin sensitivity enhancers, insulin sensitivity enhancer antibodies, and non-thiazolidinedione insulin sensitivity enhancer compositions
Methods have been developed to produce novel compounds by covalently coupling thiazolidinedione insulin sensitivity enhancers (ISEs) to proteins. These novel compounds are well suited for producing antibodies, which are specific for thiazolidinedione ISEs...
11/14/1995
5464752Automated analyzer for screening cells or formed bodies for enumeration of populations expressing selected characteristics
A method and apparatus for automatically and rapidly, retrieving, counting and/or analyzing at least one selected white blood cell population and/or subset thereof of a whole blood sample or portion thereof. A volume of a biological sample containing the ...
11/07/1995
5464741Palladium (II) octaethylporphine alpha-isothiocyanate as a phosphorescent label for immunoassays
A phosphorescence assay system. The phosphorescent label for immunoassays is palladium (II) octaethylporphine alphaisothiocyanate. The labeling agent has a Stokes shift of not less than 150 nanometers. Method for preparing the palladium (II) phosphorescen...
11/07/1995
5453359Immunoassay and kit for in vitro detection of soluble DesAABB fibrin polymers
An in vitro immunoassay to detect and quantitate soluble crosslinked and non-crosslinked DesAABB fibrin polymers in a sample from a subject. The assay can be used to support a diagnosis of, to evaluate, and to monitor, in a mammalian subject, a thrombotic...
09/26/1995
5453356Luminescent metal chelate labels and means for detection
A chemical moiety is disclosed which comprises a chemical, biochemical, or biological substance attached to one or more electrochemiluminescent organometallic compounds. In a preferred embodiment of the invention the substance is attached to one or more r...
09/26/1995
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