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| Number | Title | Issue Date |
| 8304258 | Methods of producing monoclonal antibodies specific for human hepcidin The present invention concerns antibodies specific for the C-terminus of human hepcidin, and related methods and kits for diagnosing and/or treating a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragment... | 11/06/2012 |
| 8298836 | Isolated Polynucleotide encoding modified fab' antibody, expression vector, and transformed host cell Disclosed is an isolated polynucleotide encoding a modified Fab' antibody, which includes an Fd chain and an L chain with the Fd chain including a CH1 region and the L chain including a CL region, wherein the modified Fab' antibody further includes a cysteine for bi... | 10/30/2012 |
| 7745230 | Estrogen receptors and methods of use The present invention provides isolated polypeptides having an amino acid sequence having at least 70% identity to SEQ ID NO:20, wherein the polypeptide has ER-α36 activity. The invention further provides methods for identifying agents that bind to such polypeptide... | 06/29/2010 |
| 7439025 | Antibodies binding a gamma carboxyglutamic acid displaying epitope Antibodies are described, which are suitable for identification of γ-carboxyglutamic acid (Gla), said antibodies having an ability of identifying Gla residues in proteins and/or peptides, while not reacting with glutamic (Glu) residues in corresponding proteins and... | 10/21/2008 |
| 7411050 | Monoclonal blocking antibody to human RANKL Disclosed herein are kits for detecting RANKL protein or nucleic acids, the kits comprising isolated human RANKL polypeptides, RANKL nucleic acids and/or antibodies specific for RANKL. ... | 08/12/2008 |
| 7410771 | Reagent and method for detecting a sporozoite antigen A reagent and method for the specific and highly sensitive detection of C. parvum in which the reagent is an antibody for a soluble C. parvum sporozoite antigen and the method is an immunoassay in which the antibody is used to detect or quantify C. ... | 08/12/2008 |
| 7410768 | Test methods and devices A method and test device for differentiating between states of an analyte that can exist in different forms, such as follicle stimulating hormone (FSH). The method or test device uses a pair of specific binding agents, especially monoclonal antibodies, in two assays... | 08/12/2008 |
| 7399636 | Diagnostic kit for predicting pregnancy outcome The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early ... | 07/15/2008 |
| 7399470 | Sandwich immunoassay kits for detecting ciguatoxin CTX3C A sandwich immunoassay kit for detecting ciguatoxins based on a combination of two anti-ciguatoxin CTX3C monoclonal antibodies produced by hybridomas, 3D11 (deposited at IPOD, AIST under accession number FMRM PB-8293) and 10C9 (FMRM PB-8292). In particular, one of t... | 07/15/2008 |
| 7390627 | Assays, antibodies, and standards for detection of oxidized and MDA-modified low density lipoproteins Immunoassays for malondialdehyde-modified low density lipoprotein (MDA-modified LDL) and oxidized low density lipoprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the assays, and a storage-stable standard (which may be used as a calibr... | 06/24/2008 |
| 7390631 | Diagnosis and monitoring of systemic lupus erythematosus and of scleroderma Methods for diagnosing and monitoring systemic lupus erythematosus (SLE) or scleroderma by determining, in a blood sample from the individual being diagnosed or monitored, complement component C4d deposited on surfaces of red blood cells in the sample, and optionall... | 06/24/2008 |
| 7390489 | Monoclonal antibody selectively recognizing listeria monocytogenes, hybridoma producing the antibody, test kit comprising the antibody and detection method of listeria monocytogenes using the antibody The present invention relates to a monoclonal antibody binding specifically to the p60 protein of Listeria monocytogenes, a hybridoma cell producing the monoclonal antibody, a test kit comprising the monoclonal antibody, and a method for detecting Listeria... | 06/24/2008 |
| 7385040 | Antibody purification The present invention relates to a method of separating antibodies from contaminants in a solution, which method comprises contacting the solution with a chromatography resin comprised of a support to which multi-modal ligands have been immobilised, wherein a multi-... | 06/10/2008 |
| 7374936 | Method and means for site directed therapy The present invention relates to the field of site directed therapy. More specifically the invention relates to site directed radio therapy, and provides a method for production of radioconjugates and an apparatus for radioimmunotherapy. The method, conjugates and a... | 05/20/2008 |
| 7368247 | Diagnostic assay for transmissible spongiform encephalopathies Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for TSEs, especially CJD. The invention provides a diagnostic assay for either of these markers, preferably by enzyme immunoassay using a specific antibody thereto. Since H-FABP is also a marke... | 05/06/2008 |
| 7348157 | Immunoassay A method for detection and/or quantification of cardiac troponin I (cTnI) in a sample derived from an individual's blood, the method being based on a sandwich immunoassay employing at least two capture antibodies and at least one tracer antibody, in which a first ca... | 03/25/2008 |
| 7332350 | Diagnostic device for distinguishing between normal and ectopic pregnancy and method for preparing the same A one-step diagnostic device for simultaneously detecting and distinguishing between a normal pregnancy and an ectopic pregnancy and methods for preparing the device are disclosed. Utilizing the device and principles of the present invention, normal pregnancy and ec... | 02/19/2008 |
| 7297500 | Use of Troponin I as a species marker protein for meat speciation in both raw and heat-processed products Monoclonal antibodies are provided which bind to heat-treated proteins of meats. The antibodies are useful in detecting the presence of an exogenous meat in a cooked or raw meat sample. Furthermore, the antibodies can be used to determine the end point temperature o... | 11/20/2007 |
| 7279561 | Anti-rapamycin monoclonal antibodies Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific... | 10/09/2007 |
| 7279166 | Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric in... | 10/09/2007 |
| 7276353 | Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric in... | 10/02/2007 |
| 7264939 | Method of detecting native proBNP The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a h... | 09/04/2007 |
| 7264801 | EG-VEGF nucleic acids and polypeptides and method of use The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules co... | 09/04/2007 |
| 7264938 | Method of detecting native proBNP The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a h... | 09/04/2007 |
| 7262018 | Agents that bind to and inhibit human cytochrome P450 2C19 The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 2C19 and lack of specific binding to other human ... | 08/28/2007 |
| 7259022 | Production of motif-specific and context-independent antibodies using peptide libraries as antigens A method is provided for producing motif-specific, context-independent antibodies which recognize a plurality of peptides or proteins within a genome that contain the same motif. The method includes the step of immunizing a host with a degenerate peptide library ant... | 08/21/2007 |
| 7252929 | Methods for identifying alpha PDGFR agonists and antagonists Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used successfully to produce a hitherto unknown type of human Platelet-Derived Growth Factor (PDGF) receptor protein free of other PDGF receptors. These proteins can be produ... | 08/07/2007 |
| 7252828 | Polysaccharide vaccine for infections The invention relates to compositions of the capsular polysaccharide/adhesin (PS/A) of staphylococci. The PS/A may be isolated or synthesized and includes various modifications to the structure of native PS/A based on the chemical characterization of PS/A. Th... | 08/07/2007 |
| 7244580 | Epsilon immunoglobulin chain derived peptides for induction of anti-IgE antibodies The present invention relates to identification of polypeptides useful for generating antibodies specific for non-human IgE, particularly equine IgE. The invention, therefore, also relates to antibodies that specifically bind to IgE and methods to detect IgE using t... | 07/17/2007 |
| 7241578 | Immunoassay method/equipment, biological component measurable toilet, anti-albumin monoclonal antibody, cell strain producing the same, and albumin detection kit The immunoassay method of this invention measures the content of a subject substance in a sample. The method includes the steps of: (a) preparing a mixed solution by mixing the sample and an antibody solution including a first monoclonal antibody and a second monocl... | 07/10/2007 |
| 7235641 | Bispecific antibodies The present invention discloses bispecific antibodies comprising two antibody variable domains on a single polypeptide chain, wherein a first portion of the bispecific antibody is capable of recruiting the activity of a human immune effector cell by specifically bin... | 06/26/2007 |
| 7232891 | Anti-human luteinizing hormone-related antibodies and uses thereof The subject invention provides a method for detecting the presence of human malignant cells in a sample of tumor cells, which comprises contacting the sample with an antibody directed to an epitope present on the β subunit of human luteinizing hormone or on intact ... | 06/19/2007 |
| 7229781 | Diagnostic kit for predicting the onset of menopause The present invention provides methods to quantitate the hLHβ core fragment in a sample. The present invention now makes it possible to evaluate the metabolism of hLH in premenopausal, perimenopausal and postmenopausal women and to distinguish between normal and ab... | 06/12/2007 |
| 7230085 | Anti-DOTA antibody The present invention relates to an antibody or antibody fragment that binds to 1,4,7,10-tetrazacyclododecane-N,N′,N″,N′″-tetraacetic acid (DOTA),which is bound to an alkyl-amino group through one of its pendant carb.oxyl groups. ... | 06/12/2007 |
| 7230086 | Assay for YKL-40 as a marker for degradation of mammalian connective tissue matrices The invention is a method of identifying the presence of a disease state in a mammal which is associated with degradation of connective tissue in the mammal which contains the protein known as YKL-40. The method is a competitive immunoassay for YKL-40. It can be use... | 06/12/2007 |
| 7229624 | Ordered molecular presentation of antigens, method of preparation and use The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the production of vaccines for the prevention of infectious diseases, the treatme... | 06/12/2007 |
| 7220838 | Antibodies that specifically bind hedgehog-derived polypeptides The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G↓CF site recognized by the autopro... | 05/22/2007 |
| 7220559 | Development of human monoclonal antibodies and uses thereof This invention provides: a heteromyeloma, other than B6B11, capable of producing a trioma when fused with a human lymphoid cell, wherein the trioma is capable of producing a monoclonal antibody-secreting tetroma when fused with a second, antibody-secreting human lym... | 05/22/2007 |
| 7198954 | Methods for predicting pregnancy outcome in a subject by hCG assay The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early ... | 04/03/2007 |
| 7195926 | Antibodies to a cathepsin C homolog The present invention provides nucleotide and amino acid sequences that identify and encode a new cathepsin C homolog (RCP) expressed in THP-1 cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode RCP, expression... | 03/27/2007 |
