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| Number | Title | Issue Date |
| 4351760 | Novel alkyl substituted fluorescent compounds and polyamino acid conjugates Fluorescent antigen conjugates are provided comprising antigens covalently bonded to at least one 2,7-dialiphatic substituted-9-phenyl-6-hydroxy-3H-xanthen-3-one, wherein the 1- and 8-positions are unsubstituted. Also provided are novel fluorescent c... | 09/28/1982 |
| 4331590 | ଲ-Galactosyl-umbelliferone-labeled protein and polypeptide conjugates An improved specific binding assay method and reagent for determining a ligand in a liquid medium employing, as an enzyme-cleavable substrate label, a residue having the formula: wherein G is a glycone, D is a dye indicator moiety, and R is a linking grou... | 05/25/1982 |
| 4326008 | Protein specific fluorescent microspheres for labelling a protein Highly fluorescent, stable and biocompatible microspheres are obtained by copolymerizing an acrylic monomer containing a covalent bonding group such as hydroxyl, amine or carboxyl, for example, hydroxyethylmethacrylate, with an addition polymerizable fluo... | 04/20/1982 |
| 4318707 | Macromolecular fluorescent quencher particle in specific receptor assays Homogeneous immunoassay employing a light absorbing particle to which a member of an immunological pair (mip)-ligand and antiligand is bound and a labeled mip, where the label is light emitting. The labeled mip becomes bound to the light absorbing particl... | 03/09/1982 |
| 4318846 | Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers Diether symmetrically substituted fluoresceins are provided having at least one anionic group and a linking functionality. Depending upon the site of substitution, the compounds can be used as fluorescers absorbing at wavelengths in excess of 500 nm or as... | 03/09/1982 |
| 4302438 | Antigen, antiserum and immunoassay for theophylline By injecting a host animal with a member of a particular group of antigens [a theophylline-(7)-alkanecarboxylic acid covalently bonded to an immunogenic carrier (IGC) via the carboxyl group], antibodies, advantageously employed in determining small amount... | 11/24/1981 |
| 4294817 | Method of fluoro immunoassay A new surface immunoassay method is performed with two test surfaces. The method is used where serum samples may contain both an antibody for which it is desirable to test, and also competing sera constituents which may be present in indeterminate amounts... | 10/13/1981 |
| 4287300 | Charge effects in enzyme immunoassays A method for determining a member of a specific binding pair-ligand and receptor (antiligand). Reagents employed include a first modified member which provides an electrical field due to the presence of a plurality of ionic charges and a second modified m... | 09/01/1981 |
| 4283382 | Fluorescent labels comprising rare earth chelates There are described stabilized fluorescent labels comprising rare earth chelate incorporated in polymeric beads derived from a latex. Labeled reactive proteinaceous species such as labeled immunoreagents comprising the stabilized fluorescent labels having... | 08/11/1981 |
| 4272506 | Purification of reagents by disulfide immobilization A method is provided for preparing immunoassay reagents involving labeled members of specific binding pairs substantially enriched relative to contaminating labeled materials. The method involves conjugating a member of a specific binding pair to a suppor... | 06/09/1981 |
| 4272505 | Competitive binding analysis by fluorescence Thyroid hormones such as thyroxine and triiodothyronine are assayed in biological fluid samples by a competitive binding analysis in which a fluorescent label is used. Upon formation of complexes, the fluorescence of the labelled compound is released, and... | 06/09/1981 |
| 4261968 | Fluorescence quenching with immunological pairs in immunoassays Immunoassays are provided employing antibodies and fluorescer-quencher (F-Q) chromophoric pair, wherein one or both of the chromophoric pair are bonded to antibodies. Depending on the particular ligand of interest, various reagent combinations can be empl... | 04/14/1981 |
| 4252783 | Reducing fluorescent background in fluorescent immunoassays Background fluorescence which interferes with the measurement of an analyte in fluorescent immunoassays in serum samples is substantially diminished by treating the serum sample with a sufficient amount of a peroxidic compound, either organic or inorganic... | 02/24/1981 |
| 4231750 | Methods for performing chemical assays using fluorescence and photon counting Improved methods for determining very low concentrations of substances present in fluid samples are provided by employing light emitting tracer compounds and (1) counting the photons emitted therefrom while discriminating against noise, nonspecific light,... | 11/04/1980 |
| 4201763 | Solid phase immunofluorescent assay method An assay method suitable for antigens (or haptens) including proteins and polypeptides utilizing antibodies for the unknown protein or polypeptide in which the antibodies are covalently bound to water insoluble hydrophylic polymeric particles. Appropriate... | 05/06/1980 |
| 4186182 | Serological test for Neisseria gonorrhoeae antibodies Serological method for determining presence of Neisseria gonorrhoeae antibodies in human sera and products utilized in such testing.... | 01/29/1980 |
| 4184847 | Method of indicating rheumatoid factors A method of indicating rheumatoid factors, primarily such rheumatoid factors which belong to immunoglobulin classes other than the immunoglobulin class IgM, in an aqueous sample. The sample is reacted in the presence of the complement factor C1q in non-bo... | 01/22/1980 |
| 4182856 | Reagents for use in binding assays to determine diphenylhydantoin Reagents for use in binding assays, particularly immunoassays, to determine diphenylhydantoin and for preparing reagents employed in such assays, including ଲ-galactosyl-umbelliferone-diphenylhydantoin conjugates, diphenylhydantoin immunogens, and N | 01/08/1980 |
| 4153417 | Method of indicating rheumatoid factors A method of indicating rheumatoid factors belonging to at least one of the immunoglobulin classes IgM, IgG and IgA in an aqueous sample is disclosed. According to this method any complement factor C1q present in the sample is pacified in a manner known pe... | 05/08/1979 |
| 4152411 | High specific activity labeled substances A new diagnostic labeled spine tool is disclosed for use in immunoassay techniques, e.g., determination of a component of the antigen-antibody reaction. The new tool is a labeled-spine material product of the formula ##STR1## where R is an organic gr... | 05/01/1979 |
| 4123614 | Novel assay reagents The present invention relates to novel assay reagents, their composition, methods of preparation, and use in the detection and measurement of various biological systems and/or components, e.g. enzymes, antibodies, antigens, and periodate concentration. Th... | 10/31/1978 |
| 4043989 | Oxazepam derivatives for immunoassay reagents Compounds are provided for use in the preparation of reagents which can be used in immunoassays for benzdiazepines, particularly as their urinary metabolites. The compounds are non-oxo-carbonyl derivatives conjugated to the 3-position of the benzdiazepine... | 08/23/1977 |
| 4035316 | Cell specific, variable density, polymer microspheres Biocompatible polymeric microspheres having an average diameter below about 3 microns and having density at least 15% greater or lesser than organic cells and having covalent binding sites are provided in accordance with this invention. The microspheres a... | 07/12/1977 |
| 3996344 | Phenethylamine antigenic conjugates, their preparation, antibodies and use Antigenic phenethylamine conjugates are produced by blocking the amine of the phenethylamine hapten with a group, coupling of the phenethylamine to a carrier, and removal of the blocking group. Specific phenethylamines useful in this invention are ampheta... | 12/07/1976 |
| 3992516 | Direct fluorescent antibody composition and method for P. Pneumocystis carinii A Pneumocystis carinii antiserum conjugated with fluorescein isothiocyanate composition, its use being the detection of Pneumocystis carinii organisms and the method of making this composition using an enzyme purifying technique.... | 11/16/1976 |
| 3988115 | Diagnostic method for determining pathological condition by antigen-combining capacity of lymphocytes A method for determining in a patient the presence or absence of a pathological condition producing a specific immune response. The antigen associated with the pathological condition is labeled and added to a sample of the patient's lymphocytes and to a c... | 10/26/1976 |
| 3959650 | Method for detecting and identifying allergy A method is described for determining the presence of an antigen-specific antibody in a vertebrate. Effluvial tissue is exposed to antigens from known sources and is subsequently examined to detect the presence or absence of a conjugate compound formed be... | 05/25/1976 |
| 3939350 | Fluorescent immunoassay employing total reflection for activation Receptors are employed to which one or more fluroescent molecules are bound. When the receptors are bound to the epitopic sites on the surface and light of predetermined wave length is directed toward the surface, the fluorescing molecules are activated a... | 02/17/1976 |
