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| Number | Title | Issue Date |
| 8183060 | Luminescent polymer and use thereof in bioassay It is an object of the present invention to provide a luminescent polymer that is useful as a luminescent signal probe for labeling and detecting a target substance at high sensitivity in bioassay, and to provide the application of said luminescent polymer to bioass... | 05/22/2012 |
| 8158444 | Fluorescent methods and materials for directed biomarker signal amplification Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chr... | 04/17/2012 |
| 8148173 | Polymerizable chemiluminescent compounds Disclosed are compounds having the formula: wherein R1 is selected from the group consisting of hydrogen, C1-C6 alkyl, amino, N—C1-C6-alkylam... | 04/03/2012 |
| 8137990 | Compositions for chemiluminescent detection of hydrogen peroxide Methods and compound useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of the formula: is reacted with peroxide. Sig is a non-polymeric organic group, B is a boron atom, and each... | 03/20/2012 |
| 8119422 | Stable acridinium esters with fast light emission Chemiluminescent acridinium esters are provided which are fast light emitting and hydrolytically stable. The chemiluminescent acridinium esters are useful labels in assays for detecting or quantifying analytes. ... | 02/21/2012 |
| 8034636 | Hydrophilic chemiluminescent acridinium labeling reagents In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydropho... | 10/11/2011 |
| 7883903 | Dendritic chemiluminescent substrates Chemiluminescent substrate delivery systems comprising a conjugate a dendrimer and at least one chemiluminescent substrate are provided. The substrate delivery systems can also include a chemiluminescence enhancer. The dendrimer/chemiluminescent substrate conjugates... | 02/08/2011 |
| 7875467 | Applications of acridinium compounds and derivatives in homogeneous assays Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent acridinium compounds include acridinium esters with electron donating fun... | 01/25/2011 |
| 7824928 | Hydrophilic chemiluminescent acridinium labeling reagents In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydropho... | 11/02/2010 |
| 7803638 | Fluorescent label The present invention relates to a fluorescent label characterized by containing a hydrophilic polymer having an anionic group, a polyether derivative, and a phosphor, in which the phosphor is bound to the hydrophilic polymer via the polyether derivative, and also r... | 09/28/2010 |
| 7785904 | High quantum yield acridinium compounds and their uses in improving assay sensitivity The present invention relates to hydrophilic, high quantum yield acridinium compounds. It has been discovered that the placement of electron-donating groups in the acridinium ring system increases the amount of light that is emitted by the corresponding acridinium c... | 08/31/2010 |
| 7745229 | Chemoselective fluorgenic molecular linkers and methods for their preparation and use The present invention describes a bioconjugation strategy and compounds that are useful therein in which a fluorescent signal is produced when two molecular or supramolecular entities are linked by chemoselective combination of one linker having an azido or halide s... | 06/29/2010 |
| 7736911 | Activity-based probes for protein tyrosine phosphatases Provided are compounds capable of covalently binding to a protein tyrosine phosphatase (PTP). The compounds comprise Formula A: Also provided are compositions comprising one of the above compounds covalently bound to a member... | 06/15/2010 |
| 7704756 | Fluorogenic dyes Fluorogenic or chromogenic dyes are useful as reporter molecules for detecting cell entry by a specific molecule. ... | 04/27/2010 |
| 7700375 | Fluorescent labeling of specific protein targets in vitro and in vivo New methods are provided for the post-genomic era that will permit the analysis of the dynamic expression and localization of gene products in living cells. Herein we propose the development of such a method from a bioorganic approach involving organic synthesis and... | 04/20/2010 |
| 7695980 | Chemiluminescent compounds and their use The present invention relates to novel chemiluminescent compounds, to a method for synthesizing these compounds, to derivatives and conjugates comprising these compounds, to the use of these compounds or conjugates thereof in chemiluminescence based assays, especial... | 04/13/2010 |
| 7687282 | Detection of transmembrane potentials by optical methods Methods and compositions are provided for determining the potential of a membrane. In one aspect, the method comprises: (a) introducing a first reagent comprising a hydrophobic fluorescent ion capable of redistributing from a first... | 03/30/2010 |
| 7682839 | Methods using novel chemiluminescent labels Methods using chemiluminescent label compounds and chemiluminescent labeled conjugates are provided. The compounds comprise an acridan ring bearing an exocyclic ketene dithioacetal group and further contain a labeling substituent which permits attachment to compound... | 03/23/2010 |
| 7662644 | Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation The invention provides peptide synthons having protected functional groups for attachment of desired moieties (e.g. functional molecules or probes). Also provided are peptide conjugates prepared from such synthons, and synthon and conjugate preparation methods inclu... | 02/16/2010 |
| 7611909 | Near infrared chemiluminescent acridinium compounds and uses thereof A method for the detection or quantitation of unlabeled target analyte in a biological sample, the method comprising labeling a target analyte for a biological sample suspected of containing unlabeled target analyte with an acridinium compound to form a labeled targ... | 11/03/2009 |
| 7517701 | Luminescent lanthanide complexes Systems, including compositions, kits, and methods, particularly for photoluminescence applications. The systems may include, among others, (1) organic chelators, (2) complexes between the chelators and lanthanide ions, and (3) precursors, derivatives, and uses ther... | 04/14/2009 |
| 7442558 | Phthalamide-lanthanide complexes for use as luminescent markers The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention ... | 10/28/2008 |
| 7435603 | Labeling proteins with dyes that are insoluble or only sparingly soluble in water The proteins in a biological sample that is sought to be analyzed for its protein composition by an electrophoretic or chromatographic procedure are coupled to a dye in an unusually efficient manner by combining the sample with a solid dry composition containing the... | 10/14/2008 |
| 7432105 | Self-calibration system for a magnetic binding assay A self-calibrated, magnetic binding assay (e.g., sandwich, competitive, etc.) for detecting the presence or quantity of an analyte residing in a test sample is provided. The magnetic binding assay includes detection probes capable of generating a detection signal (e... | 10/07/2008 |
| 7422908 | Chemiluminescent 1,2-dioxetanes A method of generating light through chemiluminescence involves providing a stable 1,2-dioxetane of the formula: Wherein (a) R1 and R2 are each, individually, a chemical reactive site or when fused tog... | 09/09/2008 |
| 7416898 | Chemiluminescent 1,2-dioxetanes A method of generating light through chemiluminescence involves providing a stable 1,2-dioxetane of the formula: Wherein (a) R1 and R2 are each, individually, a chemical reactive site or when fused tog... | 08/26/2008 |
| 7404912 | Salicylamide-lanthanide complexes for use as luminescent markers The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the inventio... | 07/29/2008 |
| 7402398 | Measuring receptor homodimerization The invention provides methods and kits for detecting and/or measuring receptor homodimers on a cell surface membrane. In one aspect, the methods employ pairs of probes comprising binding compounds and a cleaving probe, such that at least one binding compound binds ... | 07/22/2008 |
| 7402397 | Detecting and profiling molecular complexes Methods are provided for detecting the formation of complexes of molecules, especially proteins, in a sample, such as a cell or tissue lysate. In one aspect, a cleaving probe specific for a first protein in a complex and one or more binding compounds specific for on... | 07/22/2008 |
| 7402677 | Fluorescent through-bond energy transfer cassettes based on xanthine and pyronin derivatives A TBET cassette including at least one xanthine- or pyronin-based compound as a donor or acceptor is disclosed. Also, a method of TBET cassette design in which four criteria may be used is provided. TBET cassettes may be used to label biological molecules, in clothi... | 07/22/2008 |
| 7393656 | Methods and compositions for risk stratification The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and... | 07/01/2008 |
| 7390670 | Signalling compounds and methods for detecting hydrogen peroxide Methods and compound useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of the formula: is reacted with peroxide. Sig is a non-polymeric organic group, B is a boron atom, and each... | 06/24/2008 |
| 7390631 | Diagnosis and monitoring of systemic lupus erythematosus and of scleroderma Methods for diagnosing and monitoring systemic lupus erythematosus (SLE) or scleroderma by determining, in a blood sample from the individual being diagnosed or monitored, complement component C4d deposited on surfaces of red blood cells in the sample, and optionall... | 06/24/2008 |
| 7387880 | Method for monitoring resting and activated platelets in unfixed blood samples The amount of platelet surface proteins in a sample may be measured by collecting a sample containing platelets into a collection tube containing a platelet stabilizing composition, labeling the platelet surface protein and detecting by cytometry. ... | 06/17/2008 |
| 7381535 | Methods and compositions for detecting receptor-ligand interactions in single cells The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of co... | 06/03/2008 |
| 7381572 | Reagents and procedures for multi-label high-specificity labeling A detectable complex and methods for use thereof are provided herein. The detectable complex includes: at least one target material; a first peptide tag bound to the at least one target material; and a second peptide tag bound to the at least one target material. Th... | 06/03/2008 |
| 7376256 | Method for analyzing chemical and or biological samples by means of particle images A method for analyzing chemical and/or biological samples comprises the production of a particle image (42) of at least one particle included in the sample. Subsequently, a particle surface (10) of the at least one particle included in the particle ima... | 05/20/2008 |
| 7371524 | Substituted azaporphyrins as fluorescence labels The present invention relates to marker components, fluorescent probes, oligonucleotides, hybridization assays, and immunoassays using such products, and methods for making such products. According to the present invention, detectably labeled marker components are p... | 05/13/2008 |
| 7371829 | Haptens, immunogens, antibodies and conjugates to ketamine and its metabolites The invention provides haptens, immunogens comprising such haptens coupled to an antigenicity-conferring carrier material, conjugates comprising such haptens bonded to a labelling agent as well as, antibodies raised against such immunogens and capable of binding wit... | 05/13/2008 |
| 7368296 | Solid phases optimized for chemiluminescent detection Solid supports for chemiluminescent assays are provided. The solid support includes a plurality of probes covalently or physically attached to the support surface and a chemiluminescent enhancing moiety incorporated onto the surface or into the bulk of the support. ... | 05/06/2008 |
